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Christen Russo, Evan Trupia, Megan Campbell, Hiroko Matsumoto, John Smith, Amer Samdani, John Emans, David Roye, Michael Vitale
BACKGROUND: Early-onset scoliosis (EOS) is a complex, heterogeneous condition involving multiple etiologies, genetic associations, and treatment plans. In 2014, Williams and colleagues proposed a classification system of EOS (C-EOS) that categorizes patients by etiology, Cobb angle, and kyphosis. Shortly after, Smith and colleagues validated a classification system to report complications of growth-friendly spine instrumentation. Severity refers to the level of care and urgency required to treat the complication, and can be classified as device-related or disease-related complications...
January 19, 2019: Journal of Pediatric Orthopedics
Joëlle Lafond, Philippe Hénault, Christelle Leung, Bernard Angers
Triploid vertebrates from unisexual complexes often perpetuate themselves asexually. In the fish Chrosomus eos×eos-neogaeus, triploids are continuously produced by diploid hybrids. However, they are not expected to perpetuate since C. eos are their only known progeny. This study aims to investigate the oogenesis of these triploid hybrids through experimental crosses. A total of 337 larvae from 12 female triploids and three 2n/3n mosaics fertilized with C. eos sperm were genetically characterized. The detection of C...
December 31, 2018: Journal of Heredity
Christelle Leung, Sophie Breton, Bernard Angers
Background: Survival in temporally or spatially changing environments is a prerequisite for the perpetuation of a given species. In addition to genetic variation, the role of epigenetic processes is crucial in the persistence of organisms. For instance, mechanisms such as developmental flexibility enable the adjustment of the phenotype of a given individual to changing conditions throughout its development. However, the extent of factors other than genetic variability, like epigenetic processes, in the production of alternative phenotype and the consequences in realized ecological niches is still unclear...
2018: PeerJ
Bernard Angers, Vincent Chapdelaine, Léo Deremiens, Roland Vergilino, Christelle Leung, Simon-Luc Doucet, Hélène Glémet, Annie Angers
Allospecific mtDNA can occasionally be beneficial for the fitness of populations. It is, however, difficult to assess the effect of mtDNA in natural conditions due to genetic and/or environmental interactions. In the fish Chrosomus eos, the transfer of C. neogaeus mitochondria occurs in a single generation and results in natural cybrids. For a few lakes in Quebec, C. eos can harbor either a C. eos mtDNA (wild types) or a C. neogaeus mtDNA (cybrids). Moreover, mtDNA of cybrids originated either from Mississippian or Atlantic glacial refuges...
September 2018: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
Bernard Angers, Christelle Leung, Romain Vétil, Léo Deremiens, Roland Vergilino
Instantaneous mitochondrial introgression events allow the disentangling of the effects of hybridization from those of allospecific mtDNA. Such process frequently occurred in the fish Chrosomus eos , resulting in cybrid individuals composed of a C. eos nuclear genome but with a C. neogaeus mtDNA. This provides a valuable model to address the fundamental question: How well do introgressed individuals perform in their native environment? We infer where de novo production of cybrids occurred to discriminate native environments from those colonized by cybrids in 25 sites from two regions (West-Qc and East-Qc) in Quebec (Canada)...
March 2018: Ecology and Evolution
Nicole Michael, Patrick Carry, Mark Erickson, Nikki Bloch, Steven Gibbons, Courtney O'Donnell, Sumeet Garg
STUDY DESIGN: Reproducibility of measurements. OBJECTIVE: This study investigates the reliability and standard error of measurement of spine and thoracic height radiographic measurements in patients with early onset scoliosis (EOS). SUMMARY OF BACKGROUND DATA: Spine and thoracic height radiographic measurements are often used as a surrogate for pulmonary development in patients with EOS. There is limited literature validating the reliability of spine and thoracic height measurements in the EOS population...
February 15, 2018: Spine
Sumeet Garg, Micaela Cyr, Tricia St Hilaire, Tara Flynn, Patrick Carry, Michael Glotzbecker, John T Smith, Jeffrey Sawyer, Joshua Pahys, Scott Luhmann, John M Flynn, Ron El-Hawary, Michael Vitale
STUDY DESIGN: Retrospective review. OBJECTIVES: To describe clinical characteristics and infection rates in modern vertical expandable prosthetic titanium rib (VEPTR) surgery. SUMMARY OF BACKGROUND DATA: Prior studies have demonstrated infection rates from 10% to 30% with VEPTR surgery. METHODS: A retrospective query was done on an institutional review board-approved, multicenter prospectively collected database for patients implanted with VEPTR from 2007 to 2013 at eight sites...
January 2016: Spine Deformity
Roland Vergilino, Christelle Leung, Bernard Angers
BACKGROUND: Co-dispersal of sperm-dependent hybrids and their sexual relatives is expected to result in consistent spatial patterns between assemblages of hybrids and genetic structure of parental species. However, local hybridization events may blur this signal as assemblages could be organized under different connectivity constraints. This study aims at testing the hypothesis of local hybridization events by comparing the assemblage of hybrid fish Chrosomus eos-neogaeus to the genetic diversity of one of its parental species, Chrosomus eos...
September 6, 2016: BMC Evolutionary Biology
John H T Waldhausen, Greg Redding, Klane White, Kit Song
PURPOSE: This report describes complications using the vertical expandable prosthetic titanium rib (VEPTR) for thoracic insufficiency syndrome (TIS) at a single center. METHODS: This is a prospective cohort evaluating 65 patients with rib-rib and rib-spine VEPTR devices for TIS placed between 10/2001 and 11/2014, for children with spinal or chest wall deformity. Patients were classified using the early onset scoliosis classification system (C-EOS). RESULTS: 65 patients are available for follow up...
November 2016: Journal of Pediatric Surgery
James N Barron, Troy J Lawson, Philip A Jensen
The northern redbelly dace (Chrosomus eos) and the finescale dace (C. neogaeus) have hybridized to produce an all-female, asexual hybrid (C. eos-neogaeus) that reproduces by sperm-limited parthenogenesis (gynogenesis). However, in this system, gynogenesis is not 100 % efficient; triploid females are occasionally formed which reproduce as sexuals, producing nuclear males and females of the paternal species (generally C. eos). Thus, the asexual lineage continually produces occasional males that can serve as a sperm source...
March 2016: Oecologia
Micaela Cyr, Tricia St Hilaire, Zhaoxing Pan, George H Thompson, Michael G Vitale, Sumeet Garg
BACKGROUND: Classification systems can be useful tools for clinical care and research but must be proven as reliable. The purpose of this study was to evaluate the interobserver and intraobserver reliability of the Classification of Early Onset Scoliosis (C-EOS) scheme. METHODS: After IRB approval, 50 cases were drawn from a prospectively collected database of patients with EOS. Cases were selected using a stratified randomization scheme based on etiology. These cases were used to create an internet survey that was sent to pediatric orthopaedic faculty, research coordinators, and fellows involved in EOS care and research...
January 2017: Journal of Pediatric Orthopedics
Howard Y Park, Hiroko Matsumoto, Nicholas Feinberg, David P Roye, Wajdi W Kanj, Randal R Betz, Patrick J Cahill, Michael P Glotzbecker, Scott J Luhmann, Sumeet Garg, Jeffrey R Sawyer, John T Smith, John M Flynn, Michael G Vitale
BACKGROUND: The Classification for Early-onset Scoliosis (C-EOS) was developed by a consortium of early-onset scoliosis (EOS) surgeons. This study aims to examine if the C-EOS classification correlates with the speed (failure/unit time) of proximal anchor failure in EOS surgery patients. METHODS: A total of 106 EOS patients were retrospectively queried from an EOS database. All patients were treated with vertical expandable prosthetic titanium rib and experienced proximal anchor failure...
September 2017: Journal of Pediatric Orthopedics
Léo Deremiens, Logan Schwartz, Annie Angers, Hélène Glémet, Bernard Angers
Given the coevolution process occurring between nuclear and mitochondrial genomes, the effects of introgressive hybridization remain puzzling. In this study, we take advantage of the natural co-occurrence of two biotypes bearing a similar nuclear genome (Chrosomus eos) but harbouring mitochondria from different species (wild type: C. eos; cybrids: Chrosomus neogaeus) to determine the extent of phenotype changes linked to divergence in the mitochondrial genome. Changes were assessed through differences in gene expression, enzymatic activity, proteomic and swimming activity...
November 2015: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
Markku J Pellinen, Alexey V Solovyev
Canon Solovyev is a small genus belonging to the Parasa-complex of Limacacodidae. It is distributed from northern India to the Malayan Peninsula. The genus previously included two species: C. punica (Herrich-Schäffer) from the Indian region and C. eos Solovyev from Nepal. Canon punica is recorded from China (Yunnan), northern Thailand and Malaysia, but specimens from northern Thailand and probably those from China (Yunnan) represent a new species that is described herein: C. sripanae Pellinen and Solovyev, new species...
June 2, 2015: Zootaxa
Brendan A Williams, Hiroko Matsumoto, Daren J McCalla, Behrooz A Akbarnia, Laurel C Blakemore, Randal R Betz, John M Flynn, Charles E Johnston, Richard E McCarthy, David P Roye, David L Skaggs, John T Smith, Brian D Snyder, Paul D Sponseller, Peter F Sturm, George H Thompson, Muharrem Yazici, Michael G Vitale
BACKGROUND: Early-onset scoliosis is a heterogeneous condition, with highly variable manifestations and natural history. No standardized classification system exists to describe and group patients, to guide optimal care, or to prognosticate outcomes within this population. A classification system for early-onset scoliosis is thus a necessary prerequisite to the timely evolution of care of these patients. METHODS: Fifteen experienced surgeons participated in a nominal group technique designed to achieve a consensus-based classification system for early-onset scoliosis...
August 20, 2014: Journal of Bone and Joint Surgery. American Volume
M Volm, T Efferth, P Grabner, E Pommerenke
Murine NIH-3T3 cells were exposed to doxorubicin (DOX, 1 mu g/ml), ethanol (EtOH, 0.2%) and caffeine (CAFF, 200 mu g/ml) and analyzed for the induction of resistance proteins (P-glycoprotein, glutathione S-transferase-pi, catalase) and oncoproteins (c-EOS, c-ERBB1). P-glycoprotein (P-170), glutathione S-transferase-pi (GST-pi) and catalase (CAT) levels were found to be elevated after exposure of the cells to doxorubicin. In EtOH-treated cells the P-170 level was moderately increased (12 to 36 h after exposure), whereas the GST-pi and CAT levels were greatly increased (1 to 48 h)...
January 1995: International Journal of Oncology
Jean-Emmanuel Kahn, Virginie Dutoit-Lefevre, Sophie Duban-Deweer, Philippe Chafey, Gwenael Pottiez, Didier Lefranc, Olivier Fain, Jean-Francois Cordier, Pierre-Yves Hatron, Olivier Bletry, Lionel Prin
The FIP1L1-PDGFRA (F/P) fusion gene, which was identified as a recurrent molecular finding in hypereosinophilic syndrome (HES), lead to a constitutively increased tyrosine kinase activity of the fusion protein. Despite data obtained in animals or cell lines models, the mechanisms underlying the predominant eosinophil lineage targeting and the cytotoxicity of eosinophils in this leukemia remain unclear. To define more precisely intrinsic molecular events associated with F/P gene, we performed a proteomic analysis comparing F/P+ eosinophils (F/P-Eos) and eosinophils from healthy donors (C-Eos)...
April 1, 2011: Journal of Proteome Research
L B Oknina, N Wild-Wall, R D Oades, S A Juran, B Röpcke, U Pfueller, M Weisbrod, E Chan, E Y H Chen
Mismatch negativity (MMN) is an event-related potential measure of auditory change detection. It is widely reported to be smaller in patients with schizophrenia and may not improve along with otherwise successful clinical treatment. The main aim of this report is to explore ways of measuring and presenting four features of frequency-deviant MMN dipole sources (dipole moment, peak latency, brain location and orientation) and to relate these to the processes of psychopathology and illness progression. Data from early onset patients (EOS) at the start of the illness in adolescence, and others who had their first break in adolescence 15 years ago (S-15Y) were compared with two groups of age-matched healthy controls (C-EOS, C-15Y)...
July 1, 2005: Schizophrenia Research
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