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Very And Rare And Tumors

Zhongshun Wang, Daren Xu, Xuekui Wang, Yue Jin, Bo Huo, Yalei Wang, Chengyan He, Xueqi Fu, Nan Lu
Circulating tumor cells (CTCs) are important markers for cancer diagnosis and treatment, but it is still a challenge to recognize and isolate CTCs because they are very rare in the blood. To selectively recognize CTCs and improve the capture efficiency, micro/nanostructured substrates have been fabricated for this application; however the size of CTCs is often ignored in designing and engineering micro/nanostructured substrates. Herein, a spiky polymer micropillar array is fabricated for capturing CTCs with high efficiency...
March 22, 2019: Nanoscale
Kazuhiko Morikawa, Shigeki Misumi, Taiki Fukuda, Hiroya Ojiri, Hideki Matsudaira, Shun Sato
Pulmonary sclerosing pneumocytoma is an uncommon slow-growing benign tumor that usually occurs in middle-aged women and generally presents as a solitary well-defined nodule. An 18-year-old woman was incidentally detected to have multiple lung nodules on chest radiography that slowly increased in size over a period of 7 years. Computed tomography images showed multiple well-defined nodules surrounded by numerous smaller nodules with a maximum diameter of 3 cm in the left lung. A percutaneous core needle biopsy was performed, but malignancy could not be excluded because of the high proportion of papillary structures...
May 2019: Radiology Case Reports
Yukinori Yamagata, Kazuyuki Saito, Shinichi Ban, Akiko Fujii, Masatoshi Oya
BACKGROUND: Primary gastric squamous cell carcinoma (SCC) is a very rare disease. The origin of this tumor remains unclear, although there are some hypotheses. A 60-year-old man consulted a previous physician complaining of upper abdominal pain. Esophagogastroduodenoscopy revealed type 2 gastric cancer, and the patient was referred to our hospital. After close examination, the patient was diagnosed as cStage IIA gastric adenocarcinoma, and distal gastrectomy was performed. Histochemical studies showed typical findings of SCC, and the tumor was surrounded by intestinal metaplasia...
March 19, 2019: World Journal of Surgical Oncology
Sarthak Tripathy, Averilicia Passah, Abhinav Singhal, Arun Prashanth, Rakesh Kumar
MPNSTs (malignant peripheral nerve sheath tumors) are a highly malignant group of soft tissue sarcomas and carry a very poor prognosis. Metastasis to bilateral adrenal glands is very rare in such group of neoplasms. We discuss a case of 85-year-old man who was diagnosed with MPNST from prevertebral mass with metastases to bilateral adrenal glands and bone marrow from the beginning and role of serial F-FDG PET/CT scans in response assessment first to sunitinib (tyrosine kinase inhibitor) and then to liposomal doxorubicin...
March 15, 2019: Clinical Nuclear Medicine
Jun Wang, Diana M Merino, Nicholas Light, Brian L Murphy, Yong-Dong Wang, Xiaohui Guo, Andrew P Hodges, Lianne Q Chau, Kun-Wei Liu, Girish Dhall, Shahab Asgharzadeh, Erin N Kiehna, Ryan J Shirey, Kim D Janda, Michael David Taylor, David Malkin, David W Ellison, Scott R VandenBerg, Charles G Eberhart, Rosalie C Sears, Martine F Roussel, Richard J Gilbertson, Robert J Wechsler-Reya
Choroid plexus carcinoma (CPC) is a rare brain tumor that occurs most commonly in very young children and has a dismal prognosis despite intensive therapy. Improved outcomes for CPC patients depend on a deeper understanding of the mechanisms underlying the disease. Here we developed transgenic models of CPCs by activating the Myc oncogene and deleting the Trp53 tumor suppressor gene in murine neural stem cells or progenitors. Murine CPC resembled their human counterparts at a histological level, and like the hypodiploid subset of human CPC, exhibited multiple whole-chromosome losses, particularly of chromosomes 8, 12 and 19...
March 18, 2019: Cancer Research
Jaime Dalla Rosa, José Juan Nogales Zafra
BACKGROUND: Intra-articular lipomas are rare and very few cases have been reported in the knee. To the best of our knowledge, here we report the largest lipoma to have ever been observed in the knee. It is crucial to avoid the misdiagnose of lipoma arborescens, which is associated with degenerative joint disease. Lipoma is a homogeneous, ovoid, adipose tissue tumor that is contained within a fibrous capsule and not associated with previous disease. CASE PRESENTATION: A 48-year-old male, with a soft-tissue tumor on the superomedial aspect of the right knee...
March 18, 2019: BMC Musculoskeletal Disorders
A Košec, K Zurak, H Čupić, V Bedeković
INTRODUCTION: Primary liposarcoma is very rare in the parotid gland. To date, only 8 cases of primary parotid liposarcoma have been reported. The aim of this study is to report on a case of primary parotid liposarcoma highlighting the complexity of its treatment and analyze treatment outcomes of other reported cases. CASE SUMMARY: We report a case of parotid liposarcoma arising in the left parotid gland of a 66 year-old man, causing local morbidity, recurrence, repeated surgical treatment and death 5 months after initial treatment...
March 12, 2019: European Annals of Otorhinolaryngology, Head and Neck Diseases
Muhammad W Saif
Capecitabine, an oral prodrug of 5-fluorouracil (5-FU) is extensively used to treat many solid tumors, particularly breast and colorectal cancers. Neurotoxicity of capecitabine has been rarely reported as peripheral neuropathy, cerebellar syndrome, and multifocal leukoencephalopathy. Although very little is known about the pathogenetic mechanisms responsible for this toxicity, dihydropyrimidine dehydrogenase (DPD) deficiency has been found in few of these patients. TYMS gene encodes for the human thymidylate synthase, and is considered a candid factor for toxicity and efficacy of 5-FU and capecitabine...
April 2019: Anti-cancer Drugs
Aydan Arslan, Sila Ulus, Ümit İnce, Gonca Tekant, Ercan Karaarslan
Leiomyomas are benign, slow-growing, smooth muscle tumors, which can occur at many locations in the body. The male genitourinary tract is seldom affected and scrotal leiomyomas are extremely rare. Most of the scrotal leiomyomas are localized in the testis, epididymis, spermatic cord, subcutaneous tissue, tunica albuginea, and scrotal skin and only a few of them are reported in the origin of isolated tissue without paratesticular structures in the paratesticular region. We are presenting a case of solitary paratesticular leiomyoma in a child, which is very rare in terms of lesion location and patient age, and describing the imaging features of this lesion...
September 12, 2018: Turkish Journal of Urology
Alexandra Maby, Benoit Guay, François Thuot
BACKGROUND: Infantile myofibromatosis is the most common benign fibrous tumor in infants. Three different types have been reported in the literature. The most commonly affected areas are the head, the neck and the trunk. Our patient showed a very high level of mandibular destruction resistant to all mandibular sparing treatment strategies requiring segmental mandibulectomy and complex reconstruction. CASE PRESENTATION: We describe a rare case of multicentric infantile myofibromatosis with mandibular bone destruction...
March 14, 2019: Journal of Otolaryngology—Head & Neck Surgery
Atul Tiwari, Brij Mohan K Singh, Shubham Varshney, Mohan L Yadav
Fibroadenoma, being a very common benign tumor of the breast in young females, does not pose any threat and, thus, can be treated with lumpectomy. Breast cancer arising within a fibroadenoma is a rare phenomenon, but detecting these neoplasms is of utmost importance for complete treatment and follow-up. These lesions are an incidental finding in a lumpectomy specimen done for fibroadenoma breast. A 28-year-old female presented with multiple bilateral lumps for eight years. The lumps were mobile, non-tender, and slowly growing, with no nipple discharge, no axillary lymphadenopathy, and no family history...
December 31, 2018: Curēus
Dimitrios Siamkouris, Marc Schloesser, Amr Yousef, Elmar Offers
Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors of the gastrointestinal tract. The major cause of GIST is the presence of an abnormal form of tyrosine protein kinase (KIT) protein also known as CD117, which causes uncontrollable growth of the gastrointestinal cells. Most studies report incidences between 10 and 15 cases of GISTs per million. Metastases to the liver and peritoneum are the most frequent. We report a case of advanced GIST with a liver metastasis infiltrating the inferior vena cava (IVC) and extending to the right atrium in the form of a large, floating, isolated intracardiac liver metastasis with diastolic prolapsing through the tricuspid valve...
2019: Case Reports in Cardiology
Muhammad Asim Shahzad, Maryam Mukhtar, Asrar Ahmed, Waqas Ullah, Rehan Saeed, Mohsin Hamid
Gitelman syndrome is one of the few inherited causes of metabolic alkalosis due to salt losing tubulopathy. It is caused by tubular defects at the level of distal convoluted tubules, mimicking a thiazide-like tumor. It usually presents in late childhood or in teenage as nonspecific weakness, fatigability, polyuria, and polydipsia but very rarely with seizures. It is classically associated with hypokalemia, hypomagnesemia, hypocalciuria, hyperreninemia, and hyperaldosteronism. However, less frequently, it can present with normal magnesium levels...
2019: Case Reports in Medicine
Muge Gore Karaali, Asude Kara Polat, Ayse Esra Koku Aksu, Cem Leblebici, Mehmet Salih Gurel
Angiolipoma, a subtype of lipoma, is a benign adypocytic soft tissue tumor composed of mature adipose tissue and small vascular proliferations. This entity makes up 5-17% of all lipomas. The diagnosis is made by clinical and pathological examination, ultrasonography, and/or magnetic resonance imaging (MRI). It is generally an encapsulated tumor (noninfiltrative), but rarely has an infiltrative form. Angiolipoma mostly occurs on the trunk and extremities with male predominance. The forearm is the most frequent location for angiolipomas...
February 15, 2019: Dermatology Online Journal
Lijuan Cao, Xialing Zhang, Yin Wang, Yun Bao, Feng Tang
This report describes the clinicopathological findings of a solitary fibrous tumor (SFT)/hemangiopericytoma (HPC) of the central nervous system in a 59-year-old man with space-occupying lesions on both the left anterior basicranial and on the top tail of falx cerebri. The tumor showed small quantities of solid papillary areas and a prominent papillary structure, where atypical cells were compactly arranged along the fibrovascular core. The tumor cells of both components showed nuclear relocalization of the signal transducer and activator of transcription 6 protein, with very high specificity and sensitivity for the diagnosis of SFT/HPC...
March 12, 2019: Neuropathology: Official Journal of the Japanese Society of Neuropathology
Asiye Şafak Bulut, Aynur Albayrak, Sezer Kulaçoğlu
Salivary gland neoplasms account for approximately 3-4% of all head and neck neoplasms, almost 80% of which are solitary tumors in the parotid gland (1). Tumors with different histological types in the same gland are uncommon, and the majority of these tumors are a combination of Warthin's tumors (WT) and pleomorphic adenomas (PA) (2). The coexistence of benign and malignant tumors in the same gland is very rare, and was first reported by Tanaka in 1953 (3). Here, we present a case of synchronous unilateral parotid gland salivary duct carcinoma (SDC) and WT...
March 12, 2019: Cytopathology: Official Journal of the British Society for Clinical Cytology
Gang Wang, Gang-Gang Li, Sheng-Mao Zhu, Bao-Jia Cai, Peng-Jie Yu, Cheng-Wu Zhang
BACKGROUND: Melanotic Xp11-associated tumors are rare mesenchymal-derived tumors. So far, most primary melanotic Xp11-associated tumors have been reported in the kidney, and reports of this tumor in the gastrointestinal tract are rare. CASE SUMMARY: Here we describe the case of a 25-year-old woman who presented with a melanotic Xp11-associated tumor in the sigmoid colon. Colonoscopy revealed a large mucosal bulge in the sigmoid colon, approximately 32 cm inside the anus...
March 6, 2019: World Journal of Clinical Cases
Bo Lin, Hong-Yu Yang, Hui-Jun Yang, Shi-Yue Shen
BACKGROUND: Paraganglioma/pheochromocytoma and medullary thyroid carcinoma can coexist and are often found in multiple endocrine neoplasia (MEN). However, very few cases highlight papillary thyroid carcinoma. We present herein a rare case of head and neck paraganglioma associated with papillary thyroid carcinoma. CASE SUMMARY: A 51-year-old man presented to our department with right-sided neck swelling and hypertension. Physical examination showed neck masses with obvious pulsation...
March 6, 2019: World Journal of Clinical Cases
Priyadarshini Patro, Padma Das, Divya Sachdev, Nitinkumar Borkar, Satyaki Ganguly, Nighat Hussain
Subcutaneous zygomycosis is a rare fungal infection caused by Basidiobolus ranarum . This entity is usually endemic in South India and only limited numbers of cases have been reported from central India. We report a case of 4-year-old male child from Chhattisgarh, who presented with a painless, non-tender, large, subcutaneous swelling of 4 months duration on the right upper arm, which was initially misdiagnosed as benign spindle cell tumor and advised surgical resection. But the fungal culture of the affected tissue grown Basidiobolus ranarum and the child responded very well to itraconazole therapy only...
June 2019: Medical Mycology Case Reports
Anthony L Mikula, Michael A Paolini, William R Sukov, Michelle J Clarke, Aditya Raghunathan
Subependymomas of the spinal cord are rare, do not often involve multiple levels, and very rarely recur. Here, we present a series of spinal cord subependymomas with a detailed description of the clinical, radiological and pathological features, and characterization by chromosomal microarray analysis. Briefly, the four patients included two men and two women, between the ages of 22 and 48 years. The most common presenting symptoms were neck and arm pain with upper extremity weakness. By imaging, the tumors were found to involve multiple spinal levels, including cervical/ cervico-thoracic (three patients) and thoracic (one patient), were all eccentric, and had minimal to no post-contrast enhancement...
March 11, 2019: Neuropathology: Official Journal of the Japanese Society of Neuropathology
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