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glioma AED

Swapan Gupta, Sita Jayalakshmi, Lokesh Lingappa, Ramesh Konanki, Sudhindra Vooturi, Pushpalatha Sudhakar, Manas Panigrahi
The role of cerebellum in seizure generation is debatable. Semiology and electroencephalography (EEG) findings are non-specific and sometimes misleading, posing further difficulty in proving the epileptogenicity in pre-surgical workup. We report two cases of cerebellar lesions who presented with hemifacial seizures since the neonatal period and were refractory to antiepileptic drugs (AEDs). Both inter-ictal and ictal EEGs were non-contributory. Magnetic resonance imaging (MRI) showed a lesion in the cerebellum, in proximity to cerebellar peduncle in both the patients...
January 2019: Neurology India
M Kerkhof, J A F Koekkoek, M J Vos, M J van den Bent, W Taal, T J Postma, J E C Bromberg, M C M Kouwenhoven, L Dirven, J C Reijneveld, M J B Taphoorn
BACKGROUND: When glioma patients experience long-term seizure freedom the question arises whether antiepileptic drugs (AEDs) should be continued. As no prospective studies exist on seizure recurrence in glioma patients after AED withdrawal, we evaluated the decision-making process to withdraw AEDs in glioma patients, and seizure outcome after withdrawal. METHODS: Patients with a histologically confirmed low grade or anaplastic glioma were included. Eligible patients were seizure free ≥ 1 year from the date of last antitumor treatment, or ≥ 2 years since the last seizure when seizures occurred after the end of the last antitumor treatment...
February 18, 2019: Journal of Neuro-oncology
Xue Yang, An-Ning Li, Xiu-He Zhao, Xue-Wu Liu, Sheng-Jun Wang
PURPOSE: Antibodies against leucine-rich glioma inactivated 1 (LGI1) are associated with limbic encephalitis and faciobrachial dystonic seizures (FBDS). We present a large series of Han Chinese patients for further clinical refinement. MATERIALS AND METHODS: Serum and cerebrospinal fluid samples from patients were tested. Clinical information of patients with serum anti‑LGI1antibody positivity was retrospectively reviewed, and descriptive statistical analysis was performed...
January 9, 2019: International Journal of Neuroscience
Thomas Blauwblomme, Elena Dossi, Christophe Pellegrino, Emmanuelle Goubert, Beatriz Gal Iglesias, Christian Sainte-Rose, Nathalie Rouach, Rima Nabbout, Gilles Huberfeld
OBJECTIVE: Dysregulation of γ-aminobutyric acidergic (GABAergic) transmission has been reported in lesional acquired epilepsies (gliomas, hippocampal sclerosis). We investigated its involvement in a developmental disorder, human focal cortical dysplasia (FCD), focusing on chloride regulation driving GABAergic signals. METHODS: In vitro recordings of 47 human cortical acute slices from 11 pediatric patients who received operations for FCD were performed on multielectrode arrays...
February 2019: Annals of Neurology
Anteneh M Feyissa, Christopher Lamb, Sean J Pittock, Avi Gadoth, Andrew McKeon, Christopher J Klein, Jeffrey W Britton
Objective: To characterize seizure semiology and the utility of antiepileptic drug (AED) therapy in leucine-rich glioma inactivated-1 ( LGI1-Ab) autoimmune epilepsy (AE). Methods: Patients with voltage-gated potassium channel complex (VGKCc) titers higher than 0.02 nmol/L who were evaluated between May 2008 and June 2016 at the 3 Mayo Clinic sites (Arizona, Florida, or Minnesota) were identified. We then performed a retrospective review of those who were LGI1-Ab positive and were treated for seizures...
September 2018: Epilepsia open
Shala G Berntsson, Ryan T Merrell, E Susan Amirian, Georgina N Armstrong, Daniel Lachance, Anja Smits, Renke Zhou, Daniel I Jacobs, Margaret R Wrensch, Sara H Olson, Dora Il'yasova, Elizabeth B Claus, Jill S Barnholtz-Sloan, Joellen Schildkraut, Siegal Sadetzki, Christoffer Johansen, Richard S Houlston, Robert B Jenkins, Jonine L Bernstein, Rose Lai, Sanjay Shete, Christopher I Amos, Melissa L Bondy, Beatrice S Melin
BACKGROUND: The purpose of this study was to evaluate the distribution of glioma-related seizures and seizure control at the time of tumor diagnosis with respect to tumor histologic subtypes, tumor treatment and patient characteristics, and to compare seizure history preceding tumor diagnosis (or study enrollment) between glioma patients and healthy controls. METHODS: The Glioma International Case Control study (GICC) risk factor questionnaire collected information on demographics, past medical/medication history, and occupational history...
June 2018: Journal of Neurology
Andrew Neal, Patrick Kwan, Terence John O'Brien, Michael E Buckland, Michael Gonzales, Andrew Morokoff
OBJECTIVE: Isocitrate dehydrogenase 1 and 2 mutations (IDH1/2) have an established association with preoperative seizures in patients with grades II-IV diffuse gliomas. Here, we examined if IDH1/2 mutations are a biomarker of postoperative seizure frequency. METHODS: This was a retrospective study. Patients with grades II-IV supratentorial diffuse glioma, immunohistochemistry results of IDH1-R132H, and antiepileptic drug (AED) prescribed postoperatively were included...
January 2018: Epilepsy & Behavior: E&B
Michael C Dewan, Gabrielle A White-Dzuro, Philip R Brinson, Scott L Zuckerman, Peter J Morone, Reid C Thompson, John C Wellons, Lola B Chambless
BACKGROUND: Antiepileptic drugs (AEDs) are frequently administered prophylactically to mitigate seizures following craniotomy for brain tumor resection. However, conflicting evidence exists regarding the efficacy of AEDs, and their influence on surgery-related outcomes is limited. OBJECTIVE: To evaluate the influence of perioperative AEDs on postoperative seizure rate and hospital-reported quality metrics. METHODS: A retrospective cohort study was conducted, incorporating all adult patients who underwent craniotomy for glioma resection at our institution between 1999 and 2014...
April 1, 2017: Neurosurgery
Vincenzo Belcastro, Laura Rosa Pisani, Silvio Bellocchi, Paolo Casiraghi, Gaetano Gorgone, Marco Mula, Francesco Pisani
To explore possible correlations among brain lesion location, development of psychiatric symptoms and the use of antiepileptic drugs (AEDs) in a population of patients with brain tumor and epilepsy. The medical records of 283 patients with various types of brain tumor (161 M/122 F, mean age 64.9 years) were analysed retrospectively. Patients with grade III and IV glioma, previous history of epileptic seizures and/or psychiatric disorders were excluded. Psychiatric symptoms occurring after initiation of AED therapy were considered as treatment emergent psychiatric adverse events (TE-PAEs) if they fulfilled the following conditions: (1) onset within 4 weeks after the beginning of AED therapy; (2) disappearance on drug discontinuation; (3) absence of any other identified possible concurrent cause...
May 2017: Journal of Neurology
Andrew Neal, Andrew Morokoff, Terence John O'Brien, Patrick Kwan
OBJECTIVE: The patterns of postoperative seizure control and response to antiepileptic drugs (AEDs) in tumor-associated epilepsy (TAE) are poorly understood. We aim to document these characteristics in patients with supratentorial gliomas. METHODS: This was a retrospective analysis of 186 patients with supratentorial gliomas. Seizure patterns were classified into four groups: A, no postoperative seizure; B, early postoperative seizure control within 6 months; C, fluctuating seizure control; and D, never seizure-free...
November 2016: Epilepsia
Taranjeet Kaur, Shaffi Manchanda, Vedangana Saini, Sukhwinder S Lakhman, Gurcharan Kaur
The change in the therapeutic targets from neuron to glia has proved beneficial in the treatment of many psychiatric disorders. The anti-epileptic drugs (AEDs) have been widely prescribed for the treatment of partial and complete seizures, bipolar disorder among others. The current study was carried out to explore the efficacy of some conventional and novel AEDs for the treatment of tumor-associated epilepsy which develops in 29-49% of the patients diagnosed with brain tumors. We used C6 glioma cell line as model system to study the effect of selected AEDs, viz...
March 2016: Annals of Neurosciences
Johan A F Koekkoek, Linda Dirven, Martin J B Taphoorn
The withdrawal of antiepileptic drugs (AEDs) in World Health Organization (WHO) grade II-III glioma patients with epilepsy is controversial, as the presence of a symptomatic lesion is often related to an increased risk of seizure relapse. However, some glioma patients may achieve long-term seizure freedom after antitumor treatment, raising questions about the necessity to continue AEDs, particularly when patients experience serious drug side effects. Areas covered: In this review, we show the evidence in the literature from 1990-2016 for AED withdrawal in glioma patients...
February 2017: Expert Review of Neurotherapeutics
Michael C Dewan, Reid C Thompson, Steven N Kalkanis, Fred G Barker, Constantinos G Hadjipanayis
OBJECTIVE Antiepileptic drugs (AEDs) are often administered prophylactically following brain tumor resection. With conflicting evidence and unestablished guidelines, however, the nature of this practice among tumor surgeons is unknown. METHODS On November 24, 2015, a REDCap (Research Electronic Database Capture) survey was sent to members of the AANS/CNS Section on Tumors to query practice patterns. RESULTS Responses were received from 144 individuals, including 18.8% of board-certified neurosurgeons surveyed (across 86 institutions, 16 countries, and 5 continents)...
June 2017: Journal of Neurosurgery
Johan A F Koekkoek, Tjeerd J Postma, Jan J Heimans, Jaap C Reijneveld, Martin J B Taphoorn
BACKGROUND: During the end-of-life (EOL) phase of glioma patients, a rapid deterioration in neurological functioning may interfere with the oral intake of antiepileptic drugs (AEDs). We aimed to assess the feasibility of non-oral AED treatment in an out-of-hospital setting according to an expert-based guideline. METHODS: Glioma patients with a history of epilepsy, in whom further antitumor therapy was considered to be no longer meaningful, were recruited at two Dutch hospitals...
April 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Peter Yat-Ming Woo, Danny Tat-Ming Chan, Kwong-Yau Chan, Wai-Kei Wong, Yin-Chung Po, John Ching-Kong Kwok, Wai-Sang Poon
AIM: The aim of this present study was to determine the frequency, as well as risk factors, for seizures and antiepileptic drug (AED)-associated adverse effects among high-grade glioma (HGG) patients. PATIENTS AND METHODS: A multicentre, retrospective study of adult Chinese Hong Kong patients from three neurosurgical centres diagnosed with supratentorial HGG between 1 January 2001 and 31 December 2010 was performed. RESULTS: A total of 198 patients, with a mean age of 55 years (range: 18-88) and a mean follow up of 15 months, was recruited...
February 2015: Surgical Practice
J Rösche, J Piek, G Hildebrandt, A Grossmann, T Kirschstein, R Benecke
Malignant gliomas like glioblastoma multiforme (GBM) release glutamate which causes excitotoxic death to surrounding neurons, thereby vacating room for tumor expansion. We report the case of a patient with GBM treated with the AMPA receptor blocker Perampanel (PER) in combination therapy for partial seizures. Histological work-up of a biopsy showed the tissue of a GBM without mutation of the isocitrate dehydrogenase 1 (IDH1) and without promotor methylation of the O6-methylguanine-DNA methyltransferase (MGMT)...
May 2015: Fortschritte der Neurologie-Psychiatrie
Guilherme Lucas de Oliveira Lima, Hugues Duffau
OBJECT: Although a large amount of data supports resection for symptomatic diffuse low-grade glioma (LGG), the therapeutic strategy regarding incidental LGG (ILGG) is still a matter of debate. Indeed, early "preventive" surgery has recently been proposed in asymptomatic patients with LGG, after showing that the extent of resection was larger than in symptomatic patients with LGG. However, the quality of life should be preserved by avoiding both neurological deficit and epilepsy...
June 2015: Journal of Neurosurgery
D Mariş, D Nica, D Mohan, H Moisa, A V Ciurea
BACKGROUND: Adult hemispheric low grade gliomas (LGG) cover a pathologic spectrum which has specific clinical, histological and molecular characteristics. The optimal management of these tumors is still a controversial topic in international literature. METHODS: We evaluated scientific papers from the literature (Medline and Cochrane Library to date) and we compared the results found there with our experience, trying to create a pattern of treatment of our own. RESULTS AND CONCLUSIONS: The advances in microsurgical and neuromonitoring techniques, as well as in neuroimaging, allow for a more aggressive resection of LGG with a significant improvement in overall survival and quality of life...
September 2014: Chirurgia
Rahsan Kemerdere, Odhan Yuksel, Tibet Kacira, Naz Yeni, Cigdem Ozkara, Taner Tanriverdi, Mustafa Uzan, Emin Ozyurt
Low-grade gliomas (LGGs) are generally located in temporal lobe and cause medically-intractable seizure so that surgical treatment becomes inevitable. This study includes a retrospective analysis of our patients with temporal LGGs retrieved from our epilepsy surgery data base and tries to present appropriate surgical approach and long-term seizure and anti-epileptic drug (AED) outcomes. Fifty-three patients including children and adults underwent surgery on temporal lobe LGGs and 35 patients were reached to report seizure and AED outcomes...
November 2014: Clinical Neurology and Neurosurgery
Toshihiko Iuchi, Yuzo Hasegawa, Koichiro Kawasaki, Tsukasa Sakaida
Brain tumor-related epilepsy (BTRE) is a unique condition that is distinct from primary epilepsy. The aim of this retrospective study was to clarify the epidemiology and results of treatment of BTRE in a single institution. From a database of 121 consecutive patients with supratentorial gliomas treated at Chiba Cancer Center from 2006-2012, the incidence and control of seizures before and after surgery were retrospectively evaluated. Epilepsy occurred in 33.9% of patients before surgery. All patients received prophylactic anti-epileptic drugs (AED) during surgery; however, seizures occurred in 9...
January 2015: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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