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Diagnostic markers

Arezou Sayad, Mohammad Taheri, Mir Davood Omrani, Hamid Fallah, Vahid Kholghi Oskooei, Soudeh Ghafouri-Fard
BACKGROUND: Long non-coding RNAs (lncRNAs) have established roles in the pathogenesis of diverse human disorders including neuropsychiatric disorders. METHODS: In the current study, we evaluated expression levels of six apoptosis-related lncRNAs (CCAT2, TUG1, PANDA, NEAT1, FAS-AS1 and OIP5-AS1) in the peripheral blood of bipolar disorder (BD) patients and healthy subjects to assess their contribution in the pathogenesis of BD. RESULTS: CCAT2, TUG1 and PANDA were up-regulated in total BD patients compared with total healthy subjects (P values = 0...
February 11, 2019: Journal of Affective Disorders
Cornelia M Weyand, Ryu Watanabe, Hui Zhang, Mitsuhiro Akiyama, Gerald J Berry, Jörg J Goronzy
Giant cell arteritis and Takayasu arteritis are autoimmune vasculitides that cause aneurysm formation and tissue infarction. Extravascular inflammation consists of an intense acute phase response. Deeper understanding of pathogenic events in the vessel wall has highlighted the loss of tissue protective mechanisms, the intrusion of immune cells into "forbidden territory", and the autonomy of self-renewing vasculitic infiltrates. Adventitial vasa vasora critically control vessel wall access and drive differentiation of tissue-invasive T cells...
February 14, 2019: Clinical Immunology: the Official Journal of the Clinical Immunology Society
Daisuke Izumi, Feng Gao, Shusuke Toden, Fuminori Sonohara, Mitsuro Kanda, Takatsugu Ishimoto, Yasuhiro Kodera, Xin Wang, Hideo Baba, Ajay Goel
BACKGROUND: Although identification of lymph node (LN) metastasis is a well-recognized strategy for improving outcomes in patients with gastric cancer (GC), currently there is lack of availability of adequate molecular biomarkers that can identify such metastasis. Herein we have developed a robust gene-expression signature for detecting LN metastasis in early stage GC by using a transcriptome-wide biomarker discovery and subsequent validation in multiple clinical cohorts. METHODS: A total of 532 patients with pathological T1 and T2 GC from 4 different cohorts were analyzed...
February 13, 2019: EBioMedicine
Amardeep Ghosh Dastidar, Anna Baritussio, Estefania De Garate, Zsofia Drobni, Giovanni Biglino, Priyanka Singhal, Elena G Milano, Gianni D Angelini, Stephen Dorman, Julian Strange, Thomas Johnson, Chiara Bucciarelli-Ducci
OBJECTIVES: This study sought to assess the prognostic impact of cardiovascular magnetic resonance (CMR) and conventional risk factors in patients with myocardial infarction with nonobstructed coronaries (MINOCA). BACKGROUND: Myocardial infarction with nonobstructed coronary arteries (MINOCA) represents a diagnostic dilemma, and the prognostic markers have not been clarified. METHODS: A total of 388 consecutive patients with MINOCA undergoing cardiac magnetic resonance (CMR) assessment were identified retrospectively from a registry database and prospectively followed for a primary clinical endpoint of all-cause mortality...
February 11, 2019: JACC. Cardiovascular Imaging
M Benedetti, P Ciano, I Pergolini, S Ciotti, G Guercioni, G Ruffo, F Borghi, A Patriti, P Del Rio, M Scatizzi, S Mancini, G Garulli, A Carrara, F Pirozzi, S Scabini, A Liverani, G Baiocchi, R Campagnacci, A Muratore, G Longo, M Caricato, R Macarone Palmieri, N Vettoretto, M Ceccaroni, S Guadagni, E Bertocchi, D Cianflocca, M Lambertini, U Pace, M Baraghini, L Pandolfini, R Angeloni, A Lucchi, G Martorelli, G Tirone, M Motter, A Sciuto, A Martino, A P Luzzi, T Di Cesare, S Molfino, A Maurizi, P Marsanic, F Tomassini, S Santoni, G T Capolupo, P Amodio, E Arici, M Clementi, B Ruggeri, M Catarci
BACKGROUND: Anastomotic leakage (AL) is a dreaded major complication after colorectal surgery. There is no uniform definition of anastomotic dehiscence and leak. Over the years many risk factors have been identified (distance of anastomosis from anal verge, gender, BMI, ASA score) but none of these allows an early diagnosis of AL. The DUtch LeaKage (DULK) score, C reactive protein (CRP) and procalcitonin (PCT) have been identified as early predictors for anastomotic leakage starting from postoperative day (POD) 2-3...
January 2019: Il Giornale di Chirurgia
Vishal Sahu, Anant Mohan, Sharmistha Dey
INTRODUCTION: p38 MAPK signaling molecules plays a dual role in cancer, both progression and suppression. Elevated expression of p38α was reported in lung cancer tissue in rat model. Our objective was to explore the concentration of all 4 isoforms of p38MAPK in serum of Non Small Cell Lung Cancer (NSCLC). MATERIAL AND METHODS: The blood samples were collected from 77 NSCLC patients, 52 ethically matched healthy controls and 18 follow up patients were collected as some patients expired and some discontinued the treatment...
February 13, 2019: Experimental and Molecular Pathology
Kunal Dhiman, Kaj Blennow, Henrik Zetterberg, Ralph N Martins, Veer Bala Gupta
Alzheimer's disease (AD) is a multifactorial age-related brain disease. Numerous pathological events run forth in the brain leading to AD. There is an initial long, dormant phase before the clinical symptoms become evident. There is a need to diagnose the disease at the preclinical stage since therapeutic interventions are most likely to be effective if initiated early. Undoubtedly, the core cerebrospinal fluid (CSF) biomarkers have a good diagnostic accuracy and have been used in clinical trials as end point measures...
February 15, 2019: Cellular and Molecular Life Sciences: CMLS
Yotsapon Thewjitcharoen, Amia Jones Elizabeth, Siriwan Butadej, Soontaree Nakasatien, Phawinpon Chotwanvirat, Ekgaluck Wanothayaroj, Sirinate Krittiyawong, Tinapa Himathongkam, Thep Himathongkam
BACKGROUND: Dysglycemic status defined by prediabetes and diabetes is known to be related with future risk of diabetic complications and cardiovascular diseases. Herein, we aimed to determine the diagnostic accuracy of glycated hemoglobin (HbA1c) when compared with oral glucose tolerance test (OGTT) as a reference test in identifying dysglycemic status among high-risk Thai patients receiving care in an out-patient setting. METHODS: An 11-year retrospective cross-sectional study of high-risk Thai patients who underwent OGTT during 2007-2017 was analysed...
February 15, 2019: BMC Endocrine Disorders
Dipika R Mohan, Antonio Marcondes Lerario, Tobias Else, Bhramar Mukherjee, Madson Q Almeida, Michelle Vinco, Juilee Rege, Beatriz M P Mariani, Maria Claudia N Zerbini, Berenice B Mendonca, Ana Claudia Latronico, Suely K N Marie, William E Rainey, Thomas J Giordano, Maria Candida B V Fragoso, Gary D Hammer
PURPOSE: Adrenocortical carcinoma (ACC) is a rare, aggressive malignancy with few therapies; however, patients with locoregional disease have variable outcomes. The Cancer Genome Atlas project on ACC (ACC-TCGA) identified that cancers of patients with homogeneously rapidly recurrent or fatal disease bear a unique CpG island hypermethylation phenotype, "CIMP-high." We sought to identify a biomarker that faithfully captures this subgroup. EXPERIMENTAL DESIGN: We analyzed ACC-TCGA data to characterize differentially regulated biological processes, and identify a biomarker that is methylated and silenced exclusively in CIMP-high ACC...
February 15, 2019: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Aranka Ilea, Vlad Andrei, Claudia Nicoleta Feurdean, Anida-Maria Băbțan, Nausica Bianca Petrescu, Radu Septimiu Câmpian, Adina Bianca Boșca, Bianca Ciui, Mihaela Tertiș, Robert Săndulescu, Cecilia Cristea
BACKGROUND: Saliva has been recently proposed as an alternative to classic biofluid analyses due to both availability and reliability regarding the evaluation of various biomarkers. Biosensors have been designed for the assessment of a wide spectrum of compounds, aiding in the screening, diagnosis, and monitoring of pathologies and treatment efficiency. This literature review aims to present the development in the biosensors research and their utility using salivary assessment. METHODS: a comprehensive literature search has been conducted in the PubMed database, using the keywords "saliva" and "sensor"...
February 14, 2019: Biosensors
Konrad Pawelczyk, Aleksandra Piotrowska, Urszula Ciesielska, Karolina Jablonska, Natalia Gletzel-Plucinska, Jedrzej Grzegrzolka, Marzenna Podhorska-Okolow, Piotr Dziegiel, Katarzyna Nowinska
BACKGROUND: The latest immunotherapy, used in the treatment of non-small cell lung cancer (NSCLC), uses monoclonal antibodies directed against programmed death ligand 1 (PD-L1) to inhibit its interaction with the PD-1 receptor. Elevated levels of PD-L1 expression were observed on NSCLC cells. The association between PD-L1 expression and clinicopathological features is still unclear. Therefore, we examined this relationship and also compare PD-L1 expression levels with Ki-67, p63 and TTF-1...
February 14, 2019: International Journal of Molecular Sciences
Yan Wang, Keke Liu, Qin Ma, Yongfei Tan, Wei Du, Yidan Lv, Yuan Tian, Hao Wang
AIM: Pancreatic cancer is one of the worst malignant tumors in prognosis. Therefore, to reduce the mortality rate of pancreatic cancer, early diagnosis and prompt treatment are particularly important. RESULTS: We put forward a new feature-selection method that was used to find clinical markers for pancreatic cancer by combination of Support Vector Machine Recursive Feature Elimination (SVM-RFE) and Large Margin Distribution Machine Recursive Feature Elimination (LDM-RFE) algorithms...
February 15, 2019: Biomarkers in Medicine
Safak Ozer Balin, Ayse Sagmak Tartar, Kader Uğur, Faruk Kilinç, Selda Telo, Ali Bal, Mehmet Balin, Ayhan Akbulut
This study was undertaken to evaluate the diagnostic and prognostic values of pentraxin-3 (PTX-3) in patients with infected diabetic foot ulcers (IDFU) as well as to assess the association between PTX-3 levels and IDFU severity. This study included 60 IDFU patients (Group 1), 45 diabetic patients without DFU (Group 2), and 45 healthy controls. Patients with IDFU were divided into mild, moderate, and severe subgroups based on classification of clinical severity. Patients who underwent amputation were also documented...
February 15, 2019: International Wound Journal
Lei Zhang, Wen-Jie Fang, Ke-Ming Zhang, Wei-Wei Jiang, Min Chen, Wan-Qing Liao, Wei-Hua Pan
AIMS: LncRNAs play a vital role in the pathological and physiological process. This study aimed to explore the involvement of lncRNAs in cryptococcal meningitis. METHODS: Microarray was performed in cryptococcal meningitis patients, and then, GO and KEGG pathways were analyzed. Coexpression relationship between lncRNA and mRNA was explored. The expressions of the lncRNAs and mRNAs, and their changes after treatment were detected by PCR. RESULTS: A total of 325 mRNAs (201 upregulated and 124 downregulated) and 497 lncRNAs (263 upregulated and 234 downregulated) were identified...
February 14, 2019: CNS Neuroscience & Therapeutics
Sezen Karakus, Alan N Baer, Esen K Akpek
Background: Diagnostic criteria for Sjögren's syndrome (SS) are continually being updated in pursuit of more precise and earlier diagnosis to prevent its complications. Owing to the high rate of false negative traditional serological markers, the need for better serological testing remains. Objective: To investigate the clinical significance of three recently discovered novel autoantibodies, anti-salivary gland protein 1 (SP1), anti-carbonic anhydrase 6 (CA6), and anti-parotid secretory protein (PSP), in a cohort of dry eye patients with suspected underlying inflammatory/autoimmune disease...
2019: Journal of Immunology Research
Cecilia Carubbi, Elena Masselli, Giulia Pozzi, Maria Mattioli, Silvia Martini, Matteo Goldoni, Rosalia Aloe, Gianfranco Cervellin, Marco Vitale, Giuliana Gobbi
A rapid differential diagnosis of the clinical conditions underlying chest pain is a relevant clinical issue. Specifically, a fast rule-in or -out of acute myocardial infarction (AMI) is mandatory to improve diagnostic outcome and cost-effectiveness of patient management. We demonstrated that Protein Kinase C (PKC) epsilon is selectively expressed by platelets from AMI patients, accounting for increased platelet activation. Thus, we hypothesized that PKCepsilon-expressing platelets may represent a pathophysiological marker of AMI that could be utilized in combination with troponin-I, the conventional marker of cardiac injury, to add diagnostic information in chest pain workup...
February 14, 2019: Scientific Reports
Maiko Hongo, Yoko Inaba, Kenjiro Kotake
A 78-year-old man was referred to our hospital with diarrhea, melena, and weight loss. During a digital rectal examination, a protuberant mass located 7-8 cm above the anal verge was palpable. Computed tomography(CT)scans of his chest, abdomen, and pelvis revealed an intestinal obstruction with a target sign in the lower rectum, indicating intussusception due to a sigmoid colon mass. A gastrografin enema examination revealed a typical filling defect with a crab claw sign in the rectum. However, the enema did not reduce the intussusception...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Jie Li, Brandon A Kemp, Nancy L Howell, James Massey, Krzysztof Mińczuk, Qiao Huang, Mahendra D Chordia, R Jack Roy, James T Patrie, Giovanni E Davogustto, Christopher M Kramer, Frederick H Epstein, Robert M Carey, Heinrich Taegtmeyer, Susanna R Keller, Bijoy K Kundu
Background Sustained pressure overload leads to changes in cardiac metabolism, function, and structure. Both time course and causal relationships between these changes are not fully understood. Therefore, we studied spontaneously hypertensive rats (SHR) during early hypertension development and compared them to control Wistar Kyoto rats. Methods and Results We serially evaluated myocardial glucose uptake rates (Ki) with dynamic 2-[18 F] fluoro-2-deoxy-D-glucose positron emission tomography, and ejection fraction and left ventricular mass to body weight ratios with cardiac magnetic resonance imaging in vivo, determined glucose uptake and oxidation rates in isolated perfused hearts, and analyzed metabolites, mammalian target of rapamycin activity and endoplasmic reticulum stress in dissected hearts...
February 19, 2019: Journal of the American Heart Association
Yan Chen, Jonathan Vu, Mitchell G Thompson, William A Sharpless, Leanne Jade G Chan, Jennifer W Gin, Jay D Keasling, Paul D Adams, Christopher J Petzold
Recent improvements in the speed and sensitivity of liquid chromatography-mass spectrometry systems have driven significant progress toward system-wide characterization of the proteome of many species. These efforts create large proteomic datasets that provide insight into biological processes and identify diagnostic proteins whose abundance changes significantly under different experimental conditions. Yet, these system-wide experiments are typically the starting point for hypothesis-driven, follow-up experiments to elucidate the extent of the phenomenon or the utility of the diagnostic marker, wherein many samples must be analyzed...
2019: PloS One
Emre Ekmekci, Servet Gencdal, Emine Demirel, Sefa Kelekci
BACKGROUND: Prenatal screening for aneuploidies has seen great changes over the last 2 decades. But there is still no non-invasive diagnostic test. Therefore, prenatal invasive procedures are still being routinely performed due to maternal anxiety. The association of cardiac anomalies and abnormal findings with aneuploidies has been known for a long time. This prospective study was done to evaluate abnormal fetal cardiac examination (FCE) findings on patients undergoing diagnostic invasive procedures due to maternal anxiety and to assess the predictive value of abnormal cardiac findings on abnormal karyotype...
February 2019: Medicine (Baltimore)
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