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carcinoma of colon

Jiraporn Panmanee, Jack Bradley-Clarke, Jose M Mato, Paul M O'Neill, Svetlana V Antonyuk, S Samar Hasnain
Methylation is an underpinning process of life and provides control for biological processes such as DNA synthesis, cell growth and apoptosis. Methionine Adenosyltransferases (MAT) produce the cellular methyl donor, S-Adenosylmethionine (SAMe). Dysregulation of SAMe level is a relevant event in many diseases, including cancers such as hepatocellular carcinoma and colon cancer. In addition, mutation of Arg264 in MATα1 causes isolated persistent hypermethioninemia, which is characterized by low activity of the enzyme in liver and high level of plasma methionine...
February 18, 2019: FEBS Journal
Jie Zhang, Min Cai, Dawei Jiang, Liu Xu
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death over the world. It is well studied that long noncoding RNA colon cancer-associated transcript-1 (CCAT1) played important roles in variety of cancers promoting cell proliferation and metastasis by acting as a competing endogenous RNA (ceRNA) of microRNAs. However, whether CCAT1 could regulate HCC by serving as a ceRNA of microRNA remains to be revealed. In this study, we demonstrated that CCAT1 was highly expressed in HCC tissues and remarkably associated with metastasis...
February 18, 2019: Cell Biochemistry and Function
James Weiquan Li, Tiing Leong Ang, Lai Mun Wong, Andrew Boon Eu Kuek, Malcolm Teck Kiang Tan, Kwong Ming Fock, Eng Kiong Teo
INTRODUCTION: Endoscopic submucosal dissection (ESD) provides a higher en bloc and R0 resection rate than endoscopic mucosal resection (EMR). Colorectal ESD is not widely used because of its technical difficulty and risk of complications, especially for right-sided colonic lesions. We audited the clinical outcomes of our initial experience with colorectal ESD. METHODS: We reviewed data collected from a prospective registry of patients who underwent colorectal ESD from December 2014 to March 2018...
February 18, 2019: Singapore Medical Journal
Aniket V Mali, Subhash B Padhye, Shrikant Anant, Mahabaleshwar V Hegde, Shivajirao S Kadam
Currently cancer is the second leading cause of death globally and worldwide incidence and mortality rates of all cancers of males and females are rising tremendously. In spite of advances in chemotherapy and radiation, metastasis and recurrence are considered as the major causes of cancer related deaths. Hence there is a mounting need to develop new therapeutic modalities to treat metastasis and recurrence in cancers. A significant amount of substantiation from epidemiological, clinical and laboratory research highlights the importance of diet and nutrition in cancer chemoprevention...
February 13, 2019: European Journal of Pharmacology
Swetlana Rot, Tom Kaune, Helge Taubert, Thomas Greither, Johanna Kotrba, Antje Güttler, Henri Wichmann, Udo Bilkenroth, Andreas Wienke, Bilal Al-Nawas, Matthias Bache, Dirk Vordermark, Claudia Wickenhauser, Daniel Bethmann, Alexander W Eckert, Matthias Kappler
BACKGROUND: The human leucine-rich, repeat-containing G protein-coupled receptor 5 (LGR5) is a stem cell marker in numerous adult tissues and is overexpressed in a large number of human carcinoma including colon cancer, breast cancer and oral squamous cell carcinomas (OSCC). The role of the full length transcript (LGR5FL) in progression and prognosis of several cancers was reported. However, the biological function of three splice variants of LGR5 (LGR5Δ5, LGR5Δ8 and LGR5Δ5-8) has yet to be thoroughly investigated...
February 15, 2019: BMC Cancer
Pavel Štarha, Zdeněk Trávníček, Ján Vančo, Zdeněk Dvořák
4-Azaindole (1H-pyrrolo[3,2-b]pyridine; 4aza) and its N1-alkylated derivative N1-isopropyl-4-azaindole (1-(propan-2-yl)-1H-pyrrolo[3,2-b]pyridine; ip4aza) have been used for the preparation of the cis-diiodido-platinum(II) complexes cis-[Pt(4aza)2 I2 ] (1), cis-[PtI2 (ip4aza)2 ] (2), cis-[Pt(4aza)I2 (NH3 )] (3) and cis-[PtI2 (ip4aza)(NH3 )] (4). The prepared complexes were thoroughly characterized (e.g., multinuclear NMR spectroscopy and ESI mass spectrometry) and their in vitro cytotoxicity was assessed at human ovarian carcinoma (A2780), cisplatin-resistant ovarian carcinoma (A2780R) and colon carcinoma (HT-29) cell lines, where they showed, in some cases, significantly higher activity than the used reference-drug cisplatin...
February 14, 2019: Journal of Biological Inorganic Chemistry: JBIC
Takeshi Hijikawa, Hiroaki Kitade, Hidesuke Yanagida, Masanori Yamada, Shuhei Maruyama, Fukuki Saito, Yasushi Nakamori, Kazuhiko Yoshioka
A70 -year-old man with a diagnosis of panperitonitis caused by colon perforation due to invasion of gallbladder cancer was transferred to our hospital. The next day, an emergency operation was performed. During laparotomy, the ascending colon was perforated; therefore, ileocecal resection was performed. Six hours after the operation, the stoma became ischemic with marked abdominal distention. The intra-abdominal pressure increased to 28 mmHg, and the patient was diagnosed as having abdominal compartment syndrome(ACS)...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Ewa Kurzejamska, Mariusz Sacharczuk, Natalia Landázuri, Oksana Kovtonyuk, Marzena Lazarczyk, Sharan Ananthaseshan, Zbigniew Gaciong, Piotr Religa
Colorectal cancer is the source of one of the most common cancer-related deaths worldwide, where the main cause of patient mortality remains metastasis. The aim of this study was to determine the role of CCL7 (chemokine (C-C motif) ligand 7) in tumor progression and finding whether it could predict survival of colorectal cancer patients. Initially, our study focused on the crosstalk between mesenchymal stem cells (MSCs) and CT26 colon carcinoma cells and resulted in identifying CCL7 as a chemokine upregulated in CT26 colon cancer cells cocultured with MSCs, compared with CT26 in monoculture in vitro...
February 5, 2019: International Journal of Molecular Sciences
Johannes Klose, Stefan Trefz, Tobias Wagner, Luca Steffen, Arsalie Preißendörfer Charrier, Praveen Radhakrishnan, Claudia Volz, Thomas Schmidt, Alexis Ulrich, Sebastian M Dieter, Claudia Ball, Hanno Glimm, Martin Schneider
OBJECTIVES: Salinomycin is a polyether antibiotic with selective activity against human cancer stem cells. The impact of salinomycin on patient-derived primary human colorectal cancer cells has not been investigated so far. Thus, here we aimed to investigate the activity of salinomycin against tumor initiating cells isolated from patients with colorectal cancer. METHODS: Primary tumor-initiating cells (TIC) isolated from human patients with colorectal liver metastases or from human primary colon carcinoma were exposed to salinomycin and compared to treatment with 5-FU and oxaliplatin...
2019: PloS One
Sadettin Er, Sabri Özden, Faruk Koca, Barış Doğu Yıldız, Bülent Cavit Yüksel, Mesut Tez
Background/aim: One of the most feared complications after colon resection for carcinoma is anastomotic leakage. Prediction of anastomotic leakage can alter pre- and perioperative management of patients. This study validates an anastomotic leakage prediction system. Materials and methods: Ninety-five patients who underwent colonic resection between 1 January 2016 and 30 January 2017 were included in the study. Patient records and electronic charting system data were used to calculate anastomotic leakage risk on the http://www...
February 11, 2019: Turkish Journal of Medical Sciences
Tiphany Coralie De Bessa, Alessandra Pagano, Ana Iochabel Soares Moretti, Percillia Victoria Santos Oliveira, Samir Andrade Mendonça, Herve Kovacic, Francisco Rafael Martins Laurindo
Protein disulfide isomerases including PDIA1 are implicated in cancer progression, but underlying mechanisms are unclear. PDIA1 is known to support vascular Nox1 NADPH oxidase expression/activation. Since deregulated reactive oxygen species (ROS) production underlies tumor growth, we proposed that PDIA1 is an upstream regulator of tumor-associated ROS. We focused on colorectal cancer (CRC) with distinct KRas activation levels. Analysis of RNAseq databanks and direct validation indicated enhanced PDIA1 expression in CRC with constitutive high (HCT116) vs...
February 13, 2019: Cell Death & Disease
Alfredo F Braña, Aida Sarmiento-Vizcaíno, Ignacio Pérez-Victoria, Jesús Martín, Luis Otero, Juan José Palacios-Gutiérrez, Jonathan Fernández, Yamina Mohamedi, Tania Fontanil, Marina Salmón, Santiago Cal, Fernando Reyes, Luis A García, Gloria Bianco
The isolation and structural elucidation of a structurally new desertomycin, designated as desertomycin G ( 1 ), with strong antibiotic activity against several clinically relevant antibiotic resistant pathogens are described herein. This new natural product was obtained from cultures of the marine actinomycete Streptomyces althioticus MSM3, isolated from samples of the intertidal seaweed Ulva sp. collected in the Cantabrian Sea (Northeast Atlantic Ocean). Particularly interesting is its strong antibiotic activity against Mycobacterium tuberculosis clinical isolates, resistant to antibiotics in clinical use...
February 12, 2019: Marine Drugs
Giulia Orteca, Federica Pisaneschi, Sara Rubagotti, Tracy W Liu, Giacomo Biagiotti, David Piwnica-Worms, Michele Iori, Pier Cesare Capponi, Erika Ferrari, Mattia Asti
Colorectal cancer is the third most commonly occurring cancer in men and the second most commonly occurring cancer in women worldwide. We have recently reported that curcuminoid complexes labelled with gallium-68 have demonstrated preferential uptake in HT29 colorectal cancer and K562 lymphoma cell lines compared to normal human lymphocytes. In the present study, we report a new gallium-68-labelled curcumin derivative (68 Ga-DOTA-C21) and its initial validation as marker for early detection of colorectal cancer...
February 12, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Georgia Papachristopoulou, Apostolos Malachias, Marina Devetzi, Evdoxia Kamouza, Andreas Scorilas, Dimitris Xynopoulos, Maroulio Talieri
Background Kallikrein-related peptidases (KLKs) are a subgroup of serine proteases located on chromosome 19q13.3. Most KLKs have been extensively studied as potential biomarkers for several carcinomas and other diseases. KLK5 was originally identified from a keratinocyte library, and its enzyme was purified from the stratum corneum of human skin. KLK5 was shown to be differentially expressed in a variety of endocrine tumors, although it is not as yet examined widely in colorectal cancer (CRC). Methods In this study, we quantitatively assessed the mRNA expression status of KLK5 in 197 colorectal tissues from 133 patients (70 cancerous and their paired normal colonic mucosa for 64 of them, as well as 63 colorectal adenomas) by quantitative real-time PCR (qPCR) using TaqMan probes...
February 13, 2019: Clinical Chemistry and Laboratory Medicine: CCLM
Parisa Yousefpour, Lucie Ahn, Joel Tewksbury, Soumen Saha, Simone A Costa, Joseph J Bellucci, Xinghai Li, Ashutosh Chilkoti
Short circulation time and off-target toxicity are the main challenges faced by small-molecule chemotherapeutics. To overcome these shortcomings, an albumin-binding peptide conjugate of chemotherapeutics is developed that binds specifically to endogenous albumin and harnesses its favorable pharmacokinetics and pharmacodynamics for drug delivery to tumors. A protein-G-derived albumin-binding domain (ABD) is conjugated with doxorubicin (Dox) via a pH-sensitive linker. One to two Dox molecules are conjugated to ABD without loss of aqueous solubility...
February 13, 2019: Small
Eva-Marie Warnken, Michael Uder, Hubert Stein, Michael Wucherer, Michael Lell, Herbert Muschweck, Ralf Adamus
PURPOSE:  The goal of this study was to evaluate the experience of 11 years of wire-guided forceps biopsy via PTCD in patients with obstructive jaundice. MATERIALS AND METHODS:  In a retrospective approach, 56 biopsies in 51 patients were analyzed (22 female, 29 male). Data was collected from 2006 to 2016. Mean age was 71 years (range: 34 - 86 years). Data was extracted from dig. Patients' records (KIS, PACS, RIS) to be analyzed in Microsoft Excel. RESULTS:  All 56 procedures were technically successful...
February 2019: Zeitschrift Für Gastroenterologie
Louise F Wilson, Peter D Baade, Adele C Green, Susan J Jordan, Bradley J Kendall, Rachel E Neale, Catherine M Olsen, Danny R Youlden, Penelope M Webb, David C Whiteman
The International Agency for Research on Cancer first concluded that alcohol causes cancer in humans in 1988. The World Cancer Research Fund has declared that alcohol causes cancer of the oral cavity, pharynx, larynx, oesophagus (squamous cell carcinoma), female breast, colon, rectum, stomach and liver. It recommended that alcohol be avoided altogether to prevent cancer. We aimed to quantify the impact of reducing alcohol consumption on future cancer incidence in Australia. We used PREVENT 3.01 simulation modelling software to estimate the proportion of cancers that could potentially be prevented over a 25-year period under two hypothetical intervention scenarios and two latency periods (20 and 30 years)...
February 12, 2019: International Journal of Cancer. Journal International du Cancer
Wing-Kee Lee, Frank Thévenod
Oncogenic pituitary homeobox 2 (PITX2), a de facto master regulator of developmental organ asymmetry, previously upregulated multidrug resistance (MDR) P-glycoprotein (ABCB1) in A498 renal cell carcinoma (RCC) cells. The role of PITX2 isoforms in MDR cancers was investigated. Data mining correlated elevated PITX2 in >30% of cancers analyzed, maximally in colon (4.4-fold), confirmed in co-immunostaining of colon and renal cancer microarrays wherein ABCB1 concomitantly increased in RCC. Drug-resistant colorectal adenocarcinoma Colo320DM cells exhibited increased nuclear PITX2 (40-fold), PITX2 promoter activity (27-fold) and ABCB1 (8,000-fold) compared to drug-sensitive Colo205...
February 8, 2019: Cancer Letters
Xiaoqin La, Lichao Zhang, Zhuoyu Li, Hanqing Li, Yufei Yang
Green tea accounts for approximately 20% of the world's total tea yield. (-)-Epigallocatechin gallate (EGCG) is an active catechin in green tea, which suppresses tumor growth and enhances drug sensitivity in various cancers, but the molecular mechanism is still unclear. Chemotherapy drug, such as 5-fluorouracil (5-FU), is a common strategy for clinical treatment of cancer patients, however, the lower response rate caused by prolonged use becomes the main reason of tumor recurrence. Therefore, discovering safe and effective chemo-sensitizer is an urgent task required to be solved...
February 11, 2019: Journal of Agricultural and Food Chemistry
Elena Torreggiani, Marika Rossini, Ilaria Bononi, Silvia Pietrobon, Elisa Mazzoni, Maria Rosa Iaquinta, Carlo Feo, John Charles Rotondo, Paola Rizzo, Mauro Tognon, Fernanda Martini
Procedures for in vitro culturing of human primary keratinocytes from normal colon mucosa specimens have not been fully feasible, thus far. The protocol described herein allows primary keratinocytes from small tissue fragments of colorectal mucosa biopsies to grow in vitro. The procedure develops in three steps: (a) the enzymatic digestion of the tissue biopsy; (b) the use of cloning rings to purify primary keratinocyte colonies, (c) a defined keratinocyte medium to grow these cells in long-term culture. Our cultural method enables normal primary keratinocytes to be obtained by simple and rapid techniques...
February 10, 2019: Journal of Cellular Physiology
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