keyword
https://read.qxmd.com/read/38266947/confirmation-of-pain-related-neuromodulation-mechanism-of-bushen-zhuangjin-decoction-on-knee-osteoarthritis
#21
JOURNAL ARTICLE
Xue Tan, Danhao Zheng, Qing Lin, Lili Wang, Zaishi Zhu, Yanfeng Huang, Jiaqiu Lin, Yihui Zeng, Min Mao, Zhouping Yi, Linglong Liu, Dezun Ma, Jie Wang, Xihai Li
ETHNOPHARMACOLOGICAL RELEVANCE: Bushen Zhuangjin Decoction (BZD) are an herbal compound commonly used to treat osteoarthritis (OA) in China. AIM OF THE STUDY: This study aimed to verify the mechanism of Bushen Zhuangjin Decoction in relieving the pain of knee osteoarthritis. MATERIALS AND METHODS: Network pharmacology evaluation was used to discover the potential targets of BZD to relieve pain in KOA. The therapeutic effects of BZD treatment on KOA pain using histomorphology, behavioral assessments, suspension chip analysis, and ultra-high performance liquid chromatography/tandem mass spectrometry (UHPLC-MS/MS) assays...
January 22, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38217860/dual-antagonism-of-%C3%AE-9%C3%AE-10-nachr-and-gaba-b-receptor-coupled-ca-v-2-2-channels-by-an-analgesic-%C3%AE-o-conotoxin-analogue
#22
JOURNAL ARTICLE
Xiao Li, Han-Shen Tae, Shen Chen, Arsalan Yousuf, Linhong Huang, Jinghui Zhang, Tao Jiang, David J Adams, Rilei Yu
Pain severely affects the physical and mental health of patients. The need to develop nonopioid analgesic drugs to meet medical demands is urgent. In this study, we designed a truncated analogue of αO-conotoxin, named GeX-2, based on disulfide-bond deletion and sequence truncation. GeX-2 retained the potency of its parent peptide at the human α9α10 nAChR and exhibited potent inhibitory activity at CaV 2.2 channels via activation of the GABAB receptor (GABAB R). Importantly, GeX-2 significantly alleviated pain in the rat model of chronic constriction injury...
January 13, 2024: Journal of Medicinal Chemistry
https://read.qxmd.com/read/38200908/electro-acupuncture-effects-measured-by-functional-magnetic-resonance-imaging-a-systematic-review-of-randomized-clinical-trials
#23
REVIEW
Jorge Magalhães Rodrigues, Cristina Ventura, Manuela Abreu, Catarina Santos, Joana Monte, Jorge Pereira Machado, Rosa Vilares Santos
INTRODUCTION: Electro-acupuncture, an innovative adaptation of traditional acupuncture, combines electrical stimulation with acupuncture needles to enhance therapeutic effects. While acupuncture is widely used, its biological mechanisms remain incompletely understood. Recent research has explored the neurophysiological aspects of acupuncture, particularly through functional magnetic resonance imaging (fMRI) to investigate its effects on brain activity. METHODS: In this systematic review, we conducted an extensive search for randomized clinical trials examining electro-acupuncture effects measured by fMRI...
December 19, 2023: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/38193198/experimental-colitis-induced-visceral-hypersensitivity-is-attenuated-by-gaba-treatment-in-mice
#24
JOURNAL ARTICLE
Michael S Gold, Emanuel Loeza-Alcocer
Ulcerative colitis (UC) is linked with inflammation of the large intestine due to an overactive response of the colon-immune system. UC is associated with weight loss, rectal bleeding, diarrhea, and abdominal pain. Given that GABA suppresses immune cell activity and the excitability of colonic afferents, and that there is a decrease in colonic GABA during UC, we hypothesized that UC-pain is due to a decrease in the inhibition of colonic afferents. Thus, restoring GABA in the colon will attenuate inflammatory hypersensitivity...
January 9, 2024: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://read.qxmd.com/read/38191090/suppression-of-hcn-channels-in-the-spinal-dorsal-horn-restores-kcc2-expression-and-attenuates-diabetic-neuropathic-pain
#25
JOURNAL ARTICLE
Yanqiao Ma, Ji Chen, Chaodong Chen, Bangcong Wei, Xiaohong Liu
Previous studies have shown that the hyperpolarized cyclic nucleotide gated (HCN) ion channels in the spinal dorsal horn (SDH) might be involved in the development of diabetic neuropathic pain (DNP). Additionally, other studies have shown that the decreased potassium-chloride cotransporter 2 (KCC2) expression in the SDH promotes pain hypersensitivity. Both HCN channels and KCC2 were highly expressed in spinal substantia gelatinosa neurons. However, whether the K+ efflux induced by the activation of HCN channels in DNP modulate KCC2 function and subsequently affect the role of γ-aminobutyric acid (GABA)/GABA-A receptors of neurons in the SDH remains to be clarified...
January 6, 2024: Neuroscience Letters
https://read.qxmd.com/read/38184028/ayahuasca-and-its-major-component-harmine-promote-antinociceptive-effects-in-mouse-models-of-acute-and-chronic-pain
#26
JOURNAL ARTICLE
Pedro Santana Sales Lauria, Juliana de Medeiros Gomes, Lucas Silva Abreu, Rejane Conceição Santana, Victor Luiz Correia Nunes, Ricardo David Couto, Paulo Oliveira Colavolpe, Marcelo Sobral da Silva, Milena Botelho Pereira Soares, Cristiane Flora Villarreal
ETHNOPHARMACOLOGICAL RELEVANCE: Ayahuasca (AYA) is a psychedelic brew used in religious ceremonies. It is broadly used as a sacred medicine for treating several ailments, including pain of various origins. AIM OF THE STUDY: To investigate the antinociceptive effects of AYA and its mechanisms in preclinical models of acute and chronic pain in mice, in particular during experimental neuropathy. MATERIALS AND METHODS: The antinociceptive effects of AYA administered orally were assessed in the following models of pain: formalin test, Complete Freund's Adjuvant (CFA)-induced inflammation, tail flick test, and partial sciatic nerve ligation model of neuropathic pain...
January 4, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38170385/attenuation-of-streptozotocin-induced-diabetic-neuropathic-allodynia-by-flavone-derivative-through-modulation-of-gaba-ergic-mechanisms-and-endogenous-biomarkers
#27
JOURNAL ARTICLE
Nouman Altaf, Najeeb Ur Rehman, Nasiara Karim, Imran Khan, Sobia Ahsan Halim, Badriyah S Alotaibi, Rabab S Hamad, Gaber El-Saber Batiha, Jehad Zuhair Tayyeb, Areej Turkistani, Ajmal Khan, Ahmed Al-Harrasi
Diabetic neuropathic pain is one of the most devasting disorders of peripheral nervous system. The loss of GABAergic inhibition is associated with the development of painful diabetic neuropathy. The current study evaluated the potential of 3-Hydroxy-2-methoxy-6-methyl flavone (3-OH-2'MeO6MF), to ameliorate peripheral neuropathic pain using an STZ-induced hyperglycemia rat model. The pain threshold was assessed by tail flick, cold, mechanical allodynia, and formalin test on days 0, 14, 21, and 28 after STZ administration accompanied by evaluation of several biochemical parameters...
January 3, 2024: Neurochemical Research
https://read.qxmd.com/read/38165145/efficacy-of-remimazolam-tosilate-versus-propofol-for-total-intravenous-anaesthesia-in-urological-surgery-a-randomised-clinical-trial
#28
RANDOMIZED CONTROLLED TRIAL
Hongmeng Lan, Huiyu Cao, Susu Liu, Xiaofang Gong, Xiaofang Huang, Heng Rong, Bing Xu, Huihe Chen, Ziyin Jiao, Yuliu Lin, Xuehai Guan
BACKGROUND: Remimazolam is a novel ultra-short-acting benzodiazepine sedative that acts on the gamma-aminobutyric acid type A receptor (GABAAR). OBJECTIVE: To compare the efficacies of remimazolam (RMZ), and propofol (PROP) combined with remifentanil and cisatracurium for total intravenous anaesthesia (TIVA) in patients undergoing urological surgery. DESIGN: A prospective, single-blind, randomised, noninferiority clinical trial. SETTING: Single centre from 1 January 2022 to 30 March 2022...
March 1, 2024: European Journal of Anaesthesiology
https://read.qxmd.com/read/38154966/naringenin-modulates-gaba-mediated-response-in-a-sexdependent-manner-in-substantia-gelatinosa-neurons-of-trigeminal-subnucleus-caudalis-in-immature-mice
#29
JOURNAL ARTICLE
Seon Ah Park, Thao Thi Phuong Nguyen, Soo Joung Park, Seong Kyu Han
The substantia gelatinosa (SG) within the trigeminal subnucleus caudalis (Vc) is recognized as a pivotal site of integrating and modulating afferent fibers carrying orofacial nociceptive information. Although naringenin (4',5,7-thrihydroxyflavanone), a natural bioflavonoid, has been proven to possess various biological effects in the central nervous system (CNS), the activity of naringenin at the orofacial nociceptive site has not been reported yet. In this study, we explored the influence of naringenin on GABA response in SG neurons of Vc using whole-cell patch-clamp technique...
January 1, 2024: Korean Journal of Physiology & Pharmacology
https://read.qxmd.com/read/38146463/a-phase-i-study-to-evaluate-the-safety-tolerability-and-pharmacokinetics-of-a-novel-potent-gaba-analog-hsk16149-in-healthy-chinese-subjects
#30
JOURNAL ARTICLE
Qian Chen, Qingqing Wu, Rong Song, Yating Wang, Mengqi Zhang, Fangqiong Li, Weifang Zeng, Wei Wang, Jingying Jia, Chen Yu, Yanmei Liu
Purpose: HSK16149 is a novel, potent gamma-aminobutyric acid (GABA) analog for the treatment of neuropathic pain. This study aimed to evaluate the safety, tolerability, and pharmacokinetics of HSK16149 after single and multiple doses in healthy Chinese subjects. Methods: The randomized, double-blind, placebo-controlled study comprised two parts: SAD (single ascending-dose study) and MAD (multiple ascending-dose study). A total of 122 healthy subjects were enrolled in this study. HSK16149 capsule or placebo was administered as the protocol required...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/38144169/urine-metabolite-analysis-to-identify-pathomechanisms-of-long-covid-a-pilot-study
#31
JOURNAL ARTICLE
Maja Taenzer, Judith Löffler-Ragg, Andrea Schroll, Pablo Monfort-Lanzas, Sabine Engl, Günter Weiss, Natascha Brigo, Katharina Kurz
BACKGROUND: Around 10% of people who had COVID-9 infection suffer from persistent symptoms such as fatigue, dyspnoea, chest pain, arthralgia/myalgia, sleep disturbances, cognitive dysfunction and impairment of mental health. Different underlying pathomechanisms appear to be involved, in particular inflammation, alterations in amino acid metabolism, autonomic dysfunction and gut dysbiosis. AIM: As routine tests are often inconspicuous in patients with Long COVID (LC), similarly to patients suffering from myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), accessible biomarkers indicating dysregulation of specific pathways are urgently needed to identify underlying pathomechanisms and enable personalized medicine treatment...
2023: International Journal of Tryptophan Research: IJTR
https://read.qxmd.com/read/38140895/7%C3%A2-t-characterization-of-excitatory-and-inhibitory-systems-of-acute-pain-in-healthy-female-participants
#32
JOURNAL ARTICLE
Steven J Nichols, Julio A Yanes, Meredith A Reid, Jennifer L Robinson
Current understanding of the physiological underpinnings of normative pain processing is incomplete. Enhanced knowledge of these systems is necessary to advance our understanding of pain processes as well as to develop effective therapeutic interventions. Previous neuroimaging research suggests a network of interrelated brain regions that seem to be implicated in the processing and experience of pain. Among these, the dorsal anterior cingulate cortex (dACC) plays an important role in the affective aspects of pain signals...
December 23, 2023: NMR in Biomedicine
https://read.qxmd.com/read/38130683/spinal-gaba-transporter-1-contributes-to-evoked-pain-related-behavior-but-not-resting-pain-after-incision-injury
#33
JOURNAL ARTICLE
Bruno Pradier, Daniel Segelcke, Sylvia Reichl, P K Zahn, E M Pogatzki-Zahn
The inhibitory function of GABA at the spinal level and its central modulation in the brain are essential for pain perception. However, in post-surgical pain, the exact mechanism and modes of action of GABAergic transmission have been poorly studied. This work aimed to investigate GABA synthesis and uptake in the incisional pain model in a time-dependent manner. Here, we combined assays for mechanical and heat stimuli-induced withdrawal reflexes with video-based assessments and assays for non-evoked (NEP, guarding of affected hind paw) and movement-evoked (MEP, gait pattern) pain-related behaviors in a plantar incision model in male rats to phenotype the effects of the inhibition of the GABA transporter (GAT-1), using a specific antagonist (NO711)...
2023: Frontiers in Molecular Neuroscience
https://read.qxmd.com/read/38125496/efficacy-and-safety-of-ciprofol-hsk3486-for-procedural-sedation-and-anesthesia-induction-in-surgical-patients-a-systematic-review-and-meta-analysis
#34
JOURNAL ARTICLE
Jiaxuan Wen, Chen Liu, Xueying Ding, Zimeng Tian, Wenyu Jiang, Xiuhong Wei, Xin Liu
BACKGROUND: Ciprofol (HSK3486) is a novel gamma-aminobutyric acid type A (GABAA) receptor agonist that has attracted wide attention because of its lower injection pain and fewer adverse events. We summarized all available evidence and analyzed the efficacy and safety of ciprofol during procedural sedation and anesthesia induction. METHODS: An electronic search of PubMed, Embase, Cochrane Library, Web of Science, Google Scholar, Science Direct, the Chinese National Knowledge Infrastructure, Wan Fang Data, and the VIP Chinese Journal Service platform was conducted from inception of databases to March 1, 2023...
December 2023: Heliyon
https://read.qxmd.com/read/38124193/constitutive-kcc2-cell-and-synapse-specifically-regulates-nmda-receptor-activity-in-the-spinal-cord
#35
JOURNAL ARTICLE
Yuying Huang 黄玉莹, Hong Chen 陈红, Jian-Ying Shao 邵建英, Jing-Jing Zhou 周京京, Shao-Rui Chen 陈少瑞, Hui-Lin Pan 潘惠麟
K+ -Cl- cotransporter-2 (KCC2) critically controls neuronal chloride homeostasis and maintains normal synaptic inhibition by GABA and glycine. Nerve injury diminishes synaptic inhibition in the spinal cord via KCC2 impairment. However, how KCC2 regulates nociceptive input to spinal excitatory and inhibitory neurons remains elusive. Here, we show that basal GABA reversal potentials were significantly more depolarized in vesicular GABA transporter (VGAT)-expressing inhibitory neurons than in vesicular glutamate transporter-2 (VGluT2)-expressing excitatory neurons in spinal cords of male and female mice...
December 12, 2023: Journal of Neuroscience
https://read.qxmd.com/read/38093330/role-of-spinal-astrocytes-through-the-perisynaptic-astrocytic-process-in-pathological-pain
#36
REVIEW
Hyoung-Gon Ko, Heejung Chun, Seunghyo Han, Bong-Kiun Kaang
Pathological pain is caused by abnormal activity in the neural circuit that transmits nociceptive stimuli. Beyond homeostatic functions, astrocytes actively participate in regulating synaptic transmission as members of tripartite synapses. The perisynaptic astrocytic process (PAP) is the key structure that allows astrocytes to play these roles and not only physically supports synapse formation through cell adhesion molecules (CAMs) but also regulates the efficiency of chemical signaling. Accumulating evidence has revealed that spinal astrocytes are involved in pathological pain by modulating the efficacy of neurotransmitters such as glutamate and GABA through transporters located in the PAP and by directly regulating synaptic transmission through various gliotransmitters...
December 13, 2023: Molecular Brain
https://read.qxmd.com/read/38067133/effects-of-acute-and-chronic-gabapentin-treatment-on-cardiovascular-function-of-rats
#37
JOURNAL ARTICLE
Ved Vasishtha Pendyala, Sarah Pribil, Victoria Schaal, Kanika Sharma, Sankarasubramanian Jagadesan, Li Yu, Vikas Kumar, Chittibabu Guda, Lie Gao
Gabapentin (GBP), a GABA analogue, is primarily used as an anticonvulsant for the treatment of partial seizures and neuropathic pain. Whereas a majority of the side effects are associated with the nervous system, emerging evidence suggests there is a high risk of heart diseases in patients taking GBP. In the present study, we first used a preclinical model of rats to investigate, firstly, the acute cardiovascular responses to GBP (bolus i.v. injection, 50 mg/kg) and secondly the effects of chronic GBP treatment ( i...
November 25, 2023: Cells
https://read.qxmd.com/read/38045227/peripheral-gating-of-pain-by-glial-endozepine
#38
Xinmeng Li, Arthur Silveira Prudente, Vincenzo Prato, Xianchuan Guo, Han Hao, Frederick Jones, Sofia Figoli, Pierce Mullen, Yujin Wang, Raquel Tonnello, Sang Hoon Lee, Shihab Shah, Benito Maffei, Temugin Berta, Xiaona Du, Nikita Gamper
We report that diazepam binding inhibitor (DBI) is a glial messenger mediating satellite glia-sensory neuron crosstalk in the dorsal root ganglion (DRG). DBI is highly and specifically expressed in satellite glia cells (SGCs) of mice, rat and human, but not in sensory neurons or other DRG-resident cells. Knockdown of DBI results in a robust mechanical hypersensitivity without significant effects on other sensory modalities. In vivo overexpression of DBI in SGCs reduces sensitivity to mechanical stimulation and alleviates mechanical allodynia in neuropathic and inflammatory pain models...
November 21, 2023: bioRxiv
https://read.qxmd.com/read/38033709/neural-indices-of-multimodal-sensory-and-autonomic-hyperexcitability-in-fibromyalgia
#39
JOURNAL ARTICLE
Ksenija Marinkovic, Denali Woodruff, David R White, Morgan M Caudle, Terry Cronan
Fibromyalgia (FM) is characterized by chronic widespread musculoskeletal pain and psychological distress. Research suggests people with FM experience increased somatosensory sensitization which generalizes to other sensory modalities and may indicate neural hyperexcitability. However, the available evidence is limited, and studies including measures of neural responsivity across sensory domains and both central and peripheral aspects of the neuraxis are lacking. Thirty-nine participants (51.5 ± 13...
2023: Neurobiology of Pain
https://read.qxmd.com/read/38021980/gabapentin-induced-myoclonus-in-a-patient-with-chronic-kidney-disease
#40
Ammar N Mohamed, Marie-Alex Michel, Samy I McFarlane
Gabapentin contains a cyclohexyl group and is a form of gamma-aminobutyric acid (GABA). Despite its name, gabapentin does not affect the inhibitory neurotransmitter GABA or its receptors. Instead, it acts as a ligand, binding strongly to the α2δ (Ca) channel subunit and interfering with its regulatory function and the release of excitatory neurotransmitters. Gabapentin is approved by the FDA for treating seizure disorders and neuropathic pain, except for trigeminal neuralgia. However, it is frequently used off-label to treat other pain conditions and psychological disorders, such as anxiety...
October 2023: Curēus
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