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Sleeping disorders

Navin Cooray, Fernando Andreotti, Christine Lo, Mkael Symmonds, Michele T M Hu, Maarten De Vos
OBJECTIVE: Evidence suggests Rapid-Eye-Movement (REM) Sleep Behaviour Disorder (RBD) is an early predictor of Parkinson's disease. This study proposes a fully-automated framework for RBD detection consisting of automated sleep staging followed by RBD identification. METHODS: Analysis was assessed using a limited polysomnography montage from 53 participants with RBD and 53 age-matched healthy controls. Sleep stage classification was achieved using a Random Forest (RF) classifier and 156 features extracted from electroencephalogram (EEG), electrooculogram (EOG) and electromyogram (EMG) channels...
February 6, 2019: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Iranzo A, Stefani A, Högl B, Santamaria J
OBJECTIVE: As Franz Kafka, one of the most important writers of the 20th century, suffered from severe chronic insomnia disorder and inadequate sleep hygiene that impaired his quality of life, we speculated that sleep disorders would be found in his narrative works. METHODS: We read Kafka's complete literary works looking for references to sleep and sleep disorders, excluding insomnia. RESULTS: In Kafka's works, sleeping well and for a long time was used as an allegory of having a pleasant life...
December 31, 2018: Sleep Medicine
Paulo Bugalho, Manuel Salavisa, João Pedro Marto, Claudia Borbinha, Luísa Alves
INTRODUCTION: Sleep dysfunction is frequent in Dementia with Lewy Bodies (DLB), but polysomnographic (PSG) data is scarce. Our objectives were to: (1) compare PSG data between DLB patients and age normative values (NV), Parkinson's Disease (PD) and idiopathic REM sleep behavior disorder (iRBD) patients; (2) evaluate the relation between of OSA, Fluctuations and Hypersomnolence and PSG data. METHODS: We selected all consecutive patients with DLB, PD and iRBD that underwent video-PSG during a two year period...
December 18, 2018: Sleep Medicine
Marcin Burghard, Eliza Brożek-Mądry, Antoni Krzeski
STUDY OBJECTIVES: The purpose of this work is to present available questionnaires enabling diagnostic screening when obstructive sleep disordered breathing (SDB) in a child is suspected or its effects are observed and polysomnography is unavailable. These questionnaires are designed to facilitate further diagnostic process or even therapeutic decisions, aid in selecting the optimal one for the specified conditions of clinical practice, with the caveat that none of these represents a diagnostic equivalent to PSG...
February 5, 2019: International Journal of Pediatric Otorhinolaryngology
Laura Escobar Fernández, Alejandra Coccolo Góngora, María Vázquez López, Ana Paloma Polo Arrondo, María Concepción Miranda Herrero, Estíbaliz Barredo Valderrama, Pedro Castro de Castro
INTRODUCTION: Continuous spikes and waves during slow sleep (CSWS) is an EEG pattern that appears during childhood, and is often associated with cognitive impairment. It can appear in the course of epileptic syndromes, as well as in benign epilepsy. The aim of this study is to analyse epidemiological and clinical characteristic of patients with CSWS, in order to describe possible predictive factors in their outcome. METHODS: A retrospective study was conducted on paediatric patients with CSWS treated in a third-level hospital from November 1997 to November 2017...
February 13, 2019: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
Louis-Philippe Boulet, Julie Turmel
In the general population, particularly in individuals with asthma, cough is a common symptom, often reported after exertion, although regular exercise may be associated with a reduction in the prevalence of cough. In athletes, exercise-induced cough is also a particularly frequent symptom. The main etiologies of cough in athletes are somewhat similar to non-athletes, including asthma/airway hyperresponsiveness, upper airways disorders such as allergic or non-allergic rhinitis, and exercise-induced laryngeal obstruction, although these conditions are more frequently observed in athletes...
February 13, 2019: Pulmonary Pharmacology & Therapeutics
Terry Kit Selfe, Sijin Wen, Karen Sherman, Maryanna Klatt, Kim E Innes
BACKGROUND: Restless legs syndrome (RLS) is a common and burdensome sleep disorder associated with profound impairment of health, well-being, and quality of life. Unfortunately, the medications used for RLS management carry risk of serious side effects, including augmentation of symptoms. Yoga, an ancient mind-body discipline designed to promote physical, emotional, and mental well-being, may offer a viable, low-risk new treatment. The primary objectives of this pilot, parallel-arm, randomized controlled trial (RCT) are to assess the acceptability and feasibility of a 12-week yoga vs...
February 15, 2019: Trials
Luca Baldelli, Olga Addimanda, Marco Burattini, Giacomo Chiaro, Veronica Brusi, Elettra Pignotti, Riccardo Meliconi, Federica Provini
OBJECTIVES: To investigate the prevalence of REM sleep behavior disorder (RBD) in patients with inflammatory arthritis (IA) to ascertain if RBD could be an internal red flag signaling a fluctuating state of inflammation based on the theory of "protoconsciousness". MATERIALS & METHODS: One hundred and three patients with a confirmed diagnosis of IA were consecutively recruited. The patients underwent general (IA activity, functional status, laboratory tests) and neurological evaluations...
February 15, 2019: Brain and Behavior
V Donadio, K Doppler, A Incensi, A Kuzkina, A Janzen, G Mayer, J Volkmann, G Rizzo, E Antelmi, G Plazzi, C Sommer, R Liguori, W H Oertel
BACKGROUND: Visualization of phosphorylated α-synuclein at serine 129 (p-syn) in skin nerves is a promising test for the in vivo diagnosis of synucleinopathies. Here we aimed to establish the intra- and inter-laboratory reproducibility of quantification of intraneural p-syn immunoreactivity in two laboratories with a major expertise (Würzburg and Bologna). METHODS: We enrolled 43 patients affected by Parkinson's disease (PD: 21 patients), Dementia with Lewy Body (DLB: 1), REM sleep behavior disorder (RBD: 11), Multiple System Atrophy (MSA-P: 4) and small fiber neuropathy (SFN: 6)...
February 15, 2019: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Sonja Rutten, Chris Vriend, Jan H Smit, Henk W Berendse, Eus J W van Someren, Adriaan W Hoogendoorn, Jos W R Twisk, Ysbrand D van der Werf, Odile A van den Heuvel
OBJECTIVE: To assess the efficacy of bright light therapy (BLT) in reducing depressive symptoms in patients with Parkinson disease (PD) and major depressive disorder (MDD) compared to a control light. METHODS: In this double-blind controlled trial, we randomized patients with PD and MDD to treatment with BLT (±10,000 lux) or a control light (±200 lux). Participants were treated for 3 months, followed by a 6-month naturalistic follow-up. The primary outcome of the study was the Hamilton Depression Rating Scale (HDRS) score...
February 15, 2019: Neurology
Cinthia Amiñoso, María Gordillo-Marañón, Jaime Hernández, Jesús Solera
Glycogen storage disease type II, or Pompe disease, is an autosomal recessive disorder caused by deficiency of lysosomal acid alpha-glucosidase (GAA). We performed genetic analysis to confirm the diagnosis of Pompe disease in a 61-year-old patient with progressive weakness in extremities, severe Sleep Apnea-Hypopnea Syndrome, a significant reduction of alpha-glucosidase in liquid sample of peripheral blood and muscular biopsy diagnosis. GAA gene sequencing showed the patient is homozygous for the splice-site mutation c...
December 15, 2018: Neuromuscular Disorders: NMD
Carla Leal, Manuel Galea, Felipe Osorio
The concordance correlation coefficient (CCC) and the probability of agreement (PA) are two frequently used measures for evaluating the degree of agreement between measurements generated by two different methods. In this paper, we consider the CCC and the PA using the bivariate normal distribution for modeling the observations obtained by two measurement methods. The main aim of this paper is to develop diagnostic tools for the detection of those observations that are influential on the maximum likelihood estimators of the CCC and the PA using the local influence methodology but not based on the likelihood displacement...
February 15, 2019: Biometrical Journal. Biometrische Zeitschrift
Bhanu Prakash Kolla, Jian-Ping He, Meghna P Mansukhani, Suresh Kotagal, Mark A Frye, Kathleen R Merikangas
OBJECTIVE: Recent attention to pervasive sleep deficits in U.S. adolescents has focused on sleep patterns and insomnia, but there are limited data on the prevalence and correlates of hypersomnolence symptoms. METHOD: The sample included 6,483 adolescents ages 13-18 years who were interviewed directly and had parent reports in the National Comorbidity Survey Replication Adolescent Supplement (NCS-A), a nationally representative sample of US youth. Information on sleep patterns/symptoms that were collected in the interview was used to determine the population prevalence of DSM-5 criterion-A defined hypersomnolence and component symptoms...
October 30, 2018: Journal of the American Academy of Child and Adolescent Psychiatry
Stephen P Becker, Jeffery N Epstein, Leanne Tamm, Alina A Tilford, Clair M Tischner, Paul A Isaacson, John O Simon, Dean W Beebe
OBJECTIVE: Although poor sleep is often reported in adolescents with attention-deficit/hyperactivity disorder (ADHD), prior studies have been correlational. This study investigated whether sleep duration is causally linked to sleepiness, inattention, and behavioral functioning in adolescents with ADHD. METHOD: Seventy-two adolescents (ages 14-17 years) entered a three-week sleep protocol using an experimental crossover design. The protocol included a phase stabilization week, followed in randomized counterbalanced order by 1 week of sleep restriction (6...
November 1, 2018: Journal of the American Academy of Child and Adolescent Psychiatry
Sophie Desjadins, Sylvie Lapierre, Carol Hudon, Alain Desgagné
STUDY OBJECTIVES: Research indicates that sleep efficiency below 80% substantially increases mortality risk in elderly persons. The aim of this study was to identify factors that would best predict poor sleep efficiency in the elderly, and to determine whether associations between these factors and sleep efficiency were similar for men and women and for younger and older elderly persons. METHODS: A total of 2,468 individuals aged 65-96 years (40.7% men) participated...
February 15, 2019: Sleep
Xuan Zhang, Zhiyi Song, Jingyi Ye, Ying Fu, Jinying Wang, Lei Su, Xiaodong Zhu, Meiyun Zhang, Yan Cheng, Wei Wu, Rong Xue
OBJECTIVES: To compare the sleep characteristics and cognition between rapid eye movement sleep behavior disorder (RBD) patients and non-RBD (nRBD) healthy control subjects and to determine the correlation between sleep and cognition in RBD patients. METHODS: Polysomnography (PSG) was performed to confirm and exclude RBD. Fifteen iRBD patients, 12 PD with RBD patients, and 23 matched nRBD healthy control subjects were enrolled. Subjective sleep and neuropsychological evaluations were performed...
February 14, 2019: Brain and Behavior
R Pradeep, Dhananjay Gupta, Anish Mehta, R Srinivasa, Mahendra Javali, P T Acharya
Altered sleep architecture and stroke share a reciprocal relationship. More than half of the stroke patients display sleep abnormalities including hypersomnia, insomnia, parasomnia, periodic limb movements, or sleep-disordered breathing. Conversely, one of the major causes of severe organic hypersomnia is acute brainstem strokes, involving thalamic infarctions, which may be reversible over 6-12 months. Here, we report a patient with increased lethargy and drowsiness who was diagnosed to have a right thalamic and hypothalamic ischemic stroke...
January 2019: Journal of Neurosciences in Rural Practice
Adam Al-Diwani, Adam Handel, Leigh Townsend, Thomas Pollak, M Isabel Leite, Paul J Harrison, Belinda R Lennox, David Okai, Sanjay G Manohar, Sarosh R Irani
BACKGROUND: Early immunotherapy administration improves outcomes in patients with N-methyl-D-aspartate receptor (NMDAR)-antibody encephalitis. As most patients with NMDAR-antibody encephalitis present to psychiatrists, the psychopathology of NMDAR-antibody encephalitis needs to be clearly defined to encourage accurate clinical identification and prompt treatment. METHODS: For this systematic review, we searched PubMed for all studies published in English between Jan 1, 2005, and Oct 7, 2017, to identify individually reported adult patients (≥18 years) who satisfied consensus criteria for definite NMDAR-antibody encephalitis...
February 11, 2019: Lancet Psychiatry
A M Hawkins, C L Hawkins, K Abdul Razak, T K Khoo, K Tran, R V Jackson
Myotonic dystrophy type 1 (DM1) is one of the most common muscular dystrophies in adults. This review summarises the current literature regarding the natural history of respiratory dysfunction in DM1, the role of central respiratory drive and peripheral respiratory muscle involvement and its significance in respiratory function, and investigates the relationship between genetics (CTG repeat length) and respiratory dysfunction. The review included all articles that reported spirometry on 10 or more myotonic dystrophy patients...
December 9, 2018: Neuromuscular Disorders: NMD
Gonzalo Safont, Addisson Salazar, Luis Vergara
Alpha integration methods have been used for integrating stochastic models and fusion in the context of detection (binary classification). Our work proposes separated score integration (SSI), a new method based on alpha integration to perform soft fusion of scores in multiclass classification problems, one of the most common problems in automatic classification. Theoretical derivation is presented to optimize the parameters of this method to achieve the least mean squared error (LMSE) or the minimum probability of error (MPE)...
February 14, 2019: Neural Computation
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