keyword
https://read.qxmd.com/read/38537155/giredestrant-for-estrogen-receptor-positive-her2-negative-previously-treated-advanced-breast-cancer-results-from-the-randomized-phase-ii-acelera-breast-cancer-study
#1
JOURNAL ARTICLE
Miguel Martín, Elgene Lim, Mariana Chavez-MacGregor, Aditya Bardia, Jiong Wu, Qingyuan Zhang, Zbigniew Nowecki, Felipe Melo Cruz, Rustem Safin, Sung-Bae Kim, Christian Schem, Alberto J Montero, Sarah Khan, Reeti Bandyopadhyay, Heather M Moore, Mahesh Shivhare, Monika Patre, Jorge Martinalbo, Laura Roncoroni, Pablo Diego Pérez-Moreno, Joohyuk Sohn
PURPOSE: To compare giredestrant and physician's choice of endocrine monotherapy (PCET) for estrogen receptor-positive, HER2-negative, advanced breast cancer (BC) in the phase II acelERA BC study (ClinicalTrials.gov identifier: NCT04576455). METHODS: Post-/pre-/perimenopausal women, or men, age 18 years or older with measurable disease/evaluable bone lesions, whose disease progressed after 1-2 lines of systemic therapy (≤1 targeted, ≤1 chemotherapy regimen, prior fulvestrant allowed) were randomly assigned 1:1 to giredestrant (30 mg oral once daily) or fulvestrant/aromatase inhibitor per local guidelines (+luteinizing hormone-releasing hormone agonist in pre-/perimenopausal women, and men) until disease progression/unacceptable toxicity...
March 27, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/38537062/late-cytomegalovirus-disease-after-hematopoietic-cell-transplantation-significance-of-novel-transplantation-techniques
#2
JOURNAL ARTICLE
Alicja Sadowska-Klasa, Sezen Özkök, Hu Xie, Wendy M Leisenring, Danniel Zamora, Sachiko Seo, Jordan Sheldon, Stephanie J Lee, Keith R Jerome, Margaret L Green, Michael J Boeckh
Pre-emptive therapy (PET) and letermovir prophylaxis are effective in preventing CMV disease within the first 100 days after allogeneic hematopoietic cell transplantation (HCT) but are associated with late-onset CMV disease. We retrospectively examined the clinical manifestations, risk factors, prevention algorithm, and outcome of late CMV disease in CMV seropositive day 100 survivors transplanted between 2001-2017 (PET cohort) and 2018-2021 (letermovir cohort). There were 187 episodes of late CMV disease among 2469 day 100 survivors and the estimated cumulative incidence of first late CMV disease was 6...
March 27, 2024: Blood Advances
https://read.qxmd.com/read/38537060/prognostic-factors-for-resected-cases-with-gallbladder-carcinoma-a-systematic-review-and-meta-analysis
#3
JOURNAL ARTICLE
Tian-Run Lv, Jun-Ke Wang, Fu-Yu Li, Hai-Jie Hu
OBJECTIVE: Current meta-analysis was performed to systematically evaluate the potential prognostic factors for overall survival (OS) among resected cases with gallbladder carcinoma (GBC). METHODS: PubMed, EMBASE, and the Cochrane Library were systematically retrieved and hazard ratio (HR) and its 95% confidence interval (CI) were directly extracted from the original study or roughly estimated via Tierney's method. Standard Parmar modifications were used to determine pooled HRs...
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38536657/increased-risk-of-erythrocytosis-in-men-with-type-2-diabetes-treated-with-combined-sodium-glucose-cotransporter-2-inhibitor-and-testosterone-replacement-therapy
#4
JOURNAL ARTICLE
A R Gosmanov, D E Gemoets, K A Schumacher
PURPOSE: In clinical trials, sodium-glucose cotransporter-2 inhibitors (SGLT-2i) and testosterone replacement therapy (TRT) were shown to stimulate red blood cell production. Little is known if combination therapy poses risk of erythrocytosis in real world clinical practice. METHODS: This was a retrospective nationwide cohort study of US Veterans with type 2 diabetes (T2D) and baseline hematocrit between 38 and 50% who were prescribed SGLT-2i and/or TRT between 3/2013 and 10/2022 and had adequate adherence based on the proportion of days covered > 80%...
March 27, 2024: Journal of Endocrinological Investigation
https://read.qxmd.com/read/38536646/impact-of-immunosuppressed-status-on-prognosis-of-carbapenem-resistant-organisms-bloodstream-infections
#5
JOURNAL ARTICLE
Yuan-Yuan Li, Yan Chen, Shan Li, Yuan-Yuan Li, Ran An, Xiao-Yun Hu, Wei Jiang, Chun-Yao Wang, Run Dong, Qi-Wen Yang, Li Weng, Jin-Min Peng, Bin Du
INTRODUCTION: The impact of immunosuppression on prognosis of carbapenem-resistant organism (CRO) bloodstream infection (BSI) remains unclear. The aim of this study was to clarify the relationship between immunosuppression and mortality of CRO-BSI and to identify the risk factors associated with mortality in immunosuppressed patients. METHODS: This retrospective study included 279 patients with CRO-BSI from January 2018 to March 2023. Clinical characteristics and outcomes were compared between the immunosuppressed and immunocompetent patients...
March 27, 2024: Infectious Diseases and Therapy
https://read.qxmd.com/read/38536518/prognostic-modeling-in-early-rheumatoid-arthritis-reconsidering-the-predictive-role-of-disease-activity-scores
#6
JOURNAL ARTICLE
Alix Bird, Lauren Oakden-Rayner, Luke A Smith, Minyan Zeng, Shonket Ray, Susanna Proudman, Lyle J Palmer
OBJECTIVE: In this prospective cohort study, we provide several prognostic models to predict functional status as measured by the modified Health Assessment Questionnaire (mHAQ). The early adoption of the treat-to-target strategy in this cohort offered a unique opportunity to identify predictive factors using longitudinal data across 20 years. METHODS: A cohort of 397 patients with early RA was used to develop statistical models to predict mHAQ score measured at baseline, 12 months, and 18 months post diagnosis, as well as serially measured mHAQ...
March 27, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38536450/surgical-management-of-chiari-ii-malformation-a-systematic-review-of-literature
#7
REVIEW
Rafael C C Vencio, Adriano M Lino-Filho, Renata C F Bonfim, Nayara M Pereira, Cilmária L Franco, Paulo Ronaldo J Ribeiro, Bárbara A Morais
PURPOSE: Chiari II malformation (CM-II) is a congenital malformation of the posterior fossa associated with myelomeningocele. Of the symptomatic patients, 10-33% require surgical treatment. To this date, there is not a consensus about the best surgical technique, and whether to do duroplasty. METHODS: A literature search of the PubMed database and crossed references was performed, per PRISMA guidelines. Data regarding demographic features, extent of cervicomedullary deformity, clinical presentation, surgical techniques, and clinical outcomes were extracted...
March 27, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/38536220/benchmarking-mental-health-status-using-passive-sensor-data-protocol-for-a-prospective-observational-study
#8
JOURNAL ARTICLE
Robyn E Kilshaw, Abigail Boggins, Olivia Everett, Emma Butner, Feea R Leifker, Brian R W Baucom
BACKGROUND: Computational psychiatry has the potential to advance the diagnosis, mechanistic understanding, and treatment of mental health conditions. Promising results from clinical samples have led to calls to extend these methods to mental health risk assessment in the general public; however, data typically used with clinical samples are neither available nor scalable for research in the general population. Digital phenotyping addresses this by capitalizing on the multimodal and widely available data created by sensors embedded in personal digital devices (eg, smartphones) and is a promising approach to extending computational psychiatry methods to improve mental health risk assessment in the general population...
March 27, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38536173/patient-reported-adverse-events-and-early-treatment-discontinuation-among-patients-with-multiple-myeloma
#9
JOURNAL ARTICLE
John Devin Peipert, Fengmin Zhao, Ju-Whei Lee, Shu-En Shen, Edward Ip, Nathaniel O'Connell, Ruth C Carlos, Noah Graham, Mary Lou Smith, Ilana F Gareen, Pamela J Raper, Matthias Weiss, Shaji K Kumar, S Vincent Rajkumar, David Cella, Robert Gray, Lynne I Wagner
IMPORTANCE: There is substantial interest in capturing cancer treatment tolerability from the patient's perspective using patient-reported outcomes (PROs). OBJECTIVE: To examine whether a PRO question, item 5 from the Functional Assessment of Cancer Therapy-General General Physical Wellbeing Scale (GP5), was associated with early treatment discontinuation (ETD) due to adverse events. DESIGN, SETTING, AND PARTICIPANTS: This prospective survey study was conducted from February to April 2023...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38536131/brain-abscess-secondary-to-streptococcus-intermedius-following-an-egd-with-biopsy-in-a-patient-with-eosinophilic-esophagitis
#10
JOURNAL ARTICLE
N Begum Ozturk, Tatjana Blazin, Aparna Hariharan, Naveen Reddy
Brain abscess is a rare complication of esophagogastro- duodenoscopy (EGD) with few reported cases in the literature. In this report, we discuss a patient presenting with altered mental status, headache, and dysarthria due to brain abscess caused by S. intermedius shortly after an EGD with an esophageal biopsy showing a new diagnosis of eosinophilic esophagitis. We highlight the rare association of EGD and brain abscess, and discuss the importance of prompt diagnosis and treatment.
April 1, 2024: Rhode Island Medical Journal
https://read.qxmd.com/read/38536044/acetazolamide-as-an-effective-treatment-for-pilomotor-seizures-in-autoimmune-encephalitis
#11
JOURNAL ARTICLE
Kia Gilani, Apameh Tarazi, Richard Wennberg
Pilomotor seizures are strongly associated with autoimmune encephalitis (AE), particularly anti-LGI1 encephalitis. The carbonic anhydrase inhibitor acetazolamide may have special efficacy for treating AE-associated pilomotor seizures. Six patients with AE (five anti-LGI1, one seronegative) and temporal lobe pilomotor seizures (five with seizures inducible by hyperventilation) were treated with acetazolamide, administered in a cycling (2-days-ON, 4-days-OFF) regimen to offset tolerance. Seizures were assessed during epilepsy monitoring unit (EMU) recordings in four inpatients (one of whom also maintained an outpatient seizure diary chronicling 1203 seizures over 1079 days); two outpatients self-reported seizure frequencies...
March 27, 2024: Epilepsia
https://read.qxmd.com/read/38535966/women-living-with-fibromyalgia-during-the-covid-19-pandemic-a-qualitative-study
#12
JOURNAL ARTICLE
Helena Vall-Roqué, Rubén Nieto, Mayte Serrat, Beatriz Sora, Pau Tolo, Patricia Ureña, Albert Feliu-Soler, Juan V Luciano, Rebeca Pardo
We explored the experiences of women with fibromyalgia during the COVID-19 pandemic from a qualitative approach by interviewing eighteen women. We identified seven main themes after performing a thematic analysis: pain description, pain triggers, impact, coping strategies, treatment for pain, pain onset and general situation. In general, pain worsened during the pandemic, and activity restrictions and changes in social interactions were particularly related with that. Pain negatively impacted different life domains: mental health, physical health, cognitive status, social activities and daily activities...
March 27, 2024: Health Care for Women International
https://read.qxmd.com/read/38535900/acute-toxicity-assessment-of-orally-administered-microplastic-particles-in-adult-male-wistar-rats
#13
JOURNAL ARTICLE
Ivana Guševac Stojanović, Dunja Drakulić, Ana Todorović, Jelena Martinović, Nenad Filipović, Zoran Stojanović
While the effects of chronic exposure to microplastic particles (MPs) are extensively studied, the outcomes of a single treatment have received relatively less attention. To investigate MPs' potential acute toxicity, including their impact on general health status (victual consumption, sensorimotor deficits, and clinical toxicity signs) and serum biochemical parameters (markers of organ/tissue function and oxidative stress indicators), we administered thoroughly characterized MPs (1.4, 35, or 125 mg/kg), generated from polyethylene terephthalate (PET) bottles, to adult male Wistar rats via oral gavage...
February 22, 2024: Toxics
https://read.qxmd.com/read/38535845/influence-of-maternal-supplementation-with-vitamins-minerals-and-or-protein-energy-on-placental-development-and-angiogenic-factors-in-beef-heifers-during-pregnancy
#14
JOURNAL ARTICLE
Bethania J Dávila Ruiz, Carl R Dahlen, Kacie L McCarthy, Joel S Caton, Jennifer L Hurlbert, Friederike Baumgaertner, Ana Clara B Menezes, Wellison J S Diniz, Sarah R Underdahl, James D Kirsch, Kevin K Sedivec, Kerri A Bochantin, Pawel P Borowicz, Sebastián Canovas, Lawrence P Reynolds
The effect of vitamins and minerals supplementation (VTM) and/or two rates of body weight gain (GAIN) on bovine placental vascular development and angiogenic factors gene expression were evaluated in two experiments: In Exp. 1, crossbred Angus heifers ( n = 34) were assigned to VTM/NoVTM treatments at least 71 days before breeding to allow changes in the mineral status. At breeding, through artificial insemination (AI), heifers were assigned to low-gain (LG) 0.28 kg/d or moderate-gain (MG) 0.79 kg/d treatments, resulting in NoVTM-LG (Control; n = 8), NoVTM-MG ( n = 8), VTM-LG ( n = 9), and VTM-MG ( n = 9) until day 83 of gestation; In Exp...
March 2, 2024: Veterinary Sciences
https://read.qxmd.com/read/38535817/red-orange-and-lemon-extract-ameliorates-the-renal-oxidative-stress-and-inflammation-induced-by-ochratoxin-a-through-the-modulation-of-nrf2
#15
JOURNAL ARTICLE
Consiglia Longobardi, Sara Damiano, Simona Fabroni, Serena Montagnaro, Valeria Russo, Emanuela Vaccaro, Antonio Giordano, Salvatore Florio, Roberto Ciarcia
BACKGROUND: The presence of ochratoxin A (OTA) in food and feed is a public health concern. OTA intoxication is caused by several mechanisms, one of which consists of the alteration of the antioxidant activity of the cell due to the oxidative stress (OS). In this context, the use of natural antioxidant substances could be a potential biological decontamination method of mitigating the negative outcomes induced by OTA. METHODS: we aimed to investigate how a red orange and lemon extract (RLE), rich in anthocyanins, would affect OTA-treated rats...
March 14, 2024: Toxins
https://read.qxmd.com/read/38535380/validation-and-evaluation-of-reference-genes-for-quantitative-real-time-pcr-analysis-in-mythimna-loreyi-lepidoptera-noctuidae
#16
JOURNAL ARTICLE
Liuyang Wang, Chaoxia Yang, Qingyu Liu, Xiaofang Zhang, Xiangdong Mei, Tao Zhang, Jun Ning
Quantitative real-time PCR (qRT-PCR) is a widely applied technique for accurately assessing the expression of target genes. In practice, the evaluation of gene expression requires appropriate reference genes. To screen reliable reference genes for evaluating gene expression via qRT-PCR in Mythimna loreyi , a notorious migratory pest across Asia, Africa, Europe, and Australia, we assessed the expression stability of 13 candidate reference genes in M. loreyi using the ΔCt method, BestKeeper, Normfinder, GeNorm, and the web-based comprehensive platform RefFinder...
March 10, 2024: Insects
https://read.qxmd.com/read/38535343/cyantraniliprole-and-thiamethoxam-exposure-changes-expression-of-transcripts-associated-with-small-non-coding-rna-processing-in-the-colorado-potato-beetle
#17
JOURNAL ARTICLE
Pierre Bastarache, Kenan Timani, Mariem Ben Youssef, Enock Omakele, Jess L Vickruck, Pier Jr Morin
The Colorado potato beetle ( Leptinotarsa decemlineata (Say)) can cause extensive damage to agricultural crops worldwide and is a significant insect pest. This insect is notorious for its ability to evade various strategies deployed to control its spread and is known for its relative ease in developing resistance against different insecticides. Various molecular levers are leveraged by L. decemlineata for this resistance to occur, and a complete picture of the genes involved in this process is lacking. While small non-coding RNAs, including miRNAs, are differentially expressed in insects exposed to insecticides, levels of transcript coding for proteins underlying their synthesis remain to be characterized fully...
February 22, 2024: Insects
https://read.qxmd.com/read/38535328/application-of-clinical-blood-metabogram-to-type-2-diabetes-mellitus
#18
JOURNAL ARTICLE
Petr G Lokhov, Elena E Balashova, Oxana P Trifonova, Dmitry L Maslov, Ekaterina A Shestakova, Marina V Shestakova, Ivan I Dedov
The clinical blood metabogram (CBM) was developed to match a tailored analysis of the blood metabolome to the time, cost, and reproducibility constraints of clinical laboratory testing. By analyzing the main blood metabolite groups, CBM offers clinically relevant information about the intake of low-molecular substances into the organism, humoral regulation, liver function, amino acid level, and the lipid and carbohydrate metabolism. The purpose of this work was to investigate the relevance of using the CBM in patients with diabetes mellitus...
March 18, 2024: Metabolites
https://read.qxmd.com/read/38535325/the-effect-of-dietary-protein-hydrolysate-from-black-soldier-fly-larvae-and-schizochytrium-on-palatability-nutrient-metabolites-and-health-status-in-beagle-dogs
#19
JOURNAL ARTICLE
Yu Wei, Lingfeng Xue, Deying Ma, Yuxiao Weng, Mingkang Liu, Luyang Li, Ziyi Dai, Ziyun Zhao, Haifeng Wang, Xiao Xu
Protein hydrolysate from black soldier fly larvae (BSFP) has garnered great attention with its lower allergenicity, high amount of essential amino acids, and small bioactive peptides. Schizochytrium is a promising alternative source of n-3 FUFA because it has enriched docosahexaenoic acid (DHA, C22: 6). The aim of this study was to assess palatability, the presence of diarrhea, plasma biochemistry panels, anti-oxidative and anti-inflammatory effects, and immune function in beagle dogs when supplementing a mixture of protein hydrolysate from black soldier fly larvae and schizochytrium (BSFPs) into their diets...
March 14, 2024: Metabolites
https://read.qxmd.com/read/38535156/survival-analysis-of-male-patients-with-brain-metastases-at-initial-breast-cancer-diagnosis-over-the-last-decade
#20
JOURNAL ARTICLE
Jorge Avila, Julieta Leone, Carlos T Vallejo, José P Leone
Breast cancer in men represents approximately 1% of all breast cancer diagnoses. Among all patients with breast cancer, approximately 30% will develop brain metastases. Over the past decade, there have been multiple advances in the treatment of metastatic breast cancer; however, long-term outcomes of this presentation in male patients are lacking. We evaluated male patients with de novo stage IV breast cancer using the Surveillance, Epidemiology and End Results (SEER) database from 2010 to 2019. Overall survival (OS) was estimated using the Kaplan-Meier method and differences between groups were compared using log rank tests...
March 10, 2024: Medical Sciences: Open Access Journal
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