keyword
https://read.qxmd.com/read/38530451/the-longitudinal-follow-up-of-a-newly-proposed-octa-imaging-finding-sspim-and-the-importance-of-it-as-a-new-biomarker-for-treatment-response-in-diabetic-macular-edema
#21
JOURNAL ARTICLE
Gülsüm Genç, Özge Yanık, Sibel Demirel, Figen Batioglu, Emin Özmert
PURPOSE: This study aimed to evaluate the frequency of SSPiM (suspended scattering particles in motion), systemic risk factors, ocular findings, progression characteristics, and treatment response in diabetic retinopathy (DR) patients. METHODS: In this prospective study, a total of 109 eyes of 109 patients with diabetic macular edema (DME) were included. Demographic characteristics and systemic data of the patients were recorded. In addition to a detailed ophthalmological examination, optical coherence tomography (OCT) and OCT angiography (OCTA) imaging were performed...
March 26, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38530415/the-association-of-islet-autoantibodies-with-the-neural-retinal-thickness-and-microcirculation-in-type-1-diabetes-mellitus-with-no-clinical-evidence-of-diabetic-retinopathy
#22
JOURNAL ARTICLE
Tong Wang, Tong Zhang, Ning Dong, Yao Tan, Xia Li, Yuting Xie, Liang Li, Yandan Zhou, Pu Zhang, Ming Li, Qianxin Li, Ruixuan Wang, Ronghan Wu, Ling Gao
OBJECTIVE: To examine the association between islet autoantibodies (IAbs) and the retinal neurovascular changes in type 1 diabetes mellitus (T1DM) with no diabetic retinopathy (NDR). METHODS: This cross-sectional study measured the neural retinal structure and microvascular density of 118 NDR eyes using spectral-domain optical coherence tomography angiography. Retinal structure parameters included retinal thickness (RT), inner retinal thickness (iRT), retina never fibral layer thickness (RNFL thickness), ganglion cell complex thickness (GCC thickness), and loss volume of GCC...
March 26, 2024: Acta Diabetologica
https://read.qxmd.com/read/38529001/exacerbation-of-diabetic-retinopathy-following-hypoxia-inducible-factor-prolyl-hydroxylase-inhibitor-administration-a-case-report
#23
Nobuaki Ariyoshi, Fumiaki Higashijima, Makiko Wakuta, Tadahiko Ogata, Manami Ohta, Kazuhiro Kimura
INTRODUCTION: Hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitors, used in the treatment of renal anemia, hold the potential to increase the production of vascular endothelial growth factors. Therefore, HIF-PH inhibitors may exacerbate retinal hemorrhage in diseases such as diabetic retinopathy. Here, we present a case involving the administration of an HIF-PH inhibitor, resulting in the exacerbation of retinal hemorrhage in a patient with diabetic retinopathy. CASE PRESENTATION: A 32-year-old man with diabetes mellitus and renal anemia caused by diabetic nephropathy was referred to our department for ophthalmic examination, revealing diabetic retinopathy with scattered retinal hemorrhages, exudates, and diabetic maculopathy in both eyes...
2024: Case Reports in Ophthalmology
https://read.qxmd.com/read/38528638/correction-sight-threatening-diabetic-retinopathy-in-patients-with-macular-telangiectasia-type-2
#24
Josef Huemer, Tjebo Fc Heeren, Abraham Olvera-Barrios, Livia Faes, Antonio M B Casella, Edward Hughes, Adnan Tufail, Catherine Egan
No abstract text is available yet for this article.
March 25, 2024: International Journal of Retina and Vitreous
https://read.qxmd.com/read/38528132/prevalence-of-diabetic-kidney-disease-and-the-associated-factors-among-patients-with-type-2-diabetes-in-a-multi-ethnic-asian-country
#25
JOURNAL ARTICLE
Kim Sui Wan, Noran Naqiah Hairi, Feisul Mustapha, Muhammad Fadhli Mohd Yusoff, Halizah Mat Rifin, Mastura Ismail, Foong Ming Moy, Noor Ani Ahmad
The actual prevalence of diabetic kidney disease (DKD) in patients with type 2 diabetes (T2D) in Malaysia is unknown. We aimed to determine the prevalence of DKD and its associated risk factors among T2D patients in Malaysia. An analytical cross-sectional study was conducted using the year 2022 clinical audit dataset from the National Diabetes Registry. DKD was defined as albuminuria, a decreased glomerular filtration rate, or both. Among 80,360 patients, 62.2% were female, 68.4% were Malay, and the mean age was 61...
March 25, 2024: Scientific Reports
https://read.qxmd.com/read/38527858/the-retinal-oxygen-metabolism-and-hemodynamics-as-a-substitute-for-biochemical-tests-to-predict-nonproliferative-diabetic-retinopathy
#26
JOURNAL ARTICLE
Chuanqing Zhou, Zixia Zhou, Ximeng Feng, Da Zou, Yilin Zhou, Bin Zhang, Jiabao Chen, Fei Wang, Dingying Liao, Jinying Li, Zi Jin, Qiushi Ren
Predicting the occurrence of nonproliferative diabetic retinopathy (NPDR) using biochemical parameters is invasive, which limits large-scale clinical application. Noninvasive retinal oxygen metabolism and hemodynamics of 215 eyes from 73 age-matched healthy subjects, 90 diabetic patients without DR, 40 NPDR, and 12 DR with postpanretinal photocoagulation were measured with a custom-built multimodal retinal imaging device. Diabetic patients underwent biochemical examinations. Two logistic regression models were developed to predict NPDR using retinal and biochemical metrics, respectively...
March 25, 2024: Journal of Biophotonics
https://read.qxmd.com/read/38527395/relationship-of-microvascular-complications-and-healthy-lifestyle-with-all-cause-and-cardiovascular-mortality-in-women-compared-with-men-with-type-2-diabetes
#27
JOURNAL ARTICLE
Yu-Jie Liu, Fu-Rong Li, Wen-Wen Han, Yan Liu, Yu Liu, Jia-Min Wang, Meng-Yuan Miao, Jie-Qiong Lyu, Zhong-Xiao Wan, Li-Qiang Qin, Guo-Chong Chen
BACKGROUND: Sex differences exist in the prevalence of microvascular disease (MVD) and healthy-lifestyle adherence. Whether MVD and healthy lifestyles are associated with mortality risk similarly for women and men who have type 2 diabetes mellitus (T2DM) remains unknown. METHODS: The present study included 9992 women and 15,860 men with T2DM from the UK Biobank. MVDs included retinopathy, peripheral neuropathy, and chronic kidney disease. Healthy lifestyle factors consisted of ideal BMI, nonsmoking, healthy diet, regular exercise, and appropriate sleep duration...
March 20, 2024: Clinical Nutrition
https://read.qxmd.com/read/38526804/diabetic-disease-of-the-eye-in-canada-consensus-statements-from-a-retina-specialist-working-group
#28
JOURNAL ARTICLE
Amer Omar, R Geoff Williams, James Whelan, Jason Noble, Michael H Brent, Michel Giunta, Sébastien Olivier, Mustapha Lhor
Despite advances in systemic care, diabetic disease of the eye (DDE) remains the leading cause of blindness worldwide. There is a critical gap of up-to-date, evidence-based guidance for ophthalmologists in Canada that includes evidence from recent randomized controlled trials. Previous guidance has not always given special consideration to applying treatments and managing DDE in the context of the healthcare system. This consensus statement aims to assist practitioners in the field by providing a spectrum of acceptable opinions on DDE treatment and management from recognized experts in the field...
March 23, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38524349/progression-of-diabetic-retinopathy-following-uncomplicated-phacoemulsification-a-prospective-study-from-south-india
#29
JOURNAL ARTICLE
R Sruthi, Seshadri J Saikumar, Mahesh Gopalakrishnan
AIM: The aim of this study was to study the progression of diabetic retinopathy (DR) and macular edema in uncomplicated phacoemulsification in patients with diabetes mellitus with a follow-up of 6 months. METHODS: A prospective, nonrandomized study was conducted on patients with established or no DR in a known case of diabetes mellitus undergoing cataract surgery by phacoemulsification, with no intraoperative complications. Detailed ophthalmic evaluation including fundus examination was done in all cases, and DR staging was done...
2024: Oman Journal of Ophthalmology
https://read.qxmd.com/read/38524324/comment-on-the-long-term-effect-of-panretinal-photocoagulation-on-optic-nerve-head-parameters-in-diabetic-retinopathy-using-heidelberg-retinal-tomography-iii
#30
JOURNAL ARTICLE
Pradeep Kumar Panigrahi
No abstract text is available yet for this article.
2024: Oman Journal of Ophthalmology
https://read.qxmd.com/read/38524319/phacoemulsification-in-patients-with-diabetic-macular-edema-a-real-world-data-of-75-eyes
#31
JOURNAL ARTICLE
Shikha Talwar Bassi, Shebin Salim, Ekta Rishi
PURPOSE: The purpose of this study was to evaluate the outcomes of phacoemulsification with intravitreal triamcinolone acetonide (IVTA) injection in patients with cataract and diabetic macular edema (DME) across the grades of diabetic retinopathy (DR). MATERIALS AND METHODS: It was a retrospective observational study. The study included 70 patients (75 eyes) with cataract and clinically significant macular edema in diabetics with nonproliferative (61 eyes) or proliferative (14 eyes) DR who underwent phacoemulsification with IVTA...
2024: Oman Journal of Ophthalmology
https://read.qxmd.com/read/38524313/optical-coherence-tomography-angiography-findings-of-prediabetic-patients
#32
JOURNAL ARTICLE
Sinan Emre, Cihan Altin, Mahmut Oguz Ulusoy, Elcin Aydin
PURPOSE: The purpose of this study was to evaluate prediabetic patients for microvascular changes using optical coherence tomography-angiography (OCT-A) and compare with diabetic patients and healthy controls. METHODS: OCT-A images of 60 eyes of 30 patients with diabetes mellitus (DM), 72 eyes of 36 prediabetic patients, and 108 eyes of 54 healthy controls were retrospectively evaluated and compared in this study. A swept-source OCTA (Triton, Topcon) instrument was used for collecting OCT-A images...
2024: Oman Journal of Ophthalmology
https://read.qxmd.com/read/38523956/innovations-in-diabetic-macular-edema-management-a-comprehensive-review-of-automated-quantification-and-anti-vascular-endothelial-growth-factor-intervention
#33
REVIEW
Soumya Sharma, Sachin Daigavane, Pranaykumar Shinde
Diabetic macular edema (DME) poses a significant threat to the vision and quality of life of individuals with diabetes. This comprehensive review explores recent advancements in DME management, focusing on integrating automated quantification techniques and anti-vascular endothelial growth factor (anti-VEGF) interventions. The review begins with an overview of DME, emphasizing its prevalence, impact on diabetic patients, and current challenges in management. It then delves into the potential of automated quantification, leveraging machine learning and artificial intelligence to improve early detection and monitoring...
February 2024: Curēus
https://read.qxmd.com/read/38523849/a-woman-with-hnf1a-associated-monogenic-diabetes-treated-successfully-with-repaglinide-monotherapy
#34
Katherine Cuan, Ilana R Bass
BACKGROUND/OBJECTIVE: Monogenic diabetes is a rare type of diabetes that is commonly misdiagnosed as type 1 or 2 diabetes mellitus, which adversely impacts patient care. Such cases are particularly challenging given the heterogeneity in presentation and overlap with other types of diabetes. As the sole use of meglitinides, especially repaglinide, to treat HNF1A -associated monogenic diabetes has been rarely reported in a few other observational studies, we describe a patient who was treated successfully with repaglinide...
2024: AACE Clinical Case Reports
https://read.qxmd.com/read/38523326/an-eye-for-a-foot-alarming-unawareness-of-diabetic-retinopathy-among-diabetic-foot-patients
#35
JOURNAL ARTICLE
Hikmet Erhan Güven, Eyüpcan Sensoy, Mehmet Citirik
This study aims to determine the awareness of diabetic retinopathy in patients hospitalized for diabetic foot ulcers, examine their clinical and demographic characteristics, and evaluate their treatment needs. In this prospective study, 62 consequent patients with diabetic foot ulcers who were hospitalized for further treatment in Diabetic Foot Department between June and August 2023 were subjected to ophthalmological examinations. Detailed anterior and posterior segment examinations were performed. Clinical and demographic characteristics and HbA1c levels were recorded...
March 24, 2024: International Journal of Lower Extremity Wounds
https://read.qxmd.com/read/38523129/the-incidence-and-prevalence-of-diabetic-macular-edema-and-proliferative-diabetic-retinopathy-their-progression-to-visual-impairment-and-patterns-in-their-intravitreal-treatment-in-the-finnish-population
#36
JOURNAL ARTICLE
Hanna Heloterä, Martti Arffman, Reijo Sund, Ilmo Keskimäki, Kai Kaarniranta
PURPOSE: The worldwide prevalence of diabetes mellitus (DM) continues to increase. As DM is linked to various ophthalmological comorbidities, it is crucial to understand the incidence and the treatment patterns of these complications to minimise the treatment burden for the patient and the healthcare system. This study aims to evaluate the incidence and prevalence of diabetic macular oedema (DME) and proliferative diabetic retinopathy (PDR) and to analyse intravitreal (IVT) treatment patterns and responses in the Finnish population with diabetes...
March 24, 2024: Acta Ophthalmologica
https://read.qxmd.com/read/38522916/molecular-basis-of-angiogenesis-and-its-application
#37
JOURNAL ARTICLE
Napoleone Ferrara
Angiogenesis, the development of new blood vessels, is a fundamental physiological process. In addition, angiogenesis plays a key role in the pathogenesis of several disorders, including cancer and eye disorders such as diabetic retinopathy and age-related macular degeneration (AMD). However, identifying the regulators of angiogenesis proved challenging. Numerous factors that stimulated angiogenesis in various bioassays were identified, but their pathophysiological role remained unclear. In 1989, we reported the isolation and cloning of vascular endothelial growth factor (VEGF, VEGF-A) as an endothelial cell-specific mitogen and angiogenic factor...
2024: Keio Journal of Medicine
https://read.qxmd.com/read/38521951/the-role-of-long-noncoding-rnas-in-ocular-angiogenesis-and-vascular-oculopathy
#38
REVIEW
Pranali Gandhi, Yuzhi Wang, Guigang Li, Shusheng Wang
Long noncoding RNAs (lncRNAs) are RNA transcripts over 200 nucleotides in length that do not code for proteins. Initially considered a genomic mystery, an increasing number of lncRNAs have been shown to have vital roles in physiological and pathological conditions by regulating gene expression through diverse mechanisms depending on their subcellular localization. Dysregulated angiogenesis is responsible for various vascular oculopathies, including diabetic retinopathy, retinopathy of prematurity, age-related macular degeneration, and corneal neovascularization...
March 23, 2024: Cell & Bioscience
https://read.qxmd.com/read/38521836/associations-between-lipid-abnormalities-and-diabetic-retinopathy-across-a-large-united-states-national-database
#39
JOURNAL ARTICLE
Hejin Jeong, Christopher M Maatouk, Matthew W Russell, Rishi P Singh
BACKGROUND/OBJECTIVES: While dyslipidaemia has been suggested as a potential risk factor for diabetic retinopathy (DR), previous studies have reported conflicting findings. This study aimed to better characterize the relationship between abnormal serum levels of various lipid markers and the risk of the development and progression of DR. SUBJECTS/METHODS: This retrospective cohort study utilized a United States national database of electronic medical records. Adults with a history of type 2 diabetes mellitus without type 1 diabetes mellitus were divided into cohorts based on the presence of abnormal serum levels of various lipid markers...
March 23, 2024: Eye
https://read.qxmd.com/read/38521801/the-clinical-evaluation-of-a-widefield-lens-to-expand-the-field-of-view-in-optical-coherence-tomography-oct-a
#40
JOURNAL ARTICLE
Fritz Soecknick, Katharina Breher, Zahra Nafar, Sophie Kubach, Jochen Straub, Siegfried Wahl, Focke Ziemssen
This study aimed to evaluate the clinical benefits of incorporating a widefield lens (WFL) in optical coherence tomography angiography (OCT-A) in patients with retinal vascular diseases in comparison to standard single-shot OCT-A scans. Sixty patients with retinal vascular diseases including diabetic retinopathy (DR) and retinal vein occlusion (RVO) were recruited. OCT-A imaging (PlexElite 9000) with and without WFL was performed in randomized order. The assessment included patient comfort, time, field of view (FoV), image quality and pathology detection...
March 23, 2024: Scientific Reports
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