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Cataract etiology

Kristin Neatrour, Allison McAlpine, Timothy Brooks Owens, Rupal H Trivedi, Lynn J Poole Perry
BACKGROUND: The purpose of this study was to evaluate patients with persistent iritis after cataract surgery to determine its incidence and risk factors. Adjusting the management of patients at risk could allow for a more predictable post-operative course and outcome. A retrospective chart review was performed of patients who had post-operative iritis longer than 1 month after cataract surgery during a 2-year period at Storm Eye Institute at the Medical University of South Carolina (MUSC) in Charleston, South Carolina...
February 18, 2019: Journal of Ophthalmic Inflammation and Infection
Eun Young Choi, Jae Yong Han, Hyukmin Lee, Sung Chul Lee, Hyoung Jun Koh, Sung Soo Kim, Min Kim
PURPOSE: Infectious endophthalmitis (IE) is a severe complication that can lead to blindness even with treatment. However, the impact of antibiotic resistance and early vitrectomy on its prognosis has scarcely been documented. This study investigated the impact of antibiotic resistance of pathogen and early vitrectomy on the prognosis of IE. METHODS: The medical records of 171 patients treated for IE at a tertiary referral center between 2007 and 2016 were retrospectively reviewed and analyzed for etiology, pathogen, drug resistance to vancomycin or third-generation cephalosporins, treatment types and timing, and visual outcomes...
February 13, 2019: Graefe's Archive for Clinical and Experimental Ophthalmology
Nathaniel P Violette, Eric C Ledbetter
OBJECTIVE: To describe clinical features of dogs with lipemic uveitis (LU). ANIMALS STUDIED: Seventy-five dogs (114 eyes) with LU. PROCEDURES: Medical records of dogs examined by the Cornell University ophthalmology service with a clinical diagnosis of LU between 2008 and 2017 were analyzed. Signalment and clinical case aspects, including concurrent ocular disease, systemic disease, and previous ophthalmic surgery, were recorded. RESULTS: Lipemic uveitis was diagnosed in 114 eyes of 75 dogs...
February 4, 2019: Veterinary Ophthalmology
Anita Ambastha, Rakhi Kusumesh, Shalini Sinha, Bibhuti P Sinha, Gyan Bhasker
Purpose: To analyze applications for blindness certificates to find causes of visual impairment (VI), handicap, and blindness in a tertiary hospital of Bihar. Methods: Applications for blindness certificates were analyzed over a two-year period. The main cause of blindness, visual handicap, and VI in these applications was ascertained by age group and etiology. VI disability percentages and definitions proposed by Governmen of India (category 0-4; 20-100%) were used to categorize and give percentage to all applicants...
February 2019: Indian Journal of Ophthalmology
Daphné Lehalle, Umut Altunoglu, Ange-Line Bruel, Mirna Assoum, Yannis Duffourd, Alice Masurel, Geneviève Baujat, Bettina Bessieres, Guillaume Captier, Patrick Edery, Nursel H Elçioğlu, David Geneviève, Alice Goldenberg, Delphine Héron, Sarah Grotto, Sandrine Marlin, Audrey Putoux, Massimiliano Rossi, Pascale Saugier-Veber, Stéphane Triau, Christelle Cabrol, Myriam Vézain, Catherine Vincent-Delorme, Christel Thauvin-Robinet, Julien Thevenon, Pierre Vabres, Patrick Callier, Hulya Kayserili, Laurence Faivre
The oculoauriculofrontonasal syndrome (OAFNS) is a rare disorder characterized by the association of frontonasal dysplasia (widely spaced eyes, facial cleft, and nose abnormalities) and oculo-auriculo-vertebral spectrum (OAVS)-associated features, such as preauricular ear tags, ear dysplasia, mandibular asymmetry, epibulbar dermoids, eyelid coloboma, and costovertebral anomalies. The etiology is unknown so far. This work aimed to identify molecular bases for the OAFNS. Among a cohort of 130 patients with frontonasal dysplasia, accurate phenotyping identified 18 individuals with OAFNS...
December 10, 2018: American Journal of Medical Genetics. Part A
Rafael Guerra, Ricardo Cabeças, Jesus Diaz, Tim Knott, Inês Freitas, Hugo Vilhena, Sofia Duarte
Cataracts are among the most common ocular diseases, and are a leading cause of vision loss in humans and dogs. Jack Russell Terriers (JRT) and Labrador Retrievers (LR) are among the most popular canine breeds in the United Kingdom, and also among the most affected by cataracts. This study aimed to analyze the clinical features and the surgical outcome of cataracts in JRT and LR in an ophthalmologic reference Veterinary Hospital in the United Kingdom. For that purpose, medical records from JRT and LR diagnosed with cataracts between January 2015 and December 2016 were retrospectively evaluated...
December 2018: Topics in Companion Animal Medicine
Vivek Pravin Dave, Joveeta Joseph, Avinash Pathengay, Rajeev R Pappuru
AIM: To describe the clinical presentations and management outcomes of Kocuria endophthalmitis and discuss diagnostic dilemmas DESIGN: Retrospective interventional comparative case series INTERVENTION: Eight unilateral cases with culture-proven Kocuria endophthalmitis from January 2013 to December 2017 underwent vitrectomy/vitreous biopsy and intravitreal antibiotic with or without additional procedures. The undiluted vitreous was subjected to microbiologic evaluation. MAIN OUTCOME MEASURES: The mean age at presentation, etiology, number of interventions, interval between inciting event and presentation, type of intravitreal antibiotic used, and anatomic and functional outcomes were reported...
November 20, 2018: Journal of Ophthalmic Inflammation and Infection
Yoichi Wada, Atsuo Kikuchi, Natsuko Arai-Ichinoi, Osamu Sakamoto, Yusuke Takezawa, Shinya Iwasawa, Tetsuya Niihori, Hiromi Nyuzuki, Yoko Nakajima, Erika Ogawa, Mika Ishige, Hiroki Hirai, Hideo Sasai, Ryoji Fujiki, Matsuyuki Shirota, Ryo Funayama, Masayuki Yamamoto, Tetsuya Ito, Osamu Ohara, Keiko Nakayama, Yoko Aoki, Seizo Koshiba, Toshiyuki Fukao, Shigeo Kure
PURPOSE: Galactosemia is caused by metabolic disturbances at various stages of galactose metabolism, including deficiencies in enzymes involved in the Leloir pathway (GALT, GALK1, and GALE). Nevertheless, the etiology of galactosemia has not been identified in a subset of patients. This study aimed to explore the causes of unexplained galactosemia. METHODS: Trio-based exome sequencing and/or Sanger sequencing was performed in eight patients with unexplained congenital galactosemia...
October 19, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Anton M Kolomeyer, Christopher K Hwang, Benjamin J Kim
BACKGROUND: Ibrutinib is a tyrosine kinase inhibitor commonly used in patients with chronic lymphocytic leukemia. Based on the published literature, it has a very sound ophthalmologic safety profile. In the following, we describe a case of anterior chamber fibrinoid syndrome in a patient on ibrutinib for B-cell chronic lymphocytic leukemia after uncomplicated cataract extraction. CASE PRESENTATION: A 75-year-old white man with B-cell chronic lymphocytic leukemia on ibrutinib therapy and without significant past ocular history presented 1 day after uncomplicated phacoemulsification with in-the-bag intraocular lens implantation with multiple, discrete, pigmented cords in the anterior chamber...
November 16, 2018: Journal of Medical Case Reports
Jelena Juri Mandić, Petra Kristina Ivkić, Krešimir Mandić, Dina Lešin, Tomislav Jukić, Jasenka Petrović Jurčević
BACKGROUND: The aim of this study was to assess subjective, human aspect of the medical condition, evaluate the quality of life (QOL) and level of depressive symptoms in patients with watery eye and compare it with patients with two most common causes of visual deterioration: cataract and macular region pathology. The results of this study may serve to raise awareness of watery eye impact on a large number of patients and subsequently promote their treatment in order to restore full visual and life quality necessary for normal human functioning...
December 2018: Psychiatria Danubina
John H Niffenegger, Arysol Soltero, James S Niffenegger, Sufang Yang, Grazyna Adamus
Objective: The goal was to test the hypothesis that high serum hepatocyte growth factor (HGF) and retinal autoantibodies against α-HGF contribute to the pathology of bilateral diffuse melanocytic proliferation (BDUMP). Methods: Case report of an elderly diagnosed with neovascular age-related macular degeneration (n-AMD) treated with bilateral Bevacizumab injections. Examination included comprehensive ophthalmic examination and images obtained by fundus photography, fundus autofluorescence, fluorescein angiography, spectral-domain optical coherence tomography (OCT), and B-scan ultrasonography...
2018: Journal of Clinical & Experimental Ophthalmology
Choul Yong Park, Jimmy K Lee, Roy S Chuck
BACKGROUND: Toxic anterior segment syndrome (TASS) can be a rare complication of anterior segment surgery. Here we reviewed the most recent advances in the understanding of TASS. METHODS: English articles related to TASS were retrieved from "PubMed" using the following keywords; "toxic anterior segment syndrome" or "TASS". The authors of this paper reviewed all the retrieved literature and critical findings were summarized. RESULTS: The onset of TASS can vary from hours to months...
October 25, 2018: BMC Ophthalmology
Vivek Pravin Dave, Joveeta Joseph, Avinash Pathengay, Rajeev R Pappuru, Taraprasad Das
PURPOSE: To describe the clinical presentation and management of Curvularia endophthalmitis and compare with previous published literature. METHODS: Retrospective interventional comparative case series and literature review. Eight cases with culture-proven Curvularia endophthalmitis from January 2000 to March 2018 underwent vitrectomy/vitreous biopsy, intravitreal antibiotic with or without additional procedures as appropriate. The undiluted vitreous biopsy was subjected to microbiologic evaluation...
October 23, 2018: Retina
Xin-Yu Zhao, Song Xia, You-Xin Chen
PURPOSE: To estimate the success and safety of diagnostic pars plana vitrectomy (PPV) in determining the etiology of uveitis initially unknown and analyze their characteristics. METHODS: The PubMed, Embase, and Ovid were searched up to October 2017 to identify relevant studies. The PRISMA guidelines were followed. Statistical analyses were performed with R version 3.3.1. Result in proportion were transformed by the Freeman-Tukey variant of arcsine square to attain symmetry of confidence intervals (CIs)...
October 23, 2018: Retina
Zohar Habot-Wilner, Liran Tiosano, Juan M Sanchez, Shiri Shulman, Dana Barequet, Ori Rahat, Gil Amarilyo, Radgonde Amer
PURPOSE: To report the epidemiology, etiology, ocular characteristics, treatment and visual outcome of pediatric uveitis in Israel. METHODS: Retrospective study from two tertiary uveitis centers. RESULTS: Included were 107 patients (182 eyes), 55% females. Mean age at diagnosis 8.8 years. Uveitis was predominantly anterior, idiopathic, bilateral, and chronic. Systemic associations were seen in 36% of patients of which the most common disease was juvenile idiopathic arthritis...
October 17, 2018: Ocular Immunology and Inflammation
F H Verhagen, E C A Stigter, M L Pras-Raves, B M T Burgering, S M Imhof, T R D J Radstake, J H de Boer, J J W Kuiper
PURPOSE: HLA-B27 positive acute anterior uveitis has a higher recurrence rate and shows more anterior chamber cell infiltration compared to HLA-B27-negative patients, suggesting distinct etiology of these clinically overlapping conditions. To advance our understanding of the biology of acute anterior uveitis, we characterized the metabolic profile of aqueous humor (AqH) of patients with HLA-B27 associated anterior uveitis (B27-AAU) and non-infectious idiopathic anterior uveitis (idiopathic AAU)...
October 9, 2018: American Journal of Ophthalmology
Idan Hecht, Asaf Bar, Lior Rokach, Romi Noy Achiron, Marion R Munk, Wolfgang Huf, Zvia Burgansky-Eliash, Asaf Achiron
PURPOSE: In diabetic patients presenting with macular edema (ME) shortly after cataract surgery, identifying the underlying pathology can be challenging and influence management. Our aim was to develop a simple clinical classifier able to confirm a diabetic etiology using few spectral domain optical coherence tomography parameters. METHODS: We analyzed spectral domain optical coherence tomography data of 153 patients with either pseudophakic cystoid ME (n = 57), diabetic ME (n = 86), or "mixed" (n = 10)...
October 3, 2018: Retina
J Fernando Arevalo, Andres F Lasave, Vishali Gupta, Igor Kozak, Hanan Nasser Al Shamsi, Sulaiman Mohammad Al Suliman, Abdulaziz Adel Al Rushood, Yahya A Al-Zahrani, Ammar M Al-Mahmood, Hassan A Al Dhibi
PURPOSE: To describe the clinical characteristics and surgical outcomes of panuveitis over a 10-year period. METHODS: Data were collected on panuveitis etiology, treatment, surgery and change in vision. RESULTS: Overall, 308 patients (594 eyes) were evaluated, 54.9% with non-granulomatous and 45.1% with granulomatous uveitis. Fifty-four patients had infectious and 254 had non-infectious uveitis. In infectious panuveitis, vision remained unchanged at last visit...
October 10, 2018: Ocular Immunology and Inflammation
Charoula Matalliotaki, Michail Matalliotakis, Maria I Zervou, Alexandra Trivli, Ioannis Matalliotakis, George Mavromatidis, Demetrios A Spandidos, Hans M Albertsen, Rakesh Chettier, Kenneth Ward, George N Goulielmos
Endometriosis is an enigmatic condition with an unknown etiology and poorly understood pathogenesis and women with endometriosis represent a high-risk population group for a large category of chronic conditions. The study focused on a 67-year-old woman who presented with a 40-year history of familial endometriosis associated with various non-gynecological co-morbidities, thus representing a unique case from a cohort of 1,000 patients with endometriosis. Her family history included infertile members suffering from endometriosis...
December 2018: Molecular Medicine Reports
Vivek Pravin Dave, Avinash Pathengay, Savitri Sharma, N Naveen, Soumyava Basu, Rajeev R Pappuru, Taraprasad Das
PURPOSE: To describe the clinical presentations, diagnosis, and management outcomes of Nocardia endophthalmitis. DESIGN: Retrospective, interventional, multicenter case series. METHODS: The study was conducted in a multicentric institutional practice setup and included 25 eyes of 25 patients with culture-proven Nocardia endophthalmitis. Anterior chamber fluid and/or vitreous and/or intraocular lens were submitted for microbiological evaluation in all cases...
January 2019: American Journal of Ophthalmology
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