Philip F Halloran, Katelynn Madill-Thomsen, Arezu Z Aliabadi-Zuckermann, Martin Cadeiras, Marisa G Crespo-Leiro, Eugene C Depasquale, Mario Deng, Johannes Gökler, Shelley Hall, Aayla Jamil, Daniel H Kim, Jon Kobashigawa, Peter Macdonald, Vojtech Melenovsky, Jignesh Patel, Luciano Potena, Keyur Shah, Josef Stehlik, Andreas Zuckermann
The first-generation Molecular Microscope® (MMDx) system for heart transplant endomyocardial biopsies used expression of rejection-associated transcripts (RATs) to diagnose T cell-mediated rejection (TCMR) and antibody-mediated rejection (ABMR) but also detected acute injury. However, the ideal system should detect rejection without being influenced by injury, to permit analysis of the relationship between rejection and parenchymal injury. To achieve this, we developed a new rejection classification in an expanded cohort of 3230 biopsies: 1641 from INTERHEART (ClinicalTrials...
March 23, 2024: American Journal of Transplantation