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Akif Evren Parlak, Suat Tekin, Arzu Karatepe, Pelin Koparir, Hafize Telceken, Ali Osman Ceribası, Mustafa Karatepe
1,2,4-Triazoles are used as antifungal, antibacterial, antimicrobial, and antioxidant against some oxidative radical species. Recently, many 1,2,4-triazoles continue to be synthesized. In this study, the effect of the 1,2,4-triazole derivatives on human colon cancer (HT29) was investigated in vitro and in vivo in rats. MTT test was applied to in in vitro experiments. For in vivo study, rats were divided into seven groups as follows: Control group (negative control), azoxymethane (AOM), AOM + cisplatin 15, AOM + L1, AOM + L2, AOM + L3, and AOM + L4...
February 15, 2019: Journal of Cellular Biochemistry
Mustafa Ege Babadagli, Ron Sloboda, John Doucette
Low dose rate (LDR) brachytherapy is a minimally invasive form of radiation therapy, used to treat prostate cancer, and it involves permanent implantation of radioactive sources (seeds) inside of the prostate gland. Treatment planning in brachytherapy involves a decision making process for the placement of the sources in order to deliver an effective dose of radiation to cancerous tissue in the prostate while sparing the surrounding healthy tissue. Such a decision making process can be modeled as a mixed-integer linear programming (MILP) problem...
February 15, 2019: Physics in Medicine and Biology
Erkan Somuncu, İnanc S Sarici, Yahya K Caliskan, Mustafa U Kalayci
PURPOSE: Endoscopic retrograde cholangiopancreaticography (ERCP) is performed for diagnostic and therapeutic purposes in patients with pancreaticobiliary diseases. We investigated the role of simethicone and concomitant otilonium bromide during ERCP. PATIENTS AND METHODS: This prospective randomized study included 120 patients who underwent ERCP (study and control group=60 patients each). The study group received otilonium bromide and simethicone. The control group received no medication...
February 12, 2019: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
Sibel Yalçın, Mustafa Özyürek
The present work focused on the potential use of brown algae Cystoseira barbata and Cystoseira crinita from the Black Sea coast for removal and speciation analyses of Cr(III,VI) ions from aqueous and wastewater solutions. The biosorption process of Cr(III) and Cr(VI) was designed as a function of pH and contact time. Potentiometric titration and Fourier transform infrared spectroscopy (FT-IR) analysis techniques revealed the potential binding sites present at the surface of the algae for both oxidation states of Cr...
December 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Anusha Etikala, Mustafa Tattan, Houssam Askar, Hom-Lay Wang
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly prescribed group of drugs in dentistry for managing postoperative pain and discomfort. Little is known regarding their effects on the healing of periodontal and peri-implant tissues. METHODS: The authors conducted a review of the literature to provide an overview of knowledge about NSAIDs and their potential effects on periodontal and implant wound healing. RESULTS: A Pubmed (MEDLINE) database search was conducted to identify articles evaluating the influence of administration of NSAID drugs on outcomes following periodontal treatments (nine clinical studies) and dental implant placement (four animal studies and two human clinical studies)...
February 2019: Compendium of Continuing Education in Dentistry
Gökhan Kasnak, Dareen Fteita, Olli Jaatinen, Eija Könönen, Mustafa Tunali, Mervi Gürsoy, Ulvi K Gürsoy
Dental implant material has an impact on adhesion and spreading of oral mucosal cells on its surface. Platelet-rich fibrin (PRF), a second-generation platelet concentrate, can enhance cell proliferation and adhesion. The aim was to examine the regulatory effects of PRF and titanium surfaces on cellular adhesion, spread, and cytokine expressions of gingival keratinocytes. Human gingival keratinocytes were cultured on titanium grade 4, titanium grade 5 (Ti5), and HA discs at 37 °C in a CO2 incubator for 6 h and 24 h, using either elutes of titanium-PRF (T-PRF) or leukocyte and platelet-rich fibrin (L-PRF), or mammalian cell culture medium as growth media...
February 14, 2019: Histochemistry and Cell Biology
Doyoung Chang, Srini Tummala, Dax Sotero, Eric Tong, Luai Mustafa, Moawiah Mustafa, William F Browne, Ronald S Winokur
With the advances in affordable three-dimensional (3D) printing technology, 3D reconstruction and patient-specific 3D printed models are establishing a crucial role in the field of medicine for both educational purposes and procedural planning. 3D printed models provide physicians with increased 3D perception and tactile feedback, and enable a team-based approach to operational planning. However, performing an effective 3D reconstruction requires an in-depth understanding of the software features to accurately segment and reconstruct the human anatomy of interest from preacquired image data from multiple modalities such as computer tomography, 3D angiography and magnetic resonance imaging, and the different 3D printers/materials available in the market today...
March 2019: Techniques in Vascular and Interventional Radiology
Mustafa Citak, Thorsten Gehrke, Olaf Thieme
No abstract text is available yet for this article.
December 24, 2018: Deutsches Ärzteblatt International
Tim Gutierrez, Greg Hambright, Tahir Mustafa, Anthony Cahill, Vaidehi Agrawal, Michael S Truitt
No abstract text is available yet for this article.
January 1, 2019: American Surgeon
Ashok Sharma, Mustafa Albahrani, Wa Zhang, Christina N Kufel, Smitha R James, Kunle Odunsi, David Klinkebiel, Adam R Karpf
The POTE gene family consists of 14 homologous genes localized to autosomal pericentromeres, and a sub-set of POTEs are cancer-testis antigen (CTA) genes. POTEs are over-expressed in epithelial ovarian cancer (EOC), including the high-grade serous subtype (HGSC), and expression of individual POTEs correlates with chemoresistance and reduced survival in HGSC. The mechanisms driving POTE overexpression in EOC and other cancers is unknown. Here, we investigated the role of epigenetics in regulating POTE expression, with a focus on DNA hypomethylation...
February 14, 2019: Epigenetics: Official Journal of the DNA Methylation Society
Refik Kunt, Mustafa Kürşad Kutluk, Bedile İrem Tiftikçioğlu, Nazire Afşar, Ali Kemal Erdemoğlu, Muhteşem Gedizlioğlu, Vesile Öztürk
Background/aim: This study aimed to investigate the consistency between stroke and general neurologists in subtype assignment using the Trial of ORG-10172 in Acute Stroke Treatment (TOAST) and Causative Classification of Stroke (CCS) systems. Materials and methods: Fifty consecutive acute ischemic stroke patients admitted to the stroke unit were recruited. Patients were classified by two stroke and two general neurologists, each from different medical centers, according to TOAST followed by the CCS...
February 11, 2019: Turkish Journal of Medical Sciences
Caitlin Murphy, Andrea Muscat, David Ashley, Violet Mukaro, Linda West, Yang Liao, David Chisanga, Wei Shi, Ian Collins, Sally Baron-Hay, Sujata Patil, Geoffrey Lindeman, Mustafa Khasraw
BACKGROUND: This study evaluated the feasibility of achieving high response rates in stage II or III breast cancer by tailoring neoadjuvant therapy using clinical and histopathological features and the Oncotype DX Breast Recurrence Score. Genomic determinants of response and resistance were also explored. PATIENTS AND OUTCOME MEASURES: Fifty-one patients were enrolled. The primary cohort comprised 40 patients: 15 human epidermal growth factor receptor type 2 (HER2)-amplified; 15 triple-negative (TNBC); and ten hormone receptor (HR)-positive, HER2-non-amplified tumours; with recurrence scores ≥25...
2019: PloS One
Hatice Ataş, Müzeyyen Gönül, Yasin Öztürk, Mustafa Kavutçu
Background/aim: Results show that oxidative stress is a pathophysiologic factor for alopecia areata (AA); however, the markers used can be confounding. Thus, we aimed to investigate the role of oxidative stress in the pathogenesis of AA through an evaluation of ischemia-modified albumin (IMA); other markers of the oxidant/antioxidant system, such as SOD, CAT, GSH-ST, and MDA; and contributing clinical risk factors. Materials and methods: The usefulness of IMA as a new marker for oxidative stress was compared with that of other markers and evaluated in patients with AA...
February 11, 2019: Turkish Journal of Medical Sciences
Davut Sinan Kaplan, Cahit Bağcı, Mustafa Örkmez, Özge Kömürcü Karuserci, Seyhan Sucu, Hakim Çelik, Seyithan Taysı
Background/aim: The aims of this study were to determine the levels of the total antioxidant status (TAS), the total oxidant status (TOS), the oxidative stress index (OSI), and the concentration of immunoglobulin A (IgA) and M (IgM) in colostrum, and evaluate relationships between these parameters and maternal age, maternal parity, and infant sex. Materials and methods: The analysis was performed in serum samples of colostrum which were collected from 90 mothers on the first day of lactation between 10:00 and 12:00 AM Results: The measurements established that no significant association existed between the TAS level of colostrum and parity, maternal age, or infant sex...
February 11, 2019: Turkish Journal of Medical Sciences
Serdar Karakaya, Mustafa Altay, Fatma Kaplan Efe, İbrahim Karadağ, Oktay Ünsal, Oktay Bulur, Murat Eser, Derun Taner Ertuğrul
Background/aim: In this study, our aim was to investigate the neutrophil/lymphocyte (N/L) ratio, variations in leukocytes and leukocyte subtypes, and the relationship between N/L ratio and insulin resistance (IR) in obesity. Materials and methods: Ninety-six patients and 40 healthy controls were included in this study. Patients’ blood glucose levels, insulin levels, and hemogram parameters upon 8 h of fasting were determined. Body mass index (BMI) and Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) values were calculated...
February 11, 2019: Turkish Journal of Medical Sciences
Mustafa Çalışkan, Muhammed Kızılgül, Selvihan Beysel, Bekir Uçan, Fatih Akcan, Mümtaz Takır, Mustafa Özbek, Erman Çakal
Background/aim: Prolonged hypercalcemia impairs renal function, and a reduced glomerular filtration rate (GFR) is typical in advanced primary hyperparathyroidism (PHPT). There are scarce data related to predictors of renal impairment in patients with PHPT. Hence, we aimed to evaluate changes in kidney function in PHPT patients after parathyroidectomy (PTX) and identify factors associated with GFR variation in these patients. Materials and methods: One hundred and twenty-five patients with PHPT who underwent surgery between 2012 and 2014 were enrolled in the study...
February 11, 2019: Turkish Journal of Medical Sciences
Hamza Özavcı, Mustafa Kaplan
Background/aim: Thiol-specific antioxidant (TSA) protein is one of the most promising molecules among candidates for vaccine against cutaneous leishmaniasis. It was found to be significantly protective against different Leishmania species. In this study, cloning and molecular characterization of thiol-specific antioxidant gene of L. tropica Turkey isolate (LtTSA) were aimed. Materials and methods: LtTSA was amplified by PCR using the specific primers of TSA gene and cloned into the pcDNA3...
February 11, 2019: Turkish Journal of Medical Sciences
Ravza Yilmaz, Yunus Akpinar, Ibrahim Ozyavuz, Semen Önder, Mustafa Tukenmez, Memduh Dursun
No abstract text is available yet for this article.
February 14, 2019: Breast Journal
Tim Gutierrez, Greg Hambright, Tahir Mustafa, Anthony Cahill, Vaidehi Agrawal, Michael S Truitt
No abstract text is available yet for this article.
January 1, 2019: American Surgeon
Mustafa Akarcay, M Tayyar Kalcioglu, Ozan Tuysuz, Emine Timurlenk, Hasan Guclu
PURPOSE: The aim of this study was to evaluate the ossicular chain erosions (OCE) in chronic otitis media patients with cholesteatoma (COM-C) or without cholesteatoma (COM). MATERIALS AND METHODS: The OCE and preoperative hearing levels of a total of 915 patients were evaluated retrospectively. Patients were divided into three groups. Of the 915 patients, 615 (67.2%) had COM, 234 (25.6%) had COM-C, and 66 (7.2%) had chronic otitis media with granulation tissue (COM-G)...
February 13, 2019: European Archives of Oto-rhino-laryngology
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