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Low Ovarian reserv

Elisabeth Pasquier, Luc de Saint-Martin, Gisèle Marhic, Celine Chauleur, Caroline Bohec, Florence Bretelle, Véronique Lejeune-Saada, Jacob Hannigsberg, Geneviève Plu-Bureau, Virginie Cogulet, Philippe Merviel, Dominique Mottier
INTRODUCTION: Recurrent miscarriage (RM), defined by three or more consecutive losses during the first trimester of pregnancy, affects 1%-2% of fertile couples. Standard investigations fail to reveal any apparent cause in ~50% of couples. However, on the basis of animal models and clinical studies, several hypotheses have been put forward concerning underlying mechanisms of RM: altered ovarian reserve, progesterone defect, thrombotic and/or endothelial dysfunction and immunological disturbances...
March 20, 2019: BMJ Open
Ana Carina Heil da Silva Matos, Juliana da Silva Leite, Angélica Consalter, Marcela Freire Valim de Melo, Maria de Lourdes Gonçalves Ferreira, Ana Beatriz Monteiro Fosenca, Ana Maria Reis Ferreira
Granulosa cell tumor (GCT) is a majorly observed ovarian tumor in female dogs. It is essential to diagnose GCT in its initial phase before any symptoms occur, as histological and physiological differences may be observed based on the evolution of this neoplasia. This study aimed to analyze the anatomic histopathology of GCT in its initial stage, with findings of ovaries not yet with the suspicion of neoplasms in the Canis familiaris. A sample including 55 ovaries that presented GCT in 40 female dogs. The histopathological analysis was performed considering the intensity of pleomorphism, vascularization, and inflammatory infiltrate...
March 11, 2019: Reproduction in Domestic Animals
(no author information available yet)
OBJECTIVES: This work assessed sexual and neurobehavioral parameters after ovarian treatment with autologous PRP. DESIGN: Questionnaire study. MATERIAL AND METHODS: Patients receiving ovarian PRP injection (n=80) due to low ovarian reserve and/or at least 1 prior failed IVF cycle were sampled. Pre- and post-treatment levels in self-reported daily energy, sleep quality, skin tone/hair thickness/nail growth, cognitive clarity, menstrual pattern, cervical mucus/vaginal lubrication, libido, sexual activity, ability to achieve orgasm, and overall sexual experience were measured...
January 23, 2019: Neuro Endocrinology Letters
Julia Kopeika, Adeola Oyewo, Sinthiya Punnialingam, Nivedita Reddy, Yacoub Khalaf, Jo Howard, Sofia Mononen, Eugene Oteng-Ntim
BACKGROUND: It has been proposed that ovarian sickling and/or iron overload in women with sickle cell disease (SCD) could contribute to gonadal dysfunction, but there are very few published studies. We hypothesised that the above phenomena might impair ovarian reserve. METHODS: A total of 50 SCD patients were case-matched by age, ethnicity, and presence of regular cycles (28±5 days) with 73 patients without a known haemoglobinopathy who required anti-Müllerian hormone (AMH) assessment in a gynaecology clinic...
2019: PloS One
Yong Zhuo, Lun Hua, Bin Feng, Xuemei Jiang, Jing Li, Dandan Jiang, Xiaohua Huang, Yingguo Zhu, Zhen Li, Lijun Yan, Chao Jin, Lianqiang Che, Zhengfeng Fang, Yan Lin, Shengyu Xu, Jian Li, De Wu
BACKGROUND: Global consumption of protein per capita is rising, while rates of infertility are increasing. However, a clear relationship between protein intake and reproductive health has not been demonstrated. The activation of the quiescent primordial follicles is the first step of folliculogenesis, and their activation must be tightly controlled to prevent premature exhaustion of the ovarian follicular reserve. METHODS: The primordial follicle reserve of wild-type or liver-specific ablation of fibroblast growth factor 21 (FGF21) in mice, subjected to limited or excessive protein diets or oral gavage test, were detected in vivo...
February 13, 2019: EBioMedicine
Salvador Hernández-Martínez, Víctor Cardoso-Jaime, Marcela Nouzova, Veronika Michalkova, Cesar E Ramirez, Francisco Fernandez-Lima, Fernando G Noriega
Anophelinae mosquitoes are vectors of human malaria, a disease that infects hundreds of millions of people and causes almost 600,000 fatalities annually. Despite their medical importance, laboratory studies on key aspects of Anophelinae reproductive biology have been limited, and in particular, relatively little is known about the role of juvenile hormone (JH) in the control of female reproduction. The study presented here attempts to fill a gap of knowledge in our understanding of the JH control of ovarian development in female Anophelinae mosquitoes, using Anopheles albimanus as a model...
February 14, 2019: Scientific Reports
Haroon Latif Khan, Shahzad Bhatti, Samina Suhail, Rohina Gul, Aisha Awais, Humaira Hamayun, Farah Enver, Sana Abbas, Zahira Hassan, Rameen Nisar, Saba Sardar, Warda Asif
BACKGROUND: Despite being born with a significant number of primordial cells which representing the ancestor cells of the germ-line, women experience a depletion of ovarian reserve and sub-fertility mid-way into their healthy lives. The poor ovarian response is a substantial limiting factor amplified with higher maternal age and associated with a considerably lower likelihood of pregnancy. METHODS: A present analytical prospective cross-sectional study was conducted to explore whether infertile women below the age of 40 years have low ovarian reserve than fertile women of same age, assessed by Antral follicle count (AFC) and anti-Müllerian hormone (AMH), at tertiary care infertility center: Lahore Institute of Fertility and Endocrinology, Hameed Latif Hospital...
February 11, 2019: Reproductive Biology and Endocrinology: RB&E
Johnny S Younis, Nora Shapso, Richard Fleming, Izhar Ben-Shlomo, Ido Izhaki
BACKGROUND: Ovarian endometrioma is a frequent manifestation of endometriosis in women of reproductive age. Several issues related to its space occupying effects, local reactions and surgical removal continue to be actively debated today. The impact of ovarian endometrioma per se on ovarian reserve is still controversial and the effect of ovarian surgery is still actively discussed. Furthermore, the optimal biomarker of ovarian reserve estimation in women with ovarian endometrioma is still under examination...
February 1, 2019: Human Reproduction Update
Verena Wieser, Irina Tsibulak, Christine Degasper, Hannah Welponer, Katharina Leitner, Walther Parson, Alain G Zeimet, Christian Marth, Heidelinde Fiegl
Inflammation plays a crucial role in the pathogenesis of cancer with tumor necrosis factor alpha (TNFα) as a key mediator. Recently, spermatogenesis-associated protein 2 (SPATA2) was identified as a TNF receptor modulator which is required for TNF-induced inflammation and apoptosis. The available data on TNFα in ovarian cancer (OC) are inconsistent and SPATA2 is completely uncharacterized in tumorigenesis. We analyzed expression of SPATA2 and TNFA by quantitative real-time PCR in tissues of 171 patients with low grade serous (LGSOC), high grade serous (HGSOC), endometrioid and clear cell OC compared to 28 non-malignant control tissues...
January 30, 2019: Cancer Science
Alexander Volodarsky-Perel, Yoni Cohen, Suha Arab, Weon-Young Son, Eva Suarthana, Michael Haim Dahan, Togas Tulandi, William Buckett
STUDY QUESTION: Do the stage and grade of malignancy affect the fertility preservation outcome in females? SUMMARY ANSWER: Patients with high-grade cancer have a decreased number of retrieved mature oocytes and cryopreserved embryos. WHAT IS KNOWN ALREADY: Cancer has local and systemic effects on the host. The effects of cancer spread and aggressiveness on the ovarian function and stimulation response remain unclear. STUDY DESIGN, SIZE, DURATION: Retrospective cohort study evaluating data of all fertility preservation treatment cycles among women with cancer at the reproductive unit of the McGill University Health Centre in the period from 2008 to 2017...
January 28, 2019: Human Reproduction
Francesca Mossa, James J Ireland
This review summarizes studies we conducted to test the hypothesis that size of the ovarian reserve (number of healthy follicles and oocytes in ovaries) positively impacts ovarian function and fertility in cattle. Key results, primarily in Bos Taurus dairy cattle, show that antral follicle count (AFC) during follicular waves is highly variable between individuals, but very highly repeatable within individuals. Cycling heifers with low (≤ 15 follicles ≥ 3 mm, ~20% of a herd) vs a high AFC (≥ 25, ~20% of a herd) have a smaller ovarian reserve, higher FSH but lower AMH, androstenedione, estradiol and progesterone concentrations...
January 21, 2019: Journal of Animal Science
Su Mi Kim, Yun Oh Kim, Min Kyoung Lee, Youn Jee Chung, In Cheul Jeung, Mee Ran Kim, Jang Heub Kim
Müllerian inhibiting substance/anti-Müllerian hormone (MIS/AMH) is a regulator of the female reproductive system, an indicator of ovarian reserve and a growth inhibitor of Müllerian duct-derived tumors in vivo and in vitro . The objective of the present study was to analyze MIS/AMH type II receptor (MIS/AMHRII) protein and mRNA expression in healthy human endometria compared with patients with endometrial hyperplasia and endometrial cancer, providing a foundation for MIS/AMH as a biological modifier for treatment of endometrial hyperplasia and endometrial cancer...
January 2019: Oncology Letters
Marta Garrido-Marín, Pedro Maria Argacha, Luís Fernández, Florencia Molfino, Fina Martínez-Soler, Avelina Tortosa, Pepita Gimenez-Bonafé
A 43-year-old woman with an associated history of gynecological pathology and breast cancer with only one cryopreserved embryo wished to be a mother. Several factors that influenced the success of the pregnancy in this case were analyzed. Favorable factors included: triple positive breast cancer [positive hormone receptors and positive human epidermal growth factor receptor 2], which is more hormosensitive and chemosensitive; absence of metastasis; correct endometrium preparation; and the patient's optimistic attitude and strict health habits...
January 6, 2019: World Journal of Clinical Cases
A G Grynnerup, K Løssl, F Pilsgaard, S A Lunding, M Storgaard, J W Bogstad, L Prætorius, A Zedeler, L Bungum, A Nyboe Andersen, A Pinborg
BACKGROUND: In assisted reproductive technology, prediction of treatment failure remains a great challenge. The development of more sensitive assays for measuring anti-Müllerian hormone (AMH) has allowed for the possibility to investigate if a lower threshold of AMH can be established predicting very limited or no response to maximal ovarian stimulation. METHODS: A prospective observational multicenter study of 107 women, < 40 years of age with regular menstrual cycle and serum AMH levels ≤ 12 pmol/L, treated with 300 IU/day of HP-hMG in a GnRH-antagonist protocol...
January 11, 2019: Reproductive Biology and Endocrinology: RB&E
Jiali Cai, Lanlan Liu, Yingpei Xu, Zhenfang Liu, Xiaoming Jiang, Ping Li, Aiguo Sha, Jianzhi Ren
OBJECTIVE: To investigate whether supraphysiologic estradiol (E2 ) in controlled ovarian stimulation (COS) cycles affect the subsequent frozen-thawed embryo transfer (FET) in terms of the neonatal birth weight. DESIGN: Retrospective cohort study. SETTING: University affiliated hospital. POPULATION: Two thousand and sixty six patients undergoing FET cycles that result in live singleton births between July 2011 and Dec 2016...
January 9, 2019: BJOG: An International Journal of Obstetrics and Gynaecology
Joshua R Freeman, Brian W Whitcomb, Amrita Roy, Elizabeth R Bertone-Johnson, Nicholas G Reich, Andrew J Healy
Background: Anti-Mϋllerian hormone (AMH) plays an important role regulating ovarian sensitivity to follicle-stimulating hormone and luteinizing hormone in folliculogenesis. Anti-Mϋllerian hormone is well established as a biomarker of ovarian reserve but may also have utility in predicting pregnancy outcomes. Few studies have described AMH levels in pregnancy and, among those that have, most have used cross-sectional study designs and are limited to participants seeking fertility treatment...
August 2018: Health Science Reports
Lingjuan Wang, Su Song, Xuemei Liu, Mengdi Zhang, Wenpei Xiang
RESEARCH QUESTION: Is low MFN2 expression associated with ageing in granulosa cells as well as assisted reproductive technology (ART) outcome, and what is the underlying mechanism of action of MFN2? DESIGN: In a prospective study, fresh granulosa cells were obtained from 161 women aged 20-40 years who underwent IVF with embryo transfer and who were divided into two groups: the diminished ovarian reserve (DOR) group (n = 51) and the control group (n = 110)...
December 14, 2018: Reproductive Biomedicine Online
Michaël Grynberg, Bénédicte Dagher Hayeck, Evangelos G Papanikolaou, Christophe Sifer, Nathalie Sermondade, Charlotte Sonigo
STUDY QUESTION: Are the maturation rates of oocytes recovered from small antral follicles different between breast cancer patients presenting with or without a BRCA 1/2 gene mutation? SUMMARY ANSWER: BRCA 1/2 gene mutations do not affect the capacity of oocytes from breast cancer candidates for fertility preservation to mature in vitro. WHAT IS KNOWN ALREADY: Mutations in the BRCA1 and BRCA2 genes are associated with an increased risk for developing breast and ovarian cancer...
February 1, 2019: Human Reproduction
Anna Nyström, Helena Mörse, Hanna Nordlöf, Karin Wiebe, Maria Artman, Ingrid Øra, Aleksander Giwercman, Emir Henic, Maria Elfving
BACKGROUND: Gonadal dysfunction is one of the major late complications after cancer diagnosis and treatment. The best markers of ovarian reserve in clinical practice are antral follicle count (AFC) and ovarian volume. We aimed to study the prevalence of premature ovarian insufficiency (POI) and evaluate anti-Müllerian hormone (AMH) and other serum markers for ovarian function in adult women who were childhood cancer survivors (CCS) in comparison with a control group. MATERIAL AND METHODS: Altogether, 167 female CCS were compared to 164 matched controls...
February 2019: Acta Oncologica
M G Favoreto, B Loureiro, R L Ereno, A G Pupulim, V Queiroz, Natieli Andrade da Silva, C M Barros
The number of antral follicles counted by ultrasound (AFC) is associated with fertility in cattle. Cows with higher follicle count (HFC) have higher performance in reproductive-assisted technologies than cows with lower follicle count (LFC). In this study, we aimed to define the preantral follicle count by histology and to identify differentially expressed genes (DEGs) using a microarray in Nelore and Angus heifers with HFC and LFC. The ovaries of each animal were scanned with an ultrasound device 12-24 hours after estrus...
December 8, 2018: Molecular Reproduction and Development
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