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Hematology guideline

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https://read.qxmd.com/read/30769959/bioactivity-determination-of-a-therapeutic-recombinant-human-keratinocyte-growth-factor-by-a-validated-cell-based-bioassay
#1
Wenrong Yao, Ying Guo, Xi Qin, Lei Yu, Xinchang Shi, Lan Liu, Yong Zhou, Jinpan Hu, Chunming Rao, Junzhi Wang
The therapeutic recombinant human keratinocyte growth factor 1 (rhKGF-1) was approved by the FDA for oral mucositis resulting from hematopoietic stem cell transplantation for hematological malignancies in 2004. However, no recommended bioassay for rhKGF-1 bioactivity has been recorded in the U.S. Pharmacopoeia. In this study, we developed an rhKGF-1-dependent bioassay for determining rhKGF-1 bioactivity based on HEK293 and HaCat cell lines that stably expressed the luciferase reporter driven by the serum response element (SRE) and human fibroblast growth factor receptor (FGFR2) IIIb...
February 15, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/30761222/treatment-of-multiple-myeloma-in-elderly-patients-a-review-of-literature-and-practice-guidelines
#2
REVIEW
Suresh Manapuram, Hamza Hashmi
Multiple myeloma (MM) is a clonal disorder of malignant plasma cells that comprises approximately 10% of hematologic malignancies. With median age of 66 at the time of presentation, multiple myeloma is predominantly a disease of the elderly. The availability of new combination regimens and the enhanced safety of autologous hematopoietic stem cell transplant has increased the treatment options for elderly patients with multiple myeloma. We provide a summary of data supporting the current management of elderly patients with newly diagnosed multiple myeloma...
December 1, 2018: Curēus
https://read.qxmd.com/read/30754019/development-and-validation-of-lc-ms-ms-methods-for-the-quantification-of-the-novel-anticancer-agent-guadecitabine-and-its-active-metabolite-%C3%AE-%C3%A2-decitabine-in-human-plasma-whole-blood-and-urine
#3
Jeroen Roosendaal, Kai Wang, Hilde Rosing, Luc Lucas, Abadi Gebretensae, Aram Oganesian, Jan H M Schellens, Jos H Beijnen, Zhongping John Lin
Guadecitabine (SGI-110), a dinucleotide of β‑decitabine and deoxyguanosine, is currently being evaluated in phase II/III clinical trials for the treatment of hematological malignancies and solid tumors. This article describes the development and validation of bioanalytical assays to quantify guadecitabine and its active metabolite β‑decitabine in human plasma, whole blood and urine using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Since β‑decitabine is rapidly metabolized further by cytidine deaminase, plasma and whole blood samples were kept on ice-water after collection and stabilized with tetrahydrouridine (THU) directly upon sample collection...
January 22, 2019: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://read.qxmd.com/read/30737868/the-impact-of-a-multimodal-approach-to-vancomycin-discontinuation-in-hematopoietic-stem-cell-transplant-recipients-hsct-with-febrile-neutropenia-fn
#4
Sarah Perreault, Dayna McManus, Noffar Bar, Francine Foss, Lohith Gowda, Iris Isufi, Stuart Seropian, Maricar Malinis, Jeffrey E Topal
BACKGROUND: Current guidelines recommend adding vancomycin to empiric treatment of FN in patients who meet specific criteria. After 48 hours, the guidelines recommend discontinuing vancomycin if resistant Gram-positive organisms are not identified. Based on these recommendations, a vancomycin stewardship team defined criteria for discontinuation of vancomycin at 48 hours and increased surveillance of vancomycin usage through a multimodal approach. The purpose of this retrospective analysis is to assess the impact of this multimodal approach on the discontinuation of empiric vancomycin at 48 hours in FN...
February 8, 2019: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/30734241/age-associated-hematological-toxicity-in-patients-with-metastatic-castration-resistant-prostate-cancer-treated-with-docetaxel-in-clinical-practice
#5
Marie-Rose B S Crombag, Aurelia H M de Vries Schultink, Jacobine G C van Doremalen, Hans-Martin Otten, Andries M Bergman, Jan H M Schellens, Jos H Beijnen, Alwin D R Huitema
BACKGROUND: Older patients with metastatic castration-resistant prostate cancer (mCRPC) may be more prone to chemotherapy-induced hematological toxicity, but tailored docetaxel dosing guidelines in older patients are lacking because of conflicting data. OBJECTIVE: This study aims to evaluate the impact of older age on the incidence of hematological toxicity in patients with mCRPC treated with docetaxel in daily clinical practice. METHODS: This study included patients with mCRPC treated with docetaxel between January 2006 and January 2016 at the Netherlands Cancer Institute and Medical Center Slotervaart for whom dosing and hematological toxicity data were available from electronic patient records...
February 8, 2019: Drugs & Aging
https://read.qxmd.com/read/30719282/catheter-related-bloodstream-infections-with-coagulase-negative-staphylococci-are-antibiotics-necessary-if-the-catheter-is-removed
#6
Ursula Patricia Hebeisen, Andrew Atkinson, Jonas Marschall, Niccolò Buetti
Background: Catheter-related bloodstream infections (CRBSI) with coagulase-negative Staphylococci (CoNS) are a common source of hospital-acquired bloodstream infections. The main objective of this study was to elucidate the role of systemic antibiotic therapy in the setting of catheter removal in adult patients with CoNS-CRBSI. Methods: We conducted a retrospective cohort study on patients with CoNS-CRBSI diagnosed between 2008 and 2016 with follow-up for up to 12 months...
2019: Antimicrobial Resistance and Infection Control
https://read.qxmd.com/read/30717781/treatment-of-oral-cancers-during-pregnancy-a-case-based-discussion
#7
Kiyoshi Sato, Hiroaki Shimamoto, Yumi Mochizuki, Hideaki Hirai, Hirofumi Tomioka, Risa Shimizu, Eriko Marukawa, Haruhisa Fukayama, Ryoichi Yoshimura, Hiroo Ishida, Hiroyuki Harada
BACKGROUND: Malignancies occur in approximately 1:1000 pregnancies; the most common being breast (46%) and hematological (18%) malignancies. Oral cancers account for only 2% of all cancers in pregnant women, and there are no standard guidelines for the treatment of oral cancer during pregnancy. METHODS: Between 2007 and 2014, our department managed 1109 patients with oral cancers; four (0.4%) had tongue carcinomas during pregnancy. These cases were retrospectively reviewed...
February 4, 2019: Journal of Otolaryngology—Head & Neck Surgery
https://read.qxmd.com/read/30712406/treatment-patterns-in-patients-with-acute-myeloid-leukemia-in-the-united-states-a-cross-sectional-real-world-survey
#8
Bruno C Medeiros, Bhavik J Pandya, Anna Hadfield, James Pike, Samuel Wilson, Cynthia Mueller, Cat N Bui, Scott C Flanders, Alex Rider, Laura E Horvath
OBJECTIVE: The aim of this analysis was to examine treatment patterns in patients with acute myeloid leukemia (AML) in routine clinical practice in the United States, including factors influencing the choice of front-line treatment intensity and the effect of age and treatment line. METHODS: We used data from the Adelphi AML Disease Specific Programme, a real-world, cross-sectional survey conducted in 2015. Physicians completed patient record forms providing patients' demographic and clinical characteristics...
February 2, 2019: Current Medical Research and Opinion
https://read.qxmd.com/read/30706680/turner-syndrome-new-insights-from-prenatal-genomics-and-transcriptomics
#9
Diana W Bianchi
In some parts of the world, prenatal screening using analysis of circulating cell-free (cf) DNA in the plasma of pregnant women has become part of routine prenatal care with limited professional guidelines and without significant input from the Turner syndrome community. In contrast to the very high positive predictive values (PPVs) achieved with cfDNA analysis for trisomy 21 (91% for high-risk and 82% for low-risk cases), the PPVs for monosomy X are much lower (~26%). This is because the maternal plasma sample contains both maternal cfDNA and placental DNA, which is a proxy for the fetal genome...
January 31, 2019: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://read.qxmd.com/read/30704220/-chinese-guideline-on-the-diagnosis-and-treatment-of-primary-myelofibrosis-2019
#10
(no author information available yet)
No abstract text is available yet for this article.
January 14, 2019: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://read.qxmd.com/read/30701465/jsh-practical-guidelines-for-hematological-malignancies-2018-ii-lymphoma-8-adult-t-cell-leukemia-lymphoma
#11
Kunihiro Tsukasaki, Takuya Fukushima
No abstract text is available yet for this article.
January 30, 2019: International Journal of Hematology
https://read.qxmd.com/read/30701071/using-local-clinical-and-microbiological-data-to-develop-an-institution-specific-carbapenem-sparing-strategy-in-sepsis-a-nested-case-control-study
#12
Merel M C Lambregts, Bart J C Hendriks, Leo G Visser, Sandra T Bernards, Mark G J de Boer
Background: From a stewardship perspective it is recommended that antibiotic guidelines are adjusted to the local setting, accounting for the local epidemiology of pathogens. In many settings the prevalence of Gram-negative pathogens with resistance to empiric sepsis therapy is increasing. How and when to escalate standard sepsis therapy to a reserve antimicrobial agent, is a recurrent dilemma. The study objective was to develop decision strategies for empiric sepsis therapy based on local microbiological and clinical data, and estimate the number needed to treat with a carbapenem to avoid mismatch of empiric therapy in one patient (NNTC)...
2019: Antimicrobial Resistance and Infection Control
https://read.qxmd.com/read/30689456/thrombotic-complications-in-adult-patients-with-severe-single-coagulation-factor-or-platelet-defects-an-overview
#13
Hanne Skaadel, Øystein Bruserud
Even though thrombotic events are rare in patients with coagulation deficiencies, several cases of both arterial and venous thromboses have been reported in patients with single coagulation factor defects and platelet defects. Thromboses have been described both in hemophilia A and B, von Willebrand disease as well as in many other rare congenital coagulation factor and platelet defects. Thromboses may also occur in patients with acquired hemophilia and in patients with severe thrombocytopenia due to hematological malignancies or intensive chemotherapy...
January 28, 2019: Expert Review of Hematology
https://read.qxmd.com/read/30681025/factors-affecting-same-day-cancelation-of-outpatient-pediatric-oncologic-procedural-sedation
#14
Jocelyn R Grunwell, Lillian D Long, Leah N Bryan, Tammy Kelley, Himalee S Sabnis, Harold K Simon, Pradip P Kamat
BACKGROUND: Children with cancer undergo serial invasive, painful procedures as a part of their diagnosis, treatment, and surveillance regimens that require procedural sedation (PS). Some may have a delay in their treatment plan due to same-day cancelation (SDC) of the procedure due to issues related to sedation or other factors. The objective of this report was to evaluate the factors resulting in the SDC of hematology and oncology patients in an outpatient pediatric sedation service...
January 25, 2019: Pediatric Hematology and Oncology
https://read.qxmd.com/read/30673943/the-efficacy-and-safety-of-a-catheter-removal-only-strategy-for-the-treatment-of-picc-line-thrombosis-versus-standard-of-care-anticoagulation-a-retrospective-review
#15
Joseph J Shatzel, Dylan Mart, Jeffrey Y Bien, Ashray Maniar, Sven Olson, Timothy K Liem, Thomas G DeLoughery
Peripherally-inserted central catheters (PICCs) are commonly used during hospitalization. Unfortunately, their use can be complicated by catheter-related thrombosis (CRT). Current guidelines recommend 3-6 months of anticoagulation for patients with CRT after catheter removal. This recommendation is based on extrapolation of data on lower extremity thrombosis, as data is lacking regarding the efficacy and safety of more specific management strategies. Many providers feel catheter removal alone is a reasonable treatment option, particularly for patients at risk for bleeding...
January 23, 2019: Journal of Thrombosis and Thrombolysis
https://read.qxmd.com/read/30672336/combined-pathology-driven-algorithmic-testing-and-integrated-reporting-for-bone-marrow-examination
#16
Lauren N Pearson, Jill M Miller, John H Lunde, Ronald J Bryant, Michael R Lewis, Mary E Tang
CONTEXT.—: The College of American Pathologists published guideline recommending bone marrow synoptic reporting for hematologic neoplasms. OBJECTIVE.—: To evaluate the impact of pathology-driven algorithmic testing (PDAT) with integrated reporting for bone marrow examination on test utilization, ability to render a specific World Health Organization diagnosis, and clinician satisfaction 1 year after implementation. DESIGN.—: We reviewed the hematopathology reports, integrated synoptic reports, and ancillary test results generated during a 12-month period...
January 23, 2019: Archives of Pathology & Laboratory Medicine
https://read.qxmd.com/read/30671910/jsh-practical-guidelines-for-hematological-malignancies-2018-7-peripheral-t-cell-lymphoma-ptcl
#17
Motoko Yamaguchi, Ritsuro Suzuki
No abstract text is available yet for this article.
January 22, 2019: International Journal of Hematology
https://read.qxmd.com/read/30665627/partial-splenectomy-who-when-and-how-a-systematic-review-of-the-2130-published-cases
#18
REVIEW
Renato Costi, Carolina Castro Ruiz, Andrea Romboli, Philippe Wind, Vincenzo Violi, Alban Zarzavadjian Le Bian
BACKGROUND/PURPOSE: In order to avoid consequences of total splenectomy (including severe postsplenectomy sepsis), partial splenectomy (PS) is increasingly reported. Without guidelines and indications concerning a rarely-indicated procedure, a review of literature should be an asset. METHODS: A systematic review of all PSs from 1960 to December 2017 was performed, with special focus on surgical indications, sites of resection, approaches and techniques of vascular dissection and parenchymal section/hemostasis of the spleen, perioperative morbidity/mortality, including complications compelling to perform total splenectomy...
December 5, 2018: Journal of Pediatric Surgery
https://read.qxmd.com/read/30652618/implementation-of-computerized-physician-order-entry-for-chemotherapy-a-latin-american-experience
#19
Fernando S Valencia, Rossana Ruiz, Silvia P Neciosup, Luis A Mas, Karina M Aliaga, Flor Huaman, Jenny Ruiz, Edinson Vasquez, Noel Llacctahuaman, Robert Pedraza, Missael Paz, Willam Aguirre, Henry L Gomez
PURPOSE: We describe the implementation process of a computerized physician order entry (CPOE) for outpatient chemotherapy at a Latin American hospital, with the intent of providing other institutions with general guidance and insight through our experience. METHODS: In 2012, under the direction of the Department of Medicine of the Instituto Nacional de Enfermedades Neoplásicas, a multidisciplinary team composed of oncologists, nurses, pharmacists, and informatics engineers was formed to develop software for a CPOE for chemotherapy within a preexistent homegrown electronic medical record system in various phases...
December 2018: JCO Clinical Cancer Informatics
https://read.qxmd.com/read/30635666/-diagnosis-and-treatment-of-kidney-involvement-in-plasma-cell-diseases-renal-involvement-in-multiple-myeloma-and-monoclonal-gammopathies
#20
REVIEW
V Gödecke, J J Schmidt, J H Bräsen, C Koenecke, H Haller
BACKGROUND: Kidney involvement is a common complication in patients with plasma cell diseases. OBJECTIVE: This article outlines the spectrum of renal involvement in plasma cell dyscrasia and describes diagnostic and therapeutic measures to guide clinical management. MATERIAL AND METHODS: Evaluation and discussion of the current literature as well as existing guidelines and recommendations of professional societies. RESULTS: The clinical manifestations of renal involvement in plasma cell disorders are heterogeneous and range from acute cast nephropathy in multiple myeloma to rare forms of glomerulonephritis...
January 2019: Der Internist
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