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Sydney Chi-Wai Tang, Andrew Kui-Man Wong, Siu-Ka Mak
No abstract text is available yet for this article.
March 2019: Nephrology
Yonggang Wang, Yao Wang, Feng Liu
Following the publication of this article, the authors have realized that the affiliation for the third author, Feng Liu, was presented incorrectly: Dr Liu is based at the Department of Nephrology at the China‑Japan Union Hospital of Jilin University. Therefore, the author affiliations for this paper should have appeared as follows: Yonggang Wang1, Yao Wang1 and Feng Liu2. Departments of 1Urology and 2Nephrology, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China. The authors regret that this was not corrected prior to the publication of the paper, and apologize to the readership for any inconvenience caused...
March 19, 2019: International Journal of Molecular Medicine
Yuki Kondo, Yoichi Ishitsuka, Nobuhiro Kawabata, Nobuhide Iwamoto, Risa Takahashi, Yuki Narita, Daisuke Kadowaki, Sumio Hirata, Satoru Uchino, Tetsumi Irie
INTRODUCTION: Patients with chronic kidney disease (CKD) depend on advice from healthcare professionals to avoid using unsuitable over-the-counter (OTC) drugs. Recently, qualified, registered nonpharmacist salespersons became licensed to sell OTC drugs in Japan. However, registered salespersons' knowledge and awareness of precautions regarding unsuitable OTC drugs for use in patients with CKD are unclear. OBJECTIVES: This study aimed to clarify the awareness, knowledge, and implementation of precautions by registered salespersons regarding OTC drugs used by patients with CKD...
2019: PloS One
Zubin J Modi, Yee Lu, Nan Ji, Alissa Kapke, David T Selewski, Xue Dietrich, Kevin Abbott, Brahmajee K Nallamothu, Douglas E Schaubel, Rajiv Saran, Debbie S Gipson
Importance: Cardiovascular disease (CVD) is a leading cause of death among patients with end-stage renal disease (ESRD). Young adult (ages 22-29 years) have risks for ESRD-associated CVD that may vary from other ages. Objective: To test the hypothesis that young adult-onset ESRD is associated with higher cardiovascular (CV) hospitalizations and mortality with different characteristics than childhood-onset disease. Design, Setting, and Participants: This population-based cohort study used the US Renal Data System to categorize patients who initiated ESRD care between 2003 and 2013 by age at ESRD onset (1-11, 12-21, and 22-29 years)...
March 20, 2019: JAMA Cardiology
Valérie Metzinger-Le Meuth, Laurent Metzinger
microRNAs (miRNAs) represent a recent breakthrough regarding gene expression regulation. They are instrumental players known to regulate post-transcriptional expression. miRNAs are short single stranded RNAs that base-pair with target mRNAs in specific regions mainly within their 3' untranslated region. We know now that miRNAs are involved in kidney physiopathology. We outline in this review the recent discoveries made on the roles of miRNAs in cellular and animal models of kidney disease but also in patients suffering from chronic kidney disease, acute kidney injury and so forth...
March 2019: Non-Coding RNA Research
Giorgina B Piccoli, Gilberto Richiero, Hayley Henderson
Listening to the interview of Natalia Tomilina is an inspiring experience, and not one reserved purely for young physicians. Within these pages, one can discover Tomilina's determination and passion for learning that has been with her throughout her life, even during difficult and testing times. A great resolve that she developed through the teachings of her parents and her mentor, Prof. Maria Ratner.It is clear that her ties to her cultural roots are strong, allowing her to have a greater understanding of her patients ("the doctor has to understand the patient"), and with this, she has developed a humanist approach to medicine...
March 19, 2019: BMC Nephrology
Shivendra Singh, Prem Shankar Patel, Prodip Kumar Doley, Shiv Shankar Sharma, Mohd Iqbal, Anupam Agarwal, Neelam Singh, Alok Kumar
BACKGROUND: HAAKI is a common clinical problem in hospitalized patients. Its incidence is high in older patients and carries worse prognosis. The presence of multiple co-morbidities, aging process, and frequent diagnostic and therapeutic interventions predispose elderly patients to HAAKI. This study aims to evaluate the spectrum, risk factors and determinants of outcome of elderly patients with HAAKI. METHODS: This prospective study was conducted during January 2014 to September 2015 in the Department of nephrology, Institute of Medical Sciences, BHU, Varanasi, UP, India...
March 19, 2019: International Urology and Nephrology
A Midhat Elmaci, M İrfan Dönmez
Data regarding spontaneous resolution of mild hydronephrosis consist of different etiologies, and hence, it is heterogeneous. The aim of this study is to evaluate spontaneous resolution rates and the time to complete resolution of antenatally detected isolated hydronephrosis in patients with renal pelvis antero-posterior diameter (RPAPD) ≤ 20 mm. Retrospective chart review of patients who were admitted to our pediatric nephrology clinic for the evaluation of antenatal hydronephrosis between 2011 and 2017 was conducted...
March 19, 2019: European Journal of Pediatrics
Anja Haase-Fielitz, Martin Ernst, Franziska Lehmanski, Julia Gleumes, Gundwara Blödorn, Anke Spura, Bernt-Peter Robra, Saban Elitok, Annemarie Albert, Christian Albert, Christian Butter, Michael Haase
BACKGROUND: Delayed diagnosis and undertherapy of acute-on-chronic kidney injury (AKI-on-CKD) may trigger multiple organ injury and worsen clinical outcome. OBJECTIVES: This study focused on description of in-hospital care and cross-sectoral information transmission of patients with AKI-on-CKD including subgroup analyses (under surgical vs. non-surgical and nephrology vs. non-nephrology care). MATERIALS AND METHODS: At a university clinic, we analysed clinical measures and documentation in patients with AKI-on-CKD...
March 18, 2019: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Deidra C Crews, Aminu K Bello, Gamal Saadi
Kidney disease is a global public health problem, affecting more than 750 million persons worldwide. The burden of kidney disease varies substantially across the world, as does its detection and treatment. In many settings, rates of kidney disease and the provision of its care are defined by socioeconomic, cultural, and political factors leading to significant disparities. World Kidney Day 2019 offers an opportunity to raise awareness of kidney disease and highlight disparities in its burden and current state of global capacity for prevention and management...
2019: Canadian Journal of Kidney Health and Disease
Alexandru Burlacu, Simonetta Genovesi, Alberto Ortiz, Christian Combe, Carlo Basile, Daniel Schneditz, Frank van der Sande, Grigore T Popa, Cornel Morosanu, Adrian Covic
Dialysis patients manifest both an increased thrombotic risk and a haemorrhagic tendency. A great number of patients with chronic kidney disease requiring dialysis have cardiovascular comorbidities (coronary artery disease, atrial fibrillation or venous thromboembolism) and different indications for treatment with antithrombotics (primary or secondary prevention). Unfortunately, few randomized controlled trials deal with antiplatelet and/or anticoagulant therapy in dialysis. Therefore cardiology and nephrology guidelines offer ambiguous recommendations and often exclude or ignore these patients...
March 16, 2019: Nephrology, Dialysis, Transplantation
Chiara Gai, Margherita A C Pomatto, Cristina Grange, Maria Chiara Deregibus, Giovanni Camussi
Extracellular vesicles (EVs) are important mediators of intercellular communication in cancer and in normal tissues. EVs transfer biologically active molecules from the cell of origin to recipient cells. This review summarizes the studies on EVs derived from renal cell carcinoma and from a subpopulation of CD105-positive renal cancer stem cells. While EVs from renal cell carcinoma show mild biological activity, EVs from renal cancer stem cells enhance tumor angiogenesis and metastasis formation. The effect is probably due to the transfer of proangiogenic RNA cargo to endothelial cells, which acquire an activated angiogenic phenotype...
March 15, 2019: Experimental & Molecular Medicine
International Journal Of Nephrology
[This retracts the article DOI: 10.1155/2018/2903139.].
2019: International Journal of Nephrology
Osama Y Safder, Khalid A Alhasan, Mohamed A Shalaby, Norah Khathlan, Suleman A Al Rezgan, Amr S Albanna, Jameela A Kari
BACKGROUND: Acute kidney injury (AKI) in critically ill children is associated with increased mortality and morbidity. In this study we evaluated the effect of AKI severity on the incidence of short-term mortality and morbidity. METHODS: Multicenter prospective cohort study was conducted over two years period. We used the Kidney Disease Improving Global Outcomes (KDIGO) to diagnose and stage AKI. RESULTS: A total of 511 out of 1367 included children (37...
March 12, 2019: BMC Nephrology
John A Thompson, Bryan J Schneider, Julie Brahmer, Stephanie Andrews, Philippe Armand, Shailender Bhatia, Lihua E Budde, Luciano Costa, Marianne Davies, David Dunnington, Marc S Ernstoff, Matthew Frigault, Brianna Hoffner, Christopher J Hoimes, Mario Lacouture, Frederick Locke, Matthew Lunning, Nisha A Mohindra, Jarushka Naidoo, Anthony J Olszanski, Olalekan Oluwole, Sandip P Patel, Sunil Reddy, Mabel Ryder, Bianca Santomasso, Scott Shofer, Jeffrey A Sosman, Momen Wahidi, Yinghong Wang, Alyse Johnson-Chilla, Jillian L Scavone
The aim of the NCCN Guidelines for Management of Immunotherapy-Related Toxicities is to provide guidance on the management of immune-related adverse events resulting from cancer immunotherapy. The NCCN Management of Immunotherapy-Related Toxicities Panel is an interdisciplinary group of representatives from NCCN Member Institutions and ASCO, consisting of medical and hematologic oncologists with expertise in a wide array of disease sites, and experts from the fields of dermatology, gastroenterology, neuro-oncology, nephrology, emergency medicine, cardiology, oncology nursing, and patient advocacy...
March 1, 2019: Journal of the National Comprehensive Cancer Network: JNCCN
Deidra C Crews, Aminu K Bello, Gamal Saadi
Kidney disease is a global public health problem, affecting over 750 million persons worldwide. The burden of kidney disease varies substantially across the world, as does its detection and treatment. In many settings, rates of kidney disease and the provision of its care are defined by socio-economic, cultural, and political factors leading to significant disparities. World Kidney Day 2019 offers an opportunity to raise awareness of kidney disease and highlight disparities in its burden and current state of global capacity for prevention and management...
February 28, 2019: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Emmanuel Ademola Anigilaje, Temilade Christianah Adesina
Introduction: Renal disorders contribute to childhood morbidity and mortality in developing countries. Therefore, the knowledge of the burden of childhood renal diseases is required for preventive and management purposes. This article determines the pattern and the outcomes of childhood renal diseases seen at the University of Abuja Teaching Hospital (UATH), Gwagwalada, Abuja, Nigeria. Materials and Methods: This was a retrospective review of children aged 1 month to 17 years, who were seen at the paediatric nephrology clinic, emergency paediatric unit and paediatric ward of the UATH over 4 years from January 2013 to December 2016...
January 2019: Nigerian Postgraduate Medical Journal
Alejandro Balestracci, Micaela Montecuco, Carla Serviddio, Lourdes Domínguez Figueredo, Virginia Montiel, Cecilia Torres Perez, Iris Puyol, Marina A Capone
OBJECTIVE: To determine the performance of late dimercaptosuccinic acid (DMSA) renal scans in identifying high-grade (III-V) vesicoureteral reflux (VUR) in children aged over 3 y with a febrile urinary tract infection (fUTI) history that has not been timely investigated. METHODS: In this retrospective study of diagnostic accuracy, the clinical records of children aged between 3 and 18 y with fUTI history evaluated consecutively at Nephrology Unit of Hospital General de Niños Pedro de Elizalde, Argentina between 2006 and 2016 were reviewed...
March 11, 2019: Indian Journal of Pediatrics
Rolf A K Stahl, Elion Hoxha
BACKGROUND: Membranous glomerulonephritis (MGN) is the most frequent cause of a nephrotic syndrome in adults. It is an autoimmune disease caused by binding of autoantibodies to endogenous proteins expressed on glomerular podocytes. Antibody binding and activation of inflammatory mediators result in the onset of proteinuria. Recently, two endogenous podocytic target antigens in MGN have been characterized and their clinical role is a main focus of research in nephrology. OBJECTIVE: The discovery that antibodies against phospholipase A2 receptor 1 (PLA2 R1) and thrombospondin type 1 domain containing 7A (THSD7A) mediate the pathogenesis of MGN leads to the question of what clinical role these antibodies have in patients with MGN...
March 11, 2019: Der Internist
Rukshana Shroff, Francis Calder, Sevcan Bakkaloğlu, Evi V Nagler, Sam Stuart, Lynsey Stronach, Claus P Schmitt, Karl H Heckert, Pierre Bourquelot, Ann-Marie Wagner, Fabio Paglialonga, Sandip Mitra, Constantinos J Stefanidis
BACKGROUND: There are three principle forms of vascular access available for the treatment of children with end stage kidney disease (ESKD) by haemodialysis: tunnelled catheters placed in a central vein (central venous lines, CVLs), arteriovenous fistulas (AVF), and arteriovenous grafts (AVG) using prosthetic or biological material. Compared with the adult literature, there are few studies in children to provide evidence based guidelines for optimal vascular access type or its management and outcomes in children with ESKD...
March 11, 2019: Nephrology, Dialysis, Transplantation
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