Pompeo Volpe, Alessandra Bosutti, Alessandra Nori, Riccardo Filadi, Gaia Gherardi, Gabor Trautmann, Sandra Furlan, Gabriele Massaria, Marina Sciancalepore, Aram Megighian, Paola Caccin, Annalisa Bernareggi, Michele Salanova, Roberta Sacchetto, Dorianna Sandonà, Paola Pizzo, Paola Lorenzon
Inositol 1,4,5-trisphosphate receptors (IP3Rs) are enriched at postsynaptic membrane compartments of the neuromuscular junction (NMJ), surrounding the subsynaptic nuclei and close to nicotinic acetylcholine receptors (nAChRs) of the motor endplate. At the endplate level, it has been proposed that nerve-dependent electrical activity might trigger IP3-associated, local Ca2+ signals not only involved in excitation-transcription (ET) coupling but also crucial to the development and stabilization of the NMJ itself...
November 7, 2022: Journal of General Physiology