Balazs Veres, Krisztian Eros, Csenge Antus, Nikoletta Kalman, Fruzsina Fonai, Peter Balazs Jakus, Eva Boros, Zoltan Hegedus, Istvan Nagy, Laszlo Tretter, Ferenc Gallyas, Balazs Sumegi
Microorganisms or LPS (lipopolysaccharide), an outer membrane component of Gram-negative bacteria, can induce a systemic inflammatory response that leads to sepsis, multiple organ dysfunction, and mortality. Here, we investigated the role of cyclophilin D (CypD)-dependent mitochondrial permeability transition (mPT) in the immunosuppressive phase of LPS-induced endotoxic shock. The liver plays an important role in immunity and organ dysfunction; therefore, we used liver RNA sequencing (RNAseq) data, Ingenuity® Pathway Analysis (IPA ® ) to investigate the complex role of mPT formation in inflammatory reprogramming and disease progression...
January 20, 2021: FEBS Open Bio