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Michael kheir

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https://read.qxmd.com/read/30661831/genetic-meningococcal-antigen-typing-system-gmats-a-genotyping-tool-that-predicts-4cmenb-strain-coverage-worldwide
#1
Alessandro Muzzi, Alessandro Brozzi, Laura Serino, Margherita Bodini, Raquel Abad, Dominique Caugant, Maurizio Comanducci, Ana Paula Lemos, Maria Cecilia Gorla, Pavla Křížová, Claudia Mikula, Robert Mulhall, Michael Nissen, Hanna Nohynek, Maria João Simões, Anna Skoczyńska, Paola Stefanelli, Muhamed-Kheir Taha, Maija Toropainen, Georgina Tzanakaki, Kumaran Vadivelu-Pechai, Philip Watson, Julio A Vazquez, Gowrisankar Rajam, Rino Rappuoli, Ray Borrow, Duccio Medini
BACKGROUND: The Meningococcal Antigen Typing System (MATS) was developed to identify meningococcus group B strains with a high likelihood of being covered by the 4CMenB vaccine, but is limited by the requirement for viable isolates from culture-confirmed cases. We examined if antigen genotyping could complement MATS in predicting strain coverage by the 4CMenB vaccine. METHODS: From a panel of 3912 MATS-typed invasive meningococcal disease isolates collected in England and Wales in 2007-2008, 2014-2015 and 2015-2016, and in 16 other countries in 2000-2015, 3481 isolates were also characterized by antigen genotyping...
January 17, 2019: Vaccine
https://read.qxmd.com/read/30533595/culture-negative-periprosthetic-joint-infection-an-update-on-what-to-expect
#2
Timothy L Tan, Michael M Kheir, Noam Shohat, Dean D Tan, Matthew Kheir, Chilung Chen, Javad Parvizi
Background: Culture-negative periprosthetic joint infection (PJI) is a challenging condition to treat. The most appropriate management of culture-negative PJI is not known, and there is immense variability in the treatment outcome of this condition. The purpose of this study was to elucidate the characteristics, outcomes, and risk factors for failure of treatment of culture-negative PJI. Methods: A retrospective review of 219 patients (138 hips and 81 knees) who had undergone surgery for the treatment of culture-negative PJI was performed utilizing a prospectively collected institutional PJI database...
September 25, 2018: JB & JS open access
https://read.qxmd.com/read/30516637/serum-erythrocyte-sedimentation-rate-and-c-reactive-protein-level-have-weaknesses-but-are-the-best-screening-so-far-commentary-on-an-article-by-michael-m-kheir-md-et-al-routine-diagnostic-tests-for-periprosthetic-joint-infection-demonstrate-a-high-false-negative
#3
https://read.qxmd.com/read/30516629/routine-diagnostic-tests-for-periprosthetic-joint-infection-demonstrate-a-high-false-negative-rate-and-are-influenced-by-the-infecting-organism
#4
Michael M Kheir, Timothy L Tan, Noam Shohat, Carol Foltz, Javad Parvizi
BACKGROUND: Current guidelines recommend serum erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) as the first-line testing for evaluation of suspected periprosthetic joint infection, in addition to synovial white blood-cell (WBC) count and polymorphonuclear percentage. However, the sensitivity and other diagnostic measures of these tests using a standardized definition of periprosthetic joint infection and the influence of organisms on these inflammatory markers remain inadequately investigated...
December 5, 2018: Journal of Bone and Joint Surgery. American Volume
https://read.qxmd.com/read/30499850/outcomes-of-patients-presenting-with-mild-acute-respiratory-distress-syndrome-insights-from-the-lung-safe-study
#5
Tài Pham, Ary Serpa Neto, Paolo Pelosi, John Gerard Laffey, Candelaria De Haro, Jose Angel Lorente, Giacomo Bellani, Eddy Fan, Laurent Jean Brochard, Antonio Pesenti, Marcus Josephus Schultz, Antonio Artigas
WHAT WE ALREADY KNOW ABOUT THIS TOPIC: Hospital mortality in acute respiratory distress syndrome is approximately 40%, but mortality and trajectory in "mild" acute respiratory distress syndrome (classified only since 2012) are unknown, and many cases are not detected WHAT THIS ARTICLE TELLS US THAT IS NEW: Approximately 80% of cases of mild acute respiratory distress syndrome persist or worsen in the first week; in all cases, the mortality is substantial (30%) and is higher (37%) in those in whom the acute respiratory distress syndrome progresses BACKGROUND:: Patients with initial mild acute respiratory distress syndrome are often underrecognized and mistakenly considered to have low disease severity and favorable outcomes...
February 2019: Anesthesiology
https://read.qxmd.com/read/30463166/impacts-of-rising-temperature-carbon-dioxide-concentration-and-sea-level-on-wheat-production-in-north-nile-delta
#6
Ahmed M S Kheir, Ahmed El Baroudy, Mahmoud A Aiad, Medhat G Zoghdan, Mohamed A Abd El-Aziz, Marwa G M Ali, Michael A Fullen
Climate change poses a serious threat to arid and low elevation coastal zones. Kafrelsheikh governorate, as a large agricultural and coastal region on the Egyptian North Nile Delta, is one of the most vulnerable areas to higher temperature and global sea level rise. Two DSSAT wheat models (CERES and N-Wheat) were calibrated using a local cultivar (Misr3) grown under irrigated conditions in Egypt. Experimental data of two successive growing seasons during 2014/2015 and 2015/2016 were used for calibration using different treatments of irrigation, planting dates and fertilization...
February 15, 2019: Science of the Total Environment
https://read.qxmd.com/read/30401576/an-international-perspective-on-hospitalized-patients-with-viral-community-acquired-pneumonia
#7
Dejan Radovanovic, Giovanni Sotgiu, Mateja Jankovic, Padukudru Anand Mahesh, Pedro Jorge Marcos, Mohamed I Abdalla, Marta Francesca Di Pasquale, Andrea Gramegna, Silvia Terraneo, Francesco Blasi, Pierachille Santus, Stefano Aliberti, Luis F Reyes, Marcos I Restrepo
BACKGROUND: Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP. METHODS: Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab...
November 4, 2018: European Journal of Internal Medicine
https://read.qxmd.com/read/30360983/general-assembly-prevention-host-related-general-proceedings-of-international-consensus-on-orthopedic-infections
#8
Suraya Zainul-Abidin, Derek F Amanatullah, Michael B Anderson, Matthew Austin, João Mauricio Barretto, Andrew Battenberg, Nicholas A Bedard, Kerri Bell, Kier Blevins, John J Callaghan, Li Cao, Laura Certain, Yuhan Chang, Jui Ping Chen, Zlatan Cizmic, Jonathan Coward, David E DeMik, Efrain Diaz-Borjon, Mohammad Ali Enayatollahi, James E Feng, Navin Fernando, Jeremy M Gililland, Stuart Goodman, Susan Goodman, Max Greenky, Katherine Hwang, Richard Iorio, Vasili Karas, Riaz Khan, Matthew Kheir, Mitchell R Klement, Setor Kunustor, Ruben Limas, Ruben Alejandro Morales Maldonado, Jorge Manrique, Wadih Y Matar, Lipalo Mokete, Ngai Nung, Christopher E Pelt, Jurek R T Pietrzak, Ajay Premkumar, Alexander Rondon, Marisa Sanchez, Camila Novaes de Santana, Neil Sheth, Jasvinder Singh, Bryan D Springer, Kae Sian Tay, Daniel Varin, Samuel Wellman, Lidong Wu, Chi Xu, Adolph J Yates
No abstract text is available yet for this article.
October 22, 2018: Journal of Arthroplasty
https://read.qxmd.com/read/30348584/general-assembly-prevention-antimicrobials-systemic-proceedings-of-international-consensus-on-orthopedic-infections
#9
Stanislav Bondarenko, Chong Bum Chang, José Cordero-Ampuero, Stephen Kates, Michael Kheir, Mitchell R Klement, Ed McPherson, Laura Morata, Randi Silibovsky, Gábor Skaliczki, Alex Soriano, Rolando Suárez, Attila Szatmári, Jason Webb, Simon W Young, Werner Zimmerli
No abstract text is available yet for this article.
October 19, 2018: Journal of Arthroplasty
https://read.qxmd.com/read/30348582/hip-and-knee-section-treatment-antimicrobials-proceedings-of-international-consensus-on-orthopedic-infections
#10
Craig A Aboltins, Ruben Anemüller, Katherine Belden, Barry Brause, Mustafa Citak, Jose L Del Pozo, Lars Frommelt, Thorsten Gehrke, Angela Hewlett, Carlos A Higuera, Harriet Hughes, Michael Kheir, Kang-Il Kim, Sujith Konan, Christian Lausmann, Dorothy Ling, Camelia Marculescu, Laura Morata, Isabel Ramirez, Markus Rossmann, Randi Silibovsky, Alex Soriano, Gina Ann Suh, Charles Vogely, Andrea Volpin, Jean Yombi, Akos Zahar, Werner Zimmerli
No abstract text is available yet for this article.
October 19, 2018: Journal of Arthroplasty
https://read.qxmd.com/read/30343970/hip-and-knee-section-prevention-operating-room-environment-proceedings-of-international-consensus-on-orthopedic-infections
#11
Moneer M Abouljoud, Abtin Alvand, Petros Boscainos, Antonia F Chen, Gustavo A Garcia, Thorsten Gehrke, Jeffrey Granger, Michael Kheir, Plamen Kinov, Michel Malo, Jorge Manrique, Dominic Meek, Carlos Meheux, Robert Middleton, Francisco Montilla, Mike Reed, Marie-Jacque Reisener, Adrian van der Rijt, Markus Rossmann, Mark Spangehl, Greg Stocks, Peter Young, Simon W Young, Akos Zahar, Xianlong Zhang
No abstract text is available yet for this article.
October 18, 2018: Journal of Arthroplasty
https://read.qxmd.com/read/30312588/the-prevalence-of-gastroesophageal-reflux-in-patients-with-excessive-centralairway-collapse
#12
Adnan Majid, Fayez Kheir, Daniel Alape, Michael Kent, Anthony Lembo, Vikram V Rangan, Megan Carreiro, Sidhu P Gangadharan
BACKGROUND: Gastroesophageal reflux (GER) is increasingly recognized as an exacerbating or causal factor in several respiratory diseases. There is a high prevalence of GER in infants with airway malacia. However, such data are lacking in adults. METHODS: This retrospective study was conducted to determine the relationship between GER and excessive central airway collapse (ECAC). The study included consecutive patients with ECAC referred to the Complex Airway Center at Beth Israel Deaconess Medical Center who underwent esophageal pH testing for GER between July 2014 and June 2018...
October 9, 2018: Chest
https://read.qxmd.com/read/30281077/failure-after-two-stage-exchange-arthroplasty-for-treatment-of-periprosthetic-joint-infection-the-role-of-antibiotics-in-the-cement-spacer
#13
Marjan Wouthuyzen-Bakker, Michael M Kheir, Ignacio Moya, Alexander J Rondon, Matthew Kheir, Luis Lozano, Javad Parvizi, Alex Soriano
Introduction: Failure after a two-stage exchange surgery for periprosthetic joint infections (PJI) is high. Previous studies demonstrated that positive cultures at reimplantation are associated with failure afterwards. The aim of this multicenter study was to define the role of antibiotics in the cement spacer in relation to reimplantation cultures and subsequent failure. Methods: We retrospectively evaluated two-stage exchange procedures between 2000 and 2015. Culture-negative PJIs, cases in whom no cultures were obtained during reimplantation and cases without data on cement spacers were excluded...
October 3, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://read.qxmd.com/read/30106833/can-higher-postoperative-blood-glucose-levels-lead-to-periprosthetic-joint-infection-commentary-on-an-article-by-michael-m-kheir-md-et-al-postoperative-blood-glucose-levels-predict-infection-after-total-joint-arthroplasty
#14
https://read.qxmd.com/read/30106824/postoperative-blood-glucose-levels-predict-infection-after-total-joint-arthroplasty
#15
Michael M Kheir, Timothy L Tan, Matthew Kheir, Mitchell G Maltenfort, Antonia F Chen
BACKGROUND: Perioperative hyperglycemia has many etiologies, including medication, impaired glucose tolerance, uncontrolled diabetes mellitus, or stress, the latter of which is common in patients postoperatively. Our study investigated the influence of postoperative blood glucose levels on periprosthetic joint infection after elective total joint arthroplasty to determine a threshold for glycemic control for which surgeons should strive during a patient's hospital stay. METHODS: A single-institution retrospective review was conducted on 24,857 primary total joint arthroplasties performed from 2001 to 2015...
August 15, 2018: Journal of Bone and Joint Surgery. American Volume
https://read.qxmd.com/read/30093266/cefazolin-prophylaxis-for-total-joint-arthroplasty-obese-patients-are-frequently-underdosed-and-at-increased-risk-of-periprosthetic-joint-infection
#16
Alexander J Rondon, Michael M Kheir, Timothy L Tan, Noam Shohat, Max R Greenky, Javad Parvizi
BACKGROUND: One of the most effective prophylactic strategies against periprosthetic joint infection (PJI) is administration of perioperative antibiotics. Many orthopedic surgeons are unaware of the weight-based dosing protocol for cefazolin. This study aimed at elucidating what proportion of patients receiving cefazolin prophylaxis are underdosed and whether this increases the risk of PJI. METHODS: A retrospective study of 17,393 primary total joint arthroplasties receiving cefazolin as perioperative prophylaxis from 2005 to 2017 was performed...
November 2018: Journal of Arthroplasty
https://read.qxmd.com/read/30093264/culturing-periprosthetic-joint-infection-number-of-samples-growth-duration-and-organisms
#17
Michael M Kheir, Timothy L Tan, Colin T Ackerman, Ronuk Modi, Carol Foltz, Javad Parvizi
BACKGROUND: Owing to the difficulty isolating microorganisms in periprosthetic joint infection (PJI), current guidelines recommend that 3-5 intraoperative samples be cultured and maintained for 3-14 days. We investigated (1) the optimal number of culture samples and growth duration to diagnose PJI and (2) the microbiology profile at our institution. METHODS: A retrospective review of 711 patients (329 hips, 382 knees) with PJI that met Musculoskeletal Infection Society criteria from 2000 to 2014 was performed...
November 2018: Journal of Arthroplasty
https://read.qxmd.com/read/30075878/tourniquetless-total-knee-arthroplasty-with-modern-perioperative-protocols-decreases-pain-and-opioid-consumption-in-women
#18
Michael M Kheir, Mary Ziemba-Davis, Julian E Dilley, Mark J Hood, R Michael Meneghini
BACKGROUND: This study examined whether a modern total knee arthroplasty (TKA) protocol without a tourniquet results in less patient-reported pain and in-hospital opioid consumption compared to TKA with a tourniquet. METHODS: A retrospective study of 203 primary unilateral cemented TKAs consecutively performed with or without tourniquet was performed. Identical perioperative pain and blood loss protocols were used in all cases. In tourniquetless TKAs, the tourniquet was not inflated at any time, and sterile CO2 gas compression maximized cement interdigitation...
November 2018: Journal of Arthroplasty
https://read.qxmd.com/read/29939888/convex-probe-ebus-guided-fiducial-placement-for-malignant-central-lung-lesions
#19
Adnan Majid, Atul Palkar, Fayez Kheir, Daniel Alape, Sebastian Fernandez-Bussy, Joseph Aronovitz, Jorge Guerrero, Sidhu Gangadharan, Michael Kent, Richard Whyte, Erik Folch
BACKGROUND: Stereotactic body radiotherapy (SBRT) had become a therapeutic modality in patients with primary tumors, locally recurrent as well as oligometastasis involving the lung. Some modalities of SBRT require fiducial marker (FM) for dynamic tumor tracking. Previous studies have focused on evaluating bronchoscopic-guided FM placement for peripheral lung nodules. We describe the safety and feasibility of placing FM using real-time convex probe endobronchial ultrasound (CP-EBUS) for SBRT in patients with centrally located hilar/mediastinal masses or lymph nodes...
June 22, 2018: Journal of Bronchology & Interventional Pulmonology
https://read.qxmd.com/read/29885971/development-and-evaluation-of-a-prognostic-calculator-for-the-surgical-treatment-of-periprosthetic-joint-infection
#20
Michael M Kheir, Timothy L Tan, Jaiben George, Carlos A Higuera, Mitchell G Maltenfort, Javad Parvizi
BACKGROUND: Preoperative identification of patients at risk of failing surgical treatment for periprosthetic joint infection (PJI) is imperative to allow medical optimization and targeted prevention. The purpose of this study was to create a preoperative prognostic calculator for PJI treatment by assessing a patient's individual risk for treatment failure based on many preoperative variables. METHODS: A retrospective review was performed of 1438 PJIs, treated at 2 institutions from 2000 to 2014...
September 2018: Journal of Arthroplasty
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