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Rosalie Heller, H Stammers
INTRODUCTION: The 1.5-mile best-effort run is used in the British Army to assess the fitness of all recruits and trained service personnel by means of the physical fitness assessment (PFA). The 1.5-mile run is a basic measure of fitness and slower times have been associated with an increased risk of musculoskeletal injury (MSkI), particularly during this early stage of training. The aim of this study was to establish whether 1.5-mile run times were associated with subsequent MSkIs among female recruits during their 14-week basic training...
February 12, 2019: Journal of the Royal Army Medical Corps
Carole Kenner, Kristin Ashford, Lina Kurdahi Badr, Beth Black, Joan Bloch, Rosalie Mainous, Jacqueline McGrath, Shahirose Premji, Susan Sinclair, Mary Terhaar, M Terese Verklan, Marlene Walden, Deborah S Walker, SeonAe Yeo, Linda B Zekas, Elizabeth A Kostas-Polston, Cindy Smith Greenberg, Marina Boykova
No abstract text is available yet for this article.
February 7, 2019: Nursing Outlook
David Powell, Abby Alpert, Rosalie L Pacula
The hepatitis C virus is responsible for more deaths in the United States than any other infectious disease, and hepatitis C infections have been rising at an alarming rate since 2010. We evaluated the role of the opioid epidemic and, in particular, the 2010 introduction of an abuse-deterrent version of OxyContin. The OxyContin reformulation led some users of the drug to switch to heroin, which could have exposed them to the hepatitis C virus. We used difference-in-differences methods, using data for the period 2004-15, to assess whether states with higher rates of OxyContin misuse prior to reformulation-states where the reformulation had more impact-experienced faster growth in infections after the reformulation...
February 2019: Health Affairs
Judy S LaKind, Cian O'Mahony, Thomas Armstrong, Rosalie Tibaldi, Benjamin C Blount, Daniel Q Naiman
Recent rapid technological advances are producing exposure data sets for which there are no available data quality assessment tools. At the same time, regulatory agencies are moving in the direction of data quality assessment for environmental risk assessment and decision-making. A transparent and systematic approach to evaluating exposure data will aid in those efforts. Any approach to assessing data quality must consider the level of quality needed for the ultimate use of the data. While various fields have developed approaches to assess data quality, there is as yet no general, user-friendly approach to assess both measured and modeled data in the context of a fit-for-purpose risk assessment...
January 25, 2019: Environmental Research
Rosalie A Carr, Panagiotis Bletsis, Alexandra M Roch, Michael G House, Nicholas J Zyromski, Attila Nakeeb, C Max Schmidt, Eugene P Ceppa
BACKGROUND: Pancreatic neuroendocrine tumors (PNETs) are predominantly solid lesions with malignant potential. Cystic PNETs are a small subset in which data are scarce. The aim of this study was to compare clinical and biologic differences between cystic and solid PNETs. METHODS: Patients with PNETs undergoing pancreatectomy between 1988 and 2016 at a high-volume center were reviewed retrospectively. Demographic, clinical, and histopathologic data were collected and analyzed...
January 22, 2019: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Rosalie S Braun, Nilmini Mendis, Laam Li, Sebastien P Faucher
Legionella pneumophila, among other bacteria, may enter a viable but non-culturable state as a means for survival in stressful conditions. Bacterial cells in the viable but non-culturable state cannot grow on standard medium; however, they continue to exhibit characteristics that are associated with live cells, such as respiration, transcription, and cell wall integrity. The present paper outlines a detailed protocol for the detection of viable but non-culturable L. pneumophila cells via Syto® 9 and propidium iodide staining coupled with flow cytometry...
2019: Methods in Molecular Biology
Marike van der Leeden, Chloé Balland, Edwin Geleijn, Rosalie J Huijsmans, Joost Dekker, Marinus A Paul, Chris Dickhoff, Martijn M Stuiver
BACKGROUND: Apart from clinical experience and theoretical considerations, there is a lack of evidence that the level of adherence to in-hospital mobilization protocols is related to functional recovery in patients following lung cancer surgery. The objectives of the study were to determine (1) the relationship between adherence to the in-hospital mobilization protocol and physical fitness at hospital discharge and (2) the value of physical fitness measures at discharge in predicting physical functioning six weeks and three months post-surgery...
January 25, 2019: Annals of Thoracic Surgery
Joël Tremblay, Karine Bertrand, Nadine Blanchette-Martin, Brian Rush, Annie-Claude Savard, Nadia L'Espérance, Geneviève Demers-Lessard, Rosalie Genois
OBJECTIVE: In the field of health care services, resource allocation is increasingly determined based on a population needs model. Although service needs models have been developed for adults with substance use problems, it would seem inappropriate to apply them indiscriminately to young people. METHOD: The method used proposes six steps: (1) targeting the population, (2) estimating the proportion of the population affected by substance misuse and (3) the proportion of youths who should receive services, (4) identifying categories of services, (5) estimating the proportions of youths who should have access to each category of services, and (6) applying the model to real use of services by youths to recalibrate it...
January 2019: Journal of Studies on Alcohol and Drugs. Supplement
Yuliya Lytvyn, Lucas C Godoy, Rosalie A Scholtes, Daniël H van Raalte, David Z Cherney
PURPOSE OF REVIEW: Type 2 diabetes (T2D) is associated with an increased risk of diabetic kidney disease (DKD), cardiovascular disease, and heart failure, in part through activation of the renin-angiotensin-aldosterone system (RAAS). Although recent cardiovascular outcome trials have identified newer therapeutic agents such as sodium-glucose cotransporter-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1)-receptor agonists that reduce the risk of these complications, patients still exhibit residual cardiorenal morbidity and mortality...
January 23, 2019: Current Diabetes Reports
Berthold Koletzko, K M Godfrey, Lucilla Poston, Hania Szajewska, Johannes B van Goudoever, Marita de Waard, Brigitte Brands, Rosalie M Grivell, Andrea R Deussen, Jodie M Dodd, Bernadeta Patro-Golab, Bartlomiej M Zalewski
BACKGROUND: A considerable body of evidence accumulated especially during the last decade, demonstrating that early nutrition and lifestyle have long-term effects on later health and disease ("developmental or metabolic programming"). METHODS: Researchers involved in the European Union funded international EarlyNutrition research project consolidated the scientific evidence base and existing recommendations to formulate consensus recommendations on nutrition and lifestyle before and during pregnancy, during infancy and early childhood that take long-term health impact into account...
January 23, 2019: Annals of Nutrition & Metabolism
Rémy Rosalie, Mathieu Léchaudel, Marc Chillet, Laurent Dufossé, Jacques Joas
BACKGROUND: Large improvements have been realized on the accuracy of the determination of fruit quality. The relevance of the relationship between commonly used quality descriptors and their related chemical contents was here questioned under the influence of water supply reduction and post-harvest cold storage. The study relied on three analyses: (1) correlations table between quality descriptors and compound contents, (2) Principal Component Analysis using the selected variables to see the quality discrimination dictated by treatments; and (3) linear correlation between content and descriptors according to treatments...
January 21, 2019: Journal of the Science of Food and Agriculture
Malak M Tfaily, Rachel M Wilson, Heather M Brewer, Rosalie K Chu, Heino M Heyman, David W Hoyt, Jennifer E Kyle, Samuel O Purvine
Natural organic matter (NOM) is composed of a highly complex mixture of thousands of organic compounds which, historically, proved difficult to characterize. However, to understand the thermodynamic and kinetic controls on greenhouse gas (carbon dioxide [CO2] and methane [CH4]) production resulting from the decomposition of NOM, a molecular-level characterization coupled with microbial proteome analyses is necessary. Further, climate and environmental changes are expected to perturb natural ecosystems, potentially upsetting complex interactions that influence both the supply of organic matter substrates and the microorganisms performing the transformations...
January 7, 2019: Journal of Visualized Experiments: JoVE
Ellen M Langer, Brittany L Allen-Petersen, Shelby M King, Nicholas D Kendsersky, Megan A Turnidge, Genevra M Kuziel, Rachelle Riggers, Ravi Samatham, Taylor S Amery, Steven L Jacques, Brett C Sheppard, James E Korkola, John L Muschler, Guillaume Thibault, Young Hwan Chang, Joe W Gray, Sharon C Presnell, Deborah G Nguyen, Rosalie C Sears
The tumor microenvironment plays a critical role in tumor growth, progression, and therapeutic resistance, but interrogating the role of specific tumor-stromal interactions on tumorigenic phenotypes is challenging within in vivo tissues. Here, we tested whether three-dimensional (3D) bioprinting could improve in vitro models by incorporating multiple cell types into scaffold-free tumor tissues with defined architecture. We generated tumor tissues from distinct subtypes of breast or pancreatic cancer in relevant microenvironments and demonstrate that this technique can model patient-specific tumors by using primary patient tissue...
January 15, 2019: Cell Reports
Rosalie Power, Rahena Akhter, Mohammad Muhit, Sabrina Wadud, Eamin Heanoy, Tasneem Karim, Nadia Badawi, Gulam Khandaker
BACKGROUND: Measuring the health-related quality of life (HRQoL) of adolescents, including those with cerebral palsy (CP) (the major cause of childhood physical disability worldwide) in Bangladesh is pertinent although there is a dearth of validated instruments for assessing this concept. For application in a case-control study comparing HRQoL between adolescents with CP and peers without disability in Bangladesh (a typical low- and middle-income country) we cross-culturally translated and psychometrically tested KIDSCREEN-27...
January 15, 2019: BMC Pediatrics
Alexandra M Roch, Justine Schneider, Rosalie A Carr, William P Lancaster, Michael G House, Nicholas J Zyromski, Attila Nakeeb, C Max Schmidt, Eugene P Ceppa
BACKGROUND: Breast cancer (BRCA) mutations account for the highest proportion of hereditary causes of pancreatic ductal adenocarcinoma (PDAC). Screening is currently recommended only for patients with one first-degree relative or two family members with PDAC. We hypothesized that screening all BRCA1/2 patients would identify a higher rate of pancreatic abnormalities. METHODS: All BRCA1/2 patients at a single academic center were retrospectively reviewed (2005-2015)...
January 12, 2019: Journal of Surgical Oncology
A Y Rosalie Kühlmann, Joost van Rosmalen, Lonneke M Staals, Claudia M G Keyzer-Dekker, Jaap Dogger, Tom G de Leeuw, Fred van der Toorn, Johannes Jeekel, Rene M H Wijnen, Monique van Dijk
BACKGROUND: Perioperative music interventions have been shown to reduce anxiety and pain in adults. This inexpensive, easily applicable intervention could be of benefit to children as well. Our objective was to determine the effects of music interventions on distress, anxiety, and postoperative pain in infants undergoing surgery. METHODS: The Music Under Surgery In Children study was designed as a parallel, single-blind, randomized controlled trial with an a priori formulated hypothesis...
January 8, 2019: Anesthesia and Analgesia
Alison E Brown, Rosalie Hayes, Teymur Noori, Yusef Azad, Andrew J Amato-Gauci, Anastasia Pharris, Valerie C Delpech, The Ecdc Dublin Declaration Monitoring Network
In 2018, 52 of 55 European and Central Asian countries reported data against the UNAIDS 90-90-90 targets. Overall, 80% of people living with HIV (PLHIV) were diagnosed, of whom 64% received treatment and 86% treated were virally suppressed. Subregional outcomes varied: West (87%-91%-93%), Centre (83%-73%-75%) and East (76%-46%-78%). Overall, 43% of all PLHIV were virally suppressed; intensive efforts are needed to meet the 2020 target of 73%.
November 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
Nicolas Dauby, Catherine Adler, Veronique Y Miendje Deyi, Rosalie Sacheli, Laurent Busson, Mustapha Chamekh, Arnaud Marchant, Patricia Barlow, Stéphane De Wit, Jack Levy, Pierrette Melin, Tessa Goetghebuer
Background: Group B streptococcus (GBS) infection is a leading cause of severe neonatal infection. Maternal GBS carriage during pregnancy is the main risk factor for both early-onset and late-onset GBS disease. High incidence of GBS infection has been reported in HIV-exposed but -uninfected infants (HEU). We aimed to determine the prevalence, characteristics, and risk factors for GBS colonization in HIV-infected and HIV-uninfected pregnant women living in Belgium. Methods: Between January 1, 2011, and December 31, 2013, HIV-infected (n = 125) and -uninfected (n = 120) pregnant women had recto-vaginal swabs at 35-37 weeks of gestation and at delivery for GBS detection...
December 2018: Open Forum Infectious Diseases
Darryl Tio, Fazira R Kasiem, Marcella Willemsen, Remco van Doorn, Nienke van der Werf, Rick Hoekzema, Rosalie M Luiten, Marcel W Bekkenk
The cancer/testis antigen (CTA) family is a group of antigens whose expression is restricted to male germline cells of the testis and various malignancies. This expression pattern makes this group of antigens potential targets for immunotherapy. The aim of this study was to create an overview of CTA expressed by melanoma cells at mRNA and protein level. A systematic literature search was performed in Medline (PubMed) and Embase from inception up to and including February 2018. Studies were screened for eligibility by two independent reviewers...
January 4, 2019: Melanoma Research
Shiuh-Wen Luoh, Wendy Wagoner, Xiaoyan Wang, Zhi Hu, Xinhe Lai, Koei Chin, Rosalie Sears, Elizabeth Ramsey
GRB7 gene encodes a multi-domain signal transduction molecule and is part of the core of the HER-2 amplicon. GRB7 is commonly co-amplified and overexpressed with HER-2 in human breast cancer. This study addresses the role of GRB7 in HER-2 positive human breast cancers resistant to HER-2 targeted therapy. HCC1954, 21MT1 and JIMT1 are basal like HER-2 positive breast cancer cell lines based on expression profiling. These three cell lines are resistant to trastuzumab and lapatinib treatment. Knockdown of GRB7 protein expression with siRNA transfection as well as lentiviral vector mediated shRNA over-expression decreased the growth of HCC1954, 21MT1 and JIMT1 cells invitro and the growth of tumor xenograft these cells formed in animal models...
January 3, 2019: Molecular Carcinogenesis
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