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Mikenzy Fassel, Brian Grieve, Sameen Hosseini, Resmiye Oral, Colette Galet, Colleen Ryan, Lewis Kazis, Ni Pengsheng, Lucy Wibbenmeyer
Adverse Childhood Experiences (ACEs), including child maltreatment and household dysfunction, define adverse events that occur before 18 years of age. National and state data show that between 12.5 and 14.5% of the adult population report ≥4 ACEs (HIGH-ACE), respectively. HIGH-ACEs are associated with more chronic health problems. To date, the interaction between ACEs and burn injuries has not been studied. Herein, we sought to define the ACE exposure in our burn patients and its impact on early outcomes...
March 12, 2019: Journal of Burn Care & Research: Official Publication of the American Burn Association
José Antonio Climent-Rodríguez, Yolanda Navarro-Abal, María José López-López, Juan Gómez-Salgado, Marta Evelia Aparicio García
Introduction: Loss of employment is an experience that is lived and interpreted differently depending on a series of individual variables, including the psychological resources available to the affected person as well as their perception of their degree of employability. Losing one's job can be one of the most painful and traumatic events a person has to withstand. Following a dismissal, the worker needs to overcome a period of emotional adaptation to the loss. But that period of grieving can also condition the job searching process of the individual and can be influenced by different variables, highlighting the age and work experience...
2019: Frontiers in Psychology
Baptiste Leurent, Manuel Gomes, Rita Faria, Stephen Morris, Richard Grieve, James R Carpenter
The Open Access license, which previously read.
March 9, 2019: PharmacoEconomics
Ruth Endacott
No abstract text is available yet for this article.
February 26, 2019: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
Jules Scholler, Viacheslav Mazlin, Olivier Thouvenin, Kassandra Groux, Peng Xiao, José-Alain Sahel, Mathias Fink, Claude Boccara, Kate Grieve
We describe recent technological progress in multimodal en face full-field optical coherence tomography that has allowed detection of slow and fast dynamic processes in the eye. We show that by combining static, dynamic and fluorescence contrasts we can achieve label-free high-resolution imaging of the retina and anterior eye with temporal resolution from milliseconds to several hours, allowing us to probe biological activity at subcellular scales inside 3D bulk tissue. Our setups combine high lateral resolution over a large field of view with acquisition at several hundreds of frames per second which make it a promising tool for clinical applications and biomedical studies...
February 1, 2019: Biomedical Optics Express
Florence Rossant, Kate Grieve, Michel Paques
Optical Coherence Tomography (OCT), which is routinely used in ophthalmology, enables transverse optical imaging of the retina and hence the identification of the different neuronal layers. Directional OCT (D-OCT) extends this technology by acquiring sets of images at different incidence angles of the light beam. In this way, reflectance properties of photoreceptor substructures are highlighted, enabling physicians to study their orientation, which is potentially an interesting biomarker for retinal diseases...
February 19, 2019: IEEE Transactions on Bio-medical Engineering
Jerome J Maller, Thomas Welton, Matthew Middione, Fraser M Callaghan, Jeffrey V Rosenfeld, Stuart M Grieve
The hippocampus is a key component of emotional and memory circuits and is broadly connected throughout the brain. We tracked the whole-brain connections of white matter fibres from the hippocampus using ultra-high angular resolution diffusion MRI in both a single 1150-direction dataset and a large normal cohort (n = 94; 391-directions). Using a connectomic approach, we identified six dominant pathways in terms of strength, length and anatomy, and characterised them by their age and gender variation. The strongest individual connection was to the ipsilateral thalamus...
February 20, 2019: Scientific Reports
Dorothy M Wade, Paul R Mouncey, Alvin Richards-Belle, Jerome Wulff, David A Harrison, M Zia Sadique, Richard D Grieve, Lydia M Emerson, Alexina J Mason, David Aaronovitch, Nicole Als, Chris R Brewin, Sheila E Harvey, David C J Howell, Nicholas Hudson, Monty G Mythen, Deborah Smyth, John Weinman, John Welch, Chris Whitman, Kathryn M Rowan
Importance: A meta-analysis of outcomes during the 6 months after intensive care unit (ICU) discharge indicate a prevalence for clinically important posttraumatic stress disorder (PTSD) symptoms of 25%. Objective: To determine whether a nurse-led preventive, complex psychological intervention, initiated in the ICU, reduces patient-reported PTSD symptom severity at 6 months. Design, Setting, and Participants: A multicenter, parallel-group, cluster-randomized clinical trial with integrated economic and process evaluations conducted in 24 ICUs in the United Kingdom...
February 19, 2019: JAMA: the Journal of the American Medical Association
Richard Grieve, Stephen O'Neill, Anirban Basu, Luke Keele, Kathryn M Rowan, Steve Harris
Importance: It is unknown which deteriorating ward patients benefit from intensive care unit (ICU) transfer. Objectives: To use an instrumental variable (IV) method that assesses heterogeneity and to evaluate estimates of person-centered treatment effects of ICU transfer and 28-day hospital mortality by age and illness severity. Design, Setting, and Participants: An analysis of a prospective cohort study from November 1, 2010, to December 31, 2011...
February 1, 2019: JAMA Network Open
Victoria Ross, Kairi Kõlves, Diego De Leo
Bereavement by suicide is a unique form of grief characterized by features such as stigma, shame, and rejection that may complicate the grieving process and place people at heightened risk for specific mental health disorders, suicide attempts, and dying by suicide. To better understand the unique support needs of the suicide-bereaved and how these can be met, this Australian study qualitatively explored the experiences of people bereaved by suicide. Fifteen individuals who had lost a spouse or partner or a family member to suicide formed three focus groups across different locations in Queensland, Australia...
February 13, 2019: Omega
Shandeigh N Berry, Karen Colorafi
Congenital anomalies are the leading cause of infant death in the United States, accounting for 20% of the annual infant mortality. Advancements in ultrasound diagnostic technology allow practitioners to diagnose fetal anomalies as early as 11 weeks' gestational age, 75% of which are detected in low-risk pregnancies. Communicating a fetal anomaly diagnosis to parents and initiating perinatal end-of-life discussions are difficult for healthcare providers and parents alike. Furthermore, poorly communicated diagnoses have had long-term negative impacts on perinatal grief intensity, which manifested into lifelong symptoms of adverse psychosocial outcomes such as anxiety, depression, substance abuse, and suicidal ideation...
February 6, 2019: Journal of Perinatal & Neonatal Nursing
Yael Hashiloni-Dolev, Ori Katz
This article examines Israeli discourse on posthumous reproduction (PR) and the related cultural construction of "(un)natural" grief. Based mainly on an analysis of in-depth interviews with family members who submitted a request for PR, we examine the regimes of justification used by supporters and opponents of this technology. With both sides using the notion of "nature" to support their claim, the dispute centers on whether PR constructs a new social expression of grief (and hence should be seen as unnatural) or is only a reflection of an age-old grieving process (and is thus natural)...
February 8, 2019: Medical Anthropology Quarterly
Rais Latypov, Sofya Chistyakova, Richard Grieve, Hannu Huhma
Bolide impact is a ubiquitous geological process in the Solar System, which produced craters and basins filled with impact melt sheets on the terrestrial planets. However, it remains controversial whether these sheets were able to undergo large-scale igneous differentiation, or not. Here, we report on the discovery of large discrete bodies of melanorites that occur throughout almost the entire stratigraphy of the 1.85-billion-year-old Sudbury Igneous Complex (SIC) - the best exposed impact melt sheet on Earth - and use them to reaffirm that conspicuous norite-gabbro-granophyre stratigraphy of the SIC is produced by fractional crystallization of an originally homogeneous impact melt of granodioritic composition...
January 31, 2019: Nature Communications
Charles Veys, Fokion Chatziavgerinos, Ali AlSuwaidi, James Hibbert, Mark Hansen, Gytis Bernotas, Melvyn Smith, Hujun Yin, Stephen Rolfe, Bruce Grieve
Background: The use of spectral imaging within the plant phenotyping and breeding community has been increasing due its utility as a non-invasive diagnostic tool. However, there is a lack of imaging systems targeted specifically at plant science duties, resulting in low precision for canopy-scale measurements. This study trials a prototype multispectral system designed specifically for plant studies and looks at its use as an early detection system for visually asymptomatic disease phases, in this case Pyrenopeziza brassicae in Brassica napus ...
2019: Plant Methods
Éléonore Duvelle, Roddy M Grieves, Vincent Hok, Bruno Poucet, Angelo Arleo, Kate Jeffery, Etienne Save
Hippocampal place cells show position-specific activity, thought to reflect a self-localization signal. Several reports also point to some form of goal encoding by place cells. We investigated this by asking whether they also encode the value of spatial goals, which is a crucial information for optimizing goal-directed navigation. We used a continuous place navigation task in which male rats navigate to one of two (freely chosen) unmarked locations and wait, triggering the release of reward which is then located and consumed elsewhere...
January 29, 2019: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Anne-Marie Martinez, Sonia Castiglione, France Dupuis, Alain Legault, Marie-Claude Proulx, Franco Carnevale
A child's death is a traumatic life experience for parents. Health-care professionals (HCPs) have sought guidance on how to intervene with grieving parents, particularly with fathers. Having therapeutic conversations is an effective way for HCPs to support grieving fathers. In our previous study, fathers identified core beliefs that influenced their experience of grief and coping. In this article, the Illness Beliefs Model was integrated with the findings to provide a framework for interventions to create open conversations, ease fathers' suffering, and thereby help their spouse and family suffering as well...
January 28, 2019: Omega
Matt Lyon, Thomas Welton, Adrina Varda, Jerome J Maller, Kathryn Broadhouse, Mayuresh S Korgaonkar, Stephen H Koslow, Leanne M Williams, Evian Gordon, A John Rush, Stuart M Grieve
BACKGROUND: Major depressive disorder (MDD) is a chronic disease with a large global impact. There are currently no clinically useful predictors of treatment outcome, and the development of biomarkers to inform clinical treatment decisions is highly desirable. METHODS: In this exploratory study we performed fixel-based analysis of diffusion MRI data from the International Study to Predict Optimized Treatment in Depression with the aim of identifying novel biomarkers at baseline that may relate to diagnosis and outcome to treatment with antidepressant medications...
January 8, 2019: NeuroImage: Clinical
Robin J Slaughter, Martin Watts, J Allister Vale, Jacob R Grieve, Leo J Schep
INTRODUCTION: Sodium hypochlorite is used as a bleaching and disinfecting agent and is commonly found in household bleach. OBJECTIVE: The objective is to review critically the epidemiology, mechanisms of toxicity, clinical features, diagnosis, and management of hypochlorite poisoning. METHODS: PubMed was searched from January 1950 to June 2018 using the terms "Hypochlorite", "Sodium Hypochlorite", "Sodium Oxychloride", "Hypochlorous Acid", "Bleach", "Chlorine Bleach", in combination with the keywords "poisoning", "poison", "toxicity", "ingestion", "adverse effects", "overdose", and "intoxication"...
January 28, 2019: Clinical Toxicology
Camilla Somers, Eleanor Grieve, Marilyn Lennon, Matt-Mouley Bouamrane, Frances S Mair, Emma McIntosh
BACKGROUND: Changing population demographics and technology developments have resulted in growing interest in the potential of consumer-facing digital health. In the United Kingdom, a £37 million (US $49 million) national digital health program delivering assisted living lifestyles at scale (dallas) aimed to deploy such technologies at scale. However, little is known about how consumers value such digital health opportunities. OBJECTIVE: This study explored consumers' perspectives on the potential value of digital health technologies, particularly mobile health (mHealth), to promote well-being by examining their willingness-to-pay (WTP) for such health solutions...
January 17, 2019: JMIR MHealth and UHealth
Graham M Wheeler, Adrian P Mander, Alun Bedding, Kristian Brock, Victoria Cornelius, Andrew P Grieve, Thomas Jaki, Sharon B Love, Lang'o Odondi, Christopher J Weir, Christina Yap, Simon J Bond
INTRODUCTION: The continual reassessment method (CRM) is a model-based design for phase I trials, which aims to find the maximum tolerated dose (MTD) of a new therapy. The CRM has been shown to be more accurate in targeting the MTD than traditional rule-based approaches such as the 3 + 3 design, which is used in most phase I trials. Furthermore, the CRM has been shown to assign more trial participants at or close to the MTD than the 3 + 3 design. However, the CRM's uptake in clinical research has been incredibly slow, putting trial participants, drug development and patients at risk...
January 18, 2019: BMC Medical Research Methodology
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