keyword
https://read.qxmd.com/read/38530491/multicenter-randomized-controlled-trial-of-intensive-uric-acid-lowering-therapy-for-ckd-patients-with-hyperuricemia-target-ua
#21
JOURNAL ARTICLE
Tetsuya Yamamoto, Masato Kasahara, Kenji Ueshima, Shiro Uemura, Naoki Kashihara, Kenjiro Kimura, Tsuneo Konta, Tetsuo Shoji, Akira Mima, Masashi Mukoyama, Yoshihiko Saito
BACKGROUND: We investigate whether Intensive uric acid (UA)-lowering therapy (ULT) provides increased renal protection compared with standard therapy in chronic kidney disease (CKD) patients. METHODS: This was a multicenter randomized controlled trial. Only CKD patients with hyperuricemia were included in this study. The participants were randomly assigned to either the Intensive therapy group (target serum UA level ≥ 4.0 mg/dL and < 5...
March 26, 2024: Clinical and Experimental Nephrology
https://read.qxmd.com/read/38530490/factors-affecting-responsiveness-of-vadadustat-in-patients-with-anemia-associated-with-chronic-kidney-disease-a-post-hoc-subgroup-analysis-of-japanese-phase-3-randomized-studies
#22
JOURNAL ARTICLE
Masaomi Nangaku, Kiichiro Ueta, Kenichi Nishimura, Kazuyo Sasaki, Takafumi Hashimoto
BACKGROUND: Vadadustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor developed for treating anemia in chronic kidney disease (CKD). The purpose of this post-hoc analysis was to investigate the factors affecting the responsiveness to vadadustat in anemia patients with nondialysis-dependent (NDD) or hemodialysis-dependent (HDD) CKD in two Japanese phase 3 studies. METHODS: Of 151 and 162 patients enrolled in NDD-CKD and HDD-CKD studies, 136 and 140 patients, respectively, were included and divided into subgroups for the analysis...
March 26, 2024: Clinical and Experimental Nephrology
https://read.qxmd.com/read/38530365/rab35-is-required-for-embryonic-development-and-kidney-and-ureter-homeostasis-through-regulation-of-epithelial-cell-junctions
#23
JOURNAL ARTICLE
Kelsey R Clearman, Napassawon Timpratoom, Dharti Patel, Addison B Rains, Courtney J Haycraft, Mandy J Croyle, Jeremy F Reiter, Bradley K Yoder
BACKGROUND: Rab35 is a member of a GTPase family of endocytic trafficking proteins. Studies in cell lines have indicated that Rab35 participates in cell adhesion, polarity, cytokinesis, and primary cilia length and composition. Additionally, sea urchin Rab35 regulates actin organization and is required for gastrulation. In mice, loss of Rab35 in the CNS disrupts hippocampal development and neuronal organization. Outside of the CNS, the functions of mammalian Rab35 in vivo are unknown...
March 26, 2024: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/38530359/genome-wide-crispr-screen-identifies-phospholipid-scramblase-3-as-the-biological-target-of-mitoprotective-drug-ss-31
#24
JOURNAL ARTICLE
Josie A Silvaroli, Bijay Bisunke, Ji Young Kim, Amanda Stayton, Laura A Jayne, Shirely A Martinez, Christopher Nguyen, Prisha S Patel, Thitinee Vanichapol, Vivek Verma, Juheb Akhter, Subhashini Bolisetty, Sethu M Madhavan, Cem Kuscu, Christopher C Coss, Diana Zepeda-Orozco, Samir V Parikh, Anjali A Satoskar, Alan J Davidson, James D Eason, Hazel H Szeto, Navjot Singh Pabla, Amandeep Bajwa
BACKGROUND: The synthetic tetra-peptide SS-31 shows promise in alleviating mitochondrial dysfunction associated with common diseases. However, the precise pharmacological basis of its mitoprotective effects remains unknown. METHODS: To uncover the biological targets of SS-31, we performed a genome-scale CRISPR screen in HK-2 cells, a cell culture model where SS-31 mitigates cisplatin-associated cell death and mitochondrial dysfunction. The identified hit candidate gene was functionally validated using knockout cell lines, siRNA mediated downregulation, and tubular epithelial specific conditional knockout mice...
March 26, 2024: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/38529931/acute-kidney-injury-in-children-with-lymphoma
#25
JOURNAL ARTICLE
Hejia Zhang, Yanlong Duan, Xiaoxue Li, Zhi Chen, Xiaorong Liu
OBJECTIVE: To analyze the epidemiology of acute kidney injury (AKI) in children with lymphoma and to assess the incidence, risk profile of AKI, and effects on renal function in children with lymphoma during their first 30 days of hospitalization. MATERIALS AND METHODS: This was a retrospective screen of electronic hospital and laboratory databases to select hospitalized children who were first diagnosed and treated for lymphoma at Beijing Children's Hospital between 2020 and 2021...
March 26, 2024: Clinical Nephrology
https://read.qxmd.com/read/38528482/effect-of-multidisciplinary-care-on-diabetic-kidney-disease-a-retrospective-cohort-study
#26
JOURNAL ARTICLE
Ayano Hayashi, Kayoko Mizuno, Kanna Shinkawa, Kazunori Sakoda, Satomi Yoshida, Masato Takeuchi, Motoko Yanagita, Koji Kawakami
BACKGROUND: Diabetic kidney disease (DKD) is the most common disease among patients requiring dialysis for the first time in Japan. Multidisciplinary care (MDC) may prevent the progression of kidney failure. However, the effectiveness and timing of MDC to preserve kidney function in patients with DKD is unclear. Therefore, the aim of this study was to investigate whether MDC for patients with DKD affects the preservation of kidney function as well as the timing of MDC in clinical practice...
March 25, 2024: BMC Nephrology
https://read.qxmd.com/read/38528290/apparent-differences-in-prostate-zones-susceptibility-to-prostate-cancer-benign-prostatic-hyperplasia-and-prostatitis
#27
REVIEW
Xu-Dong Yu, Shao-Shuai Yan, Rui-Jia Liu, Yao-Sheng Zhang
Men are inevitably plagued by prostate disease throughout their lives. However, the understanding of the pathogenesis of prostate diseases is still limited. In the 1960s, McNeal proposed the theory of prostate zones: the prostate was divided into three main zones: transition zone, central zone, and peripheral zone. Over the past 50 years, significant differences between different prostate zones have been gradually revealed. We summarized the most significant differences in different zones of the prostate...
March 25, 2024: International Urology and Nephrology
https://read.qxmd.com/read/38528249/positive-response-of-a-hemodialysis-patient-with-pure-red-cell-aplasia-on-recombinant-human-erythropoietin-therapy-to-cyclosporine-and-roxadustat
#28
JOURNAL ARTICLE
Xuejuan Ma, Pearl Pai, Wenjuan Zhu, Xiaowei Chen, Liwen Cui
Recombinant human erythropoietin (rHuEPO) is commonly used to treat anemia associated with chronic kidney disease (CKD). EPO-induced Pure Red Cell Aplasia (PRCA) is a rare condition of profound anemia with EPO treatment. Upon finding the development of EPO-induced PRCA, the treatment requires immediate withdrawal of EPO therapy and initiate new treatments with immunosuppression or renal transplantation. Anti-EPO antibody assay is not always positive in EPO-induced PRCA. Here, we report a case on the sudden development of PRCA in a hemodialysis patient receiving EPO and how we treated the condition successfully with cyclosporine and subsequently maintained the hemoglobin with Roxadustat, a hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI)...
March 25, 2024: CEN Case Reports
https://read.qxmd.com/read/38527995/non-lupus-full-house-nephropathy
#29
JOURNAL ARTICLE
Martina Uzzo, Andreas Kronbichler, Federico Alberici, Ingeborg Bajema
BACKGROUND: The presence of a full house pattern at immunofluorescence on kidney biopsy in a patient without clinical and laboratory features of systemic lupus erythematosus (SLE) has led to the descriptive term non-lupus full house nephropathy. This systematic review and meta-analysis focus on non-lupus full house nephropathy nomenclature, clinical findings and outcomes. METHODS: In a reiterative process, all identified terms for non-lupus full house nephropathy and other MeSH terms were searched in PubMed...
March 26, 2024: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/38527975/associations-between-different-antivirals-and-hospital-acquired-acute-kidney-injury-in-adults-with-herpes-zoster
#30
JOURNAL ARTICLE
Ruqi Xu, Qi Gao, Yuping Zhang, Yuxin Lin, Yanqin Li, Licong Su, Shiyu Zhou, Yue Cao, Peiyan Gao, Pingping Li, Fan Luo, Ruixuan Chen, Xiaodong Zhang, Sheng Nie, Xin Xu
BACKGROUND: To examine the association of use of different antivirals with hospital acquired acute kidney injury (AKI) among Chinese adults with herpes zoster. METHODS: The study selected 3273 adult patients who received antiviral therapy for herpes zoster during hospitalization from the China Renal Data System (CRDS). We identified and staged AKI using patient-level serum creatinine data according to the Kidney Disease Improving Global Outcomes (KDIGO) criteria...
March 26, 2024: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/38526813/-secondary-fracture-prevention-update-osteoporosis-guidelines-2023-of-the-umbrella-organization-osteology
#31
REVIEW
Ulla Stumpf, Ralf Schmidmaier
The S3 guidelines on the prophylaxis, diagnostics and treatment of osteoporosis 2023 were completely revised and updated between 2021 and 2023 in accordance with the Association of the Scientific Medical Societies of Germany (AWMF) regulations. The guideline committee consisted of delegates from the 20 specialist societies of the Umbrella Organization Osteology (Dachverband Osteologie, DVO) as well as delegates from the German Society of General Medicine and Family Medicine (DEGAM), the German Society for Nephrology (DGfN) and the Federal Self-help Association for Osteoporosis (BfO)...
April 2024: Unfallchirurgie (Heidelb)
https://read.qxmd.com/read/38526762/pharmacovigilance-of-nephrotoxic-drugs-in-neonates-the-pottel-method-for-acute-kidney-injury-detection-in-elbw-neonates
#32
JOURNAL ARTICLE
Mathilde Dumoulin, Hans Pottel, Djalila Mekahli, Annouschka Laenen, Anne Smits, Karel Allegaert
BACKGROUND: Extremely low birth weight (ELBW) neonates (birth weight ≤ 1000 g) are at high risk to develop drug-induced acute kidney injury (AKI). However, we lack a pragmatic detection tool to capture their time-dependent (patho)physiologic serum creatinine (Scr) patterns. Pottel et al. suggested rescaling Scr by dividing Scr with the mean Scr value of the age- and sex-specific reference population. We explored if this Pottel method can detect drug-related nephrotoxicity in ELBW neonates...
March 25, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38526761/intraoperative-kidney-replacement-therapy-in-acute-liver-failure
#33
JOURNAL ARTICLE
Daniel Henderson, Anish Gupta, Shina Menon, Akash Deep
Paediatric acute liver failure (PALF) is often characterised by its rapidity of onset and potential for significant morbidity and even mortality. Patients often develop multiorgan dysfunction/failure, including severe acute kidney injury (AKI). Whilst the management of PALF focuses on complications of hepatic dysfunction, the associated kidney impairment can significantly affect patient outcomes. Severe AKI requiring continuous kidney replacement therapy (CKRT) is a common complication of both PALF and liver transplantation...
March 25, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38526665/lymphatic-vessels-in-patients-with%C3%A2-crescentic-glomerulonephritis-association-with-renal-pathology-and-prognosis
#34
JOURNAL ARTICLE
Danni Hu, Zheng Wang, Shujie Wang, Yueqiang Li, Guangchang Pei, Rui Zeng, Gang Xu
BACKGROUND: Various immune cells, including T cells, B cells, macrophages, and neutrophils contribute to the development of crescentic glomerulonephritis. Previous animal studies have suggested that lymphangiogenesis is involved in the migration of inflammatory cells and the activation of adaptive immunity. However, the extent of the association between lymphatic vessels and crescentic glomerulonephritis severity and prognosis remains unknown. METHODS AND RESULTS: In this study, we assessed lymphatic vessel density in 71 patients with crescentic glomerulonephritis who underwent renal biopsies between June 2017 and June 2022...
March 25, 2024: Journal of Nephrology
https://read.qxmd.com/read/38526140/kidney-stones-account-for-increased-imaging-studies-in-autosomal-dominant-polycystic-kidney-disease
#35
JOURNAL ARTICLE
Kathryn E Simmons, Lawrence S Ullman, Neera K Dahl
INTRODUCTION: ADPKD patients may have more imaging studies than patients with other forms of chronic kidney disease (CKD). We characterized the imaging burden of ADPKD patients relative to a CKD population to determine which factors lead to increased imaging in ADPKD patients. METHODS: We retrospectively reviewed patients seen at Yale Nephrology between January 2012 and January 2021. We collected demographic, clinical, and imaging data through automated query and manual chart review...
March 25, 2024: Kidney360
https://read.qxmd.com/read/38525412/advances-in-human-centered-care-to-address-contemporary-unmet-needs-in-chronic-dialysis
#36
REVIEW
Sumedh Jayanti, Gopala K Rangan
Advances in the treatment of kidney failure with chronic dialysis have stagnated over the past three decades, with over 50% of patients still managed by conventional in-hospital haemodialysis. In parallel, the demands of chronic dialysis medical care have changed and evolved due to a growing population that has higher frailty and multimorbidity. Thus, the gap between the needs of kidney failure patients and the healthcare capability to provide effective overall management has widened. To address this problem, healthcare policy has increasingly aligned towards a human-centred approach...
2024: International Journal of Nephrology and Renovascular Disease
https://read.qxmd.com/read/38525052/the-tunnelled-atrial-catheter-a-promising-solution-for-vascular-capital-depletion-in-dialysis-despite-associated-thrombi
#37
Meriam Hajji, Salah Saied, Ikram Mami, Yassine Khadhar, Tasnim Ben Ayed, Imen Gorsane, Fethi Ben Hamida, Jalel Ziadi, Mohamed Karim Zouaghi, Ezzeddine Abderrahim
INTRODUCTION: Longer survival in dialysis led to a higher incidence of vascular access complications and failure. With the limited access to kidney transplantation programs and peritoneal dialysis, exhaustion of vascular access for hemodialysis is an increasingly common situation. Among the available options, atrial tunneled dialysis catheter (ATDC) has been reported as an effective vascular access in this population. Methodology . We report the experiences of two nephrology centers in Tunis with ATDC as an ultimate vascular access for dialysis...
2024: Case Reports in Nephrology
https://read.qxmd.com/read/38524801/impact-of-the-2021-ckd-epi-egfr-equation-on-kidney-care-referral-criteria-in-ontario-canada-a-population-based-cross-sectional-study
#38
JOURNAL ARTICLE
Eric McArthur, Graham Smith, Manish M Sood, Peter G Blake, K Scott Brimble, Flory T Muanda, Amit X Garg, Stephanie N Dixon
BACKGROUND: In some jurisdictions, individuals become eligible or recommended for referral for different types of kidney care using criteria based on their estimated glomerular filtration rate (eGFR). Historically, GFR was estimated with an equation developed in 2009, which included a Black race term. An updated, race-free equation was developed in 2021. It is unclear how adoption of the 2021 equation will influence the number of individuals meeting referral criteria to receive different types of kidney care...
2024: Canadian Journal of Kidney Health and Disease
https://read.qxmd.com/read/38524730/overlap-syndrome-of-diffuse-systemic-sclerosis-sj%C3%A3-gren-syndrome-and-anca-associated-renal-limited-vasculitis-three-entities-in-one-patient-case-report
#39
Angela Maria Cordoba-Hurtado, Laura Fuentes-Mendez, Lucia Monserrat Perez-Navarro, Virgilia Soto-Abraham, Rafael Valdez-Ortiz
INTRODUCTION: The presence of three different entities in a single patient is usually of clinical interest and mostly anecdotal. The overlap of systemic sclerosis (SSc), Sjögren syndrome (SS), and ANCA-associated renal-limited vasculitis has been reported only once previously. CASE PRESENTATION: A 61-year-old female was evaluated at consultation with 2 years of symptomatology, presenting cardboard-like skin, sclerodactyly, limited oral opening, and dry skin and eyes...
2024: Case Reports in Nephrology and Dialysis
https://read.qxmd.com/read/38524729/telitacicept-treatment-refractory-lupus-nephritis-a-case-report
#40
Sijia Li, Shuting Deng, Sichun Wen, Siqi Peng, Nan Jiang, Bohou Li, Boxi Chen, Ye Yuan, Qiong Wu, Yiming Tao, Jianchao Ma, Ting Lin, Feng Wen, Zhuo Li, Hao Dai, Renwei Huang, Zhonglin Feng, Zhilian Li, Shuangxin Liu, Lixia Xu
INTRODUCTION: Refractory lupus nephritis (LN) causes kidney disease progression and increases the risk of loss of renal function. Due to the high specificity and few side effects of biological agents, they are recommended for the treatment of systemic lupus erythematosus. There are few data on telitacicept for the treatment of refractory LN. CASE PRESENTATION: Here, we report the efficacy and safety of telitacicept in the treatment of refractory LN in a 25-year-old female patient...
2024: Case Reports in Nephrology and Dialysis
keyword
keyword
169412
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.