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https://read.qxmd.com/read/30877788/reduced-hippocampal-dendrite-branching-spine-density-and-neurocognitive-function-in-premature-rabbits-and-reversal-with-estrogen-or-trkb-agonist-treatment
#1
Damon Klebe, Mahima Tibrewal, Deep R Sharma, Rachna Vanaparthy, Sunil Krishna, Merina Varghese, Bokun Cheng, Peter R Mouton, Jana Velíšková, Kostantin Dobrenis, Patrick R Hof, Praveen Ballabh
Preterm-born children suffer from neurological and behavioral disorders. Herein, we hypothesized that premature birth and non-maternal care of preterm newborns might disrupt neurobehavioral function, hippocampal dendritic arborization, and dendritic spine density. Additionally, we assessed whether 17β-estradiol (E2) replacement or the TrkB receptor agonist, 7,8-dihydroxyflavone (DHF), would reverse compromised dendritic development and cognitive function in preterm newborns. These hypotheses were tested by comparing preterm (E28...
March 16, 2019: Cerebral Cortex
https://read.qxmd.com/read/30875744/disease-entities-in-mucormycosis
#2
REVIEW
Alexandra Serris, François Danion, Fanny Lanternier
Mucormycosis is an emerging life-threatening fungal infection caused by Mucorales . This infection occurs mainly in immunocompromised patients, especially with hematological malignancy, transplantation, or diabetes mellitus. Rhino-orbito-cerebral and pulmonary mucormycosis are the predominant forms. Interestingly, location is associated with the underlying disease as pulmonary mucormycosis is more frequent in hematological malignancy patients whereas rhino-orbito-cerebral mucormycosis is associated with diabetes...
March 14, 2019: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/30868020/unprepared-and-misinformed-parents-of-children-with-sickle-cell-disease-time-to-rethink-awareness-campaigns
#3
Seyi Aderotoye-Oni, Ijeoma N Diaku-Akinwumi, Adeyinka Adeniran, Bode Falase
Worldwide, sickle cell disease (SCD) poses a significant public health concern. It causes recurrent morbidity, and premature death is a distinct possibility, especially in Nigeria, which bears half the world's burden of SCD patients. Nigeria has yet to establish a newborn screening program; consequently, most affected children are diagnosed between one and three years of age when a health problem arises. Parents are unprepared to identify SCD and seek comprehensive management early enough for the best outcome...
December 31, 2018: Curēus
https://read.qxmd.com/read/30866580/quality-of-life-of-women-after-giving-birth-associated-factors-related-with-the-birth-process
#4
Juan Miguel Martínez-Galiano, Antonio Hernández-Martínez, Julián Rodríguez-Almagro, Miguel Delgado-Rodríguez
The World Health Organization (WHO) considers quality of life a fundamental indicator. The effect of birth on women's long-term quality of life (QoL) has barely been studied. The purpose of this study was to determine the factors related with the pregnancy, delivery and puerperium, and assess women's QoL after giving birth. A cross-sectional study with Spanish puerperal women was carried out; it collected data on socio-demographic variables, obstetric variables, newborn data, and several quality of life parameters...
March 7, 2019: Journal of Clinical Medicine
https://read.qxmd.com/read/30860484/early-identification-of-preterm-neonates-at-birth-with-a-tablet-app-for-the-simplified-gestational-age-score-t-sgas-when-ultrasound-gestational-age-dating-is-unavailable-protocol-for-a-validation-study
#5
Archana B Patel, Kunal Kurhe, Amber Prakash, Savita Bhargav, Suchita Parepalli, Elizabeth V Fogleman, Janet L Moore, Dennis D Wallace, Hemant Kulkarni, Patricia L Hibberd
BACKGROUND: Although rates of preterm birth continue to increase globally, identification of preterm from low birth weight infants remains a challenge. The burden of low birth weight vs preterm is greatest in resource-limited settings, where gestational age (GA) prior to delivery is frequently not known because ultrasound in early pregnancy is not available and estimates of the date of the mother's last menstrual period (LMP) may not be reliable. An alternative option is to assess GA at birth to optimize referral and care of preterm newborns...
March 12, 2019: JMIR Research Protocols
https://read.qxmd.com/read/30842119/prematurity-detection-evaluating-interaction-between-the-skin-of-the-newborn-and-light-protocol-for-the-preemie-test-multicentre-clinical-trial-in-brazilian-hospitals-to-validate-a-new-medical-device
#6
Zilma Silveira Nogueira Reis, Rodney Nascimento Guimarães, Maria Albertina Santiago Rego, Roberta Maia de Castro Romanelli, Juliano de Souza Gaspar, Gabriela Luiza Nogueira Vitral, Marconi Augusto Aguiar Dos Reis, Enrico Antônio Colósimo, Gabriela Silveira Neves, Marynea Silva Vale, Paulo de Jesus Hartamann Nader, Marta David Rocha de Moura, Regina Amélia Pessoa Lopes de Aguiar
INTRODUCTION: Recognising prematurity is critical in order to attend to immediate needs in childbirth settings, guiding the extent of medical care provided for newborns. A new medical device has been developed to carry out the preemie-test, an innovative approach to estimate gestational age (GA), based on the photobiological properties of the newborn's skin. First, this study will validate the preemie-test for GA estimation at birth and its accuracy to detect prematurity. Second, the study intends to associate the infant's skin reflectance with lung maturity, as well as evaluate safety, precision and usability of a new medical device to offer a suitable product for health professionals during childbirth and in neonatal care settings...
March 5, 2019: BMJ Open
https://read.qxmd.com/read/30825876/unplanned-out-of-hospital-birth-and-risk-factors-of-adverse-perinatal-outcome-findings-from-a-prospective-cohort
#7
François Javaudin, Valérie Hamel, Arnaud Legrand, Sybille Goddet, François Templier, Christine Potiron, Philippe Pes, Gilles Bagou, Emmanuel Montassier
BACKGROUND: In France, while most babies are delivered at hospital, emergency medical services (EMS) weekly manage calls for unplanned out-of-hospital births. The objective of our study was to describe neonatal morbidity and mortality, defined as death or neonatal intensive care unit hospitalization at Day 7, in a prospective multicentric cohort of unplanned out-of-hospital births. METHODS: We prospectively analyzed out-of-hospital births from 25 prehospital EMS units in France...
March 2, 2019: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://read.qxmd.com/read/30820239/the-effects-of-kangaroo-mother-care-on-the-time-to-breastfeeding-initiation-among-preterm-and-lbw-infants-a-meta-analysis-of-published-studies
#8
Alemayehu Gonie Mekonnen, Sisay Shewasinad Yehualashet, Alebachew Demelash Bayleyegn
Background: Kangaroo mother care is a comprehensive intervention given for all newborns especially for premature and low birthweight infants. It is the most feasible and preferred intervention for decreasing neonatal morbidity and mortality. Even though time to initiating breastfeeding has been examined by randomized controlled trials, varying findings have been reported. Therefore, the main objective of this meta-analysis was to estimate the pooled mean time to initiate breastfeeding among preterm and low birthweight infants...
2019: International Breastfeeding Journal
https://read.qxmd.com/read/30820222/neonatal-intensive-care-unit-nurses-perceptions-and-knowledge-of-newborn-individualized-developmental-care-and-assessment-program-a-multicenter-study
#9
Rouya Baghlani, Mohammad-Bagher Hosseini, Abdolrasoul Safaiyan, Maedeh Alizadeh, Mohammad Arshadi Bostanabad
Background: The newborn individualized developmental care and assessment program (NIDCAP) is a new multifaceted approach, which is developmentally and functionally supportive of health especially in premature newborns at the neonatal intensive care unit (NICU). This study is designed for assessing the knowledge and perception of nurses as the most important members of the multidisciplinary team of NIDCAP about this program. Materials and Methods: This cross-sectional study was conducted on 120 nurses working in the NICUs of Alzahra, Taleghani, and Children hospitals affiliated to the educational and treatment centers of Tabriz University of Medical Sciences as well as 29 Bahman Hospital affiliated to Tabriz Social Security Organization in 2016 using census sampling method...
March 2019: Iranian Journal of Nursing and Midwifery Research
https://read.qxmd.com/read/30819344/late-preterm-infants-morbidities-mortality-and-management-recommendations
#10
REVIEW
Katie Huff, Rebecca S Rose, William A Engle
Infants born between 34 weeks 0 days and 36 weeks 6 days of gestation are termed late preterm. This group accounts for the majority of premature births in the United States, with rates increasing in each of the last 3 years. This increase is significant given their large number: nearly 280,000 in 2016 alone. Late preterm infants place a significant burden on the health care and education systems because of their increased risk of morbidities and mortality compared with more mature infants. This increased risk persists past the newborn period, leading to the need for continued health monitoring throughout life...
April 2019: Pediatric Clinics of North America
https://read.qxmd.com/read/30801969/achieving-the-targets-of-sustainable-development-goals-2030-agenda-for-congenital-disorders-in-asia-bottlenecks-and-interventions
#11
REVIEW
Meow-Keong Thong
The United Nations General Assembly adopted the 2030 Agenda for Sustainable Development in November 2015 which included a set of 17 measurable "sustainable development goals" (SDGs). The SDGs included targets to end preventable deaths of newborns and children under 5 years of age by 2030, universal health care coverage, reduction of premature mortality from noncommunicable diseases (NCDs) by 33% as well as support the development and research for medicines for both communicable and NCDs. Although some successes were achieved in combating communicable diseases and improved childhood mortality rates, health systems in Asia are generally characterized by lack of accurate epidemiological information on congenital disorders, lack of human and financial resources, and inadequate focus on public health strategies to ensure targeted interventions, low level knowledge on congenital disorders amongst the community and healthcare providers and the ethical dilemma of managing rare congenital disorders in an environment of low national health expenditures...
February 23, 2019: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://read.qxmd.com/read/30786305/syphilis-in-pregnancy-the-reality-in-a-public-hospital
#12
Rafael Garcia Torres, Ana Laura Neves Mendonça, Grazielle Cezarine Montes, Jacqueline Jácome Manzan, João Ulisses Ribeiro, Marina Carvalho Paschoini
OBJECTIVE:  The present study assessed epidemiological and obstetrical data from pregnant women with syphilis at the Hospital de Clínicas of the Universidade Federal do Triângulo Mineiro (UFTM, in the Portuguese acronym), describing this disease during pregnancy and its vertical transmission for future healthcare actions. METHODS:  Records from pregnant women who had been admitted to the Obstetrics Department of the Hospital de Clínicas of the UFTM and were diagnosed with syphilis between 2007 and 2016 were reviewed...
February 2019: Revista Brasileira de Ginecologia e Obstetrícia
https://read.qxmd.com/read/30777715/-follow-up-recommendations-for-the-late-preterm-infant
#13
Mercedes García Reymundo, José Antonio Hurtado Suazo, M José Calvo Aguilar, Francisco Javier Soriano Faura, Gemma Ginovart Galiana, Yolanda Martín Peinador, Ana Jiménez Moya, Xavier Demestre Guasch
The population of late preterm infants (PT), those born between 34+0 and 36+6 weeks of gestation, accounts for 70-74% of all premature infants, and is not specifically included in most of the follow-up protocols for preterm infants. For many years, PTs have been handled as if they were term newborns, which has led to a limited knowledge of their outcome in the medium and long term. Their neonatal morbidity is associated with a higher incidence of postnatal complications, with an increased rate of hospital re-admissions due to malnutrition, hyperbilirubinaemia, and respiratory problems, when compared to term infants...
February 15, 2019: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://read.qxmd.com/read/30775282/a-low-cost-re-usable-electricity-free-infant-warmer-evaluation-of-safety-effectiveness-and-feasibiliy
#14
E Nahimana, L May, A Gadgil, V Rapp, H Magge, M Kubwimana, A Nshimyiryo, F Kateera, H A Feldman, F Nkikabahizi, F Sayinzoga, A Hansen
Setting: Rural Rwandan hospitals, where thermoregulation is critical yet a challenge for pre-term, low-birth-weight (LBW) or sick newborns. Objective: To assess the safety, effectiveness, and feasibility of an inexpensive, reusable, non-electric warmer to complement kangaroo mother care (KMC). Methods: Prospective single-arm, non-randomized intervention study. Enrolled infants were hypothermic or at risk of hypothermia due to prematurity/LBW. Infants used the warmer in conjunction with KMC or as the sole source of external heat...
December 21, 2018: Public Health Action
https://read.qxmd.com/read/30746164/algorithm-for-calculating-the-protein-intake-in-enteral-and-parenteral-nutrition-in-premature-infants
#15
E C Stoicănescu, F Popescu, A Zavate
INTRODUCTION: Calculating the exact nutritional balance especially for the premature infant has always been a challenge for the daily practice of the clinician. PURPOSE: we intend to establish a simplified formula and mathematical algorithms to calculate the necessary amino acids and proteins for the nutrition of the premature newborn, covering most of the international recommendations and also to give to the neonatal intensive care physician the opportunity of their rapid customization for each case...
April 2018: Current Health Sciences Journal
https://read.qxmd.com/read/30744679/effect-of-multi-lumen-perfusion-line-on-catheter-related-bacteremia-in-premature-infants-study-protocol-for-a-cluster-randomized-crossover-trial
#16
Aurélie Maiguy-Foinard, Bertrand Décaudin, Pierre Tourneux, Bernard Guillois, Thierry Blanc, Sophie Galène-Gromez, Morgane Masse, Pascal Odou, Fannette Denies, Benoît Dervaux, Alain Duhamel, Laurent Storme
BACKGROUND: Catheter-related bacteremia (CRB) is the most frequent nosocomial infection in neonatal intensive care unit (NICU) patients, especially in very low-birth-weight infants. Administration of injectable drugs in premature newborn infants has many particularities and several types of infusion incidents have been reported. The Edelvaiss® Multiline NEO device is a novel multi-lumen access infusion device adapted to the specificities of infusion in neonatology. This multicenter, randomized, controlled study was therefore designed to determine whether or not Edelvaiss® Multiline NEO reduces the risk of CRB in preterm newborn infants in an NICU...
February 11, 2019: Trials
https://read.qxmd.com/read/30721652/randomized-controlled-trial-of-a-prefeeding-oral-motor-therapy-and-its-effect-on-feeding-improvement-in-a-thai-nicu
#17
Brenda S Lessen Knoll, Tipawan Daramas, Victoria Drake
OBJECTIVE: To evaluate the effect of the Premature Infant Oral Motor Intervention (PIOMI) on preterm newborns' feeding efficiency and rates of improvement across Days 1, 3, and 5 of oral feeding in a Thai NICU. DESIGN: Randomized controlled trial. SETTING: A 20-bed special neonatal ward and 8-bed NICU in urban Thailand. PARTICIPANTS: Stable newborns (N = 30) born between 26 and 34 weeks postmenstrual age (PMA) without comorbidities...
February 2, 2019: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://read.qxmd.com/read/30694609/flora-colonization-and-oral-care-in-high-risk-newborns
#18
Youngmee Ahn, Yonghoon Jun, Namhee Kim, Min Sohn
PURPOSE: A randomized intervention study was conducted to explore the impact of oral care with sterile normal saline to oral flora colonization of high-risk newborns at the third day after birth. DESIGN AND METHODS: Ninety-two newborns were allocated to either intervention or control group. After obtaining oral secretion for prepoint data, the intervention group received oral care with sterile normal saline only. Oral secretions for postpoint data were obtained 8 hr after the prepoint...
January 29, 2019: Journal for Specialists in Pediatric Nursing: JSPN
https://read.qxmd.com/read/30683041/-results-of-the-use-of-micafungin-in-newborns
#19
Salih Çağrı Çakır, Solmaz Çelebi, Hilal Özkan, Nilgün Köksal, Bayram Ali Dorum, Edanur Yeşil, Mustafa Hacımustafaoğlu
Invasive candidiasis is a common and serious infection in premature newborns. Preventing and treating fungal infections is very important to improve the prognosis of premature infants. Fluconazole and amphotericin B are used as the first choice in the treatment of invasive fungal infections of the newborns. In some cases, fluconazole and amphotericin B cannot be used due to nephrotoxicity, hepatotoxicity or resistant strains. Micafungin, which is among recently developed echinocandins, is the drug of choice in these cases...
January 2019: Mikrobiyoloji Bülteni
https://read.qxmd.com/read/30676221/maternal-human-papillomavirus-and-preterm-premature-rupture-of-membranes-a-retrospective-cohort-study
#20
Amaya Caballero, Donald Dudley, James Ferguson, Kate Pettit, Annelee Boyle
INTRODUCTION: To determine whether maternal human papillomavirus (HPV) infection is associated with preterm premature rupture of membranes (PPROM). MATERIALS AND METHODS: We conducted a retrospective cohort study of singleton deliveries at our institution from 2010 to 2015. Women, ages 16-49, with HPV genotyping or cervical cytology results 3 years before delivery were included. Chi-squared and logistic regression analyses were used. RESULTS: In our cohort of 2153 women, 38...
January 24, 2019: Journal of Women's Health
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