Emanuel Boudriot, Vanessa Gabriel, David Popovic, Pauline Pingen, Vladislav Yakimov, Sergi Papiol, Lukas Roell, Genc Hasanaj, Simiao Xu, Joanna Moussiopoulou, Siegfried Priglinger, Christoph Kern, Eva C Schulte, Alkomiet Hasan, Oliver Pogarell, Peter Falkai, Andrea Schmitt, Benedikt Schworm, Elias Wagner, Daniel Keeser, Florian J Raabe
BACKGROUND: Optical coherence tomography (OCT) and electroretinography (ERG) studies have revealed structural and functional retinal alterations in individuals with schizophrenia spectrum disorders (SSD). However, it remains unclear which specific retinal layers are affected, how the retina, brain, and clinical symptomatology are connected, and how alterations of the visual system are related to genetic disease risk. METHODS: OCT, ERG, and brain magnetic resonance imaging (MRI) were applied to comprehensively investigate the visual system in a cohort of 103 patients with SSD and 130 healthy control individuals...
April 26, 2024: Biological Psychiatry