keyword
https://read.qxmd.com/read/38398359/cardiomyopathy-in-celiac-disease-a-systematic-review
#1
REVIEW
Stefan Milutinovic, Predrag Jancic, Adam Adam, Milan Radovanovic, Charles W Nordstrom, Marshall Ward, Marija Petrovic, Dorde Jevtic, Maja Delibasic, Magdalena Kotseva, Milan Nikolajevic, Igor Dumic
(1) Background : Cardiomyopathy in celiac disease or celiac cardiomyopathy (CCM) is a serious and potentially life-threatening disease that can occur in both adults and children. However, data supporting the causal relationship between celiac disease (CD) and cardiomyopathy (CMP) are still inconsistent. The aim of this study was to review and synthesize data from the literature on this topic and potentially reveal a more evidence-based causal relationship. (2) Methods : The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used to search Medline, Embase, and Scopus databases from database inception until September 2023...
February 12, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38076444/portal-embolisation-as-treatment-of-severe-portal-hypertension-due-to-idiopathic-intrahepatic-arterioportal-fistula-a-case-report
#2
Anne J Klompenhouwer, Adriaan Moelker, Sarwa D Murad, Caroline M den Hoed, Raoel Maan
Intrahepatic arterioportal fistula (IAPF) is a rare cause of portal hypertension. Treatment is usually aimed at restoring the normal portal hemodynamics by obliterating the shunt. This report describes a case of idiopathic IAPF with severe portal hypertension complicated by portal enteropathy with vomiting, gastrointestinal hemorrhage and sepsis. The patient was successfully treated with portal embolization.
2024: Journal of Clinical and Experimental Hepatology
https://read.qxmd.com/read/37751975/localised-intestinal-kaposi-sarcoma-in-a-patient-with-non-coeliac-seronegative-villous-atrophy
#3
JOURNAL ARTICLE
Benjamin Norton, Otso Pelkonen, Jennifer Watkins, Steven Mann
Seronegative villous atrophy (SNVA) is a diagnostic challenge for gastroenterologists, which is defined by villous atrophy and negative coeliac serology. Non-coeliac forms of SNVA, such as autoimmune enteropathy, can be life-threatening leading to intractable diarrhoea and severe malabsorption that require systemic immunosuppression. When all known causes have been excluded, it is termed idiopathic villous atrophy (IVA). We present a case of non-coeliac SNVA complicated by Kaposi sarcoma (KS). A previously well HIV-negative man in his 30s presented with a 4-month history of watery diarrhoea and 25 kg weight loss...
September 26, 2023: BMJ Case Reports
https://read.qxmd.com/read/37681754/isolation-of-malassezia-yeasts-from-dogs-with-gastrointestinal-disease-undergoing-duodenal-endoscopy
#4
JOURNAL ARTICLE
A Kathrani, B Theelen, R Bond
OBJECTIVES: To culture Malassezia and other fungi from the duodenum of dogs with gastrointestinal signs undergoing routine endoscopic examination. MATERIALS AND METHODS: Quantitative microbial culture was performed on duodenal juice aspirated from dogs with suspected enteropathy during routine upper gastrointestinal endoscopy; samples were cultured on Sabouraud's dextrose agar (30, 32 and 37°C) and modified Dixon agar (32°C) for 14 days. Isolates were identified phenotypically and by matrix-assisted laser desorption ionisation-time of flight, and internal transcribed spacer sequencing...
July 15, 2023: Journal of Small Animal Practice
https://read.qxmd.com/read/37554746/the-differential-diagnoses-for-severe-enteropathy-or-severely-damaged-small-intestinal-mucosa
#5
JOURNAL ARTICLE
Chao Ling Aran Jian, David T S Hayman, Bruce Lockett, Kamran Rostami
AIM: The aim of this study was to explore the aetiology of severe duodenal mucosal abnormality in consecutive patients who underwent gastroscopy and duodenal biopsy over the past 10 years. BACKGROUND: A range of differential diagnoses have been reported for severe duodenal architectural distortion. METHODS: Clinical and laboratory data of all the patients with severe duodenal architectural distortion diagnosed at MidCentral District Health Board (DHB), New Zealand were collected and statistically analysed...
2023: Gastroenterology and Hepatology From Bed to Bench
https://read.qxmd.com/read/37456955/time-to-eraase-chronic-inflammation-current-advances-and-future-perspectives-on-renin-angiotensin-aldosterone-system-and-chronic-intestinal-inflammation-in-dogs-and-humans
#6
JOURNAL ARTICLE
Romy M Heilmann, Georg Csukovich, Iwan A Burgener, Franziska Dengler
Chronic idiopathic intestinal inflammation is an increasing worldwide problem that affects companion animals, especially dogs, and human patients. Although these disease entities have been intensely investigated recently, many questions remain, and alternative therapeutic options are needed. Diarrhea caused by dysregulation of intestinal electrolyte transport and subsequent fluid and electrolyte losses often leads to secondary consequences for the patient. Currently, it is not exactly clear which mechanisms are involved in the dysregulation of intestinal fluid absorption, but differences in intestinal electrolyte shifts between human and canine patients suggest species-specific regulatory or counterregulatory mechanisms...
2023: Frontiers in Veterinary Science
https://read.qxmd.com/read/37245211/faecal-microbiome-transplantation-improves-clinical-signs-of-chronic-idiopathic-large-bowel-diarrhoea-in-working-dogs
#7
JOURNAL ARTICLE
João C Alves, Ana Santos, Patrícia Jorge, Ângelo Pitães
BACKGROUND: Chronic diarrhoea is a common clinical sign in dogs with chronic enteropathy, and psyllium husk has been shown to improve clinical signs in affected dogs. The aim of this study was to investigate whether faecal microbiome transplant has a similar effect in alleviating clinical signs in dogs with chronic large bowel diarrhoea. METHOD: Thirty large-breed working dogs with chronic large bowel diarrhoea were divided into a psyllium group (PG) and a faecal microbiome transplant group (FMTG)...
May 28, 2023: Veterinary Record
https://read.qxmd.com/read/37186013/serum-proteome-of-dogs-with-chronic-enteropathy
#8
JOURNAL ARTICLE
Jane Yu, Craig Ruaux, Christine Griebsch, Lara Boland, Nadia Wong, Peter Bennett, Valerie C Wasinger
BACKGROUND: Chronic enteropathy (CE) is common in dogs and can occur with multiple etiologies including food-responsive enteropathy (FRE) and idiopathic inflammatory bowel disease (IBD). HYPOTHESIS/OBJECTIVE: To study the protein profile and pathway differences among dogs with FRE, IBD, and healthy controls using serum proteome analysis. ANIMALS: Nine CE dogs with signs of gastrointestinal disease and histologically confirmed chronic inflammatory enteropathy and 16 healthy controls...
2023: Journal of Veterinary Internal Medicine
https://read.qxmd.com/read/36574307/humoral-immunogenicity-of-covid-19-vaccines-in-patients-with-coeliac-disease-and-other-noncoeliac-enteropathies-compared-to-healthy-controls
#9
JOURNAL ARTICLE
Davide Scalvini, Annalisa Schiepatti, Stiliano Maimaris, Emanuele Cosentini, Roberta Muscia, Virginia Gregorio, Elisa Roda, Federico Fassio, Paola Baiardi, Carlo Alessandro Locatelli, Federico Biagi
OBJECTIVES: Data are lacking on the immunogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in patients affected by coeliac disease, Whipple's disease and other noncoeliac enteropathies (NCE), characterised by primary or drug-related immunosuppression. We aimed to assess humoral response to SARS-CoV-2 vaccination in these patients compared to controls. METHODS: Between December 2021 and January 2022, IgG anti-SARS-CoV-2 spike protein antibodies were measured in serum samples of coeliac disease, Whipple's disease and NCE patients attending our gastroenterology outpatient clinic for follow-up, who had received their first SARS-CoV-2 vaccination dose 3-6-9 (±1) months prior...
February 1, 2023: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/36503523/underlying-ipex-syndrome-in-a-patient-with-idiopathic-juvenile-arthritis-and-vitiligo
#10
JOURNAL ARTICLE
Leonardo Oliveira Mendonça, Adriana Pitchon Dos Reis Chuster, Mayra Barros Dorna, Samar Freschi Barros, Janaina Baptista Alves, Victor Lucas Gonçalves, Ariana Campos Yang, Jorge Kalil, Myrthes Anna Maragna Toledo-Barros, Cristina Maria Kokron
BACKGROUND: IPEX syndrome is an X-linked inborn error of immunity clinically characterized by the triad of: enteropathy, polyendocrinopathy and eczema. However many other clinical presentations lacking the triad above described have been reported what underpin the need of careful clinical suspicion, immunological evaluation and genetic sequencing. CASE PRESENTATION: Here we report a case of a Brazilian boy with severe eczema as the first and only presentation requiring cyclosporin therapy...
December 12, 2022: Allergy, Asthma, and Clinical Immunology
https://read.qxmd.com/read/36452011/case-of-hypereosinophilic-syndrome-with-gastrointestinal-involvement-showing-tissue-eosinophil-cytolysis
#11
Shin-Ichiro Hagiwara, Shigeharu Ueki, Ken Watanabe, Keinosuke Hizuka, Yuri Etani
Hypereosinophilic syndrome (HES), which is characterized by eosinophilia in the peripheral blood, often causes various organ disorders, including those of the gastrointestinal (GI) tract. The eosinophils play a key role in inflammation in eosinophilic GI disorders (EGIDs), including HES with GI involvement. Here, we report a case of HES with GI involvement that showed major basic proteins (MBPs) deposition in the absence of marked eosinophilic infiltration in the mucosa of the GI tract. An 11-year-old boy presented with nausea and epigastric pain for one week...
October 2022: Asia Pacific Allergy
https://read.qxmd.com/read/36321188/outcome-of-chronic-inflammatory-enteropathy-in-cats-65-cases-2011-2021
#12
JOURNAL ARTICLE
Y Bandara, S L Priestnall, Y M Chang, A Kathrani
OBJECTIVES: Feline chronic inflammatory enteropathy is an idiopathic disease with limited information on variables that might affect treatment outcome and survival. The aim of this study was to determine if clinicopathological variables were associated with death due to gastrointestinal disease in cats with chronic inflammatory enteropathy. MATERIALS AND METHODS: Three medical records databases were retrospectively searched for cats diagnosed with chronic inflammatory enteropathy at the Royal Veterinary College between June 2008 and November 2021...
November 1, 2022: Journal of Small Animal Practice
https://read.qxmd.com/read/36157923/who-to-screen-and-how-to-screen-for-celiac-disease
#13
REVIEW
Prashant Singh, Achintya Dinesh Singh, Vineet Ahuja, Govind K Makharia
Celiac disease (CeD) is a chronic gluten-induced enteropathy with plethoric manifestations. The typical manifestations of CeD such as chronic diarrhea and malabsorption are widely recognized, however, many patients have atypical manifestations like iron deficiency anemia, idiopathic short stature, hypertransaminesemia or infertility, etc. These patients often present to the primary care physicians and/or non-gastrointestinal specialties. However, due to a lack of awareness among the healthcare professionals about the various atypical manifestations, many patients are not screened for CeD...
August 28, 2022: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/36076104/nonsense-mutation-in-the-novel-percc1-gene-as-a-genetic-cause-of-congenital-diarrhea-and-enteropathy
#14
JOURNAL ARTICLE
Dina Marek-Yagel, Emily Stenke, Ben Pode-Shakked, Cara Dunne, Ellen Crushell, Anthea Bryce-Smith, Michael McDermott, Maureen J O'Sullivan, Alvit Veber, Mansa Krishnamurthy, James M Wells, Yair Anikster, Billy Bourke
Congenital diarrheas and enteropathies (CODEs) constitute a heterogeneous group of individually rare disorders manifesting with infantile-onset chronic diarrhea. Genomic deletions in chromosome 16, encompassing a sequence termed the 'intestine-critical region (ICR)', were recently identified as the cause of an autosomal recessive congenital enteropathy. The regulatory sequence within the ICR is flanked by an unannotated open reading frame termed PERCC1, which plays a role in enteroendocrine cell (EEC) function...
September 9, 2022: Human Genetics
https://read.qxmd.com/read/36014031/the-role-of-the-human-gut-microbiome-in-inflammatory-bowel-disease-and-radiation-enteropathy
#15
REVIEW
Darren Fernandes, Jervoise Andreyev
The human gut microbiome plays a key role in regulating host physiology. In a stable state, both the microbiota and the gut work synergistically. The overall homeostasis of the intestinal flora can be affected by multiple factors, including disease states and the treatments given for those diseases. In this review, we examine the relatively well-characterised abnormalities that develop in the microbiome in idiopathic inflammatory bowel disease, and compare and contrast them to those that are found in radiation enteropathy...
August 9, 2022: Microorganisms
https://read.qxmd.com/read/36009057/n-palmitoyl-d-glucosamine-inhibits-tlr-4-nlrp3-and-improves-dnbs-induced-colon-inflammation-through-a-ppar-%C3%AE-dependent-mechanism
#16
JOURNAL ARTICLE
Irene Palenca, Luisa Seguella, Alessandro Del Re, Silvia Basili Franzin, Chiara Corpetti, Marcella Pesce, Sara Rurgo, Luca Steardo, Giovanni Sarnelli, Giuseppe Esposito
Similar to canine inflammatory enteropathy, inflammatory bowel disease (IBD) is a chronic idiopathic condition characterized by remission periods and recurrent flares in which diarrhea, visceral pain, rectal bleeding/bloody stools, and weight loss are the main clinical symptoms. Intestinal barrier function alterations often persist in the remission phase of the disease without ongoing inflammatory processes. However, current therapies include mainly anti-inflammatory compounds that fail to promote functional symptoms-free disease remission, urging new drug discoveries to handle patients during this step of the disease...
August 22, 2022: Biomolecules
https://read.qxmd.com/read/35382952/are-plasma-proteins-a-valid-alternative-for-assessing-nephrotic-syndrome-in-children-from-low-income-countries
#17
JOURNAL ARTICLE
A A Ndongo, B Ranchin, R Cartier, A Bertholet-Thomas, J Bacchetta, P Cochat
BACKGROUND: A diagnosis of nephrotic syndrome (NS) in children with edema relies on urinary albumin excretion and usually plasma protein (Pprot) and albumin (Palb) concentrations. METHODS: In order to fit laboratory tests to optimal healthcare in low-resource countries, we established correlations between Pprot and Palb in children with NS (217 measurements in 60 patients) and in children with exudative enteropathy and chronic hepatopathy/liver insufficiency (186 measurements in 21 patients); all patients had repeated measurements at various stages of their disease...
May 2022: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://read.qxmd.com/read/35107061/constrictive-pericarditis-rare-but-reversible-cause-of-protein-losing-enteropathy
#18
JOURNAL ARTICLE
Nishant C Shah, Laszlo Kiraly, Hazem El Badaoui
Constrictive pericarditis is uncommon in children. It results from scarring and consequent loss of the normal elasticity of the pericardial sac and is most commonly seen as a late sequelae of idiopathic or viral pericarditis. Here, we report a case of protein losing enteropathy as a complication of constrictive pericarditis in a 2-year-old child. Pericardial thickening was demonstrated by cardiac MRI and subsequent pericardiectomy led to remarkable improvement and resolution of protein losing enteropathy.
February 2, 2022: Cardiology in the Young
https://read.qxmd.com/read/35014071/measurement-and-clinical-applications-of-c-reactive-protein-in-gastrointestinal-diseases-of-dogs
#19
REVIEW
Marshal A Covin, Joerg M Steiner
C-reactive protein (CRP) is a positive acute-phase protein, serum concentrations of which increase nonspecifically in response to inflammatory processes of the dog. As such, it can aid in the identification of inflammatory disease and, maybe more importantly, the objective monitoring of disease progression. In dogs, CRP is frequently used to evaluate dogs with gastrointestinal diseases, such as chronic inflammatory enteropathies (also termed idiopathic inflammatory bowel disease), acute pancreatitis, canine parvovirus infection, hepatic disease, acute abdomen, and protein-losing enteropathy...
February 2022: Veterinary Clinical Pathology
https://read.qxmd.com/read/34991182/dietary-management-of-chronic-enteropathy-in-dogs
#20
REVIEW
M K Tolbert, M Murphy, L Gaylord, A Witzel-Rollins
Chronic idiopathic enteropathy is a clinical condition defined by the exclusion of infectious, metabolic or neoplastic causes of gastrointestinal signs and is categorised by a response to treatment including management with diet change, immunosuppressant medication or interventions that directly target the microbiome (e.g. antibiotics, faecal transplantation or probiotics). Animals that fail these therapies are categorised as non-responsive or refractory chronic idiopathic enteropathy. This specific categorisation implies that nutritional intervention is only needed for a subset of patients with enteropathy...
June 2022: Journal of Small Animal Practice
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