keyword
https://read.qxmd.com/read/38527143/soluble-biomarkers-of-cerebrovascular-pathologies
#1
REVIEW
Kate E Foley, Donna M Wilcock
Vascular contributions to cognitive impairment and dementia (VCID) is an all-encompassing term that describes cognitive impairment due to cerebrovascular origins. With the advancement of imaging and pathological studies, we now understand that VCID is often comorbid with Alzheimer disease. While researchers in the Alzheimer disease field have been working for years to establish and test blood-based biomarkers for Alzheimer disease diagnosis, prognosis, clinical therapy discovery, and early detection, blood-based biomarkers for VCID are in their infancy and also face challenges...
April 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38425039/chronic-constipation-in-people-with-intellectual-disabilities-in-the-community-cross-sectional-study
#2
JOURNAL ARTICLE
Richard Laugharne, Indermeet Sawhney, Bhathika Perera, Delia Wainwright, Paul Bassett, Briony Caffrey, Maire O'Dwyer, Kirsten Lamb, Mike Wilcock, Ashok Roy, Katy Oak, Sharon Eustice, Nick Newton, James Sterritt, Ruth Bishop, Rohit Shankar
BACKGROUND: One-third to half of people with intellectual disabilities suffer from chronic constipation (defined as two or fewer bowel movements weekly or taking regular laxatives three or more times weekly), a cause of significant morbidity and premature mortality. Research on risk factors associated with constipation is limited. AIMS: To enumerate risk factors associated with constipation in this population. METHOD: A questionnaire was developed on possible risk factors for constipation...
March 1, 2024: BJPsych Open
https://read.qxmd.com/read/38377676/an-occupational-perspective-on-psychedelic-therapy-a-scoping-review
#3
JOURNAL ARTICLE
Gabriella Ann Hogan, Karen Elaine Wagner, Erin Tichenor, Tim Barlott
Background. Interest in the use of psychedelics for mental health therapy is burgeoning. Qualitative research methods are increasingly used to understand patient's experiences; however, there is a lack of literature that explores psychedelic use from an occupational perspective. Purpose. To conduct a scoping review of qualitative literature on the experiences of psychedelic use for the purpose of mental health therapy, through an occupational lens. Key Issues. Wilcock's occupational perspective of health was employed to analyze the use of psychedelics in mental health from an occupational perspective...
February 20, 2024: Canadian Journal of Occupational Therapy. Revue Canadienne D'ergothérapie
https://read.qxmd.com/read/38376077/patient-and-public-involvement-and-engagement-with-underserved-communities-in-dementia-research-reporting-on-a-partnership-to-co-design-a-website-for-postdiagnostic-dementia-support
#4
JOURNAL ARTICLE
Claudio Di Lorito, Sarah Griffiths, Marie Poole, Chandrika Kaviraj, Martin Robertson, Neil Cutler, Jane Wilcock
INTRODUCTION: Despite the advancements in Patient and Public Involvement and Engagement (PPIE), the voices of traditionally underserved groups are still poorly reflected in dementia research. This study aimed to report on a PPIE partnership between academics and members of the public from underserved communities to co-design Forward with Dementia-Social Care, a resource and information website supporting people receiving a dementia diagnosis. METHODS: The PPIE partnership was set up in four stages: 1-identifying communities that have been under-represented from PPIE in dementia research; 2-recruiting PPIE partners from these communities; 3-supporting PPIE partners to become confident to undertake their research roles and 4-undertaking research co-design activities in an equitable fashion...
February 2024: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://read.qxmd.com/read/38353570/the-brief-case-dirofilaria-species-causing-a-subcutaneous-nodule-after-a-visit-to-the-beach-in-florida
#5
REVIEW
Jonathan Wilcock, Bobbi S Pritt, Andrew P Norgan
No abstract text is available yet for this article.
February 14, 2024: Journal of Clinical Microbiology
https://read.qxmd.com/read/38341731/estimating-distances-to-baleen-whales-using-multipath-arrivals-recorded-by-individual-seafloor-seismometers-at-full-ocean-depth
#6
JOURNAL ARTICLE
Rose Hilmo, William S D Wilcock
Ocean bottom seismometer networks can record opportunistic data sets of 20-Hz fin whale calls. Because networks are often too sparse for multi-station tracking, single-station methods are needed to estimate call density. We investigated a method to range to singing fin whales at full ocean depths using the spacing of water column multiples. Calls were detected by cross-correlating a spectrogram with a template call. To enhance multipath signals, we considered 20-min windows and either summed the spectrograms of all calls aligned on the strongest detection before measuring the multipath spacing or measured the spacing directly from the autocorrelation of the cross correlation time series...
February 1, 2024: Journal of the Acoustical Society of America
https://read.qxmd.com/read/38291425/promoting-a-more-diverse-and-inclusive-research-workforce-through-the-research-scholars-program
#7
JOURNAL ARTICLE
Nancy E Schoenberg, Jimmy Robinson, Margaret McGladrey, Lisa A Cassis, Darwin Conwell, Kevin J Pearson, Lisa R Tannock, Donna Wilcock, Stephanie White
BACKGROUND: Novel and comprehensive approaches are needed to address shortcomings in the diversity and inclusiveness of the scientific workforce. In response to this need and informed by multiple programs and data sources, we created the Research Scholars Program (RSP). The RSP is a yearlong program for early-career faculty with an overall objective to overcome barriers to the academic success, retention, progression, and promotion of groups underrepresented in biomedical and behavioral research...
January 30, 2024: BMC Medical Education
https://read.qxmd.com/read/38277170/clinical-risk-and-outpatient-therapy-utilization-for-covid-19-in-the-medicare-population
#8
JOURNAL ARTICLE
Andrew D Wilcock, Stephen Kissler, Ateev Mehrotra, Brian E McGarry, Benjamin D Sommers, David C Grabowski, Yonatan H Grad, Michael L Barnett
IMPORTANCE: Multiple therapies are available for outpatient treatment of COVID-19 that are highly effective at preventing hospitalization and mortality. Although racial and socioeconomic disparities in use of these therapies have been documented, limited evidence exists on what factors explain differences in use and the potential public health relevance of these differences. OBJECTIVE: To assess COVID-19 outpatient treatment utilization in the Medicare population and simulate the potential outcome of allocating treatment according to patient risk for severe COVID-19...
January 5, 2024: JAMA health forum
https://read.qxmd.com/read/38232957/connecting-concussion-care-with-research-across-ontario
#9
JOURNAL ARTICLE
Cindy Hunt, Heather MacKenzie, Anil Dosaj, Justina Zych, Carmela Tartaglia, Mark Bayley, Ruth Wilcock, Karl Zabjek, Matthew Burke, Vicki Kristman, Billie Hardy, Lisa K Fischer, Andrew Baker
No abstract text is available yet for this article.
January 18, 2024: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://read.qxmd.com/read/38199792/limiting-drugs-prescribed-in-primary-care
#10
JOURNAL ARTICLE
Michael Wilcock
No abstract text is available yet for this article.
January 10, 2024: Drug and Therapeutics Bulletin
https://read.qxmd.com/read/38077088/terminally-differentiated-effector-memory-t-cells-associate-with-cognitive-and-ad-related-biomarkers-in-an-aging-based-community-cohort
#11
Edric Winford, Jenny Lutshumba, Barbara J Martin, Donna M Wilcock, Gregory A Jicha, Barbara S Nikolajczyk, Ann M Stowe, Adam D Bachstetter
BACKGROUND AND PURPOSE: The immune response changes during aging and the progression of Alzheimer's disease (AD) and related dementia (ADRD). Terminally differentiated effector memory T cells (called T EMRA ) are important during aging and AD due to their cytotoxic phenotype and association with cognitive decline. However, it is not clear if the changes seen in T EMRAs are specific to AD-related cognitive decline specifically or are more generally correlated with cognitive decline. This study aimed to examine whether T EMRAs are associated with cognition and plasma biomarkers of AD, neurodegeneration, and neuroinflammation in a community-based cohort of older adults...
November 28, 2023: bioRxiv
https://read.qxmd.com/read/38076904/cerebrovascular-disease-drives-alzheimer-plasma-biomarker-concentrations-in-adults-with-down-syndrome
#12
Natalie C Edwards, Patrick J Lao, Mohamad J Alshikho, Olivia M Ericsson, Batool Rizvi, Melissa E Petersen, Sid O'Bryant, Lisi Flores-Aguilar, Sabrina Simoes, Mark Mapstone, Dana L Tudorascu, Shorena Janelidze, Oskar Hansson, Benjamin L Handen, Bradley T Christian, Joseph H Lee, Florence Lai, H Diana Rosas, Shahid Zaman, Ira T Lott, Michael A Yassa, José Gutierrez, Donna M Wilcock, Elizabeth Head, Adam M Brickman
IMPORTANCE: By age 40 years over 90% of adults with Down syndrome (DS) have Alzheimer's disease (AD) pathology and most progress to dementia. Despite having few systemic vascular risk factors, individuals with DS have elevated cerebrovascular disease (CVD) markers that track with the clinical progression of AD, suggesting a role for CVD that is hypothesized to be mediated by inflammatory factors. OBJECTIVE: To examine the pathways through which small vessel CVD contributes to AD-related pathophysiology and neurodegeneration in adults with DS...
November 30, 2023: medRxiv
https://read.qxmd.com/read/38031737/clinical-characteristics-of-people-with-intellectual-disability-admitted-to-hospital-with-constipation-identifying-possible-specific-high-risk-factors
#13
JOURNAL ARTICLE
R Laugharne, M Wilcock, J Rees, D Wainwright, N Newton, J Sterritt, S Badger, R Bishop, P Bassett, R Shankar
BACKGROUND: People with intellectual disabilities (ID) die on an average 20 years earlier to the general population. They have higher rates of multimorbidity and polypharmacy. Around 25% of people with ID report chronic constipation. The England Learning Disabilities Mortality Review found that nearly 25% of deaths identified constipation as a long-term health problem. However, the likely risk factors for constipation related harm are poorly enumerated. We sought to identify possible specific high-risk factors by examining the clinical characteristics of people with ID admitted to hospital with constipation...
November 30, 2023: Journal of Intellectual Disability Research: JIDR
https://read.qxmd.com/read/38011580/alzheimer-s-disease-and-inflammatory-biomarkers-positively-correlate-in-plasma-in-the-uk-adrc-cohort
#14
JOURNAL ARTICLE
Kate E Foley, Zachary Winder, Tiffany L Sudduth, Barbara J Martin, Peter T Nelson, Gregory A Jicha, Jordan P Harp, Erica M Weekman, Donna M Wilcock
INTRODUCTION: Protein-based plasma assays provide hope for improving accessibility and specificity of molecular diagnostics to diagnose dementia. METHODS: Plasma was obtained from participants (N = 837) in our community-based University of Kentucky Alzheimer's Disease Research Center cohort. We evaluated six Alzheimer's disease (AD)- and neurodegeneration-related (Aβ40, Aβ42, Aβ42/40, p-tau181, total tau, and NfLight) and five inflammatory biomarkers (TNF𝛼, IL6, IL8, IL10, and GFAP) using the SIMOA-based protein assay platform...
November 27, 2023: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38010982/the-longitudinal-early-onset-alzheimer-s-disease-study-leads-advancing-our-understanding-of-alzheimer-s-disease-in-individuals-aged-40-64
#15
EDITORIAL
Donna M Wilcock
No abstract text is available yet for this article.
November 2023: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38010078/development-of-a-decision-support-framework-to-support-professionals-and-promote-comfort-among-older-hospital-inpatients-living-with-dementia
#16
JOURNAL ARTICLE
Nathan Davies, Emily West, Ellen M Smith, Victoria Vickerstaff, Jill Manthorpe, Malvi Shah, Greta Rait, Jane Wilcock, Jane Ward, Elizabeth L Sampson
BACKGROUND: Acute hospital wards can be difficult places for many people living with dementia. Promoting comfort and wellbeing can be challenging in this environment. There is little evidence-based support for professionals working on acute care wards on how to respond to distress and maximise comfort and wellbeing among patients living with dementia. OBJECTIVES: Our overall aim was to codesign an evidence-based easy-to-use heuristic decision-support framework, which was acceptable and practical but acknowledges the complex and acute nature of caring for patients with dementia in the hospital...
November 27, 2023: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://read.qxmd.com/read/37988134/using-digital-pathology-to-analyze-the-murine-cerebrovasculature
#17
JOURNAL ARTICLE
Dana M Niedowicz, Jenna L Gollihue, Erica M Weekman, Panhavuth Phe, Donna M Wilcock, Christopher M Norris, Peter T Nelson
Research on the cerebrovasculature may provide insights into brain health and disease. Immunohistochemical staining is one way to visualize blood vessels, and digital pathology has the potential to revolutionize the measurement of blood vessel parameters. These tools provide opportunities for translational mouse model research. However, mouse brain tissue presents a formidable set of technical challenges, including potentially high background staining and cross-reactivity of endogenous IgG. Formalin-fixed paraffin-embedded (FFPE) and fixed frozen sections, both of which are widely used, may require different methods...
November 21, 2023: Journal of Cerebral Blood Flow and Metabolism
https://read.qxmd.com/read/37961444/pathways-linking-pulse-pressure-to-dementia-in-adults-with-down-syndrome
#18
Batool Rizvi, Patrick J Lao, Mithra Sathishkumar, Lisa Taylor, Nazek Queder, Liv McMillan, Natalie Edwards, David B Keator, Eric Doran, Christy Hom, Dana Nguyen, H Diana Rosas, Florence Lai, Nicole Schupf, Jose Gutierrez, Wayne Silverman, Ira T Lott, Mark Mapstone, Donna M Wilcock, Elizabeth Head, Michael A Yassa, Adam M Brickman
Individuals with Down syndrome (DS) are less likely to have hypertension than neurotypical adults. However, whether blood pressure measures are associated with brain health and clinical outcomes in this population has not been studied in detail. Here, we assessed whether pulse pressure is associated with markers of cerebrovascular disease, entorhinal cortical atrophy, and diagnosis of dementia in adults with DS. Participants with DS from the Biomarkers of Alzheimer's Disease in Adults with Down Syndrome study (ADDS; n=195, age=50...
October 26, 2023: medRxiv
https://read.qxmd.com/read/37934954/clinicopathologic-features-of-breast-carcinoma-with-2018-american-society-of-clinical-oncology-college-of-american-pathologists-fluorescence-in-situ-hybridization-group-3-human-epidermal-growth-factor-receptor-2-chromosome-17-centromere-ratio-2-0-and-average
#19
JOURNAL ARTICLE
Diane Wilcock, Deepika Sirohi, Daniel Albertson, Allison S Cleary, Joshua F Coleman, Jolanta Jedrzkiewicz, Jonathan Mahlow, Ana L Ruano, H Evin Gulbahce
CONTEXT.—: The American Society of Clinical Oncology/College of American Pathologists 2018 update of the human epidermal growth factor receptor 2 (HER2) testing guideline includes a fluorescence in situ hybridization (FISH) group with a HER2 to chromosome 17 centromere (CEP17) ratio less than 2.0 and HER2 copy number 6.0 or greater (group 3), which requires integrated review of HER2 immunohistochemistry (IHC). OBJECTIVE.—: To assess the clinicopathologic features of group 3 patients and determine features associated with HER2-positive status after workup...
November 7, 2023: Archives of Pathology & Laboratory Medicine
https://read.qxmd.com/read/37901041/a-blunted-t-h-17-cytokine-signature-in-women-with-mild-cognitive-impairment-insights-from-inflammatory-profiling-of-a-community-based-cohort-of-older-adults
#20
JOURNAL ARTICLE
Adam D Bachstetter, Jenny Lutshumba, Edric Winford, Erin L Abner, Barbra J Martin, Jordan P Harp, Linda J Van Eldik, Frederick A Schmitt, Donna M Wilcock, Ann M Stowe, Gregory A Jicha, Barbara S Nikolajczyk
People with dementia have an increase in brain inflammation, caused in part by innate and adaptive immune cells. However, it remains unknown whether dementia-associated diseases alter neuro-immune reflex arcs to impact the systemic immune system. We examined peripheral immune cells from a community-based cohort of older adults to test if systemic inflammatory cytokine signatures associated with early stages of cognitive impairment. Human peripheral blood mononuclear cells were cultured with monocyte or T-cell-targeted stimuli, and multiplex assays quantitated cytokines in the conditioned media...
2023: Brain communications
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