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https://read.qxmd.com/read/30740048/cerebrovascular-smooth-muscle-cells-as-the-drivers-of-intramural-periarterial-drainage-of-the-brain
#1
Roxana Aldea, Roy O Weller, Donna M Wilcock, Roxana O Carare, Giles Richardson
The human brain is the organ with the highest metabolic activity but it lacks a traditional lymphatic system responsible for clearing waste products. We have demonstrated that the basement membranes of cerebral capillaries and arteries represent the lymphatic pathways of the brain along which intramural periarterial drainage (IPAD) of soluble metabolites occurs. Failure of IPAD could explain the vascular deposition of the amyloid-beta protein as cerebral amyloid angiopathy (CAA), which is a key pathological feature of Alzheimer's disease...
2019: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/30738144/bisphosphonates
#2
REVIEW
Claire Stark Toller, Sarah Charlesworth, Mary Mihalyo, Paul Howard, Andrew Wilcock
No abstract text is available yet for this article.
February 6, 2019: Journal of Pain and Symptom Management
https://read.qxmd.com/read/30661639/assessing-emotional-functioning-with-increased-power-relative-validity-of-a-customized-eortc-short-form-in-the-international-action-trial
#3
Lea J Jabbarian, Mogens Groenvold, Morten Aa Petersen, Caroline Arnfeldt Christensen, Luc Deliens, Agnes van der Heide, Marijke C Kars, Guido Miccinesi, Sheila Payne, Andrew Wilcock, Ida J Korfage
OBJECTIVES: There is a need to improve the assessment of emotional functioning (EF). In the international Advance Care Planning: an Innovative Palliative Care Intervention to Improve Quality of Life in Cancer Patients - a Multi-Centre Cluster Randomized Clinical Trial (ACTION) trial involving patients with advanced cancer, EF was assessed by a customized 10-item short form (EF10). The EF10 is based on the European Organisation for Research and Treatment of Cancer (EORTC) EF item bank and has the potential for greater precision than the common EORTC Quality of Life Questionnaire Core 30 four-item scale (EF4)...
January 2019: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://read.qxmd.com/read/30636741/identification-and-preliminary-validation-of-a-plasma-profile-associated-with-cognitive-decline-in-dementia-and-at-risk-individuals-a-retrospective-cohort-analysis
#4
M Florencia Iulita, Aravind Ganesh, Rowan Pentz, Lisi Flores Aguilar, Palma Gubert, Adriana Ducatenzeiler, Sharon Christie, Gordon K Wilcock, A Claudio Cuello
Biomarker discovery is a major need for earlier dementia diagnosis. We evaluated a plasma signature of amyloid, metallo-proteinases (MMPs), and inflammatory markers in a cohort of at-risk individuals and individuals clinically diagnosed with probable Alzheimer's disease (pAD). Using multiplex arrays, we measured Aβ40, Aβ42, MMP-1, MMP-3, MMP-9, IFN-γ, TNF-α, IL-6, IL-8, and IL-10 in plasma from 107 individuals followed every 6 months for 3 years. Final diagnoses included: pAD (n = 28), mild cognitive impairment (MCI, n = 30), subjective memory impairment (SMI, n = 30), and asymptomatic (NCI, n = 19)...
2019: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/30633671/how-is-telemedicine-being-used-in-opioid-and-other-substance-use-disorder-treatment
#5
Haiden A Huskamp, Alisa B Busch, Jeffrey Souza, Lori Uscher-Pines, Sherri Rose, Andrew Wilcock, Bruce E Landon, Ateev Mehrotra
Only a small proportion of people with a substance use disorder (SUD) receive treatment. The shortage of SUD treatment providers, particularly in rural areas, is an important driver of this treatment gap. Telemedicine could be a means of expanding access to treatment. However, several key regulatory and reimbursement barriers to greater use of telemedicine for SUD (tele-SUD) exist, and both Congress and the states are considering or have recently passed legislation to address them. To inform these efforts, we describe how tele-SUD is being used...
December 2018: Health Affairs
https://read.qxmd.com/read/30617325/exercise-linked-fndc5-irisin-rescues-synaptic-plasticity-and-memory-defects-in-alzheimer-s-models
#6
Mychael V Lourenco, Rudimar L Frozza, Guilherme B de Freitas, Hong Zhang, Grasielle C Kincheski, Felipe C Ribeiro, Rafaella A Gonçalves, Julia R Clarke, Danielle Beckman, Agnieszka Staniszewski, Hanna Berman, Lorena A Guerra, Letícia Forny-Germano, Shelby Meier, Donna M Wilcock, Jorge M de Souza, Soniza Alves-Leon, Vania F Prado, Marco A M Prado, Jose F Abisambra, Fernanda Tovar-Moll, Paulo Mattos, Ottavio Arancio, Sergio T Ferreira, Fernanda G De Felice
Defective brain hormonal signaling has been associated with Alzheimer's disease (AD), a disorder characterized by synapse and memory failure. Irisin is an exercise-induced myokine released on cleavage of the membrane-bound precursor protein fibronectin type III domain-containing protein 5 (FNDC5), also expressed in the hippocampus. Here we show that FNDC5/irisin levels are reduced in AD hippocampi and cerebrospinal fluid, and in experimental AD models. Knockdown of brain FNDC5/irisin impairs long-term potentiation and novel object recognition memory in mice...
January 2019: Nature Medicine
https://read.qxmd.com/read/30601709/two-year-evaluation-of-mandatory-bundled-payments-for-joint-replacement
#7
Michael L Barnett, Andrew Wilcock, J Michael McWilliams, Arnold M Epstein, Karen E Joynt Maddox, E John Orav, David C Grabowski, Ateev Mehrotra
BACKGROUND: In 2016, Medicare implemented Comprehensive Care for Joint Replacement (CJR), a national mandatory bundled-payment model for hip or knee replacement in randomly selected metropolitan statistical areas. Hospitals in such areas receive bonuses or pay penalties based on Medicare spending per hip- or knee-replacement episode (defined as the hospitalization plus 90 days after discharge). METHODS: We conducted difference-in-differences analyses using Medicare claims from 2015 through 2017, encompassing the first 2 years of bundled payments in the CJR program...
January 2, 2019: New England Journal of Medicine
https://read.qxmd.com/read/30596298/mirtazapine-for-chronic-breathlessness-a-review-of-mechanistic-insights-and-therapeutic-potential
#8
N Lovell, A Wilcock, S Bajwah, S N Etkind, C J Jolley, M Maddocks, I J Higginson
Chronic breathlessness is a common and distressing symptom of advanced disease with few effective treatments. Central nervous system mechanisms are important in respiratory sensation and control. Consequently, drugs which may modify processing and perception of afferent information in the brain may have a role. Antidepressants have been proposed; however, current evidence is limited. Of potentially suitable antidepressants, mirtazapine is an attractive option given its tolerability profile, low cost, and wide availability, along with additional potential benefits...
December 30, 2018: Expert Review of Respiratory Medicine
https://read.qxmd.com/read/30567853/stopping-rationalising-or-optimising-antipsychotic-drug-treatment-in-people-with-intellectual-disability-and-or-autism
#9
REVIEW
Rohit Shankar, Mike Wilcock, Katy Oak, Paula McGowan, Rory Sheehan
No abstract text is available yet for this article.
January 2019: Drug and Therapeutics Bulletin
https://read.qxmd.com/read/30567845/challenging-the-supremacy-of-intravenous-antibiotics
#10
EDITORIAL
Neil Powell, Michael Wilcock
No abstract text is available yet for this article.
January 2019: Drug and Therapeutics Bulletin
https://read.qxmd.com/read/30555031/perspectives-on-ethnic-and-racial-disparities-in-alzheimer-s-disease-and-related-dementias-update-and-areas-of-immediate-need
#11
Ganesh M Babulal, Yakeel T Quiroz, Benedict C Albensi, Eider Arenaza-Urquijo, Arlene J Astell, Claudio Babiloni, Alex Bahar-Fuchs, Joanne Bell, Gene L Bowman, Adam M Brickman, Gaël Chételat, Carrie Ciro, Ann D Cohen, Peggye Dilworth-Anderson, Hiroko H Dodge, Simone Dreux, Steven Edland, Anna Esbensen, Lisbeth Evered, Michael Ewers, Keith N Fargo, Juan Fortea, Hector Gonzalez, Deborah R Gustafson, Elizabeth Head, James A Hendrix, Scott M Hofer, Leigh A Johnson, Roos Jutten, Kerry Kilborn, Krista L Lanctôt, Jennifer J Manly, Ralph N Martins, Michelle M Mielke, Martha Clare Morris, Melissa E Murray, Esther S Oh, Mario A Parra, Robert A Rissman, Catherine M Roe, Octavio A Santos, Nikolaos Scarmeas, Lon S Schneider, Nicole Schupf, Sietske Sikkes, Heather M Snyder, Hamid R Sohrabi, Yaakov Stern, Andre Strydom, Yi Tang, Graciela Muniz Terrera, Charlotte Teunissen, Debora Melo van Lent, Michael Weinborn, Linda Wesselman, Donna M Wilcock, Henrik Zetterberg, Sid E O'Bryant
Alzheimer's disease and related dementias (ADRDs) are a global crisis facing the aging population and society as a whole. With the numbers of people with ADRDs predicted to rise dramatically across the world, the scientific community can no longer neglect the need for research focusing on ADRDs among underrepresented ethnoracial diverse groups. The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART; alz.org/ISTAART) comprises a number of professional interest areas (PIAs), each focusing on a major scientific area associated with ADRDs...
December 13, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/30455220/diagnosis-and-referral-delays-in-primary-care-for-oral-squamous-cell-cancer-a-systematic-review
#12
Ciaran Grafton-Clarke, Kai Wen Chen, Jane Wilcock
BACKGROUND: The incidence of oral cancer is increasing. Guidance for oral cancer from the National Institute for Health and Care Excellence (NICE) is unique in recommending cross-primary care referral from GPs to dentists. AIM: This review investigates knowledge about delays in the diagnosis of symptomatic oral squamous cell carcinoma (OSCC) in primary care. DESIGN AND SETTING: An independent multi-investigator literature search strategy and an analysis of study methodologies using a modified data extraction tool based on Aarhus checklist criteria relevant to primary care...
November 19, 2018: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://read.qxmd.com/read/30429785/hyperhomocysteinemia-as-a-risk-factor-for-vascular-contributions-to-cognitive-impairment-and-dementia
#13
REVIEW
Brittani R Price, Donna M Wilcock, Erica M Weekman
Behind only Alzheimer's disease, vascular contributions to cognitive impairment and dementia (VCID) is the second most common cause of dementia, affecting roughly 10-40% of dementia patients. While there is no cure for VCID, several risk factors for VCID, such as diabetes, hypertension, and stroke, have been identified. Elevated plasma levels of homocysteine, termed hyperhomocysteinemia (HHcy), are a major, yet underrecognized, risk factor for VCID. B vitamin deficiency, which is the most common cause of HHcy, is common in the elderly...
2018: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/30427873/guiding-practitioners-through-end-of-life-care-for-people-with-dementia-the-use-of-heuristics
#14
Nathan Davies, Jill Manthorpe, Elizabeth L Sampson, Kethakie Lamahewa, Jane Wilcock, Rammya Mathew, Steve Iliffe
BACKGROUND: End of life care (EOLC) for people with dementia can present a multitude of challenges and difficult decisions for practitioners. These challenges may include assessment and management of difficulties with eating and swallowing, responding to agitation, treating pain, and managing recurrent infections. Practitioners sometimes lack both confidence in making end of life decisions and guidance. This study developed an alternative to lengthy guidelines, in the form of heuristics which were tested in clinical settings...
2018: PloS One
https://read.qxmd.com/read/30400099/distinct-white-matter-changes-associated-with-cerebrospinal-fluid-amyloid-%C3%AE-1-42-and-hypertension
#15
Omar M Al-Janabi, Christopher A Brown, Ahmed A Bahrani, Erin L Abner, Justin M Barber, Brian T Gold, Larry B Goldstein, Ronan R Murphy, Peter T Nelson, Nathan F Johnson, Leslie M Shaw, Charles D Smith, John Q Trojanowski, Donna M Wilcock, Gregory A Jicha
BACKGROUND: Alzheimer's disease (AD) pathology and hypertension (HTN) are risk factors for development of white matter (WM) alterations and might be independently associated with these alterations in older adults. OBJECTIVE: To evaluate the independent and synergistic effects of HTN and AD pathology on WM alterations. METHODS: Clinical measures of cerebrovascular disease risk were collected from 62 participants in University of Kentucky Alzheimer's Disease Center studies who also had cerebrospinal fluid (CSF) sampling and MRI brain scans...
2018: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/30390314/mast-cell-disorders-from-infancy-to-maturity
#16
REVIEW
Amy Wilcock, Rajia Bahri, Silvia Bulfone-Paus, Peter D Arkwright
Mast cells are typically linked to immediate hypersensitivity and anaphylaxis. This review looks beyond this narrow role, focusing on how these cells have evolved and diversified via natural selection promoting serine protease gene duplication, augmenting their innate host defense function against helminths and snake envenomation. Plasticity of mast cell genes has come at a price. Somatic activating mutations in the mast cell growth factor KIT gene cause cutaneous mastocytosis in young children and systemic mastocytosis with a more guarded prognosis in adults who may also harbor other gene mutations with oncogenic potential as they age...
November 3, 2018: Allergy
https://read.qxmd.com/read/30349735/developing-an-integrated-rehabilitation-model-for-thoracic-cancer-services-views-of-patients-informal-carers-and-clinicians
#17
Joanne Bayly, Bethany M Edwards, Nicola Peat, Geoffrey Warwick, Ivo M Hennig, Arvind Arora, Andrew Wilcock, Irene J Higginson, Matthew Maddocks
Background: Access to rehabilitation to prevent disability and optimise function is recommended for patients with cancer, including following cancer diagnosis. Models to integrate rehabilitation within oncology services as cancer treatment commences are required, but must be informed by those they are intended to support. We aimed to identify views of patients, carers and clinicians to develop and refine a rehabilitation model to be tested in a feasibility trial for people newly diagnosed with lung cancer or mesothelioma...
2018: Pilot and Feasibility Studies
https://read.qxmd.com/read/30340480/medication-review-plus-person-centred-care-a-feasibility-study-of-a-pharmacy-health-psychology-dual-intervention-to-improve-care-for-people-living-with-dementia
#18
Ian D Maidment, Sarah Damery, Niyah Campbell, Nichola Seare, Chris Fox, Steve Iliffe, Andrea Hilton, Graeme Brown, Nigel Barnes, Jane Wilcock, Emma Randle, Sarah Gillespie, Garry Barton, Rachel Shaw
BACKGROUND: "Behaviour that Challenges" is common in people living with dementia, resident in care homes and historically has been treated with anti-psychotics. However, such usage is associated with 1800 potentially avoidable deaths annually in the UK. This study investigated the feasibility of a full clinical trial of a specialist dementia care pharmacist medication review combined with a health psychology intervention for care staff to limit the use of psychotropics. This paper focuses on feasibility; including recruitment and retention, implementation of medication change recommendations and the experiences and expectations of care staff...
October 19, 2018: BMC Psychiatry
https://read.qxmd.com/read/30287717/comparison-of-frictional-resistance-in-conventional-brackets-with-different-stainless-steel-wires
#19
Sangeeta Sunda, Anil Miglani, Reena R Kumar, Vikram Panghal, Puja Khanna, Nishtha Arora
AIM: The aim of the study was to evaluate and compare static and kinetic friction of round (0.018") and rectangular (0.019 × 0.025") stainless steel (SS) wires of different brands with conventional preadjusted edgewise brackets. MATERIALS AND METHODS: Maxillary canine and two bicuspids of 0.022 × 0.028" slot sized MBT prescription (Gemini, 3M Unitek, Monrovia, California) brackets were chosen. The wires selected were 0.018" SS (3M Unitek); 0...
September 1, 2018: Journal of Contemporary Dental Practice
https://read.qxmd.com/read/30272110/letter-to-the-editor-hospitalization-drug-regimen-changes-in-geriatric-patients-and-adherence-to-modifications-by-general-practioners-in-primary-care
#20
M Wilcock, L Kelly, A Hill
No abstract text is available yet for this article.
2018: Journal of Nutrition, Health & Aging
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