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JOURNAL ARTICLE
Marina Itagaki, Osamu Iketani, Yuki Enoki, Victor Tuan Giam Chuang, Kazuaki Taguchi, Shunsuke Uno, Sho Uchida, Ho Namkoong, Yoshifumi Uwamino, Yaoko Takano, Naoki Hasegawa, Kazuaki Matsumoto
Biologic medications have dramatically improved the treatment outcomes of immunological inflammatory diseases, but their immunosuppressive effects put patients at risk for tuberculosis (TB). We investigated the risk factors for developing TB in patients treated for latent tuberculosis infection (LTBI) who also had experience of using biologic medications. At Keio University Hospital, we retrospectively investigated patients treated with anti-mycobacterial drugs before or concurrently with biologic medications from January 2012 to August 2020...
2023: Biological & Pharmaceutical Bulletin
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JOURNAL ARTICLE
Kazuki Aoyama, Yuya Nakajima, Shu Meguro, Yasunori Sato, Rei Goto, Mariko Hida, Takeshi Arimitsu, Yoshifumi Kasuga, Mamoru Tanaka, Hiroshi Itoh
BACKGROUND: Strict glycemic control is important to prevent perinatal complications in patients with gestational diabetes mellitus (GDM). Patients often require insulin injection, and frequent hospital visits are necessary to adjust the dose of insulin, which is considered burdensome for pregnant patients. Telemedicine may reduce the burden of hospital visits, and previous studies have reported its safety in GDM patients. This study aimed to evaluate the efficacy of telemedicine in GDM patients, focusing on patient satisfaction and health economic indicators...
November 2023: Heliyon
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JOURNAL ARTICLE
Ryunosuke Sugimoto, Tomohiro Inoguchi, Aiko Isobe, Sachiko Kaburagi, Masayuki Akashi
Eosinophilic gastroenteritis (EGE) can occur throughout the gastrointestinal tract, from the stomach to the colon. Typical known symptoms are abdominal pain, nausea, vomiting, and diarrhea. In addition, lesions in the intestinal mucosa may cause weight loss, protein-losing enteropathy (PLE), and other problems. A 6-month-old girl with no previous medical history was brought to our hospital after an afebrile 1-min clonic seizure. Blood tests showed low concentrations of serum calcium and albumin. After the correction of hypocalcemia with gluconic acid, there was no recurrence of seizure...
November 30, 2023: Keio Journal of Medicine
#24
MULTICENTER STUDY
Toshiki Kuno, Takanori Ohata, Ryo Nakamaru, Mitsuaki Sawano, Masaki Kodaira, Yohei Numasawa, Ikuko Ueda, Masahiro Suzuki, Shigetaka Noma, Keiichi Fukuda, Shun Kohsaka
Long-term outcomes of iatrogenic coronary dissection and perforation in patients undergoing percutaneous coronary intervention (PCI) remains under-investigated. We analyzed 8,721 consecutive patients discharged after PCI between 2008 and 2019 from Keio Cardiovascular (KiCS) PCI multicenter prospective registry in the Tokyo metropolitan area. Significant coronary dissection was defined as persistent contrast medium extravasation or spiral or persistent filling defects with complete distal and impaired flow. The primary outcome was a composite of all-cause death, acute coronary syndrome, heart failure, bleeding, stroke requiring admission, and coronary artery bypass grafting two years after discharge...
November 20, 2023: Scientific Reports
#25
JOURNAL ARTICLE
Toshiyuki Shimizu, Mitsuru Yagi, Satoshi Suzuki, Yohei Takahashi, Masahiro Ozaki, Osahiko Tsuji, Narihito Nagoshi, Yoshiyuki Yato, Morio Matsumoto, Masaya Nakamura, Kota Watanabe
PURPOSE: The importance of coronal alignment is unclear, while the importance of sagittal alignment in the treatment of adult patients with spinal deformities is well described. This study sought to elucidate the impact of global coronal malalignment (GCMA) in surgically treated adult symptomatic lumbar deformity (ASLD) patients. METHODS: A multicentre retrospective analysis of a prospective ASD database. GCMA was defined as GCA (C7PL-CSVL) ≥ 3 cm...
November 18, 2023: Spine Deformity
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JOURNAL ARTICLE
Seiya Ohtani, Narumi Watanabe, Keiko Ihara, Nobuyuki Takahashi, Naoki Miyazaki, Kei Ishizuchi, Ryo Takemura, Satoko Hori, Jin Nakahara, Tsubasa Takizawa
BACKGROUND: There have been very few real-world studies reported in the literature solely focusing on fremanezumab in Asia. This study aimed to evaluate the efficacy and safety of fremanezumab in a real-world setting in Japan. METHOD: This single-centered, observational, retrospective study examined patients with migraines who received four doses of fremanezumab between December 2021 and August 2022 at Keio University Hospital. We assessed the changes in monthly migraine days, responder rates, and migraine-associated symptoms, as well as injection site reactions and adverse events...
November 14, 2023: BMC Neurology
#27
JOURNAL ARTICLE
Impact of wound management strategies after revascularization for chronic limb-threatening ischemia.
Tsunehiro Shintani, Hideaki Obara, Kentaro Matsubara, Masanori Hayashi, Hidenori Kita, Shigeshi Ono, Susumu Watada, Naoya Kikuchi, Yasuhito Sekimoto, Yukiko Torizaki, Atsunori Asami, Taku Fujii, Keita Hayashi, Hirohisa Harada, Naoki Fujimura, Kyousuke Hosokawa, Eiji Nakatani, Yuko Kitagawa
OBJECTIVE: There is no established consensus or guidelines for wound management after revascularization for patients with chronic limb-threatening ischemia (CLTI) without severe infection. This study is designed to evaluate the clinical effect of the wound management strategy on toe wounds after revascularization for CLTI. METHODS: This retrospective cohort study was performed at eight institutions affiliated with Keio University School of Medicine in Japan and included 261 patients who underwent revascularization for CLTI between April 2019 and July 2021...
November 7, 2023: Journal of Vascular Surgery
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JOURNAL ARTICLE
Hiroyuki Oikawa, Yuya Morooka, Munehiro Furuichi, Masayoshi Shinjoh, Shotaro Nozaki, Emiri Nishi, Mizuki Yaginuma, Tomohiro Inoguchi, Kentaro Tomita, Kenji Furuno, Takao Takahashi
INTRODUCTION: Studies investigating the role of urinary tract abnormalities in the development of catheter-associated urinary tract infections (CAUTI) in young children are limited. Thus, in the present study, we aimed to determine whether there is an association between CAUTI and urinary tract abnormalities. METHODS: We performed abdominal imaging studies on all patients aged <6 years with CAUTI admitted to the pediatric intensive care units (PICU) and high care unit (HCU) at Keio university or Fukuoka Children's Hospital from April 1, 2018 to July 31, 2022...
October 5, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
#29
JOURNAL ARTICLE
Seiichi Koike, Kazuko Keio-Masu, Yoko Tanimoto, Satoru Takahashi, Masayuki Masu
Autotaxin, encoded by the Enpp2 gene, is an exoenzyme that produces lysophosphatidic acid, thereby regulating many biologic functions. We previously reported that Enpp2 mRNA was abundantly expressed in yolk sac visceral endoderm (VE) cells and that Enpp2-/- mice were lethal at embryonic day 9.5 owing to angiogenic defects in the yolk sac. Enpp2-/- mice showed lysosome fragmentation in VE cells and embryonic abnormalities including allantois malformation, neural tube defects, no axial turning, and head cavity formation...
October 5, 2023: Biology Open
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JOURNAL ARTICLE
Takashi Sasaki, Yoshinori Nishimoto, Takumi Hirata, Yukiko Abe, Nobuyoshi Hirose, Michiyo Takayama, Toru Takebayashi, Hideyuki Okano, Yasumichi Arai
Background: High levels of circulating adiponectin are associated with increased insulin sensitivity, low prevalence of diabetes, and low body mass index (BMI); however, high levels of circulating adiponectin are also associated with increased mortality in the 60-70 age group. In this study, we aimed to clarify factors associated with circulating high-molecular-weight (cHMW) adiponectin levels and their association with mortality in the very old (85-89 years old) and centenarians. Methods: The study included 812 (women: 84...
September 28, 2023: ELife
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JOURNAL ARTICLE
Rebecca L Mccarthy, Marianne De Brito, Edel O'toole
Pachyonychia congenita (PC) is a rare, autosomal dominant inherited disorder of keratinization that is characterized by a triad of focal palmoplantar keratoderma, plantar pain, and hypertrophic nail dystrophy. It can be debilitating, causing significantly impaired mobility. PC is diagnosed clinically alongside identification of a heterozygous pathogenic mutation in one of five keratin genes: KRT6A, KRT6B, KRT6C, KRT16, or KRT17. Each keratin gene mutation is associated with a distinct clinical phenotype, with variable age of onset and additional features, which has allowed classification by genotype...
September 28, 2023: Keio Journal of Medicine
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JOURNAL ARTICLE
Keiko Ihara, Seiya Ohtani, Narumi Watanabe, Nobuyuki Takahashi, Naoki Miyazaki, Ryo Takemura, Satoko Hori, Jin Nakahara, Tsubasa Takizawa
BACKGROUND: Anti-calcitonin gene-related peptide monoclonal antibodies (CGRPmAbs) have dramatically changed preventive treatment options for patients with migraine. Although there is emerging real-world evidence on the use of CGRPmAbs globally, the change in efficacy and safety after switching between CGRPmAbs owing to patients' frequency of hospital visits preference remains unknown. METHODS: We conducted a single-centre, retrospective, real-world study of patients with migraine who first received galcanezumab for 3 or 4 months and then switched to fremanezumab at Keio University Hospital...
September 16, 2023: Journal of the Neurological Sciences
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JOURNAL ARTICLE
Kotaro Miura, Ryuichiro Yagi, Hiroshi Miyama, Mai Kimura, Hideaki Kanazawa, Masahiro Hashimoto, Sayuki Kobayashi, Shiro Nakahara, Tetsuya Ishikawa, Isao Taguchi, Motoaki Sano, Kazuki Sato, Keiichi Fukuda, Rahul C Deo, Calum A MacRae, Yuji Itabashi, Yoshinori Katsumata, Shinichi Goto
BACKGROUND: Atrial septal defect (ASD) increases the risk of adverse cardiovascular outcomes. Despite the potential for risk mitigation through minimally invasive percutaneous closure, ASD remains underdiagnosed due to subtle symptoms and examination findings. To bridge this diagnostic gap, we propose a novel screening strategy aimed at early detection and enhanced diagnosis through the implementation of a convolutional neural network (CNN) to identify ASD from 12-lead electrocardiography (ECG)...
September 2023: EClinicalMedicine
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JOURNAL ARTICLE
Yuji Kato, Takashi Osada, Nobuo Araki, Shinichi Takahashi
We encountered a-27-year-old female patient who developed refractory severe headache and photophobia after the first dose of COVID-19 vaccine. Despite her prior history of migraine, we diagnosed COVID-19 vaccine-induced aseptic meningitis. Symptoms were significantly resolved after methylprednisolone therapy. On reviewing the literature, we could find only nine similar cases, with over half of them affecting women aged 20-40 years. Although uncommon, aseptic meningitis should be suspected in patients with persistent or delayed onset of headache following COVID-19 vaccination...
September 23, 2023: Keio Journal of Medicine
#35
JOURNAL ARTICLE
Taylor M Ranson, Marilynn E Barton, Robert J C McLean
Biofilms are widely recognized as a prominent mode of microbial growth and strategy of antimicrobial tolerance in many environments. Characteristics that are often overlooked in biofilm investigations include the examination of metabolic pathways as the assumption might be that interference with central pathways such as glycolysis would only reduce growth and thus not be meaningful. Using the Keio collection of Escherichia coli mutants, we investigated the influence of biofilm formation and planktonic growth in full strength and diluted Luria-Bertani (LB) broth using strains with a disruption of glycolysis (Δpgi), the Entner-Doudoroff pathway (Δedd), or the pentose phosphate pathway (Δgnd)...
September 20, 2023: Canadian Journal of Microbiology
#36
JOURNAL ARTICLE
Koji Sekiguchi, Sunjun Huh, Narumi Watanabe, Naoki Miyazaki, Kei Ishizuchi, Chisato Iba, Yu Tagashira, Mamoru Shibata, Ryo Takemura, Jin Nakahara, Tsubasa Takizawa
Objective This study examined the prevalence of migraine in nurses in Japan, which, to our knowledge, has not been documented in English. Methods From April to May 2021, we administered a questionnaire to 229 nurses working at Keio University Hospital to investigate the prevalence and characteristics of headache among nurses in Japan. Headaches were classified as migraine or tension-type headache (TTH) based on the International Classification of Headache Disorders-3 (ICHD-3). Results In total, 80 patients (34...
September 15, 2023: Internal Medicine
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JOURNAL ARTICLE
Ryo Yamamoto, Kazuma Yamakawa, Akira Endo, Koichiro Homma, Yasunori Sato, Ryo Takemura, Takeshi Yamagiwa, Keiki Shimizu, Daiki Kaito, Masayuki Yagi, Taku Yonemura, Takayuki Shibusawa, Ginga Suzuki, Takahiro Shoji, Naoya Miura, Jiro Takahashi, Chihiro Narita, Saori Kurata, Kazunobu Minami, Takeshi Wada, Yoshihisa Fujinami, Yohei Tsubouchi, Mai Natsukawa, Jun Nagayama, Wataru Takayama, Ken Ishikura, Kyoko Yokokawa, Yasuo Fujita, Hirofumi Nakayama, Hideki Tokuyama, Kota Shinada, Takayuki Taira, Shoki Fukui, Noritaka Ushio, Masaki Nakane, Eisei Hoshiyama, Akihito Tampo, Hisako Sageshima, Hiroki Takami, Shinichi Iizuka, Hitoshi Kikuchi, Jun Hagiwara, Takashi Tagami, Yumi Funato, Junichi Sasaki, Study Group Er-Oxytrac
INTRODUCTION: Cardiac arrest is a critical condition, and patients often experience postcardiac arrest syndrome (PCAS) even after the return of spontaneous circulation (ROSC). Administering a restricted amount of oxygen in the early phase after ROSC has been suggested as a potential therapy for PCAS; however, the optimal target for arterial partial pressure of oxygen or peripheral oxygen saturation (SpO2 ) to safely and effectively reduce oxygen remains unclear. Therefore, we aimed to validate the efficacy of restricted oxygen treatment with 94%-95% of the target SpO2 during the initial 12 hours after ROSC for patients with PCAS...
September 15, 2023: BMJ Open
#38
JOURNAL ARTICLE
Satoshi Takanashi, Yasushi Kondo, Shuntaro Saito, Jun Kikuchi, Hironari Hanaoka, Tsutomu Takeuchi, Yuko Kaneko
OBJECTIVES: To elucidate the efficacy and safety of rituximab in special types of rheumatoid arthritis. METHODS: We retrospectively reviewed all patients with rheumatoid arthritis with lymphoproliferative disorder or vasculitis treated with rituximab between April 2010 and June 2022 at Keio University Hospital. We assessed the effectiveness of rituximab using the Disease Activity Score for 28 joints-erythrocyte sedimentation rate (DAS28-ESR), Clinical Disease Activity Index (CDAI), and safety of rituximab during the disease course...
September 13, 2023: International Journal of Rheumatic Diseases
#39
JOURNAL ARTICLE
Toshiki Kuno, Yoshihisa Miyamoto, Mitsuaki Sawano, Masaki Kodaira, Yohei Numasawa, Ikuko Ueda, Masahiro Suzuki, Shigetaka Noma, Keiichi Fukuda, Shun Kohsaka
Young patients who underwent percutaneous coronary intervention (PCI) have shown worse long-term outcomes but remain inadequately investigated. We analyzed 1,186 consecutive young patients (aged ≤55 years) from the Keio Cardiovascular PCI registry who were successfully discharged after PCI (2008 to 2019) and compared them to 5,048 older patients (aged 55 to 75 years). The primary outcome was a composite of all-cause death, acute coronary syndrome, heart failure, bleeding, stroke requiring admission, and coronary artery bypass grafting within 2 years after discharge...
September 11, 2023: American Journal of Cardiology
#40
JOURNAL ARTICLE
Ikuko Ueda, Shun Kohsaka, Nobuhiro Ikemura, Takehiro Kimura, Yoshinori Katsumata, Ryo Takemura, Masahiro Suzuki, Seiji Takatsuki, Daisuke Koide, Keiichi Fukuda
AIMS: The purpose of this study is to utilize PROs to determine the percentage of patients concerned about mild to moderate bleeding side effects of anticoagulants. METHODS AND RESULTS: We consecutively enrolled 3,312 newly diagnosed or referred patients for atrial fibrillation (AF) management from 11 sites within the Keio interhospital Cardiovascular Studies-Atrial Fibrillation Registry between September 2012 and May 2018. Of these patients, 2,636 (79.5%) were taking oral anticoagulants at enrollment...
September 11, 2023: European Journal of Cardiovascular Nursing
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