Ruihong Wu, Yue Gao, Xiaoxi Zhao, Shuang Guo, Hanxiao Zhou, Yakun Zhang, Yaopan Hou, Lan Mei, Hui Zhi, Peng Wang, Xia Li, Shangwei Ning, Yunpeng Zhang
BACKGROUND & AIMS: Tumor heterogeneity is jointly determined by the components of the tumor ecosystem (TES) including tumor cells, immune cells, stromal cells, and non-cellular components. We aimed to identify subtypes using TES-related genes and determine subtype specific drivers and treatments for hepatocellular carcinoma (HCC). METHODS: We collected 68 genesets depicting tumor biology, immune infiltration, and liver function, totaling 2831 genes, and collected mRNA profiles and clinical data for over 6000 tumors from 65 datasets in the GEO, TCGA, ICGC, and several other databases...
October 18, 2023: Computers in Biology and Medicine