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https://read.qxmd.com/read/30779366/vascular-targeted-low-dose-photodynamic-therapy-stabilizes-tumor-vessels-by-modulating-pericyte-contractility
#1
Sabrina Cavin, Tina Riedel, Petra Rosskopfova, Michel Gonzalez, Greg Baldini, Matthieu Zellweger, Georges Wagnières, Paul J Dyson, Hans-Beat Ris, Thorsten Krueger, Jean Y Perentes
Vascular-targeted low-dose photodynamic therapy (L-PDT) was shown to improve chemotherapy distribution in malignant pleural tumors such as malignant pleural mesothelioma (MPM). However, the mechanisms triggered by L-PDT on the tumor vasculature are still debated. In pericyte and endothelial cell co-cultures, we show that pericytes exhibit enhanced sensitivity towards L-PDT compared to endothelial cells, displaying actin stress fibers and cellular contraction via Rho/ROCK kinase signaling myosin light chain and focal adhesion kinase phosphorylation (MLC-P, FAK-P)...
February 19, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/30778130/visit-to-visit-systolic-blood-pressure-variability-in-patients-with-st-elevation-myocardial-infarction-predicts-long-term-cardiovascular-outcomes
#2
Moon-Seung Soh, Jin-Sun Park, Kyoung-Woo Seo, Hyoung-Mo Yang, Hong-Seok Lim, Byoung-Joo Choi, So-Yeon Choi, Myeong-Ho Yoon, Gyo-Seung Hwang, Seung-Jea Tahk, Joon-Han Shin
Elevated visit-to-visit blood pressure variability (BPV), independent of mean BP, has been associated with cardiovascular events. However, its impact after ST-elevation myocardial infarction (STEMI) has not been established. This study aimed to investigate the prognostic impact of BPV on patients after STEMI. We analyzed the data and clinical outcomes of STEMI survivors who underwent successful primary coronary intervention from 2003 to 2009. BP was measured at discharge and at 1, 3, 6, 12, 24, and 36 months, and we calculated BPV as the intra-individual standard deviations (SDs) of systolic BP (SBP) across these measurements...
February 18, 2019: Journal of Human Hypertension
https://read.qxmd.com/read/30777952/iris-varix-10-year-experience-with-28-eyes
#3
Puneet Jain, Paul T Finger
Purpose: The purpose of this study is to describe the clinical characteristics, multimodality imaging findings, and clinical course of iris varices. Methods: Retrospective, noncomparative, observational case series of 28 eyes of 26 patients with iris varices, diagnosed between 2007 and 2017, has been used. Results: The mean (±SD) age was 58.3 ± 12.5 years (median 57.5, range 37-81). Patients were 57.7% male and 27% hypertensive. Varices were bilateral in two patients...
March 2019: Indian Journal of Ophthalmology
https://read.qxmd.com/read/30776786/controllable-fiber-orientation-and-nonlinear-elasticity-of-electrospun-nanofibrous-small-diameter-tubular-scaffolds-for-vascular-tissue-engineering
#4
Zongwu Niu, Xiaofeng Wang, Xin Meng, Xin Guo, Yongchao Jiang, Yiyang Xu, Qian Li, Changyu Shen
Biomimetic structures play an important role in controlling the cell behaviors of adhesion, proliferation, migration, and differentiation, which is beneficial for the regeneration of defective tissues. Scaffolds with a biomimetic structure are highly desirable in tissue engineering. In this study, we successfully fabricated three different types of tubular scaffold with randomly, circumferentially, and axially aligned structures, using synthetic bioabsorbable poly(L-lactide-co-caprolactone) via electrospinning...
February 18, 2019: Biomedical Materials
https://read.qxmd.com/read/30776519/intra-arterial-dantrolene-for-refractory-cerebral-vasospasm-in-patients-with-aneurysmal-subarachnoid-hemorrhage
#5
Michael Ortiz, Muhammad Jahngir, Kathryn Qualls, N Scott Litofsky, Premkumar Nattanmai, Adnan I Qureshi
BACKGROUND: Dantrolene has a safe side-effect profile and a mechanism of action that makes it attractive as an option for treatment of cerebral vasospasm. The authors report two cases of refractory cerebral vasospasm secondary to aneurysmal subarachnoid hemorrhage that were successfully treated with intra-arterial dantrolene. CASE DESCRIPTIONS: Two patients, a 63-year-old woman and 36-year-old woman, developed severe vasospasm refractory to intra-arterial vasodilators after rupture of anterior communicating artery aneurysms...
February 15, 2019: World Neurosurgery
https://read.qxmd.com/read/30775920/raman-spectroscopic-study-of-the-effect-of-aqueous-salt-solutions-on-the-inhibition-of-carbon-dioxide-gas-hydrates
#6
Christine Carola Holzammer, Andreas Siegfried Braeuer
We present an experimental Raman study on the thermodynamic inhibition effect of different salts (NaCl, KCl, MgCl2 and CaCl2 from 2.5 - 11 wt-%) on the formation of carbon dioxide gas hydrates. We performed the experiments in a high pressure vessel with two phases: A water-rich phase and a CO2 -rich phase. We investigated the changes the inhibitors induce in the water-rich phase before the onset of hydrate formation. This includes a study of the change in molar reaction enthalpy between strongly and weakly hydrogen bonded water and the decrease in solubility of carbon dioxide in water...
February 18, 2019: Journal of Physical Chemistry. B
https://read.qxmd.com/read/30770255/aortic-pulsatility-propagates-intracranially-and-correlates-with-dilated-perivascular-spaces-and-small-vessel-compliance
#7
Owen Thomas, John Cain, Mehran Nasralla, Alan Jackson
INTRODUCTION: To test the hypotheses that changes in the aortic pulse-wave produced by arterial stiffening are (1) propagated into cerebral small vessels, (2) associated with reduced compliance of small cerebral arterial vessels, and (3) associated with the presence of dilated perivascular spaces (PVS). METHODS: Fifteen volunteers and 19 patients with late-onset depression (LOD) were prospectively recruited, of which 6 fulfilled the criteria for treatment-resistant depression (TRD)...
February 12, 2019: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://read.qxmd.com/read/30769077/a-follow-up-study-of-cerebral-microbleeds-in-patients-who-received-stents-for-symptomatic-cerebral-artery-stenosis
#8
Yuyuan Gao, Kun Nie, Zhenpeng Duan, Shuo Wang, Guixian Ma, Xiong Zhang, Changmao Li, Yuhu Zhang, Chengbo Dai, Lijuan Wang
OBJECTIVE: The aims of this study were to explore (i) the dynamic changes in cerebral microbleeds (CMBs) in symptomatic cerebral artery stenosis patients who received endovascular stent-assisted angioplasty and (ii) the risk factors associated with the new incidence of CMBs as well as whether CMBs increased the risk of vascular events in these patients. METHODS: Clinical information and magnetic resonance images were collected on admission and three months after endovascular stent-assisted angioplasty...
February 12, 2019: Annals of Vascular Surgery
https://read.qxmd.com/read/30769053/assessment-of-the-utility-of-a-vascular-early-warning-system-vews-device-in-the-assessment-of-peripheral-arterial-disease-in-patients-with-diabetes-and-incompressible-vessels
#9
D J Saunders, L Bleasdale, L Summerton, A Hancock, S Homer-Vanniasinkam, D A Russell
OBJECTIVES: To assess the ability of a novel, automated CE marked vascular early warning system (VEWS) device to detect peripheral arterial disease in patients with incompressible ankle arteries and non-measurable ankle brachial pressure index (ABPI) secondary to diabetes. RESEARCH DESIGN AND METHODS: Recruited patients had diabetes, recent MRA evidence of PAD and incompressible vessels on ABPI. VEWS indices of each leg were automatically calculated by employing optical infrared and red sensors applied to the foot with readings obtained with the subject's leg both flat and elevated...
February 12, 2019: Annals of Vascular Surgery
https://read.qxmd.com/read/30767923/turbidity-control-on-dissolved-air-flotation-process-using-fuzzy-logic
#10
Rodolpho Rodrigues Fonseca, Ivan Carlos Franco, José Pedro Thompson, Flavio Vasconcelos da Silva
This study intends to explore fuzzy logic control on clean water turbidity process with dissolved air flotation (DAF). Three different strategies were tested to regulate clean water turbidity by manipulating the saturator vessel flow output aiming for low actuators control effort. Saturator pressure was the manipulated variable (MV) in the first control loop named SISO I. The second control loop, SISO II, used recycle stream valve opening as MV. The third control loop (MISO) was developed applying fuzzy logic instead PID control...
December 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://read.qxmd.com/read/30766730/early-macular-angiography-among-patients-with-glaucoma-ocular-hypertension-and-normal-subjects
#11
Shih-Chun Chao, Shang-Jung Yang, Hung-Chi Chen, Chi-Chin Sun, Chin-Hsin Liu, Chia-Yi Lee
Purpose: To evaluate early macular circulation in open-angle glaucoma (OAG), normal-tension glaucoma (NTG), ocular hypertension (OHT), and healthy subjects via optical coherence tomography angiography (OCTA). Methods: A retrospective cross-sectional study was conducted. Medical records were reviewed, and the patients who received OCTA examinations were divided into the OAG, NTG, OHT, and normal groups. The ophthalmic data including best-corrected visual acuity, spherical equivalent, intraocular pressure, central corneal thickness, central foveal thickness, visual field deviation, retinal nerve fiber layers thickness, and ganglion cell complex thickness were obtained from medical documents...
2019: Journal of Ophthalmology
https://read.qxmd.com/read/30760775/argon-reduces-the-pulmonary-vascular-tone-in-rats-and-humans-by-gaba-receptor-activation
#12
Said Suleiman, Sergej Klassen, Ira Katz, Galina Balakirski, Julia Krabbe, Saskia von Stillfried, Svetlana Kintsler, Till Braunschweig, Aaron Babendreyer, Jan Spillner, Sebastian Kalverkamp, Thomas Schröder, Manfred Moeller, Mark Coburn, Stefan Uhlig, Christian Martin, Annette D Rieg
Argon exerts neuroprotection. Thus, it might improve patients' neurological outcome after cerebral disorders or cardiopulmonary resuscitation. However, limited data are available concerning its effect on pulmonary vessel and airways. We used rat isolated perfused lungs (IPL) and precision-cut lung slices (PCLS) of rats and humans to assess this topic. IPL: Airway and perfusion parameters, oedema formation and the pulmonary capillary pressure (Pcap ) were measured and the precapillary and postcapillary resistance (Rpost ) was calculated...
February 13, 2019: Scientific Reports
https://read.qxmd.com/read/30760548/dynamics-of-blood-circulation-during-diving-in-the-bottlenose-dolphin-tursiops-truncatus-the-role-of-the-retia-mirabilia
#13
Marco Bonato, Paola Bagnoli, Cinzia Centelleghe, Mike Maric, Ginevra Brocca, Sandro Mazzariol, Bruno Cozzi
The retia mirabilia are vascular nets composed by small vessels dispersed among numerous veins, allowing blood storage, regulation of flow, and pressure damping effects. Here we investigated their potential role during the diving phase of the bottlenose dolphin ( Tursiops truncatus ). To this effect, the whole vertebral retia mirabilia of a series of dolphins were removed during post-mortem analysis and examined to assess vessel diameters, estimate vascular volume, and flow rate. Here we formulate a new hemodynamic model to help clarify vascular dynamics throughout the diving phase, based on the total blood volume of a bottlenose dolphin, and using data available about the perfusion of the main organs and body systems...
February 13, 2019: Journal of Experimental Biology
https://read.qxmd.com/read/30760295/cerebral-metabolism-is-not-affected-by-moderate-hyperventilation-in-patients-with-traumatic-brain-injury
#14
Giovanna Brandi, Nino Stocchetti, Alberto Pagnamenta, Federica Stretti, Peter Steiger, Stephanie Klinzing
BACKGROUND: Hyperventilation-induced hypocapnia (HV) reduces elevated intracranial pressure (ICP), a dangerous and potentially fatal complication of traumatic brain injury (TBI). HV decreases the arteriolar diameter of intracranial vessels, raising the risk of cerebral ischemia. The aim of this study was to characterize the effects of moderate short-term HV in patients with severe TBI by using concomitant monitoring of cerebral metabolism, brain tissue oxygen tension (PbrO2 ), and cerebral hemodynamics with transcranial color-coded duplex sonography (TCCD)...
February 13, 2019: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/30758094/retinal-microvascular-changes-in-microvascular-angina-findings-from-the-australian-heart-eye-study
#15
Gerald Liew, Paul Mitchell, Joseph Chiha, Adam Jh Plant, Andrew White, Nichole Joachim, Sarah Wang, George Burlutsky, Pramesh Kovoor, Aravinda Thiagalingam, Bamini Gopinath
OBJECTIVE: Microvascular changes in microvascular angina are poorly understood due to difficulties in imaging the coronary microcirculation in vivo. The retinal microvasculature may reflect changes in coronary microcirculation. We assessed microvascular changes in the retina in patients with microvascular angina and compared them with patients with angiographically proven coronary artery disease. METHODS: We performed retinal photography and coronary angiography on 915 patients...
February 13, 2019: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://read.qxmd.com/read/30753867/dacomitinib-a-new-pan-egfr-inhibitor-is-effective-in-attenuating-pulmonary-vascular-remodeling-and-pulmonary-hypertension
#16
Xiufeng Yu, Xijuan Zhao, Junting Zhang, YiYing Li, Ping Sheng, Cui Ma, Lixin Zhang, XueWei Hao, XiaoDong Zheng, Yan Xing, Hui Qiao, Lihui Qu, Daling Zhu
Accumulating evidence suggests that epidermal growth factor receptor (EGFR) plays a role in the progression of pulmonary arterial hypertension (PAH). Clinically-approved epidermal growth factor inhibitors such as gefitinib, erlotinib, and lapatinib have been explored for PAH . However, None of them were able to attenuate PAH . So, we explored the role of dacomitinib, a new pan-EGFR inhibitor, in PAH. Adult male Sprague-Dawley rats were used to study hypoxia- or monocrotaline-induced right ventricular remodeling as well as systolic function and hemodynamics using echocardiography and a pressure-volume admittance catheter...
February 9, 2019: European Journal of Pharmacology
https://read.qxmd.com/read/30746192/effectiveness-of-a-4-week-rehabilitation-program-on-endothelial-function-blood-vessel-elasticity-in-patients-with-chronic-obstructive-pulmonary-disease
#17
Botond Szucs, Mate Petrekanits, Janos Varga
Background: Chronic obstructive pulmonary disease (COPD) may have considerable cardiovascular risk. Physical activity has a paramount role in COPD treatment. Our aim was to evaluate the applicability of arteriograph in COPD and measure the effectiveness of pulmonary rehabilitation on endothelial function. Methods: A total of 40 patients with COPD (FEV1 : 45.43±20.20%pred, BMI: 27.99±6.98 kg/m2 , male: female was 21:19, age: 65.47±7.39 years) participated in a 4-week rehabilitation program...
December 2018: Journal of Thoracic Disease
https://read.qxmd.com/read/30746189/how-to-prevent-adverse-events-of-vascular-stapling-in-thoracic-surgery-recommendations-based-on-a-clinical-and-experimental-study
#18
Nahoko Shimizu, Yugo Tanaka, Takeshi Okamoto, Takefumi Doi, Daisuke Hokka, Yoshimasa Maniwa
Background: Advances in the development of staplers for pulmonary vessels have contributed to safe and convenient procedures in thoracic surgery. However, adverse events (AEs) can occur during vascular stapling and cause fatal hemorrhage. We aimed to assess the risk level of using the vessel stapling procedure to reduce such AEs. Methods: First, an animal experiment using pig cardiopulmonary blocks was conducted. Pulmonary arteries were closed with staplers under stressful conditions such as lifting or twisting; vessel stump endurance was analyzed through different methods...
December 2018: Journal of Thoracic Disease
https://read.qxmd.com/read/30745108/oxygen-partial-pressure-plays-a-crucial-role-in-b16-melanoma-cell-survival-by-regulating-autophagy-and-mitochondrial-functions
#19
Yuqing Wang, Yan Wang, Jia Wu, Wei Wang, Yu Zhang
The oxygen partial pressure generally increases when cancerous cells become part of the blood vessels. The study was to investigate the influence of oxygen partial pressure on the apoptosis of B16 melanoma cells. Our results demonstrated that both short-term and long-term hypoxia/reoxygenation (H/R) treatment increased stress-induced intracellular reactive oxygen species (ROS). H/R treatment also increased apoptosis and autophagy in B16 cells. N-acetylcysteine (NAC), a ROS scavenger, can reduce ROS and aid survival...
February 8, 2019: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/30744907/circadian-rhythms-of-cardiovascular-autonomic-function-physiology-and-clinical-implications-in-neurodegenerative-diseases
#20
REVIEW
Francesca Baschieri, Pietro Cortelli
Circadian rhythms of blood pressure and heart rate are regulated by a biological clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus, which modulates the autonomic nervous system activity directed to the heart and blood vessels. Humoral mediators released with periodicity induced by the SCN as well as sleep are also important factors. Disruption of physiological cardiovascular circadian rhythms has important clinical implications, as it is associated with increased morbidity and mortality...
March 2019: Autonomic Neuroscience: Basic & Clinical
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