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Samantha K Shirk, Stephanie A Manolis, Donna S Lambers, Kathleen L Smith
BACKGROUND: It has been established that delayed umbilical cord clamping in preterm infants results in improvement in neonatal anemia, need for transfusion, incidence of necrotizing enterocolitis, and intraventricular hemorrhage by increasing neonatal circulating blood volume. However, the effects of umbilical cord milking as an alternative to delayed clamping in preterm infants are unclear. OBJECTIVE: The primary objective of this study was to compare the effect of delayed clamping versus milking of the umbilical cord on the initial hematocrit concentration in preterm births (23-34 weeks)...
February 5, 2019: American Journal of Obstetrics and Gynecology
Zheng-Zheng Zhang, Yun-Feng Zhou, Wei-Ping Li, Chuan Jiang, Zhong Chen, Huan Luo, Bin Song
BACKGROUND: Although many strategies have been developed to modify the biological and biomechanical environment of the meniscal suture repair to improve the chances of healing, the failure rates remain high. Thus, new methods to promote meniscal regeneration and repair are needed. HYPOTHESIS: Administration of magnesium (via a repair using magnesium stitches) might enhance recruitment and adherence of endogenous stem cells to the site of the lesion, thereby promoting in situ meniscal regeneration and chondroprotective functions...
February 20, 2019: American Journal of Sports Medicine
Dirk Lindenblatt, Mareike Horn, Claudia Götz, Karsten Niefind, Ines Neundorf, Markus Pietsch
The ubiquitously expressed Ser/Thr kinase CK2 is a key regulator in a variety of key processes in normal and malignant cells. Due to its distinctive anti-apoptotic and tumor-driving properties, elevated levels of CK2 have frequently been found in tumors of different origin. In recent years, development of CK2 inhibitors has largely been focused on ATP-competitive compounds; however, targeting the CK2α/CK2β interface has emerged as a further concept that might avoid selectivity issues. In order to address the CK2 subunit interaction site, we have synthesized halogenated CK2β-mimicking cyclic peptides modified with the cell-penetrating peptide sC18 to mediate cellular uptake...
February 20, 2019: ChemMedChem
Rafael Rodríguez, Emilio Quiñoá, Ricardo Riguera, Félix Freire
Interconversion between extended and bent structures at the pendant groups of a chiral polyene framework [poly(phenylacetylene) with (R)-(2-methoxy-2-phenylacetyl)glycine residues linked to 4-vinylanilines] allows the reversible colorimetric transformation from stretched to compressed helical cis-transoid polyenic structures through manipulation of the flexible spacer. This transformation generates either organogels (stretched helical form) or nanoparticles (compressed helical form) under the control of polar/low polar stimuli respectively and opens the way to the development of new sensors and stimuli-sensitive materials based on these concepts...
February 20, 2019: Small
Oliver Trapp, Jan Felix Scholtes
Supramolecular ligands offer a variety of possibilities to control selectivity in catalysis due to their non-covalent interactions with other molecules. Conceptionally, enantioselectivity can be induced by interaction of chiral additives or products with the interaction sites of a supramolecular catalyst. However, the design of such catalysts is very challenging due to the complex fusion of recognition sites and catalytically active center. Here, we report the design of a new class of fluxional biphenyl bisphosphinite (BIBIPHOS) ligands decorated with amino acid-based diamide interaction sites that undergo spontaneous desymmetrization...
February 20, 2019: Angewandte Chemie
Charly B J Brouillard, Jonathan J Crook, Thelma A Lovick
OBJECTIVES: High-frequency (kHz) stimulation of preganglionic pelvic nerve afferents can inhibit voiding in both anesthetized and conscious rats. The afferents travel via the S1 sacral nerve root, which is easier to access than the distal pelvic nerve fibers within the abdominal cavity. We therefore investigated whether voiding could be inhibited by high-frequency stimulation at S1 and how this compared to distal pelvic nerve stimulation. METHODS: Urethane-anesthetized rats were instrumented to record bladder pressure and abdominal wall electromyogram and to stimulate the distal preganglionic pelvic nerve bundle and S1 sacral root...
February 20, 2019: Neuromodulation: Journal of the International Neuromodulation Society
Xiaolan Liu, Wenwen Fan, Zhixiang Lu, Yu Qin, Shaoxiong Yang, Yuan Li, Yanxiong Liu, Qiue Cao, Li-Yan Zheng
During the last decade, the controllable reversible phase transition of functional materials has received growing interest, showing unique performances for various technological applications. Although many metal-organic frameworks (MOFs) possess lamellar structure, the reversible structural transformation of MOFs between three-dimensional (3D) phase and two-dimensional (2D) phase remains a largely unexplored area. Herein, we report for the first time a europium MOFs with unprecedented reversible morphology in the different solvent at room temperature...
February 20, 2019: Chemistry: a European Journal
Bruno S Vieira, Joao G Caramori Junior, Gerusa S S Correa, Ines G Colvara, Emanuele Brusamarelo, Thuani V S Pereira, Silvana A P V Barbosa, Cleber F S Oliveira
An experiment was conducted to evaluate the effects of phytase (PHY), alone or in combination with citric acid (CA), on growing Japanese quails under moderate and severe phosphorus (P) restriction. For this, 504 one-day-old female quails were distributed in a completely randomised design with seven treatments and six replications. Treatments consisted of the following diets: (a) positive control (PC): formulated according to quails nutritional requirements; (b) negative control 40% (NC40 ): PC with 40% less aP; (c) NC40 +PHY; (d) NC40 +PHY+CA; (e) negative control 65% (NC65 ): PC with 65% less aP; (f) NC65 +PHY; (g) NC65 +PHY+CA...
February 20, 2019: Journal of Animal Physiology and Animal Nutrition
Klaus-Peter Lesch
Converging evidence from new epidemiologic, genetic, epigenetic, neuroimaging, and experimental model findings are further refining a long-standing concept, regarding the underlying neurobiology of attention-deficit/hyperactivity disorder (ADHD): that ADHD onset and its persistence into adulthood are the result of dysregulated myelination and associated alterations in neuronal plasticity - linked to disrupted brain maturation and the persistence of cognitive and emotional impairments across the life span. If supported by further work, this concept represents a pathophysiologic mechanism amenable to therapeutic intervention...
March 2019: Journal of Child Psychology and Psychiatry, and Allied Disciplines
Juan J Costa
In this article, concepts extracted from the National Mental Health Law 22657 of the Argentine Republic are analyzed, from the perspective of the clinical practice carried out in a Center for Health and Community Action (CeSAC), located in the southern area of the Autonomous City of Buenos Aires (CABA). The following notions are analyzed: perspective of rights in health, accessibility, stigma associated with problematic consumption of substances, interdiscipline and intersectoriality. It is pointed out the scarce relative development that had in the norm the definition of notions linked to community practices in front of the extensive space occupied by the regulation of internment practices...
November 2018: Vertex: Revista Argentina de Psiquiatriá
Paula Tagliotti
The concept of gender dysphoria is used to designate the dissatisfaction resulting from the conflict between gender identity and gender assigned at birth (genetic, gonadal, genital and morphological). The most frequently encountered psychopathologies include depressive disorders, anxiety, substance abuse, disorders of the personality, and they present a suicide attempt rate of 19 to 25%. Being a manifestation of low prevalence, this report aims to describe the case of a patient with gender dysphoria and comment on the experience of the therapeutic approach...
November 2018: Vertex: Revista Argentina de Psiquiatriá
Alberto Velzi Diaz, Ana Tosi, Paola Benitez, Gisela Santanocito, Esmeralda Garcete, Yasmin Amado, Gianina Antezza, Natalia Cantero, Gabriela Córdoba
Eight years after the enactment of the National Mental Health Law (26.657), we consider it necessary to build spaces for debate on the potentialities and challenges in its practical implementation. This research addresses the mental health practices in the general public hospitals of the city of Rosario and Gran Rosario, Argentina, from the workers' perspective. Through a qualitative and exploratory / descriptive approach, semi-structured interviews were conducted with 23 mental health workers (nurses, psychiatrists, psychologists, social workers and therapeutic companions)...
November 2018: Vertex: Revista Argentina de Psiquiatriá
Katja Ried, Thomas Müller, Hans J Briegel
Collective phenomena are studied in a range of contexts-from controlling locust plagues to efficiently evacuating stadiums-but the central question remains: how can a large number of independent individuals form a seemingly perfectly coordinated whole? Previous attempts to answer this question have reduced the individuals to featureless particles, assumed particular interactions between them and studied the resulting collective dynamics. While this approach has provided useful insights, it cannot guarantee that the assumed individual-level behaviour is accurate, and, moreover, does not address its origin-that is, the question of why individuals would respond in one way or another...
2019: PloS One
Wanesa Onetti, José Carlos Fernández-García, Alfonso Castillo-Rodríguez
Self-concept influences identity and the way that people behave, and it fluctuates over time. The main purpose of this study was to analyze fluctuations in the dimensions of self-concept as a function of gender, educational level, grade, age, physical activity, and weight. In total, 712 Spanish adolescents who were in the 5th and 8th grades (354 boys and 358 girls) and 10 to 14 years old (M = 11.9; SD = 1.3) participated in this study. The Self-Concept Questionnaire, Form 5 was used to analyze several dimensions of self-concept (academic, social, emotional, family, and physical), using the average scores in each dimension...
2019: PloS One
Nynke de Groot, Gouke J Bonsel, Erwin Birnie, Nicole B Valentine
BACKGROUND: The concept 'vulnerability' is prevalent in the public domain, health care, social institutions and multidisciplinary research. Conceptual heterogeneity is present, hampering the creation of a common evidence-base of research achievements and successful policies. Recently an international expert group combined a specific literature review with a 2-stage Delphi procedure, arriving at a seemingly universal concept of vulnerability for the elderly with applications for research instruments...
2019: PloS One
Jsrg Saran, Jagadish R Padubidri
The concept of brain death has been a very intriguing topic and has taken many forms over the years. Brain stem death is a complex state of inactivity defined by the loss of reflexes of the pathways that pass through the brain stem, the 'shaft' of the brain which links the spinal cord to the cerebral cortex and the cerebellum where there is apnoea, loss of eye movement and pain sensation. There are many criteria, based on which a person can be said to be brain dead. The best recognised of these are the Harvard, Minnesota and Philadelphia criteria...
February 20, 2019: Medico-legal Journal
Maria Montefinese
Evidence from both behavioural and neuropsychological studies suggest that different types of organizational principles govern semantic representations of abstract and concrete words. The reviewed neuroimaging studies provide new evidence about the role of brain areas of the semantic network involved in the encoding of some types of information during processing of abstract and concrete concepts, characterizing better the neural underpinnings and the organizational principles of semantic representation of these types of word...
February 20, 2019: Journal of Neurophysiology
Arlene Wurzner-Ghajarzadeh, Philippe Braconnier, Michel Burnier, Menno Pruijm
The skin is the largest human organ playing an important role in protection, thermoregulation and sensation. Recent studies suggest that a new function has to be added: the storage of sodium. There is increasing evidence that sodium can accumulate in the skin, which suggests that the skin contributes to the regulation of sodium balance in humans, and possibly to the control of extracellular volume and blood pressure homeostasis. The main product of the skin is sweat. Body sweat contains electrolytes and urea...
February 20, 2019: Revue Médicale Suisse
Maria Filomena Passos Teixeira Cardoso, Olga Maria Pimenta Lopes Ribeiro, Maria Manuela Ferreira Pereira da Silva Martins
OBJECTIVE: To identify nurses' agreement on nursing conceptions with the potential to support their practice in the death and dying process context. METHOD: An exploratory and descriptive study with a quantitative approach was carried out with 3,451 nurses from 36 hospitals in Portugal, from July 2015 to March 2016. Data collection was carried out with the use of questionnaires and data analysis was carried out by means of descriptive and inferential statistics...
February 18, 2019: Revista Gaúcha de Enfermagem
Pétala Tuani Candido de Oliveira Salvador, Cláudia Cristiane Filgueira Martins Rodrigues, Marcos Antonio Ferreira Júnior, Maria Isabel Domingues Fernandes, José Carlos Amado Martins, Viviane Euzébia Pereira Santos
OBJECTIVE: To describe the process of hypermedia construction to support the teaching of the Systematization of the Nursing Care (SNC). METHOD: Methodological research of educational technology development. The hypermedia construction stages were conducted from February 2015 to March 2016 and integrated theoretical studies, focus group with professors and educational technology development process in the light of the referential Theory of Significant Learning. RESULTS: Hypermedia consists of interactive content and shows a splash screen with a concept map that guides a free way of learning about four structuring aspects in the SNC learning: concept, history and benefits; ethical-legal aspects; operationalization; and nursing process: steps and technical integration in nursing...
February 18, 2019: Revista Gaúcha de Enfermagem
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