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Echocardiography CKD

Hatice Ayan, Rabia Akilli, Bulent Kaya, Saime Paydas, Ertan Kara, Asligul Cureoglu
OBJECTIVES: In patients with advanced-stage chronic kidney disease, renal insufficiency, arterial stiffness, and vascular calcification are strong predictors of cardiovascular risk. Signal peptide-CUB-EGF-like protein-1 (SCUBE1) levels increase during platelet activation and acute ischemic events. Here, we evaluated associations between SCUBE1 levels and electrocardiographic/echocardiographic findings, epicardial adipose tissue thickness, and carotid intimamedia thickness in patients with chronic kidney disease...
January 2019: Experimental and Clinical Transplantation
Yue Zhao, Cong Wang, Xue Hong, Jinhua Miao, Yulin Liao, Fan Fan Hou, Lili Zhou, Youhua Liu
In type 2 cardiorenal syndrome, chronic heart failure is thought to cause or promote chronic kidney disease; however, the underlying mechanisms remain poorly understood. We investigated the role of Wnt signaling in heart and kidney injury in a mouse model of cardiac hypertrophy and heart failure induced by transverse aortic constriction (TAC). At 8 weeks after TAC, cardiac hypertrophy, inflammation, and fibrosis were prominent, and echocardiography confirmed impaired cardiac function. The cardiac lesions were accompanied by upregulation of multiple Wnt ligands and activation of β-catenin, as well as activation of the renin-angiotensin system (RAS)...
February 8, 2019: Kidney International
Mohamed Abdelaziz El-Gamasy, Walid Ahmed El-Shehaby, Maaly M Mabrouk
Background: Cardiovascular morbidity (CVM) is the main etiology of mortality in children and adolescents with chronic kidney disease (CKD). CKD associated cardiovascular mortality is more common in children with diastolic cardiac dysfunction which was considered as an early indicator for death, while increased left ventricular mass (LVM) is a strong independent risk factor for these patients. Vitamin D deficiency was previously studied as one of the risk factors for CVM. Aim: The aim of the work was to investigate the relationship between biomarkers of mineral bone disorder including serum 25(OH) Vitamin D3 (25-OH D3), phosphorus and calcium × phosphorus (Ca×Po4) product with diastolic cardiac function and LVM in children and adolescents with CKD...
January 2019: Annals of Pediatric Cardiology
Márta Sárközy, Renáta Gáspár, Ágnes Zvara, Andrea Siska, Bence Kővári, Gergő Szűcs, Fanni Márványkövi, Mónika G Kovács, Petra Diószegi, László Bodai, Nóra Zsindely, Márton Pipicz, Kamilla Gömöri, Krisztina Kiss, Péter Bencsik, Gábor Cserni, László G Puskás, Imre Földesi, Thomas Thum, Sándor Bátkai, Tamás Csont
Chronic kidney disease (CKD) is a public health problem that increases the risk of cardiovascular morbidity and mortality. Heart failure with preserved ejection fraction (HFpEF) characterized by left ventricular hypertrophy (LVH) and diastolic dysfunction is a common cardiovascular complication of CKD. MicroRNA-212 (miR-212) has been demonstrated previously to be a crucial regulator of pathologic LVH in pressure-overload-induced heart failure via regulating the forkhead box O3 (FOXO3)/calcineurin/nuclear factor of activated T-cells (NFAT) pathway...
February 4, 2019: Scientific Reports
T E Rudenko, E S Kamyshova, M P Vasilyeva, I N Bobkova, N I Solomakhina, M Y Shvetsov
AIM: To examine the frequency and risk factors for the development of diastolic dysfunction (DD) of the left ventricle (LV) of the heart in patients with chronic kidney disease (CKD). MATERIALS AND METHODS: The study included 225 patients with stage I-CKD of non-diabetic etiology (median age 47.0 years, 50.2% of women). Depending on the degree of decrease in the glomerular filtration rate (GFR), all patients were divided into 3 groups. Group 1 (n=70) consisted of patients with GFR 89-45 ml / min / 1...
September 20, 2018: Terapevticheskiĭ Arkhiv
Jae-Geun Lee, Jong Wook Beom, Joon Hyouk Choi, Song-Yi Kim, Ki-Seok Kim, Seung-Jae Joo
BACKGROUND: In patients with acute heart failure (AHF), diastolic dysfunction, especially pseudonormal (PN) or restrictive filling pattern (RFP) of left ventricle (LV), is considered to be implicated in a poor prognosis. However, prognostic significance of diastolic dysfunction in patients with ischemic heart disease (IHD) has been rarely investigated in Korea. METHODS: We enrolled 138 patients with IHD presenting as AHF and sinus rhythm during echocardiographic study...
December 2018: Journal of cardiovascular imaging
Rodrigue Garcia, Charles Guenancia, François Le Gal, Michaela Rehman, Vincent Tao, Luc Christiaens, Pierre Ingrand, Bruno Degand
BACKGROUND: While a multicentre trial has demonstrated that the SonR™ contractibility sensor is as effective as echocardiography-guided optimization at improving response to cardiac resynchronization therapy, an association between SonR™ values and clinical endpoints has not been established. AIMS: The primary objective was to assess the predictive value of SonR™ signal evolution regarding cardiovascular events in patients implanted with a cardiac resynchronization therapy device...
December 24, 2018: Archives of Cardiovascular Diseases
Jarrin D Penny, Fabio R Salerno, Ranveer Brar, Eric Garcia, Krista Rossum, Christopher W McIntyre, Clara J Bohm
Background: Exercise preconditioning provides immediate protection against cardiac ischemia in clinical/preclinical studies in subjects without chronic kidney disease. In individuals requiring renal replacement therapy, hemodialysis (HD) results in significant circulatory stress, causing acute ischemia with resultant recurrent and cumulative cardiac injury (myocardial stunning). Intradialytic exercise (IDE) has been utilized to improve functional status in individuals receiving HD. The objective of this study was to explore the role of IDE as a preconditioning intervention and assess its effect on HD-induced myocardial stunning...
December 22, 2018: Nephrology, Dialysis, Transplantation
Huiliang Qiu, Chunlan Ji, Wei Liu, Yuchi Wu, Zhaoyu Lu, Qizhan Lin, Zheng Xue, Xusheng Liu, Huanlin Wu, Wei Jiang, Chuan Zou
Chronic kidney disease (CKD) causes atrial structural remodeling and subsequently increases the incidence of atrial fibrillation (AF). Atrial connexins and inflammatory responses may be involved in this remodeling process. In this study, nephrectomy was used to produce the CKD rat model. Three months post-nephrectomy, cardiac structure, function and AF vulnerability were quantified using echocardiography and electrophysiology methods. The left atrial tissue was tested for quantification of fibrosis and inflammation, and for the distribution and expression of connexin (Cx) 40 and Cx43...
2018: Frontiers in Physiology
Zhuo Xu, Hui-Ping Gu, Yang Gu, Wei Sun, Kun Yu, Xi-Wen Zhang, Xiang-Qing Kong
Objective: To study the coronary microvascular function in older patients with heart failure with preserved ejection fraction (HFpEF) using an invasive pressure-temperature sensor guidewire. Methods: Patients undergoing echocardiography and cardiac catheterization examinations for exertional dyspnea and a positive stress test were retrospectively enrolled from January 2014 to November 2017, and were allocated into the control group or HFpEF group. The HFpEF group was secondary divided into two groups according to the age of 65...
November 2018: Journal of Geriatric Cardiology: JGC
A Savarese, M Probo, C Locatelli, A L Gazzonis, S A Zanzani, G Traini, T Vitiello, P G Brambilla
In humans, iron deficiency represents a relevant occurrence in heart failure (HF), with or without anaemia, and is associated with the worst outcome. Moreover, chronic kidney disease (CKD) is a well-known comorbidity of HF and is strongly associated with the risk of developing anaemia. The most common cause of HF in dogs is myxomatous mitral valve disease (MMVD). To the best of our knowledge, no studies have examined the iron status in dogs with HF, with and without CKD. The aim of this retrospective study was to evaluate the iron status in dogs affected by MMVD and how strong is the relation with HF...
September 2018: Polish Journal of Veterinary Sciences
Eglė Tamulėnaitė, Rūta Žvirblytė, Rūta Ereminienė, Edita Žiginskienė, Eglė Ereminienė
Background and objectives : Chronic kidney disease (CKD) increases the risk of cardiovascular diseases even in its early stages and is associated with structural and functional cardiac abnormalities. The aim of this study was to use speckle-tracking echocardiography (STE) to evaluate left and right ventricle mechanics and function, markers of subclinical dysfunction in patients with end-stage renal disease (ESRD) undergoing haemodialysis. Methods : Patients with ESRD undergoing regular haemodialysis and with preserved left ventricle (LV) ejection fraction (EF) ( n = 38) were enrolled in this retrospective study...
November 13, 2018: Medicina
Il Young Kim, June Hyun Kim, Min Jeong Kim, Dong Won Lee, Cheol Gu Hwang, Miyeun Han, Harin Rhee, Sang Heon Song, Eun Young Seong, Soo Bong Lee
BACKGROUND: Cardiovascular disease (CVD) is a leading cause of death in patients with chronic kidney disease (CKD). Left ventricular hypertrophy (LVH) and left ventricular diastolic dysfunction (LVDD) are known as predictors of CVD in these patients. Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker of acute kidney injury. Recently, elevated NGAL levels have been reported in patients with CVD. This study aimed to evaluate the association between plasma NGAL levels and LVH/LVDD in patients with CKD...
2018: PloS One
Yunan Zhou, Matthias Hellberg, Evangelia Kouidi, Asterios Deligiannis, Peter Höglund, Naomi Clyne
BACKGROUND: Abdominal aortic calcification (AAC) is an established risk factor for cardiovascular events in patients with chronic kidney disease (CKD). We hypothesized that AAC is associated with a decline in glomerular filtration rate (GFR) as well as with some other cardiovascular risk factors. MATERIALS AND METHODS: This is a cross-sectional analysis of baseline data from a randomized controlled clinical trial (RENEXC). A total of 151 patients (aged 66 ± 14 years) with an average measured GFR (mGFR) of 22...
October 12, 2018: Clinical Nephrology
Shun Kizawa, Takahide Ito, Kanako Akamatsu, Noboru Ichihara, Shimpei Nogi, Masatoshi Miyamura, Yumiko Kanzaki, Koichi Sohmiya, Masaaki Hoshiga
Patients with chronic kidney disease (CKD) experiencing atrial arrhythmia are hypothesized to have elevated CHADS2 and CHA2 DS2 -VASc scores, thereby predisposed to left atrial (LA) thrombus formation and subsequent thromboembolism. We examined possible association of LA thrombogenic milieu (TM) with CKD in patients with nonvalvular atrial fibrillation. A total of 581 patients (181 women; mean age, 67 years) who underwent transesophageal echocardiography were examined. Patients were divided into 4 groups based on the estimated glomerular filtration rate (eGFR) (ml/min/1...
September 13, 2018: American Journal of Cardiology
Noman Ali, Smriti Saraf, Dominik Schlosshan, Michael Cunnington, Christopher J Malkin, Daniel J Blackman
Trans-catheter aortic valve implantation (TAVI) has become an established treatment for inoperable and high-surgical risk patients with severe, symptomatic aortic stenosis (AS). Post-procedural acute kidney injury (AKI) is a frequent complication following TAVI and is associated with increased mortality. Patients with pre-existing chronic renal impairment are at particularly high risk. The etiology of post-TAVI AKI is multi-factorial, but the principal procedural issues are contrast-induced nephropathy, and renal hypoperfusion secondary to intra-procedural hypotension...
October 2018: Journal of Cardiology Cases
Anna Chuda, Joanna Berner, Małgorzata Lelonek
BACKGROUND: Care for patients with heart failure (HF) in Poland requires improvement. OBJECTIVES: The aim of this study was to define the journey of a HF patient, taking into account the specialization of the hospital ward and further highly specialized outpatient care. MATERIAL AND METHODS: Using the medical system CliniNET® we analyzed 214 consecutive patients hospitalized due to HF (ICD-10: I50) in the period from September 1, 2015, to December 31, 2015, and also the data from post-discharge outpatient care in a 3-month period...
October 2, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Giovanni Fazio, Ilaria Dentamaro, Rosanna Gambacurta, Pasquale Alcamo, Paolo Colonna
BACKGROUND AND OBJECTIVE: Patients with atrial fibrillation (AF) and advanced chronic kidney disease (CKD) are at high risk of adverse events and are complicated to manage. There is little evidence on the effects of non-vitamin K oral anticoagulants in patients with severe CKD. Preliminary data in patients taking edoxaban whose creatinine clearance fell below 30 mL/min showed a low risk of stroke and major bleeding. The aim of our study is to test the safety of edoxaban 30 mg/day in patients with severe renal impairment with an estimated glomerular filtration rate (eGFR) of 15-29 mL/min...
November 2018: Clinical Drug Investigation
Mattia Arrigo, Pietro E Cippà, Alexandre Mebazaa
PURPOSE OF THE REVIEW: To summarize current advances in the understanding and management of heart failure (HF) in patients with advanced chronic kidney disease (CKD). RECENT FINDINGS: Diagnosis of HF and treatment of congestion are crucial in the management of patients with advanced CKD to reduce symptoms, preserve organ function, and improve outcomes. Echocardiography and cardiovascular biomarkers may help to differentiate cardiac from non-cardiac components of overhydration...
October 2018: Current Heart Failure Reports
Manal Moustafa Mahmoud, Asmaa Shamseldeen, Laila Ahmed Rashed, Amal Elham Fares, Ashraf Shamaa, Doaa Mostafa Gharib
Volume overload, the common phenomenon in patients with chronic kidney disease is associated with cardiovascular risk factors.Howeverits contribution to development of adverse cardiovascular outcomes in those patients is not fully studied.Thus, the presentworkaimed to study the effect of highsalt-induced volumeoverloadin a rat model of chronic kidney disease on cardiac functions and geometry. Thirty adult male Sprague-Dawley rats were randomly divided to a sham operation anduninephrectomy, thenwere subjected to either a normal-salt (0...
August 4, 2018: Canadian Journal of Physiology and Pharmacology
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