keyword
https://read.qxmd.com/read/38353859/antiepileptic-strategies-for-patients-with-primary-and-metastatic-brain-tumors
#1
REVIEW
Herbert B Newton, Jenna Wojkowski
Seizure activity is common in patients with primary and metastatic brain tumors, affecting more than 50% of cases over the course of their disease. Several mechanisms contribute to brain tumor-related epilepsy (BTRE), including a pro-inflammatory environment, excessive secretion of glutamate and an increase in neuronal excitatory tone, reduction of GABAergic inhibitory activity, and an increase in 2-hydroxygluturate production in isocitrate dehydrogenase mutant tumors. After a verified seizure in a brain tumor patient, the consensus is that BTRE has developed, and it is necessary to initiate an antiepileptic drug (AED)...
February 14, 2024: Current Treatment Options in Oncology
https://read.qxmd.com/read/38279087/persurge-noa-30-phase-ii-trial-of-perampanel-treatment-around-surgery-in-patients-with-progressive-glioblastoma
#2
JOURNAL ARTICLE
Sophie Heuer, Ina Burghaus, Maria Gose, Tobias Kessler, Felix Sahm, Philipp Vollmuth, Varun Venkataramani, Dirk Hoffmann, Matthias Schlesner, Miriam Ratliff, Carsten Hopf, Ulrich Herrlinger, Franz Ricklefs, Martin Bendszus, Sandro M Krieg, Antje Wick, Wolfgang Wick, Frank Winkler
BACKGROUND: Glioblastoma is the most frequent and a particularly malignant primary brain tumor with no efficacy-proven standard therapy for recurrence. It has recently been discovered that excitatory synapses of the AMPA-receptor subtype form between non-malignant brain neurons and tumor cells. This neuron-tumor network connectivity contributed to glioma progression and could be efficiently targeted with the EMA/FDA approved antiepileptic AMPA receptor inhibitor perampanel in preclinical studies...
January 26, 2024: BMC Cancer
https://read.qxmd.com/read/38175548/-seizures-in-pregnancy-not-always-eclamptic-seizures
#3
JOURNAL ARTICLE
Eva S Cohen, Angelo B Hooker, Natalie J Wiendels, Roza Abdolrahimi Raeni, Niels Verburg
BACKGROUND: The differential diagnosis of seizures during pregnancy is extensive and includes potentially fatal underlying diagnoses. Both pregnancy and non-pregnancy related aetiologies should be considered. CASE DESCRIPTION: A 38-years old pregnant woman presented to the emergency department at 31 weeks and 5 days with generalized tonic-clonic seizures. Initial an eclamptic seizure was suspected. Because the seizures lasted despite treatment with magnesium sulphate and anti-epileptic medication...
November 27, 2023: Nederlands Tijdschrift Voor Geneeskunde
https://read.qxmd.com/read/38026690/differential-metabolic-alterations-in-idh1-mutant-vs-wildtype-glioma-cells-promote-epileptogenesis-through-distinctive-mechanisms
#4
REVIEW
Darrian McAfee, Mitchell Moyer, Jaden Queen, Armin Mortazavi, Ujwal Boddeti, Muzna Bachani, Kareem Zaghloul, Alexander Ksendzovsky
Glioma-related epilepsy (GRE) is a hallmark clinical presentation of gliomas with significant impacts on patient quality of life. The current standard of care for seizure management is comprised of anti-seizure medications (ASMs) and surgical resection. Seizures in glioma patients are often drug-resistant and can often recur after surgery despite total tumor resection. Therefore, current research is focused on the pro-epileptic pathological changes occurring in tumor cells and the peritumoral environment. One important contribution to seizures in GRE patients is metabolic reprogramming in tumor and surrounding cells...
2023: Frontiers in Cellular Neuroscience
https://read.qxmd.com/read/37963207/neuronal-activity-promotes-glioma-progression-by-inducing-proneural-to-mesenchymal-transition-in-glioma-stem-cells
#5
JOURNAL ARTICLE
Xiaofan Guo, Wei Qiu, Chaochao Wang, Yanhua Qi, Boyan Li, Shaobo Wang, Rongrong Zhao, Bo Cheng, Xiao Han, Hao Du, Zijie Gao, Ziwen Pan, Shulin Zhao, Gang Li, Hao Xue
Neuronal activity can drive progression of high-grade glioma by mediating mitogen production and neuron-glioma synaptic communications. Glioma stem cells (GSCs) also play a significant role in progression, therapy resistance, and recurrence in glioma, which implicates potential crosstalk between neuronal activity and GSC biology. Here, we manipulated neuronal activity using chemogenetics in vitro and in vivo to study how it influences GSCs. Neuronal activity supported glioblastoma progression and radioresistance through exosome-induced proneural-to-mesenchymal transition (PMT) of GSCs...
November 14, 2023: Cancer Research
https://read.qxmd.com/read/37755633/impact-of-timing-of-antiseizure-medication-withdrawal-on-seizure-recurrence-in-glioma-patients-a-retrospective-observational-study
#6
REVIEW
Pim B van der Meer, Linda Dirven, Marta Fiocco, Maaike J Vos, Melissa Kerkhof, Mathilde C M Kouwenhoven, Martin J van den Bent, Martin J B Taphoorn, Johan A F Koekkoek
BACKGROUND: Withdrawal of antiseizure medication treatment (ASM) can be considered after completion of antitumour treatment in glioma patients who no longer suffer from seizures. We compared the risk for recurrent seizures after ASM withdrawal between patients with short-term, medium-term versus long-term seizure freedom after antitumour treatment. METHODS: In this retrospective observational study, the primary outcome was time to recurrent seizure, from the starting date of no ASM treatment up to 36 months follow-up...
September 27, 2023: Journal of Neuro-oncology
https://read.qxmd.com/read/37553563/leucine-rich-glioma-inactivated-protein-1-antibody-associated-encephalitis-in-a-22-month-old-girl-a-case-report
#7
JOURNAL ARTICLE
JiaChang Zhao, XiaoMing Yu, GuangLi Qu, ShuQi Wang, YanJun Wang
BACKGROUND: LGI-1 antibody-associated encephalitis is a type of autoimmune encephalitis with a lower prevalence than NMDAR antibody-associated encephalitis. LGI-1 antibody-associated encephalitis is the second most prevalent of all autoimmune encephalitides. LGI-1 antibodies interfere with the interactions of inter-synaptic proteins to produce clinical manifestations (N Engl J Med 378:840-851, 2018). CASE PRESENTATION: Leucine-rich glioma-inactivated protein 1 (LGI-1) antibody-associated encephalitis is a subtype of autoimmune encephalitis with a low incidence...
August 8, 2023: BMC Pediatrics
https://read.qxmd.com/read/37469993/a-case-of-leucine-rich-glioma-inactivated-1-antibody-encephalitis-with-schizophrenia-like-symptoms-as-an-initial-clinical-manifestation
#8
Jiyeon Moon, Hyeyun Kim
Leucine-rich glioma-inactivated 1 (LGI-1) antibody encephalitis is a type of limbic encephalitis characterized by faciobrachial dystonic seizure and short-term memory loss as initial clinical symptoms. We present a case initially misdiagnosed as schizophrenia and finally diagnosed as LGI-1 antibody encephalitis. A 41-year-old female presented to the neurology clinic with a 4-month history of anxiety and disoriented speech and a new onset headache. Her explanation of symptoms was unclear, and she was unable to answer questions properly...
October 2022: Encephalitis
https://read.qxmd.com/read/37404511/risk-factors-and-predictors-of-intraoperative-seizures-during-awake-craniotomy-a-systematic-review-and-meta-analysis
#9
REVIEW
Muhammad Shakir, Aly Hamza Khowaja, Ahmed Altaf, Aimen Tameezuddin, Syed Sarmad Bukhari, Syed Ather Enam
BACKGROUND: Awake craniotomy (AC) aims to minimize postoperative neurological complications while allowing maximum safe resection. Intraoperative seizures (IOSs) have been a reported complication during AC; however, literature delving into the predictors of IOS remains limited. Therefore, we planned a systematic review and meta-analysis of existing literature to explore predictors of IOS during AC. METHODS: From the inception until June 1, 2022, systematic searches of PubMed, Scopus, the Cochrane Library, CINAHL, and Cochrane's Central Register of Controlled Trials were conducted to look for published studies reporting IOS predictors during AC...
2023: Surgical Neurology International
https://read.qxmd.com/read/37190109/the-antiepileptic-drug-oxcarbazepine-inhibits-the-growth-of-patient-derived-isocitrate-dehydrogenase-mutant-glioma-stem-like-cells
#10
JOURNAL ARTICLE
Philip Dao Trong, Gerhard Jungwirth, Andreas Unterberg, Christel Herold-Mende, Rolf Warta
Patients diagnosed with isocitrate dehydrogenase mutant (IDHmut ) gliomas suffer frequently from seizures. Although the clinical course is less aggressive than that of its IDH wildtype counterpart, recent discoveries have shown that epileptic activity can promote tumor proliferation. However, it is not known if antiepileptic drugs confer additional value by inhibiting tumor growth. In this study, the antineoplastic properties of 20 FDA-approved antiepileptic drugs (AEDs) were tested in six patient-derived IDHmut glioma stem-like cells (GSCs)...
April 20, 2023: Cells
https://read.qxmd.com/read/36895476/maximal-safe-resection-of-diffuse-lower-grade-gliomas-primarily-within-central-lobe-using-cortical-subcortical-direct-electrical-stimulation-under-awake-craniotomy
#11
JOURNAL ARTICLE
Shujing Yao, Ruixin Yang, Chenggang Du, Che Jiang, Yang Wang, Chongqi Peng, Hongmin Bai
BACKGROUND: Diffuse lower-grade glioma (DLGG) in the central lobe is a challenge for safe resection procedures. To improve the extent of resection and reduce the risk of postoperative neurological deficits, we performed an awake craniotomy with cortical-subcortical direct electrical stimulation (DES) mapping for patients with DLGG located primarily within the central lobe. We investigated the outcomes of cortical-subcortical brain mapping using DES in an awake craniotomy for central lobe DLGG resection...
2023: Frontiers in Oncology
https://read.qxmd.com/read/36831117/antitumor-potential-of-antiepileptic-drugs-in-human-glioblastoma-pharmacological-targets-and-clinical-benefits
#12
REVIEW
Manuela Stella, Giammarco Baiardi, Stefano Pasquariello, Fabio Sacco, Irene Dellacasagrande, Alessandro Corsaro, Francesca Mattioli, Federica Barbieri
Glioblastoma (GBM) is characterized by fast-growing cells, genetic and phenotypic heterogeneity, and radio-chemo-therapy resistance, contributing to its dismal prognosis. Various medical comorbidities are associated with the natural history of GBM. The most disabling and greatly affecting patients' quality of life are neurodegeneration, cognitive impairment, and GBM-related epilepsy (GRE). Hallmarks of GBM include molecular intrinsic mediators and pathways, but emerging evidence supports the key role of non-malignant cells within the tumor microenvironment in GBM aggressive behavior...
February 16, 2023: Biomedicines
https://read.qxmd.com/read/36686352/anti-leucine-rich-glioma-inactivated-protein-1-encephalitis-with-sleep-disturbance-as-the-first-symptom-a-case-report-and-review-of-literature
#13
De-Lian Kong
BACKGROUND: Anti-leucine-rich glioma inactivated protein 1 (anti-LGI1) encephalitis is an infrequent type of autoimmune encephalitis (AE) characterized by acute or subacute cognitive and psychiatric disturbance, facio-brachial dystonic seizures (FBDSs), and hyponatremia. Anti-LGI1 AE has increasingly been considered a primary form of AE. Early identification and treatment of this disease are clearly very important. CASE SUMMARY: Here, we report that a male patient developed severe anti-LGI1 encephalitis, which was initially misdiagnosed as a sleep disturbance...
January 16, 2023: World Journal of Clinical Cases
https://read.qxmd.com/read/36631762/development-of-an-integrated-predictive-model-for-postoperative-glioma-related-epilepsy-using-gene-signature-and-clinical-data
#14
RANDOMIZED CONTROLLED TRIAL
Lianwang Li, Chuanbao Zhang, Zheng Wang, Yinyan Wang, Yuhao Guo, Chong Qi, Gan You, Zhong Zhang, Xing Fan, Tao Jiang
BACKGROUND: This study aimed to develop an integrated model for predicting the occurrence of postoperative seizures in patients with diffuse high-grade gliomas (DHGGs) using clinical and RNA-seq data. METHODS: Patients with DHGGs, who received prophylactic anti-epileptic drugs (AEDs) for three months following surgery, were enrolled into the study. The patients were assigned randomly into training (n = 166) and validation (n = 42) cohorts...
January 11, 2023: BMC Cancer
https://read.qxmd.com/read/36579273/predictors-of-seizure-freedom-in-pediatric-low-grade-gliomas
#15
JOURNAL ARTICLE
Hailey C Budnick, Shawyon Baygani, Teresa Easwaran, Alexander Vortmeyer, Andrew Jea, Virendra Desai, Jeffrey Raskin
OBJECTIVE: Pediatric low-grade gliomas (LGGs) are found in approximately one to three percent of patients with childhood epilepsy. Epilepsy in these patients is often medically refractory and therefore represents a unique cohort with significant morbidity from concomitant pathology. Similar studies in adult patients with low-grade gliomas have identified predictors of seizure freedom including gross-total resection, preoperative seizure control on antiepileptic medication and duration of seizures of less than one year...
November 2022: Curēus
https://read.qxmd.com/read/36443957/improved-psychotic-symptoms-following-resection-of-amygdalar-low-grade-glioma-illustrative-case
#16
JOURNAL ARTICLE
John P Andrews, Thomas A Wozny, John K Yue, Doris D Wang
BACKGROUND: Epilepsy-associated psychoses are poorly understood, and management is focused on treating epilepsy. Chronic, interictal psychosis that persists despite seizure control is typically treated with antipsychotics. Whether resection of a mesial temporal lobe lesion may improve interictal psychotic symptoms that persist despite seizure control remains unknown. OBSERVATIONS: In a 52-year-old man with well-controlled epilepsy and persistent comorbid psychosis, brain magnetic resonance imaging (MRI) revealed an infiltrative, intraaxial, T2 fluid-attenuated inversion recovery intense mass of the left amygdala...
November 28, 2022: J Neurosurg Case Lessons
https://read.qxmd.com/read/36380710/first-line-levetiracetam-versus-enzyme-inducing-antiseizure-medication-in-glioma-patients-with-epilepsy
#17
JOURNAL ARTICLE
Pim B van der Meer, Marta Maschio, Linda Dirven, Martin J B Taphoorn, Johan A F Koekkoek
OBJECTIVE: This study aimed to directly compare the effectiveness of first-line monotherapy levetiracetam (LEV) versus enzyme-inducing antiseizure medications (EIASMs) in glioma patients. METHODS: In this nationwide retrospective observational cohort study, Grade 2-4 glioma patients were included, with a maximum duration of follow-up of 36 months. Primary outcome was antiseizure medication (ASM) treatment failure for any reason, and secondary outcomes were treatment failure due to uncontrolled seizures and due to adverse effects...
January 2023: Epilepsia
https://read.qxmd.com/read/36358611/symptoms-of-depression-and-anxiety-in-adults-with-high-grade-glioma-a-literature-review-and-findings-in-a-group-of-patients-before-chemoradiotherapy-and-one-year-later
#18
JOURNAL ARTICLE
Monica Ribeiro, Mohamed Amine Benadjaoud, Laura Moisy, Julian Jacob, Loïc Feuvret, Alexander Balcerac, Marie-Odile Bernier, Dimitri Psimaras, Khê Hoang-Xuan, Georges Noel, Nathalie Jouniaux-Delbez, Damien Ricard
High-grade glioma (HGG) is associated with several external and internal stressors that may induce mood alterations at all stages of the disease. Symptoms of depression and anxiety in persons with glioma have multifactorial etiology and require active follow-up. We reviewed the literature data on the prevalence, mechanisms likely involved in the etiology of mood alterations in persons with HGG and psychosocial interventions found beneficial in treating these symptoms. We also investigated the prevalence and clinical variables that could increase the risk of depression and anxiety symptoms in a group of patients with HGG at two disease time-points: after surgery, before and 1 year after chemoradiotherapy...
October 22, 2022: Cancers
https://read.qxmd.com/read/36284648/anti-tumor-effects-of-perampanel-in-malignant-glioma-cells
#19
JOURNAL ARTICLE
Juri Tatsuoka, Emiko Sano, Yuya Hanashima, Chihiro Yagi, Shun Yamamuro, Koichiro Sumi, Hiroyuki Hara, Kazuhide Takada, Kazunori Kanemaru, Shihoko Komine-Aizawa, Yoichi Katayama, Atsuo Yoshino
Glioblastoma has a poor prognosis even after multimodal treatment, such as surgery, chemotherapy and radiation therapy. Patients with glioblastoma frequently develop epileptic seizures during the clinical course of the disease and often require antiepileptic drugs. Therefore, agents with both antiepileptic and antitumoral effects may be very useful for glioblastoma treatment. Perampanel, an α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor antagonist, is an antiepileptic drug that is widely used for intractable epilepsy...
December 2022: Oncology Letters
https://read.qxmd.com/read/36281939/anti%C3%A2-tumor-effects-of-anti%C3%A2-epileptic-drugs-in-malignant-glioma-cells
#20
JOURNAL ARTICLE
Chihiro Yagi, Juri Tatsuoka, Emiko Sano, Yuya Hanashima, Yoshinari Ozawa, Sodai Yoshimura, Shun Yamamuro, Koichiro Sumi, Hiroyuki Hara, Yoichi Katayama, Atsuo Yoshino
Patients with glioblastoma frequently suffer epileptic seizures and often require anticonvulsant therapy during the treatment course. The present study investigated four common antiepileptic drugs, perampanel, carbamazepine (CBZ), sodium valproate (VPA) and levetiracetam (LEV), which are expected to have antitumor effects, and determined the most beneficial drug for the treatment of malignant glioma by comparing antitumor effects such as inhibition of cell proliferation and suppression of migration and invasion (using Transwell assays)...
December 2022: Oncology Reports
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