keyword
https://read.qxmd.com/read/38435193/tacrolimus-concentration-dose-ratio-a-tool-for-guiding-tacrolimus-dosage-post-renal-transplantation
#21
JOURNAL ARTICLE
Mamatha T Shenoy, Jeyakumar Manavalan, Hariharan A, Suganthy K, Pradipta Kumar Mohanty
Background The calcineurin inhibitor, Tacrolimus (Tac), exhibits variable absorption and undergoes first-pass metabolism when administered orally. The narrow therapeutic window and individual variability of this immunosuppressive agent make therapeutic drug monitoring essential. We hypothesized that the Tac metabolism rate - defined as the blood concentration normalized by its daily dose (the C/D ratio) - is associated with post-renal transplant (RTx) function. Methodology A retrospective observational study was conducted including 40 RTx patients...
February 2024: Curēus
https://read.qxmd.com/read/38426619/expression-of-ptgs2-along-with-genes-regulating-vegf-signalling-pathway-and-association-with-high-risk-factors-in-locally-advanced-oral-squamous-cell-carcinoma
#22
JOURNAL ARTICLE
Mehta Vedant Kamal, Rama Rao Damerla, Preetiparna Parida, Mahadev Rao, Vijetha Shenoy Belle, Punit Singh Dikhit, Akhil Palod, Rinsha Gireesh, Naveena An Kumar
BACKGROUND: PTGS2 encodes cyclooxygenase-2 (COX-2), which catalyses the committed step in prostaglandin synthesis. Various in vivo and in vitro data suggest that COX-2 mediates the VEGF signalling pathway. In silico analysis performed in TCGA, PanCancer Atlas for head and neck cancers, demonstrated significant expression and co-expression of PTGS2 and genes that regulate VEGF signalling. This study was designed to elucidate the expression pattern of PTGS2 and genes regulating VEGF signalling in patients with locally advanced oral squamous cell carcinoma (OSCC)...
February 2024: Cancer Medicine
https://read.qxmd.com/read/38425984/assessing-the-burden-of-covid-19-among-children-aged-6-14-years-in-karnataka-india-a-cross-sectional-survey
#23
JOURNAL ARTICLE
Padma M Rajagopal, Satyam Sil, Prameela Dinesh, Shilpa Shiju, D P Arunkumar, Srinivas S Ramaiah, Hande R Lalitha, T Mamatha, P Ainapure Kantinath, Lokesh Pujari, B S Pradeep, Anusha B Shenoy, Anita Desai, Ashok Munivenkatappa, Chetan S Gudi, Giridhara R Babu, M K Sudarshan
BACKGROUND: India experienced three coronavirus disease (COVID-19) waves, with the third attributed to the highly contagious Omicron variant. Before the national vaccination rollout for children above 6, understanding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) positivity in the pediatric population was essential. This study aims to assess the burden of Covid-19 infection and to estimate the seroprevalence in children aged 6 to 14 years in the state of Karnataka...
2024: Indian Journal of Community Medicine
https://read.qxmd.com/read/38424684/fullertubes-inhibit-mycobacterial-viability-and-prevent-biofilm-formation-by-disrupting-the-cell-wall
#24
JOURNAL ARTICLE
Varun Shenoy, Rashmika Gunda, Cora Noble, Annalisa Haraguchi, Steven Stevenson, Jaiyanth Daniel
Mycobacterium tuberculosis and nontuberculous mycobacteria such as Mycobacterium abscessus cause diseases that are becoming increasingly difficult to treat due to emerging antibiotic resistance. The development of new antimicrobial molecules is vital for combating these pathogens. Carbon nanomaterials (CNMs) are a class of carbon-containing nanoparticles with promising antimicrobial effects. Fullertubes (C90 ) are novel carbon allotropes with a structure unique among CNMs. The effects of fullertubes on any living cell have not been studied...
March 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38422128/a-far-ultraviolet-driven-photoevaporation-flow-observed-in-a-protoplanetary-disk
#25
JOURNAL ARTICLE
Olivier Berné, Emilie Habart, Els Peeters, Ilane Schroetter, Amélie Canin, Ameek Sidhu, Ryan Chown, Emeric Bron, Thomas J Haworth, Pamela Klaassen, Boris Trahin, Dries Van De Putte, Felipe Alarcón, Marion Zannese, Alain Abergel, Edwin A Bergin, Jeronimo Bernard-Salas, Christiaan Boersma, Jan Cami, Sara Cuadrado, Emmanuel Dartois, Daniel Dicken, Meriem Elyajouri, Asunción Fuente, Javier R Goicoechea, Karl D Gordon, Lina Issa, Christine Joblin, Olga Kannavou, Baria Khan, Ozan Lacinbala, David Languignon, Romane Le Gal, Alexandros Maragkoudakis, Raphael Meshaka, Yoko Okada, Takashi Onaka, Sofia Pasquini, Marc W Pound, Massimo Robberto, Markus Röllig, Bethany Schefter, Thiébaut Schirmer, Thomas Simmer, Benoit Tabone, Alexander G G M Tielens, Sílvia Vicente, Mark G Wolfire, Isabel Aleman, Louis Allamandola, Rebecca Auchettl, Giuseppe Antonio Baratta, Clément Baruteau, Salma Bejaoui, Partha P Bera, John H Black, Francois Boulanger, Jordy Bouwman, Bernhard Brandl, Philippe Brechignac, Sandra Brünken, Mridusmita Buragohain, Andrew Burkhardt, Alessandra Candian, Stéphanie Cazaux, Jose Cernicharo, Marin Chabot, Shubhadip Chakraborty, Jason Champion, Sean W J Colgan, Ilsa R Cooke, Audrey Coutens, Nick L J Cox, Karine Demyk, Jennifer Donovan Meyer, Cécile Engrand, Sacha Foschino, Pedro García-Lario, Lisseth Gavilan, Maryvonne Gerin, Marie Godard, Carl A Gottlieb, Pierre Guillard, Antoine Gusdorf, Patrick Hartigan, Jinhua He, Eric Herbst, Liv Hornekaer, Cornelia Jäger, Eduardo Janot-Pacheco, Michael Kaufman, Francisca Kemper, Sarah Kendrew, Maria S Kirsanova, Collin Knight, Sun Kwok, Álvaro Labiano, Thomas S-Y Lai, Timothy J Lee, Bertrand Lefloch, Franck Le Petit, Aigen Li, Hendrik Linz, Cameron J Mackie, Suzanne C Madden, Joëlle Mascetti, Brett A McGuire, Pablo Merino, Elisabetta R Micelotta, Jon A Morse, Giacomo Mulas, Naslim Neelamkodan, Ryou Ohsawa, Roberta Paladini, Maria Elisabetta Palumbo, Amit Pathak, Yvonne J Pendleton, Annemieke Petrignani, Thomas Pino, Elena Puga, Naseem Rangwala, Mathias Rapacioli, Alessandra Ricca, Julia Roman-Duval, Evelyne Roueff, Gaël Rouillé, Farid Salama, Dinalva A Sales, Karin Sandstrom, Peter Sarre, Ella Sciamma-O'Brien, Kris Sellgren, Matthew J Shannon, Adrien Simonnin, Sachindev S Shenoy, David Teyssier, Richard D Thomas, Aditya Togi, Laurent Verstraete, Adolf N Witt, Alwyn Wootten, Nathalie Ysard, Henning Zettergren, Yong Zhang, Ziwei E Zhang, Junfeng Zhen
Most low-mass stars form in stellar clusters that also contain massive stars, which are sources of far-ultraviolet (FUV) radiation. Theoretical models predict that this FUV radiation produces photodissociation regions (PDRs) on the surfaces of protoplanetary disks around low-mass stars, which affects planet formation within the disks. We report James Webb Space Telescope and Atacama Large Millimeter Array observations of a FUV-irradiated protoplanetary disk in the Orion Nebula. Emission lines are detected from the PDR; modeling their kinematics and excitation allowed us to constrain the physical conditions within the gas...
March 2024: Science
https://read.qxmd.com/read/38416341/role-of-sirt1-in-potentially-toxic-trace-elements-lead-fluoride-aluminum-and-cadmium-associated-neurodevelopmental-toxicity
#26
REVIEW
Aqsa Fathima, Newly Bagang, Nitesh Kumar, Somasish Ghosh Dastidar, Smita Shenoy
The formation of the central nervous system is a meticulously planned and intricate process. Any modification to this process has the potential to disrupt the structure and operation of the brain, which could result in deficiencies in neurological growth. When neurotoxic substances are present during the early stages of development, they can be exceptionally dangerous. Prenatally, the immature brain is extremely vulnerable and is therefore at high risk in pregnant women associated with occupational exposures...
February 28, 2024: Biological Trace Element Research
https://read.qxmd.com/read/38406346/developing-mathematical-models-to-compare-and-analyse-the-pharmacokinetics-of-morphine-and-fentanyl
#27
JOURNAL ARTICLE
Prathvi Shenoy, Mahadev Rao, Shreesha Chokkadi, Sushma Bhatnagar, Naveen Salins
BACKGROUND AND AIMS: The two-compartment model is generally used in pharmacokinetics to illustrate the distribution and excretion of drugs. In this study, we evaluated the distribution patterns of morphine and fentanyl by using a two-compartment model. METHODS: Using numeric analysis techniques, non-linear ordinary differential equations were used to mathematically analyse drug distribution, transition, and concentration in the body compartments. Math Works, Inc...
January 2024: Indian Journal of Anaesthesia
https://read.qxmd.com/read/38402212/kdm3b-inhibitors-disrupt-the-oncogenic-activity-of-pax3-foxo1-in-fusion-positive-rhabdomyosarcoma
#28
JOURNAL ARTICLE
Yong Yean Kim, Berkley E Gryder, Ranuka Sinniah, Megan L Peach, Jack F Shern, Abdalla Abdelmaksoud, Silvia Pomella, Girma M Woldemichael, Benjamin Z Stanton, David Milewski, Joseph J Barchi, John S Schneekloth, Raj Chari, Joshua T Kowalczyk, Shilpa R Shenoy, Jason R Evans, Young K Song, Chaoyu Wang, Xinyu Wen, Hsien-Chao Chou, Vineela Gangalapudi, Dominic Esposito, Jane Jones, Lauren Procter, Maura O'Neill, Lisa M Jenkins, Nadya I Tarasova, Jun S Wei, James B McMahon, Barry R O'Keefe, Robert G Hawley, Javed Khan
Fusion-positive rhabdomyosarcoma (FP-RMS) is an aggressive pediatric sarcoma driven primarily by the PAX3-FOXO1 fusion oncogene, for which therapies targeting PAX3-FOXO1 are lacking. Here, we screen 62,643 compounds using an engineered cell line that monitors PAX3-FOXO1 transcriptional activity identifying a hitherto uncharacterized compound, P3FI-63. RNA-seq, ATAC-seq, and docking analyses implicate histone lysine demethylases (KDMs) as its targets. Enzymatic assays confirm the inhibition of multiple KDMs with the highest selectivity for KDM3B...
February 24, 2024: Nature Communications
https://read.qxmd.com/read/38401533/enhancing-quality-assurance-in-radiotherapy-for-gynaecological-cancers-implementation-of-an-on-demand-peer-review-process
#29
JOURNAL ARTICLE
Tapesh Bhattacharyya, Santam Chakraborty, Rimpa Basu Achari, Indranil Mallick, Moses Arunsingh, Shashank Shenoy, Vishnu Harilal, Vezokhoto Phesao, Shaurav Maulik, Nisarga Vontikoppal Manjunath, Prattusha Mukherjee, Nivedita Sarkar, Avinaba Sinha, Sebanti Sarkar, Bhanu Vashistha, Hashmath Khanum, Sanjoy Chatterjee
OBJECTIVES: Ensuring high-quality radiotherapy requires peer-reviewing target volumes. The Royal College of Radiologists recommends peer review specifically for individual target volumes in cases of gynaecological cancers. This study presents the outcomes of implementing an on-demand peer review system for gynaecological cancers within our institute. METHODS: The peer review process was planned for gynaecological cancer cases intended for curative radiotherapy. After junior clinical oncologists (COs) completed the segmentation, two senior COs specializing in gynaecological cancers conducted the peer review...
January 20, 2024: British Journal of Radiology
https://read.qxmd.com/read/38398037/proteolytic-vesicles-derived-from-salmonella-enterica-serovar-typhimurium-infected-macrophages-enhancing-mmp-9-mediated-invasion-and-ev-accumulation
#30
JOURNAL ARTICLE
Alon Nudelman, Anjana Shenoy, Hyla Allouche-Arnon, Michal Fisler, Irit Rosenhek-Goldian, Lior Dayan, Paula Abou Karam, Ziv Porat, Inna Solomonov, Neta Regev-Rudzki, Amnon Bar-Shir, Irit Sagi
Proteolysis of the extracellular matrix (ECM) by matrix metalloproteinases (MMPs) plays a crucial role in the immune response to bacterial infections. Here we report the secretion of MMPs associated with proteolytic extracellular vesicles (EVs) released by macrophages in response to Salmonella enterica serovar Typhimurium infection. Specifically, we used global proteomics, in vitro, and in vivo approaches to investigate the composition and function of these proteolytic EVs. Using a model of S. Typhimurium infection in murine macrophages, we isolated and characterized a population of small EVs...
February 15, 2024: Biomedicines
https://read.qxmd.com/read/38393867/therapeutic-evaluation-of-titanium-dioxide-nanoparticles-based-herbal-dental-varnish-derived-from-rosemary-and-ginger-extracts-a-comprehensive-investigation-into-anti-inflammatory-and-antioxidant-properties
#31
JOURNAL ARTICLE
Bipin Maheshwaran, Jerry Joe Chokkatt, Amrutha Shenoy, Dhanraj Ganapathy, Pradeep Kumar Yadalam, Maria Maddalena Marrapodi, Marco Cicciù, Giuseppe Minervini
BACKGROUND: Titanium nanoparticles (NPs) offer promising applications in the treatment and prevention of inflammatory disorders due to their unique physicochemical characteristics. However, additional research is necessary to attain a thorough comprehension and validate the efficacy of this approach in dental practice. OBJECTIVE: This study scrutinizes the anti-inflammatory properties of a dental varnish infused with ginger and rosemary extracts mediated by titanium dioxide (TiO2) nanoparticles...
February 3, 2024: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://read.qxmd.com/read/38389414/early-childhood-caries-and-dental-care-utilization-in-mangalore-india-parents-perceptions
#32
JOURNAL ARTICLE
B S Suprabha, R Shenoy, K Y Mahabala, A P Nayak, A Rao, V D'Souza
BACKGROUND: Parents often underuse dental care services for their children with early childhood caries (ECC), resulting in a high burden of untreated dental caries. AIM: To describe parental perceptions and challenges in dental care utilization for their children with ECC. DESIGN: A descriptive qualitative study was conducted with parents of children with ECC seeking dental care in Mangalore, India. Data were collected through focus group discussions using an interview guide...
February 22, 2024: JDR Clinical and Translational Research
https://read.qxmd.com/read/38388636/prevalence-and-impact-of-fertility-concerns-in-young-women-with-breast-cancer
#33
JOURNAL ARTICLE
Samantha Mannion, Alexandra Higgins, Nicole Larson, Elizabeth A Stewart, Zaraq Khan, Chandra Shenoy, Hazel B Nichols, H Irene Su, Ann H Partridge, Charles L Loprinzi, Fergus Couch, Janet E Olson, Kathryn J Ruddy
Survey data from the Mayo Clinic Breast Disease Registry were used to assess fertility counseling and fertility preservation strategies in a modern cohort of young women with breast cancer. One hundred respondents were identified who were under age 50 at the time of breast cancer diagnosis and who expressed interest in future childbearing near the time of diagnosis and/or 1 year later. Ninety-three percent of the 81 respondents to the year one survey recalled fertility counseling prior to cancer treatment. Most who reported a high level of fertility concern declared that this concern had impacted their treatment decisions, often shortening their planned duration of endocrine therapy...
February 22, 2024: Scientific Reports
https://read.qxmd.com/read/38383714/overlap-chronic-gvhd-is-associated-with-adverse-survival-outcomes-compared-to-classic-chronic-gvhd
#34
JOURNAL ARTICLE
Lev Gorfinkel, Sharmila Raghunandan, Benjamin Watkins, Kyle Hebert, Donna S Neuberg, Brandi Bratrude, Kayla Betz, Alison Yu, Sung W Choi, Jeffrey Davis, Christine Duncan, Roger Giller, Michael Grimley, Andrew C Harris, David Jacobsohn, Nahal Lalefar, Nosha Farhadfar, Michael A Pulsipher, Shalini Shenoy, Aleksandra Petrovic, Kirk R Schultz, Gregory A Yanik, Bruce R Blazar, John T Horan, Amelia Langston, Leslie S Kean, Muna Qayed
Chronic graft-versus-host-disease (cGVHD) is divided into two subtypes: classic (absence of acute GVHD features) and overlap cGVHD ('ocGVHD'), in which both chronic and acute GVHD clinical features are present simultaneously. While worse outcomes with ocGVHD have been reported, there are few recent analyses. We performed a secondary analysis of data from the ABA2 trial (N = 185), in which detailed GVHD data were collected prospectively and systematically adjudicated. Analyses included cumulative incidence of classic versus ocGVHD, their specific organ manifestations, global disease severity scores, non-relapse mortality (NRM), disease-free survival (DFS) and overall survival (OS) in these two cGVHD subtypes...
February 21, 2024: Bone Marrow Transplantation
https://read.qxmd.com/read/38361673/in-vitro-evaluation-of-accuracy-and-reliability-of-tooth-shade-selection-using-different-digital-instruments
#35
JOURNAL ARTICLE
Maaz Vohra, Amrutha Shenoy
Introduction Managing tooth shade is a significant challenge in aesthetic dentistry, especially for anterior restorations. Accurate shade assessment, combined with tailored treatment strategies and effective communication, is crucial. To improve the precision and reliability of aesthetic dental treatments, new shade-matching technologies have emerged. Current clinical methods for determining tooth shade utilize both visual assessments and instrumental techniques. The current study aimed to assess and compare the reliability and accuracy of four digital methods of tooth shade matching...
January 2024: Curēus
https://read.qxmd.com/read/38353447/society-of-radiologists-in-ultrasound-consensus-conference-recommendations-for-incidental-gallbladder-polyp-management-interreader-agreement-among-ten-radiologists
#36
JOURNAL ARTICLE
Mark A Anderson, Sarah Mercaldo, Jinjin Cao, Nayla Mroueh, Felipe S Furtado, Rory L Cochran, Ryan Chung, Reece J Goiffon, Madeleine Sertic, Theodore T Pierce, Aoife Kilcoyne, Amirkasra Mojtahed, Anuradha S Shenoy-Bhangle, Onofrio A Catalano, Avinash Kambadakone
Background: The 2022 Society of Radiologists in Ultrasound (SRU) consensus conference recommendations support less-aggressive management of small gallbladder polyps on ultrasound versus earlier approaches and may help standardize polyp evaluation by radiologists. Objective: To assess radiologists' interreader agreement in applying the SRU recommendations for management of incidental gallbladder polyps on ultrasound. Methods: This retrospective study included 105 patients (median age, 52 years; 75 women, 27 men) with a gallbladder polyp on ultrasound (without features highly suspicious for invasive or malignant tumor) who underwent cholecystectomy between January 1, 2003 and January 1, 2021...
February 14, 2024: AJR. American Journal of Roentgenology
https://read.qxmd.com/read/38345582/effect-of-febuxostat-versus-allopurinol-on-the-glomerular-filtration-rate-and-hyperuricemia-in-patients-with-chronic-kidney-disease
#37
JOURNAL ARTICLE
Shankar Prasad Nagaraju, Srinivas Vinayak Shenoy, Indu Rao, Ravindra Attur Prabhu, Dharshan Rangaswamy, Mohan V Bhojaraja, Vasudeva Guddattu
Hyperuricemia is a risk factor for the progression of chronic kidney disease (CKD). We compared febuxostat versus allopurinol in the progression of CKD and hyperuricemia in 101 patients with Stage 3-4 CKD treated with febuxostat or allopurinol for at least 6 months for hyperuricemia (>7 mg/dL) between January 2012 and December 2016. Baseline characteristics, serum uric acid (SUA), serum creatinine, and estimated glomerular filtration rate (eGFR) at entry and 6 months were compared. The primary outcome was the decline in eGFR and the secondary outcomes were reductions in SUA and adverse events...
July 1, 2023: Saudi Journal of Kidney Diseases and Transplantation
https://read.qxmd.com/read/38344646/effectiveness-of-photobiomodulation-with-low-level-laser-therapy-on-the-implant-stability-quotient-at-different-time-intervals-a-randomized-clinical-trial
#38
JOURNAL ARTICLE
Amrutha Shenoy, Dhanraj Ganapathy, Subhabrata Maiti
Background Photobiomodulation techniques, particularly low-level laser therapy (LLLT), have gained traction due to their ability to accelerate osseointegration by stimulating cellular metabolism and promoting tissue healing. This study explores the effectiveness of LLLT around dental implants at various intervals after placement. Using resonance frequency analysis (RFA), the implant stability quotient (ISQ) was measured to assess implant stability. Methodology This split-mouth, randomized, single-blinded clinical trial included 20 participants undergoing dental implant placement...
January 2024: Curēus
https://read.qxmd.com/read/38343121/comparison-of-microparticle-transport-and-deposition-in-nasal-cavity-of-three-different-age-groups
#39
JOURNAL ARTICLE
John Valerian Corda, B Satish Shenoy, Kamarul Arifin Ahmad, Leslie Lewis, Prakashini K, Anoop Rao, Mohammad Zuber
Objective: The nasal cavity effectively captures the particles present in inhaled air, thereby preventing harmful and toxic pollutants from reaching the lungs. This filtering ability of the nasal cavity can be effectively utilized for targeted nasal drug delivery applications. This study aims to understand the particle deposition patterns in three age groups: neonate, infant, and adult. Materials and methods: The CT scans are built using MIMICS 21.0, followed by CATIA V6 to generate a patient-specific airway model...
February 11, 2024: Inhalation Toxicology
https://read.qxmd.com/read/38337552/critical-care-management-of-severe-asthma-exacerbations
#40
REVIEW
Shameek Gayen, Stephen Dachert, Bilal H Lashari, Matthew Gordon, Parag Desai, Gerard J Criner, Juan Carlos Cardet, Kartik Shenoy
Severe asthma exacerbations, including near-fatal asthma (NFA), have high morbidity and mortality. Mechanical ventilation of patients with severe asthma is difficult due to the complex pathophysiology resulting from severe bronchospasm and dynamic hyperinflation. Life-threatening complications of traditional ventilation strategies in asthma exacerbations include the development of systemic hypotension from hyperinflation, air trapping, and pneumothoraces. Optimizing pharmacologic techniques and ventilation strategies is crucial to treat the underlying bronchospasm...
February 1, 2024: Journal of Clinical Medicine
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