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Tomislav Milekovic, Daniel Bacher, Anish A Sarma, John D Simeral, Jad Saab, Chethan Pandarinath, Blaise Yvert, Brittany L Sorice, Christine Blabe, Erin M Oakley, Kathryn R Tringale, Emad Eskandar, Sydney S Cash, Krishna V Shenoy, Jaimie M Henderson, Leigh R Hochberg, John P Donoghue
Intracortical brain-computer interfaces (BCIs) can enable individuals to control effectors, such as a computer cursor, by directly decoding the user's movement intentions from action potentials and local field potentials (LFPs) recorded within the motor cortex. However, the accuracy and complexity of effector control achieved with such "biomimetic" BCIs will depend on the degree to which the intended movements used to elicit control modulate the neural activity. In particular, channels that do not record distinguishable action potentials and only record LFP modulations may be of limited use for BCI control...
February 20, 2019: Journal of Neurophysiology
Scott J Weinreb, Abigail J Pianelli, Sreyans R Tanga, Ira A Parness, Rajesh U Shenoy
OBJECTIVES: Previous cross-sectional studies have demonstrated obesity rates in children with CHD and the general paediatric population. We reviewed longitudinal data to identify factors predisposing to the development of obesity in children, hypothesising that age may be an important risk factor for body mass index growth.Study designRetrospective electronic health records were reviewed in all 5-20-year-old CHD patients seen between 2011 and 2015, and in age-, sex-, and race/ethnicity-matched controls...
February 2019: Cardiology in the Young
Colleen S Kraft, Mark G Kortepeter, Bruce Gordon, Lauren M Sauer, Erica S Shenoy, Daniel P Eiras, LuAnn Larson, Jennifer A Garland, Aneesh K Mehta, Kevin Barrett, Connie S Price, Caroline Croyle, Lauren R West, Brooke Noren, Susan Kline, Christa Arguinchona, Henry Arguinchona, Jonathan D Grein, Chad Connally, Susan McLellan, George F Risi, Timothy M Uyeki, Richard T Davey, Jo Ellen Schweinle, Michelle M Schwedhelm, Melissa Harvey, Richard C Hunt, Christopher J Kratochvil
The 2013-2016 epidemic of Ebola virus disease (EVD) that originated in West Africa underscored many of the challenges to conducting clinical research during an ongoing infectious disease epidemic, both in the most affected countries of Guinea, Liberia, and Sierra Leone, as well as in the United States and Europe, where a total of 27 patients with EVD received care in biocontainment units. The Special Pathogens Research Network (SPRN) was established in the United States in November 2016 to provide an organizational structure to leverage the expertise of the 10 Regional Ebola and Other Special Pathogen Treatment Centers (RESPTCs); it was intended to develop and support infrastructure to improve readiness to conduct clinical research in the United States...
January 2019: Health Security
Christin B DeStefano, Sameer Desale, Stephen J Fernandez, Aarthi G Shenoy
No abstract text is available yet for this article.
February 11, 2019: Journal of the American Academy of Dermatology
Haymenth Vasiapphan, Pradeep J Christopher, Srivatsa Kengasubbiah, Vandana Shenoy, Senthil Kumar, Ashwan Paranthaman
A dentigerous cyst is an odontogenic cyst, associated with the crown of an impacted or unerupted tooth. The occurrence of bilateral dentigerous cysts is uncommon among the odontogenic cysts of the jaw, as they are usually solitary. Multiple cysts, when reported, are generally associated with syndromes such as cleidocranial dysplasia, Maroteaux-Lamy syndrome, and systemic diseases like mucopolysaccharidosis. This article presents a case of bilateral mandibular dentigerous cysts in a nonsyndromic patient, along with a review of the literature and an examination of the treatment modality...
December 5, 2018: Curēus
Sonia Shenoy, Geetha Desai, Ganesan Venkatasubramanian, Prabha S Chandra
BACKGROUND: Difficulties in parenting and Facial Emotion Recognition deficits (FERD) in persons with schizophrenia have been demonstrated independently. However, the relationship between parenting deficits and FERD in mothers with schizophrenia is yet to be explored. AIMS AND OBJECTIVES: The aims of the study were to assess parenting in mothers with schizophrenia, to examine the clinical correlates of parenting and to examine if facial emotion recognition deficits had an association with parenting...
February 1, 2019: Asian Journal of Psychiatry
John F Heitner, Raymond J Kim, Han W Kim, Igor Klem, Dipan J Shah, Dany Debs, Afshin Farzaneh-Far, Venkateshwar Polsani, Jiwon Kim, Jonathan Weinsaft, Chetan Shenoy, Andrew Hughes, Preston Cargile, Jean Ho, Robert O Bonow, Elizabeth Jenista, Michele Parker, Robert M Judd
Importance: Stress cardiac magnetic resonance imaging (CMR) is not widely used in current clinical practice, and its ability to predict patient mortality is unknown. Objective: To determine whether stress CMR is associated with patient mortality. Design, Setting, and Participants: Real-world evidence from consecutive clinically ordered CMR examinations. Multicenter study of patients undergoing clinical evaluation of myocardial ischemia. Patients with known or suspected coronary artery disease (CAD) underwent clinical vasodilator stress CMR at 7 different hospitals...
February 8, 2019: JAMA Cardiology
Krithika Damodar Shenoy, Nicholas Stanzione, Justin E Caron, Gregory A Fishbein, Fereidoun Abtin, Gentian Lluri, Sharon L Hirschowitz
Nuclear protein in testis (NUT) midline carcinoma (NMC) is a rare and aggressive subset of poorly differentiated squamous cell carcinoma that is defined by t(15,19) and typically presents in the midline structures of the head, neck, and mediastinum. We report two cases of NMC that presented uniquely with malignant pleural and pericardial effusions including one with cardiac tamponade at presentation. The first case is of a 25-year-old male patient who presented with progressive dyspnea associated with palpitations and dizziness on standing, found to have large bilateral pleural effusions...
February 8, 2019: Diagnostic Cytopathology
Avani Jain, Baranya Shrikrishna Suprabha, Ramya Shenoy, Arathi Rao
The aim of this study was to investigate whether there is an association between temperament characteristics of preschool children, dental anxiety, and their dental behaviour. A total of 100 children, aged 3-5 yr, who were attending their initial dental visit accompanied by a parent, were included in this cross-sectional study. Dental anxiety of children was measured using the Facial Image Scale. The behaviour of children during the initial oral examination and oral prophylaxis was assessed using Frankl's behaviour rating scale...
February 6, 2019: European Journal of Oral Sciences
Ganesh Shenoy, Peter Zaki, Christina Law
No abstract text is available yet for this article.
January 29, 2019: Academic Medicine: Journal of the Association of American Medical Colleges
Anshuka A Agrawal, Abhay P Kolte, Rajashri A Kolte, Varsha Vaswani, Usha Shenoy, Prachi Rathi
Purpose: Procedures such as Periodontally Accelerated Osteogenic Orthodontics (PAOO) support the use of osteotomy to aid tooth movement and rapid distraction of the periodontal ligament by utilizing tissue engineering principles with periodontal regenerative surgery. The aim of this study was to evaluate and compare the amount of tooth movement and the associated changes in buccal bone morphology between corticotomy and flapless Micro-Osteoperforation (MOP) assisted orthodontic treatment...
January 2019: Saudi Dental Journal
Niraj Shenoy, Tushar D Bhagat, John C Cheville, Christine Lohse, Sanchari Bhattacharyya, Alexander Tischer, Venkata Machha, Shanisha Gordon-Mitchell, Gaurav S Choudhary, Li-Fan Wong, LouAnn Gross, Emily Ressegue, Bradley C Leibovich, Stephen A Boorjian, Ulrich Steidl, Xiaosheng Wu, Kith Pradhan, Benjamin Gartrell, Beamon Agarwal, Lance Pagliaro, Masako Suzuki, John M Greally, Dinesh Rakheja, R Houston Thompson, Katalin Susztak, Thomas Witzig, Yiyu Zou, Amit Verma
Although ccRCC has been shown to have widespread aberrant cytosine methylation and loss of hydroxymethylation (5hmC), the prognostic impact and therapeutic targeting of this epigenetic aberrancy has not been fully explored. Analysis of 576 primary ccRCC samples demonstrated that loss of 5hmC was significantly associated with aggressive clinicopathologic features and was an independent adverse prognostic factor. Loss of 5hmC also predicted reduced progression free survival after resection of non-metastatic disease...
January 31, 2019: Journal of Clinical Investigation
Koel Debnath, Amita Couthino, Anirban Chatterjee, Sadhana Shenoy
Enamel renal syndrome is a unique syndrome associated with kidney agenesis associated with kidney agenesis, amelogenesis imperfecta, and gingival hyperplasia. The prevalence rate of this rare syndrome is <1/1,000,000. A 17-year-old male patient came to the department of periodontics, with a chief complaint of dislodged crown in the anterior teeth region. On clinical examination, the patient had teeth with mottled enamel and gingival enlargement. The orthopantomograph and gingival biopsy revealed pulpal calcification and gingival calcification, respectively...
January 2019: Journal of Indian Society of Periodontology
Daniel S Gill, James E Greening, Trevor A Howlett, Miles J Levy, Savitha D Shenoy
Background The objective of the study was to evaluate the long-term outcome of paediatric-onset hyperthyroidism with follow-up into adulthood and to identify any early predictors of a need for definitive therapy (DT). Methods In a retrospective analysis of patients diagnosed with hyperthyroidism under the age of 18 years and at follow-up, a comparison was made by categorising them into those who underwent definitive therapy (DT group), i.e. thyroidectomy/radioactive iodine (RAI), those who remained on antithyroid drugs (ATD) (CBZ group) and those who had complete remission (RE group)...
January 26, 2019: Journal of Pediatric Endocrinology & Metabolism: JPEM
Vishnu Prasad Shenoy, Ajay Kumar, Kiran Chawla
Background and Objectives: Despite high prevalence of MDR-TB in India very limited information about MDR-TB and mutation patterns in rpoB, inhA and katG genes among MDR-isolates of Mycobacterium tuberculosis in south coastal Karnataka region is available; thus present study is an attempt to explore the extent of MDR-TB and mutation patterns prevalent among clinical isolates in this region using GenoType MTBDR plus assay. Materials and Methods: A total of 256 sputum samples from Pulmonary TB patients suspected of MDR-TB were tested by GenoType MTBDR plus as per manufacturer's guidelines for detection of mutations conferring resistance to rifampicin and isoniazid...
October 2018: Iranian Journal of Microbiology
Felipe Kazmirczak, Prabhjot S Nijjar, Lei Zhang, Andrew Hughes, Ko-Hsuan Amy Chen, Osama Okasha, Cindy M Martin, Mehmet Akçakaya, Afshin Farzaneh-Far, Chetan Shenoy
BACKGROUND: There is a critical need for non-invasive methods to detect coronary allograft vasculopathy and to risk stratify heart transplant recipients. Vasodilator stress testing using cardiovascular magnetic resonance imaging (CMR) is a promising technique for this purpose. We aimed to evaluate the safety and the prognostic value of regadenoson stress CMR in heart transplant recipients. METHODS: To evaluate the safety, we assessed adverse effects in a retrospective matched cohort study of consecutive heart transplant recipients who underwent regadenoson stress CMR matched in a 2:1 ratio to age- and gender-matched non-heart transplant patients...
January 24, 2019: Journal of Cardiovascular Magnetic Resonance
Peter G Passias, Cole Bortz, Haddy Alas, Frank A Segreto, Samantha R Horn, Yael U Ihejirika, Dennis Vasquez-Montes, Katherine E Pierce, Avery E Brown, Kartik Shenoy, Edward M DelSole, Bradley Johnson, Cheongeun Oh, Peter L Zhou, Chloe Deflorimonte, Ekhamjeet S Dhillon, Pawel P Jankowski, Bassel G Diebo, Virginie Lafage, Renaud Lafage, Shaleen N Vira, John A Bendo, Jeffrey A Goldstein, Frank J Schwab, Michael C Gerling
Introduction: This study assessed the incidence and risk factors for pseudarthrosis among primary spine fusion patients. Methods: Retrospective review of ACS-NSQIP (2005-2013). Differences in comorbidities between spine fusion patients with and without pseudarthrosis (Pseud, N-Pseud) were assessed using chi-squared tests and Independent Samples t -tests. Binary logistic regression assessed patient-related and procedure-related predictors for pseudarthrosis. Results: 52,402 patients (57yrs, 53%F, 0...
January 2019: Journal of Orthopaedics
Usha G Shenoy, Karthiyanee Kutty
Background: Chronic inhalation of dust impairs lung function and may cause respiratory symptoms. Very little attention has been paid to the health of community exposed to dust raised by mine tailing which is deposited for many years without precautionary measures. Therefore, a study of peak expiratory flow rate (PEFR), oxygen saturation (SPO2 ), and their control groups in Kolar Gold Fields and Kolar was carried out. Materials and Methods: Ventilatory function tests were done using 400 exposed community participants with the unexposed of same from Kolar who stayed in the mine tailing town for >3 years and aged 18-60 years...
October 2018: Indian Journal of Community Medicine
Nathan C Frey, Arkamita Bandyopadhyay, Hemant Kumar, Babak Anasori, Yury Gogotsi, Vivek B Shenoy
Controlling magnetism in two-dimensional (2D) materials via electric fields and doping enables robust long-range order by providing an external mechanism to modulate magnetic exchange interactions and anisotropy. In this report, we predict that transition metal carbide and nitride MXenes are promising candidates for controllable magnetic 2D materials. The surface terminations introduced during synthesis act as chemical dopants that influence the electronic structure, enabling controllable magnetic order. We show ground state magnetic ordering in Janus M2XOxF2-x (M is an early transition metal, X is carbon or nitrogen, and x = 0...
January 17, 2019: ACS Nano
Srinivas Shenoy, Shankar Prasad Nagaraju, Nileshwar R Rau, Ravindra A Prabhu, Uday Venkat Mateti, Dharshan Rangaswamy, Indu R Rao, Karan Saraf
Context: Hypertension in chronic kidney disease (CKD) is an important modifiable cardiovascular risk factor. Patients with CKD can have clinically significant white coat effect (WCE), making routine clinic blood pressure (BP) measurements an unreliable indicator of actual BP control. Automated BP monitoring is useful in identifying WCE. The utility of automated BP monitoring has seldom been part of clinical practice in developing countries. Aim: The goal of this study was to estimate the prevalence and determinants of WCE in adult patients with CKD in an outpatient setting using an automated BP device...
November 2018: Indian Journal of Nephrology
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