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Michelle Huntzinger, Klaus Bielefeldt
A specialty outreach program relied on telemedicine to reach patients with gastrointestinal and liver diseases in a large service area.
August 2018: Federal Practitioner: for the Health Care Professionals of the VA, DoD, and PHS
Aabha Nagral, Moinak S Sarma, John Matthai, Prashanth L Kukkle, Harshad Devarbhavi, Sanjib Sinha, Seema Alam, Ashish Bavdekar, Radha K Dhiman, Chundamannil E Eapen, Vinay Goyal, Neelam Mohan, Rukmini M Kandadai, Malathi Sathiyasekaran, Ujjal Poddar, Anupam Sibal, Srinivas Sankaranarayanan, Anshu Srivastava, Baburam R Thapa, Pettarusp M Wadia, Surendra K Yachha, Anil Dhawan
Clinical practice guidelines for Wilson's disease (WD) have been published by the American Association for the Study of Liver Diseases and European Association for the Study of the Liver in 2008 and 2012, respectively. Their focus was on the hepatic aspects of the disease. Recently, a position paper on pediatric WD was published by the European Society of Pediatric Gastroenterology Hepatology and Nutrition. A need was felt to harmonize guidelines for the hepatic, pediatric, and neurological aspects of the disease and contextualize them to the resource-constrained settings...
January 2019: Journal of Clinical and Experimental Hepatology
Sindhuja Kesavan, Ramakrishnan Parthasarathi, Prakhar Gupta, Chinnusamy Palanivelu
The pararectal space or presacral space is a potential site for various cysts and tumours because it consists of many types of embryonic tissues. Although epidermoid cyst is a well-known entity, encountering a pararectal epidermoid cyst is relatively rare. The incidence of cystic tumours in the pararectal space has been reported to be 1 in 40 000 to 63 000 patients. Most of the tumours are asymptomatic and are incidentally discovered during routine imaging studies. Herein, we report a case of pararectal epidermoid cyst in a 51-year-old woman which was managed laparoscopically in a gastroenterology institute in South India...
February 13, 2019: BMJ Case Reports
Abi Rimmer
No abstract text is available yet for this article.
February 14, 2019: BMJ: British Medical Journal
A M Sarkar, S Akhter, M R Khan, M Saha, M R Alam, C K Ghosh, D S Ahmed, A R Miah, P K Roy
Several mechanisms have been proposed to explain the symptoms of functional dyspepsia but actual pathogenesis is still poorly understood. Recent studies support duodenal abnormality to be the most important causal link to explain symptoms and to understand abnormal pathophysiology of functional dyspepsia. The aim of this prospective observational study is to compare eosinophil count in duodenal mucosa between patients with functional dyspepsia and control subjects without dyspepsia and was done at the department of Gastroenterology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from December 2015 to December 2016...
January 2019: Mymensingh Medical Journal: MMJ
Tero Ylisaukko-Oja, Saku Torvinen, Jaakko Aaltonen, Heikki Nuutinen, Timo Blomster, Airi Jussila, Markku Pajala, Kimmo Salminen, Veikko Moilanen, Kalle Hakala, Mikko Kellokumpu, Kari Toljamo, Henna Rautiainen, Juha Kuisma, Markku Peräaho, Pauliina Molander, Jouni Silvennoinen, Ville Liukkonen, Hans Henricson, Jyrki Tillonen, Mirva Esterinen, Christian Nielsen, Eija Hirsi, Margus Lääne, Ulla-Maija Suhonen, Ilkka Vihriälä, Petri Mäkelä, Mika Puhto, Jari Punkkinen, Hannu Sulonen, Sauli Herrala, Jari Jokelainen, Klaus Tamminen, Taina Sipponen
Limited data is available on vedolizumab combination therapies in real-world clinical practice. Here, we evaluated the concomitant corticosteroid, immunosuppressive, and 5-aminosalicylic acid utilization of inflammatory bowel disease (IBD) patients treated with vedolizumab in a nationwide, retrospective, non-interventional, multi-centre chart review study. All adult patients from 27 Finnish gastroenterology centres with a diagnosis of Crohn's disease (CD) or ulcerative colitis (UC) who had at least one vedolizumab infusion since it's availability in Finland were included in the study...
February 9, 2019: Biologicals: Journal of the International Association of Biological Standardization
Shubha Bhat, Toni Zahorian, Regine Robert, Francis A Farraye
In an effort to manage health care costs and avoid improper medication use, prior authorizations (PAs) have become a standard stipulation required by payers in the determination of medication coverage. For gastroenterologists managing patients, especially those with inflammatory bowel disease (IBD), the PA process is time-consuming and further complicated by 2 additional factors: step therapy requirements and failure of payers to recognize updated IBD treatment pathways. These factors often lead to PA denials and cause treatment delays, which in turn can lead to disease progression, ongoing patient suffering, and ultimately an increase in both direct and indirect total costs...
February 8, 2019: Inflammatory Bowel Diseases
Mattias Mandorfer, Manfred Hecking
In this issue of Hepatology, Bräsen and Mederacke et al (1) present an analysis of all kidney biopsies performed at the gastroenterology and hepatology department at Hannover Medical School over a 16-year period. The authors identified 79 patients with both liver disease and impaired renal function, 57% of whom had acute kidney injury (AKI) or AKI overlapping chronic kidney disease (CKD), while 43% had CKD, as defined by the recently updated European clinical practice guidelines. Interestingly, 8 patients were diagnosed with cholemic nephropathy (CN), who all presented as AKI...
February 11, 2019: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Srihari Mahadev, Zhezhen Jin, Benjamin Lebwohl, Richard M Rosenberg, Reuben J Garcia-Carrasquillo, Ivonne Ramirez, Daniel E Freedberg
Background  Endoscopy training remains an apprenticeship, and the characteristics that facilitate transfer of high quality procedural skills from role models to trainees are unknown. We sought to determine whether unobserved supervisor performance influences the quality of colonoscopy performed by trainees, by studying how supervisors perform alone and how trainees perform while under those same supervisors. Methods  This was a retrospective cross-sectional study conducted among ambulatory adults ≥ 50 years old who underwent colonoscopy for cancer screening or polyp surveillance from 2006 to 2015 at one academic medical center...
January 2019: Endoscopy International Open
(no author information available yet)
No abstract text is available yet for this article.
March 2019: Journal of Clinical Gastroenterology
The Lancet Gastroenterology Hepatology
No abstract text is available yet for this article.
March 2019: Lancet. Gastroenterology & Hepatology
Karel Kostev, Anna Bauer, Louis Jacob
OBJECTIVE: The goal of the present study was to investigate lines of therapy with biological drugs in patients followed in dermatology, gastroenterology, and rheumatology practices in Germany. MATERIALS AND METHODS: The study included patients aged 18 years or over who had received a biological therapy in dermatology, gastroenterology, or rheumatology practices in Germany in 2017 (index date). The primary outcome of the study was the prevalence of different lines of therapy (first-, second-, third-, and at least fourth-line therapies) by type of practice, age, and gender...
February 10, 2019: International Journal of Clinical Pharmacology and Therapeutics
Constanza Méndez, Mario Carrasco, Betty Mora, Magdalena Araya
INTRODUCTION: The worldwide prevalence of celiac disease (CD) is ~1% of the population. In Chile, the National Health Survey 2009-2010 showed a serological prevalence in individuals older than 15 years of 0.76% (IgA-tTG2), which corresponded in Concepción to 0.6%. OBJECTIVE: Determine cli nical characteristics, search, diagnosis, treatment and follow-up of CD in the two public hospitals in Concepción that have a Gastroenterology Department. PATIENTS AND METHOD: Descriptive study...
December 2018: Revista Chilena de Pediatría
S Üstün Bezgin, T Çakabay, K Irak, M Koçyiğit, B Serin Keskineğe, S Giran Örtekin
OBJECTIVE: This study aimed to examine nasal mucociliary clearance time in patients with Helicobacter pylori infection. METHODS: Fifty patients who were newly diagnosed with H pylori infection using gastric biopsy in the gastroenterology out-patient clinic, and 50 age- and gender-matched healthy adults who were admitted to the otorhinolaryngology out-patient clinic, were included in this study. After an otorhinolaryngological examination (anterior rhinoscopy and nasal endoscopic examination), the nasal mucociliary clearance time of each subject was calculated using the saccharine test...
February 6, 2019: Journal of Laryngology and Otology
Nina Yancheva, Radin Tzonev
We report a case of darunavir-induced cholestatic hepatitis in a human immunodeficiency virus (HIV)-infected patient in the third year of his combined antiretroviral therapy. During the patient's monthly follow-up with regard to his HIV infection, elevated transaminase levels were detected. The patient was subsequently hospitalised at the AIDS and gastroenterology departments. All tested viral hepatitis markers were negative. A diagnosis of autoimmune hepatitis was also ruled out. The liver biopsy revealed cholestatic hepatitis...
February 5, 2019: International Journal of STD & AIDS
Eirini Dimidi, Camilla Cox, Stephen Mark Scott, Kevin Whelan
OBJECTIVES: This study aimed to assess the use and perceived effectiveness of probiotics by the general population (with or without self-reported constipation), and their recommendation and perceived effectiveness by general practitioners (GPs) and gastroenterology specialists. METHODS: A cross-sectional, primarily online, survey was undertaken. Responses were compared between groups using χ2 tests, and logistic regression was employed to identify predictors of probiotic use...
November 23, 2018: Nutrition
Prashant Singh, Eve Takazawa, Vikram Rangan, Sarah Ballou, Jesse Katon, Courtney McMahon, Ha-Neul Lee, Johanna Iturrino, Judy Nee, Anthony Lembo
BACKGROUND: Fecal urgency is a symptom generally associated with diarrhea but is also reported by patients with constipation. Our aim was to (a) assess the prevalence and burden of fecal urgency in constipated patients (b) evaluate gastrointestinal and psychiatric predictors of moderate to severe fecal urgency in these patients. METHODS: Patients presenting consecutively to a tertiary outpatient gastroenterology clinic with constipation were included. Patients were considered to have moderate to severe fecal urgency if ≥50% of bowel movements (BMs) in the past 3 months were associated with fecal urgency...
February 3, 2019: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Ruth M Ayling, Stephen J Lewis, Finbarr Cotter
Iron deficiency anaemia (IDA) is the most common cause of anaemia and a frequent indication for colonoscopy, although the prevalence of colorectal cancer (CRC) in IDA is low. Measurement of faecal haemoglobin by immunochemical techniques (FIT) is used to detect symptomatic patients. We studied FIT in patients with anaemia attending a gastroenterology clinic in Plymouth and looked at an artificial intelligence (AI) learning algorithm (ColonFlag™) in these patients, together with a cohort who had undergone colonoscopy for IDA in London...
February 3, 2019: British Journal of Haematology
Kim A Papp, Boulos Haraoui, Deepali Kumar, John K Marshall, Robert Bissonnette, Alain Bitton, Brian Bressler, Melinda Gooderham, Vincent Ho, Shahin Jamal, Janet E Pope, A Hillary Steinhart, Donald C Vinh, John Wade
The use of immunosuppressive therapies for immune-mediated disease is associated with an elevated risk of infections and related comorbidities. While many infectious diseases can generally be prevented by vaccines, immunization rates in this specific patient population remain suboptimal, due in part to uncertainty about their efficacy or safety under these clinical situations. To address this concern, a multidisciplinary group of Canadian physicians with expertise in dermatology, gastroenterology, infectious diseases, and rheumatology developed evidence-based clinical guidelines on vaccinations featuring 13 statements that are aimed at reducing the risk of preventable infections in individuals exposed to immunosuppressive and immunomodulatory agents...
February 1, 2019: Journal of Rheumatology
Ajit Sood, Vandana Midha, Shivalingappa S Halli, Vikram Narang, Ramit Mahajan, Varun Mehta, Kirandeep Kaur, Vijay Surlikar, Subodh Kanchi, Dharmatma Singh
BACKGROUND: Financial constraints, social taboos and beliefs in alternative medicine are common reasons for delaying or not considering treatment for hepatitis C in India. The present study was planned to analyze the impact of non-banking interest free loan facility in patients affected with hepatitis C virus (HCV) in North India. METHODS: This one year observational, retrospective study was conducted in Department of Gastroenterology (January 2012-December 2013), Dayanand Medical College and Hospital Ludhiana, to evaluate the impact of program titled "Sambhav" (which provided non-banking financial assistance and counselor services) on treatment initiation and therapeutic compliance in HCV patients...
September 11, 2018: International Journal of Health Policy and Management
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