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JOURNAL ARTICLE
Mohammed Athamneh, Nassam Daya, Andreas Hentschel, Andrea Gangfuss, Tobias Ruck, Adela Della Marina, Ulrike Schara-Schmidt, Albert Sickmann, Anne-Katrin Güttsches, Marcus Deschauer, Corinna Preusse, Matthias Vorgerd, Andreas Roos
Bi-allelic variants in VWA1, encoding Von Willebrand Factor A domain containing 1 protein localized to the extracellular matrix (ECM), were linked to a neuromuscular disorder with manifestation in child- or adulthood. Clinical findings indicate a neuromyopathy presenting with muscle weakness. Given that pathophysiological processes are still incompletely understood, and biomarkers are still missing, we aimed to identify blood biomarkers of pathophysiological relevance: white blood cells (WBC) and plasma derived from six VWA1-patients were investigated by proteomics...
April 2024: Journal of Cellular and Molecular Medicine
#2
JOURNAL ARTICLE
Daniel Ritish, Preethi V Reddy, Vanteemar S Sreeraj, Harleen Chhabra, Vijay Kumar, Ganesan Venkatasubramanian, Kesavan Muralidharan
BACKGROUND: Neurological soft signs (NSSs), minor physical anomalies (MPAs), and oculomotor abnormalities were plausible biomarkers in bipolar disorder (BD). However, specific impairments in these markers in patients after the first episode mania (FEM), in comparison with first-degree relatives (high risk [HR]) of BD and healthy subjects (health control [HC]) are sparse. AIM OF THE STUDY: This study aimed at examining NSSs, MPAs, and oculomotor abnormalities in remitted adult subjects following FEM and HR subjects in comparison with matched healthy controls...
April 23, 2024: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
#3
JOURNAL ARTICLE
Rong Ma, Yu Liu, Qing Mao
OBJECTIVE: To detect the expression levels of LINC02446 and S100B in serum of patients with traumatic brain injury (TBI) and explore their values as diagnostic and prognostic indicators for TBI. METHOD: Abnormal expressed RNAs in brain injury were screened from the dataset GSE1131475. Serums were collected from moderate to severe TBI patients at 1-3 and 4-12 hours post injury. Quantitative polymerase chain reaction was used to detect the expression levels of LINC02446 and S100B in serum...
April 23, 2024: International Journal of Neuroscience
#4
JOURNAL ARTICLE
In-Seon Lee, Da-Eun Yoon, Seoyoung Lee, Jae-Hwan Kang, Younbyoung Chae, Hi-Joon Park, Junsuk Kim
PURPOSE: Only a few studies have focused on the brain mechanisms underlying the itch processing in AD patients, and a neural biomarker has never been studied in AD patients. We aimed to develop a deep learning model-based neural signature which can extract the relevant temporal dynamics, discriminate between AD and healthy control (HC), and between AD patients who responded well to acupuncture treatment and those who did not. PATIENTS AND METHODS: We recruited 41 AD patients (22 male, age mean ± SD: 24...
2024: Journal of Asthma and Allergy
#5
JOURNAL ARTICLE
Aya Hassouneh, Bradley Bazuin, Alessander Danna-Dos-Santos, Ilgin Acar, Ikhlas Abdel-Qader
INTRODUCTION: Alzheimer's disease (AD) is a progressive neurological disorder characterized by mild memory loss and ranks as a leading cause of mortality in the USA, accounting for approximately 120,000 deaths per year. It is also the primary form of dementia. Early detection is critical for timely intervention as the neurodegenerative process often starts 15-20 years before cognitive symptoms manifest. This study focuses on determining feature importance in AD classification using fused texture features from 3D magnetic resonance imaging hippocampal and entorhinal cortex and standardized uptake value ratio (SUVR) derived from positron emission tomography (PET) images...
2024: Digital Biomarkers
#6
JOURNAL ARTICLE
Yupeng Tian, Srikar Saradhi, Edward Bello, Matthew D Johnson, Gabriele D'Eleuterio, Milos R Popovic, Milad Lankarany
Introduction: Closed-loop control of deep brain stimulation (DBS) is beneficial for effective and automatic treatment of various neurological disorders like Parkinson's disease (PD) and essential tremor (ET). Manual (open-loop) DBS programming solely based on clinical observations relies on neurologists' expertise and patients' experience. Continuous stimulation in open-loop DBS may decrease battery life and cause side effects. On the contrary, a closed-loop DBS system uses a feedback biomarker/signal to track worsening (or improving) of patients' symptoms and offers several advantages compared to the open-loop DBS system...
2024: Front Netw Physiol
#7
JOURNAL ARTICLE
Jonathan Z Pan, Zhanqiang Wang, Wei Sun, Peipei Pan, Wei Li, Yongtao Sun, Shoulin Chen, Amity Lin, Wulin Tan, Liangliang He, Jacob Greene, Virginia Yao, Lijun An, Rich Liang, Qifeng Li, Jessica Yu, Lingyi Zhang, Nikolaos Kyritsis, Xuan Duong Fernandez, Sara Moncivais, Esmeralda Mendoza, Pamela Fung, Gongming Wang, Xinhuan Niu, Qihang Du, Zhaoyang Xiao, Yuwen Chang, Peiyuan Lv, J Russell Huie, Abel Torres-Espin, Adam R Ferguson, Debra D Hemmerle, Jason F Talbott, Philip R Weinstein, Lisa U Pascual, Vineeta Singh, Anthony M DiGiorgio, Rajiv Saigal, William D Whetstone, Geoffrey T Manley, Sanjay S Dhall, Jacqueline C Bresnahan, Mervyn Maze, Xiangning Jiang, Neel S Singhal, Michael S Beattie, Hua Su, Zhonghui Guan
BACKGROUND: Although many molecules have been investigated as biomarkers for spinal cord injury (SCI) or ischemic stroke, none of them are specifically induced in central nervous system (CNS) neurons following injuries with low baseline expression. However, neuronal injury constitutes a major pathology associated with SCI or stroke and strongly correlates with neurological outcomes. Biomarkers characterized by low baseline expression and specific induction in neurons post-injury are likely to better correlate with injury severity and recovery, demonstrating higher sensitivity and specificity for CNS injuries compared to non-neuronal markers or pan-neuronal markers with constitutive expressions...
April 2024: Clinical and Translational Medicine
#8
JOURNAL ARTICLE
S Chakithandy, H Nazzal, M Matoug-Elwerfelli, S Narasimhan, S Uddin, K S Prabhu, L Zarif, N Mumtaz, A Sharma, M Al-Khelaifi
PURPOSE: Neurotoxicity concerns have been raised over general anesthesia and sedation medication use in children. Such concerns are largely based on animal studies, historical anesthetic agents, and assessment tools, thus warranting further investigations. Blood biomarkers in detecting neuronal inflammation and apoptosis are novel methods for detecting neuronal damage. Therefore, the aim of this feasibility study was to assess the usefulness of the levels of four plasma biomarkers in dental general anesthesia (DGA) as surrogate markers of neurotoxicity in children...
April 22, 2024: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
#9
JOURNAL ARTICLE
Guedi Ali Barreh, Ikram Sghaier, Youssef Abida, Alya Gharbi, Amina Nasri, Saloua Mrabet, Amira Souissi, Mouna Ben Djebara, Sameh Trabelsi, Imen Kacem, Amina Gargouri-Berrachi, Riadh Gouider
BACKGROUND: LRRK2-G2019S is the most frequent mutation in North African Parkinson's disease (PD) patients.Data on its impact on disease progression and treatment response remains elusive.Therefore, we aimed to explore the clinical features,treatments,and complications through the disease course of PD Tunisian patients according to their LRRK2-G2019S profile. METHODS: Longitudinal retrospective study conducted in the department of Neurology,Razi University Hospital...
April 23, 2024: Journal of Movement Disorders
#10
JOURNAL ARTICLE
Helena Brodska, Jana Smalcova, Petra Kavalkova, Danielle R Lavage, Milan Dusik, Jan Belohlavek, Tomas Drabek
BACKGROUND: Limited evidence exists for prognostic performance of biomarkers in patients resuscitated from out-of-hospital cardiac arrest (OHCA) with extracorporeal CPR (ECPR). We hypothesized that (1) the time course and (2) prognostic performance of biomarkers might differ between CPR and ECPR in a sub-analysis of Prague-OHCA study. METHODS: Patients received either CPR (n=164) or ECPR (n=92). The primary outcome was favorable neurologic survival at 180 days [cerebral performance category (CPC) 1-2]...
April 20, 2024: Resuscitation
#11
JOURNAL ARTICLE
Robert J Fox, Bruce A C Cree, Jérôme de Sèze, Ralf Gold, Hans-Peter Hartung, Douglas Jeffery, Ludwig Kappos, Xavier Montalban, Bianca Weinstock-Guttman, Carol M Singh, Arman Altincatal, Nicholas Belviso, Robin L Avila, Pei-Ran Ho, Ray Su, Robert Engle, Dipen Sangurdekar, Carl de Moor, Elizabeth Fisher, Bernd C Kieseier, Richard A Rudick
BACKGROUND AND OBJECTIVES: Serum neurofilament light chain (sNfL) levels correlate with multiple sclerosis (MS) disease activity, but the dynamics of this correlation are unknown. We evaluated the relationship between sNfL levels and radiologic MS disease activity through monthly assessments during the 24-week natalizumab treatment interruption period in RESTORE (NCT01071083). METHODS: In the RESTORE trial, participants with relapsing forms of MS who had received natalizumab for ≥12 months were randomized to either continue or stop natalizumab and followed with MRI and blood draws every 4 weeks to week 28 and again at week 52 The sNfL was measured, and its dynamics were correlated with the development of gadolinium-enhancing (Gd+) lesions...
May 14, 2024: Neurology
#12
JOURNAL ARTICLE
Xinli Jiang, Rui Zhang, Geng Lu, Yu Zhou, Jianfeng Li, Xinrui Jiang, Shuangshuang Gu, Hongwei Liang, Jun Wang
Acute ischemic stroke (AIS), commonly known as stroke, is a debilitating condition characterized by the interruption of blood flow to the brain, resulting in tissue damage and neurological deficits. Early diagnosis is crucial for effective intervention and management, as timely treatment can significantly improve patient outcomes. Therefore, novel methods for the early diagnosis of AIS are urgently needed. Several studies have shown that bioactive molecules contained in extracellular vesicles, especially circRNAs, could be ideal markers for the diagnosis of many diseases...
April 22, 2024: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
#13
JOURNAL ARTICLE
Charlotte Zejlon, Stefan Sennfält, Johannes Finnsson, Bryan Connolly, Sven Petersson, Tobias Granberg, Caroline Ingre
OBJECTIVE: Magnetic resonance imaging can detect neurodegenerative iron accumulation in the motor cortex, called the motor band sign. This study aims to evaluate its sensitivity/specificity and correlations to symptomatology, biomarkers, and clinical outcome in amyotrophic lateral sclerosis. METHODS: This prospective study consecutively enrolled 114 persons with amyotrophic lateral sclerosis and 79 mimics referred to Karolinska University Hospital, and also 31 healthy controls...
April 22, 2024: Annals of Clinical and Translational Neurology
#14
REVIEW
Meina Zhu, Zhaohui Lan, Joohyun Park, Shuaishuai Gong, Yan Wang, Fuzheng Guo
Neuroinflammation, blood-brain barrier (BBB) dysfunction, neuron and glia injury/death and myelin damage are common central nervous system (CNS) pathologies observed in various neurological diseases and injuries. Serine protease inhibitor (Serpin) clade A member 3n (Serpina3n), and its human orthologue SERPINA3, is an acute-phase inflammatory glycoprotein secreted primarily by the liver into the bloodstream in response to systemic inflammation. Clinically, SERPINA3 is dysregulated in brain cells, cerebrospinal fluid and plasma in various neurological conditions...
April 2024: Neuropathology and Applied Neurobiology
#15
JOURNAL ARTICLE
Xueli Zhang, Zhuoting Zhu, Yu Huang, Xianwen Shang, Terence J O'Brien, Patrick Kwan, Jason Ha, Wei Wang, Shunming Liu, Xiayin Zhang, Katerina Kiburg, Yining Bao, Jing Wang, Honghua Yu, Mingguang He, Lei Zhang
BACKGROUND: Alzheimer's disease (AD) and age-related macular degeneration (AMD) share similar pathological features, suggesting common genetic aetiologies between the two. Investigating gene associations between AD and AMD may provide useful insights into the underlying pathogenesis and inform integrated prevention and treatment for both diseases. METHODS: A stratified quantile-quantile (QQ) plot was constructed to detect the pleiotropy among AD and AMD based on genome-wide association studies data from 17 008 patients with AD and 30 178 patients with AMD...
2024: BMJ neurology open
#16
REVIEW
Lauren E Yap, James E Hunt, Raymond Scott Turner
Alzheimer's disease (AD), the most common etiology of dementia in older adults, is projected to double in prevalence over the next few decades. Current treatments for AD manage symptoms or slow progressive decline, but are accompanied by significant inconvenience, risk, and cost. Thus, a better understanding of the risk factors and pathophysiology of AD is needed to develop novel prevention and treatment strategies. Aging is the most important risk factor for AD. Elucidating molecular mechanisms of aging may suggest novel therapeutic targets...
2024: Frontiers in Neurology
#17
JOURNAL ARTICLE
Elena Niccolai, Matteo Pedone, Ilaria Martinelli, Giulia Nannini, Simone Baldi, Cecilia Simonini, Leandro Di Gloria, Elisabetta Zucchi, Matteo Ramazzotti, Pietro Giorgio Spezia, Fabrizio Maggi, Gianluca Quaranta, Luca Masucci, Gianluca Bartolucci, Francesco Claudio Stingo, Jessica Mandrioli, Amedeo Amedei
Amyotrophic lateral sclerosis (ALS) is an untreatable and clinically heterogeneous condition primarily affecting motor neurons. The ongoing quest for reliable biomarkers that mirror the disease status and progression has led to investigations that extend beyond motor neurons' pathology, encompassing broader systemic factors such as metabolism, immunity, and the microbiome. Our study contributes to this effort by examining the potential role of microbiome-related components, including viral elements, such as torque tenovirus (TTV), and various inflammatory factors, in ALS...
April 21, 2024: Journal of Neurology
#18
REVIEW
YanJun Zhang, Lijuan Zhan, Xue Jiang, Xiaozhu Tang
Non-coding RNAs (ncRNAs) are an assorted collection of transcripts that are not translated into proteins. Since their discovery, ncRNAs have gained prominence as crucial regulators of various biological functions across diverse cell types and tissues, and their abnormal functioning has been implicated in disease. Notably, extensive research has focused on the relationship between microRNAs (miRNAs) and human cancers, although other types of ncRNAs, such as long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), are also emerging as significant contributors to human disease...
April 19, 2024: Biochemical Pharmacology
#19
JOURNAL ARTICLE
Haoting Zhan, Linlin Cheng, Yeling Liu, Honglin Xu, Xinxin Feng, Yongmei Liu, Haolong Li, Zhan Li, Siyu Wang, Haiqiang Jin, Wenjie Zheng, Hongjun Hao, Yongzhe Li
OBJECTIVES: Demyelination and immunocyte-infiltrated lesions have been found in neuro-Behçet's disease (NBD) pathology. Lacking satisfying laboratory biomarkers in NBD impedes standard clinical diagnostics. We aim to explore the ancillary indicators for NBD diagnosis unveiling its potential etiology. METHODS: 28 NBD with defined diagnosis, 29 patients with neuropsychiatric lupus erythematosus, 30 central nervous system idiopathic inflammatory demyelination diseases (CNS-IIDD), 30 CNS infections, 30 cerebrovascular diseases, and 30 noninflammatory neurological diseases (NIND) were retrospectively enrolled...
April 19, 2024: Clinica Chimica Acta; International Journal of Clinical Chemistry
#20
JOURNAL ARTICLE
Eline V Schaft, Dongqing Sun, Maryse A van 't Klooster, Dorien van Blooijs, Paul L Smits, Willemiek J E M Zweiphenning, Peter H Gosselaar, Cyrille H Ferrier, Maeike Zijlmans
OBJECTIVE: Focal cortical dysplasias (FCD) are characterized by distinct interictal spike patterns and high frequency oscillations (HFOs; ripples: 80-250 Hz; fast ripples: 250-500 Hz) in the intra-operative electrocorticogram (ioECoG). We studied the temporal relation between intra-operative spikes and HFOs and their relation to resected tissue in people with FCD with a favorable outcome. METHODS: We included patients who underwent ioECoG-tailored epilepsy surgery with pathology confirmed FCD and long-term Engel 1A outcome...
April 10, 2024: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
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