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J N Ma, Y Wang, Y Song, T Shao, Y Cai
Objective: To investigate the influence of corneal biomechanical properties on opaque bubble layer (OBL) in small incision lenticule extraction (SMILE). Methods: In this nested case control study, 20 patients (31 eyes) were enrolled in OBL group, while 51 patients (98 eyes) were included in non-OBL group. The parameters were obtained by Pentacam HR and Corvis ST examinations. Independent t test was used to analyze the difference of corneal biomechanical parameters between the two groups and multivariable logistics regression was applied to analysis the influence of corneal biomechanical properties on OBL...
February 11, 2019: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Magdalena Jędzierowska, Robert Koprowski
BACKGROUND: Non-contact tonometers based on the method using air puff and Scheimpflug's fast camera are one of the latest devices allowing the measurement of intraocular pressure and additional biomechanical parameters of the cornea. Biomechanical features significantly affect changes in intraocular pressure values, as well as their changes, may indicate the possibility of corneal ectasia. This work presents the latest and already known biomechanical parameters available in the new offered software...
February 13, 2019: Biomedical Engineering Online
Lisa Ramm, Robert Herber, Eberhard Spoerl, Lutz E Pillunat, Naim Terai
PURPOSE: Hyperglycemia in diabetes mellitus (DM) might induce changes in corneal biomechanics. Therefore, biomechanical properties of the cornea were measured using the ocular response analyzer and the Corvis ST. METHODS: In the study, 35 eyes of 35 diabetic patients were included. After an ophthalmological examination, measurements with the ocular response analyzer and the Corvis ST were taken. Additionally, biometry and corneal topography were performed and HbA1c values were collected...
January 23, 2019: Cornea
Andres M Alonso, Maria M Corvi, Luis Diambra
Infectious diseases are of great relevance for global health, but needed drugs and vaccines have not been developed yet or are not effective in many cases. In fact, traditional scientific approaches with intense focus on individual genes or proteins have not been successful in providing new treatments. Hence, innovations in technology and computational methods provide new tools to further understand complex biological systems such as pathogen biology. In this paper, we apply a gene regulatory network approach to analyze transcriptomic data of the parasite Toxoplasma gondii...
January 24, 2019: Scientific Reports
Rohit Shetty, Nimisha Rajiv Kumar, Pooja Khamar, Matthew Francis, Swaminathan Sethu, J Bradley Randleman, Ronald R Krueger, Abhijit Sinha Roy, Arkasubhra Ghosh
PURPOSE: To evaluate extracellular matrix regulators and inflammatory factors in a patient who developed ectasia after small incision lenticule extraction (SMILE) despite normal preoperative tomographic and biomechanical evaluation. METHODS: The SMILE lenticules from both eyes of the patient with ectasia and three control patients (5 eyes) matched for age, sex, and duration of follow-up were used for gene expression analysis of lysyl oxidase (LOX), matrix metalloproteinase 9 (MMP9), collagen types I alpha 1 (COLIA1) and IV alpha 1 chain (COLIVA1), transforming growth factor-beta (TGF-beta), bone morphogenetic protein 7 (BMP7), interleukin-6 (IL-6), cathepsin K, cluster of differentiation 68, integrin beta-1, and tissue inhibitor of metalloproteinase-1 (TIMP1)...
January 1, 2019: Journal of Refractive Surgery
Alireza Karimi, Najme Meimani, Reza Razaghi, Seyed Mohammadali Rahmati, Khosrow Jadidi, Mostafa Rostami
BACKGROUND: Keratoconus is recognized by asymmetrical thinning and bulging of the cornea, resulting a distortion in the surface of the cornea. Keratoconus also alters the biomechanical properties of the cornea, which can be an indicator of the healthy and keratoconus eyes. This study was aimed at employing a combination of clinical data, finite element method (FEM), and artificial neural network (ANN) to establish a novel biomechanical-based diagnostic method for the keratoconus eyes...
December 24, 2018: Current Pharmaceutical Design
Mario Beilmann, Harrie Boonen, Andreas Czich, Gordon Dear, Philip Hewitt, Tomas Mow, Peter Newham, Teija Oinonen, Francois Pognan, Adrian Roth, Jean-Pierre Valentin, Freddy Van Goethem, Richard J Weaver, Barbara Birk, Scott Boyer, Francesca Caloni, Alice E Chen, Raffaella Corvi, Mark T D Cronin, Mardas Daneshian, Lorna C Ewart, Rex E Fitzgerald, Geraldine A Hamilton, Thomas Hartung, Joshua D Kangas, Nynke I Kramer, Marcel Leist, Uwe Marx, Sebastian Polak, Costanza Rovida, Emanuela Testai, Bob Van der Water, Paul Vulto, Thomas Steger-Hartmann
Investigative Toxicology describes the de-risking and mechanistic elucidation of toxicities, supporting early safety decisions in the pharmaceutical industry. Recently, Investigative Toxicology has contributed to a shift in pharmaceutical toxicology, from a descriptive to an evidence-based, mechanistic discipline. This was triggered by high costs and low throughput of Good Laboratory Practice in vivo studies, and increasing demands for adhering to the 3R (Replacement, Reduction and Refinement) principles of animal welfare...
December 20, 2018: ALTEX
Mohammad-Reza Sedaghat, Hamed Momeni-Moghaddam, Renato Ambrósio, Cynthia J Roberts, Abbas-Ali Yekta, Zeynab Danesh, Sven Reisdorf, Mehdi Khabazkhoob, Hamid-Reza Heidari, Javad Sadeghi
PURPOSE: To compare the long-term changes in corneal biomechanics, topography, and tomography before and 4 years after corneal cross-linking (CXL) with the Dresden protocol and correlate these changes with visual acuity. METHODS: In this longitudinal study, 18 eyes of 18 patients with progressive keratoconus who were treated with CXL were included. All patients received a standard ophthalmological examination and were examined by Placido disc-based topography, Scheimpflug tomography, and biomechanical assessments with the Corvis ST (OCULUS Optikgeräte GmbH, Wetzlar, Germany) and Ocular Response Analyzer (ORA; Reichert Ophthalmic Instruments, Buffalo, NY) before and 4 years after CXL...
December 1, 2018: Journal of Refractive Surgery
Johannes Steinberg, Marlene Siebert, Toam Katz, Andreas Frings, Juliane Mehlan, Vasyl Druchkiv, Jens Bühren, Stephan J Linke
PURPOSE: To analyze the potential benefit of the newly developed Tomography and Biomechanical Index (TBI) for early keratoconus screening. METHODS: In this retrospective study, the discriminatory power of the corneal tomography Belin/Ambrósio Enhanced Ectasia Display (BAD-D) index and the newly developed Corvis Biomechanical Index (CBI) and TBI to differentiate between normal eyes, manifest keratoconus eyes (KCE), very asymmetric keratoconus eyes with ectasia (VAE-E), and their fellow eyes with either regular topography (VAE-NT) or regular topography and tomography (VAE-NTT) were analyzed by applying the t test (for normal distribution), Wilcoxon matched-pairs test (if not normally distributed), and receiver operating characteristic curve (ROC)...
December 1, 2018: Journal of Refractive Surgery
Pratik Kataria, Prema Padmanabhan, Aparna Gopalakrishnan, Vasanthi Padmanaban, Sanjay Mahadik, Renato Ambrósio
PURPOSE: To test the predictive accuracy of the Belin-Ambrósio deviation index (BAD-D), the stiffness parameter A1 (SPA1 ), the Corvis biomechanical index (CBI), and the tomographic and biomechanical index (TBI) assessments for distinguishing subclinical and mild keratoconic eyes from normal eyes. SETTING: Medical Research Foundation, Sankara Nethralaya, Chennai, India. DESIGN: Retrospective case series. METHOD: In this cross-sectional clinical study, the following 3 groups of eyes were analyzed: very asymmetric ectasia with normal topography (very asymmetric-normal topography), mild keratoconus, and normal control...
December 7, 2018: Journal of Cataract and Refractive Surgery
Mattia Dimitri, Fabio Staderini, Margherita Brancadoro, Francesco Frosini, Andrea Coratti, Lorenzo Capineri, Andrea Corvi, Fabio Cianchi, Guido Biffi Gentili
PURPOSE: Bleeding from parenchyma transection during a robotic hepatic surgery remains the most critical point affecting postoperative recovery and long-term survival. Various robotic devices with different types of energies have been proposed; however, each of these lack in steerability, efficacy, or accuracy. The aim of this work is to evaluate the feasibility and performance of a new steerable microwave resection device intended for minimizing intraoperative blood loss during laparoscopic and robotic liver resections...
November 28, 2018: International Journal of Hyperthermia
Henry B Wallace, Stuti L Misra, Sunny S Li, James McKelvie
IMPORTANCE: Intraocular pressure is often reduced following cataract surgery. Postoperative changes in corneal stiffness are likely to be at least partly responsible for any reduction in IOP measured with applanation tonometry. BACKGROUND: To determine the effect of cataract surgery and corneal incision size on corneal biomechanics. DESIGN: Prospective randomised trial PARTICIPANTS: One-hundred prospectively enrolled patients qualifying for cataract surgery METHODS: Participants were randomised to clear corneal incisions with a 2...
November 25, 2018: Clinical & Experimental Ophthalmology
Brice Martin Couillaud, Philippe Espeau, Nathalie Mignet, Yohann Corvis
The solid form screening of active principal ingredients is a challenge for the pharmaceutical drug development since more than 80% of the marketed drugs are formulated in the solid form. A broad and comprehensive study of the various solid forms of the matter is needed to enhance its translation to clinic. Therefore, the most suitable solid form has to be taken into consideration regarding ex- and in-vivo stability, targeting, solubility, dissolution rate, and bioavailability. In this review, techniques of solid form screening are reported, including differences in the solid forms such as polymorphs, solvates, salts, co-crystals and amorphous particles...
November 20, 2018: ChemMedChem
Hun Lee, David Sung Yong Kang, Byoung Jin Ha, Jin Young Choi, Eung Kweon Kim, Kyoung Yul Seo, Tae Im Kim
PURPOSE: To investigate biomechanical properties of the cornea using a dynamic Scheimpflug analyzer according to age. MATERIALS AND METHODS: In this prospective, cross-sectional, observational study, participants underwent ophthalmic investigations including corneal biomechanical properties, keratometric values, intraocular pressure (IOP), and manifest refraction spherical equivalent (MRSE). We determined the relationship of biomechanical parameters and ocular/systemic variables (participant's age, MRSE, IOP, and mean keratometric values) by piecewise regression analysis, association of biomechanical parameters with variables by Spearman's correlation and stepwise multiple regression analyses, and reference intervals (RI) by the bootstrap method...
November 2018: Yonsei Medical Journal
Hai Doan Do, Brice Martin Couillaud, Bich-Thuy Doan, Yohann Corvis, Nathalie Mignet
Nucleic acids (NAs) have been considered as promising therapeutic agents for various types of diseases. However, their clinical applications still face many limitations due to their charge, high molecular weight, instability in biological environment and low levels of transfection. To overcome these drawbacks, therapeutic NAs should be carried in a stable nanocarrier, which can be viral or non-viral vectors, and released at specific target site. Various controllable gene release strategies are currently being evaluated with interesting results...
October 12, 2018: Advanced Drug Delivery Reviews
Tommy C Y Chan, Yu Meng Wang, Marco Yu, Vishal Jhanji
PURPOSE: To investigate and compare the diagnostic ability of corneal tomography and biomechanical and combined parameters for detection of corneal ectasia. METHODS: Consecutive patients with subclinical keratoconus (SCKC) and age-matched controls were included. Only one eye from each patient was selected for analysis. The final D value from the Belin/Ambrósio Enhanced Ectasia Display (BAD) was obtained from the Pentacam (Oculus Optikgeräte, Wetzlar, Germany)...
September 1, 2018: Journal of Refractive Surgery
Federico Corvi, Marco Pellegrini, Maria Belotti, Carlo Bianchi, Giovanni Staurenghi
PURPOSE: To evaluate the feasibility in the clinical practice of a fast and simple mesopic microperimetry examination comparing the retinal sensitivity in eyes with drusen and reticular pseudodrusen by scotopic and mesopic testing. METHODS: In eyes with only drusen and only reticular pseudodrusen, retinal sensitivity was assessed by mesopic testing and after 35 minutes of dark adaptation by scotopic testing using 2 grids of 6 and 10 stimulus points. RESULTS: Fifteen eyes with drusen and 14 eyes with reticular pseudodrusen were enrolled with mean best-corrected visual acuity of 20/20...
August 30, 2018: Retina
Michele Lanza, Michele Rinaldi, Ugo Antonello Gironi Carnevale, Silvio di Staso, Mario Bifani Sconocchia, Ciro Costagliola
BACKGROUND: To evaluate differences of intraocular pressure (IOP) measurements performed with Goldmann applanation tonometer (GAT), dynamic contour tonometer (DCT), rebound tonometry (RT), Ocular Response Analyzer (ORA) and Corvis ST (CST) in eyes screened for refractive surgery. METHODS: One eye, only the right one, of 146 patients was included in this study. Each participant was submitted to a corneal analysis with Scheimpflug camera and IOP evaluation with GAT, DCT, RT, ORA and CST...
September 3, 2018: BMC Ophthalmology
Ramin Salouti, Ali Agha Alishiri, Reza Gharebaghi, Mostafa Naderi, Khosrow Jadidi, Ahmad Shojaei-Baghini, Mohammadreza Talebnejad, Zahra Nasiri, Seyedmorteza Hosseini, Fatemeh Heidary
AIM: To explore the relationship between different parameters of Ocular Response Analyzer (ORA) and Corvis ST (CST) in a sample of healthy Iranian school-aged children and the relationship between parameters of these 2 instruments against intraocular pressure (IOP), measured by the Goldmann applanation tonometer (GAT-IOP), age and gender, and find possible correlation between ORA and CST with GAT. METHODS: This cross-sectional study included 90 healthy children...
2018: International Journal of Ophthalmology
Juan M Spera, Francisco Guaimas, María M Corvi, Juan E Ugalde
Brucellaceae are a group of pathogenic intracellular bacteria with the ability to modulate the host response, both at the individual cell level and systemically. One of the hallmarks of the virulence process is the capacity of the bacteria to downregulate the adaptive and acquired host immune response through a plethora of virulence factors that directly impact several key signaling cascades. PrpA is one of those virulence factors that alters, via its polyclonal B-cell activity, the humoral and cellular immune responses of the host, ultimately favoring the establishment of a chronic infection...
November 2018: Infection and Immunity
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