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Antioxidant and health

M Guidoni, M M de Christo Scherer, M M Figueira, E F P Schmitt, L C de Almeida, R Scherer, S Bogusz, M Fronza
Vegetable oils have been used for a plethora of health benefits by their incorporation in foods, cosmetics, and pharmaceutical products, especially those intended for skin care. This study aimed to investigate the cutaneous benefits of a vegetable oil blend (VOB) formulation and its fatty acid composition. The anti-inflammatory activity was studied in macrophages of RAW 264.7 cells by investigating the release of nitric oxide (NO), superoxide anion generation (O2-), tumor necrosis factor-alpha (TNF-α), and interleukin 6 (IL-6)...
February 14, 2019: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
João H Reis, Roger R Gebert, Mauricio Barreta, Marcel M Boiago, Carine F Souza, Matheus D Baldissera, Ingrid D Santos, Roger Wagner, Luciane V Laporta, Lenita M Stefani, Aleksandro S Da Silva
The aim of this study was to evaluate whether the addition of grape pomace flour (GPF) in the diet of laying hens at the end of the productive cycle and on heat stress could exert benefits on their health and performance, as well as egg quality. For this, 74-week-old laying hens (n = 64) were divided into four groups with four repetitions each, as follow: T0 (the control group; without GPF), T1 (1% GPF), T2 (2% GPF) and T3 (3% GPF) during 35 days. Percentage of laid eggs was higher in the group T1 compared to T0, and the feed intake was higher in the groups T1, T2 and T3 compared to T0...
February 2019: Journal of Thermal Biology
Takumi Tochio, Yuki Ueno, Yasuyuki Kitaura, Mikako Shinohara, Yoshihiro Kadota, Kanako Minoda, Yoshiharu Shimomura, Toshihiko Osawa
Functional food ingredients, including prebiotics, have been increasingly developed for human health. The improvement of the human intestinal environment is one of their main targets. Fructooligosaccarides (FOS) are oligosaccharide fructans that are well studied and commercialized prebiotics. 1-Kestose, one of the components of FOS, is considered to be a key prebiotic component in FOS. However, to our knowledge, no studies have been reported on the physiological efficacy of 1-Kestose regarding its anti-oxidative activity...
February 13, 2019: Foods (Basel, Switzerland)
Akinobu Takaki, Seiji Kawano, Daisuke Uchida, Masahiro Takahara, Sakiko Hiraoka, Hiroyuki Okada
Oxidative stress is recognized as a cancer-initiating stress response in the digestive system. It is produced through mitochondrial respiration and induces DNA damage, resulting in cancer cell transformation. However, recent findings indicate that oxidative stress is also a necessary anticancer response for destroying cancer cells. The oxidative stress response has also been reported to be an important step in increasing the anticancer response of newly developed molecular targeted agents. Oxidative stress might therefore be a cancer-initiating response that should be downregulated in the precancerous stage in patients at risk of cancer but an anticancer cell response that should not be downregulated in the postcancerous stage when cancer cells are still present...
February 13, 2019: Cancers
Sosmitha Girisa, Bano Shabnam, Javadi Monisha, Lu Fan, Clarissa Esmeralda Halim, Frank Arfuso, Kwang Seok Ahn, Gautam Sethi, Ajaikumar B Kunnumakkara
Cancer is still a major risk factor to public health globally, causing approximately 9.8 million deaths worldwide in 2018. Despite advances in conventional treatment modalities for cancer treatment, there are still few effective therapies available due to the lack of selectivity, adverse side effects, non-specific toxicities, and tumour recurrence. Therefore, there is an immediate need for essential alternative therapeutics, which can prove to be beneficial and safe against cancer. Various phytochemicals from natural sources have been found to exhibit beneficial medicinal properties against various human diseases...
February 18, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Ana Lloret, Daniel Esteve, Paloma Monllor, Ana Cervera-Ferri, Angeles Lloret
Vitamin E was proposed as treatment for Alzheimer's disease many years ago. However, the effectiveness of the drug is not clear. Vitamin E is an antioxidant and neuroprotector and it has anti-inflammatory and hypocholesterolemic properties, driving to its importance for brain health. Moreover, the levels of vitamin E in Alzheimer's disease patients are lower than in non-demented controls. Thus, vitamin E could be a good candidate to have beneficial effects against Alzheimer's. However, evidence is consistent with a limited effectiveness of vitamin E in slowing progression of dementia; the information is mixed and inconclusive...
February 18, 2019: International Journal of Molecular Sciences
Roberto Berni, Claudio Cantini, Massimo Guarnieri, Massimo Nepi, Jean-Francois Hausman, Gea Guerriero, Marco Romi, Giampiero Cai
Background: A diet rich in fruits and vegetables contributes to lowering the risk of chronic diseases. The fruits of Malus x domestica are a rich dietary source of bioactive compounds, namely vitamins and antioxidants, with recognized action on human health protection. Tuscany is known for its rich plant biodiversity, especially represented by ancient varieties of fruit trees. Particularly noteworthy are the many ancient Tuscan varieties of apple trees. Methods: Sugar quantification via HPLC and spectrophotometric assays to quantify the antioxidant power and total polyphenol content revealed interesting differences in 17 old varieties of Malus x domestica Borkh...
February 18, 2019: Medicines (Basel, Switzerland)
Taiwo O Elufioye, Solomon Habtemariam
Liver diseases such as hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma are one of the major health challenges in the world and many conditions such as inadequate nutrition, viral infection, ethanol and drug abuse, xenobiotic exposure, and metabolic diseases have been implicated in the development and progression of liver diseases. Several factors including lipid peroxidation, production of reactive oxygen species (ROS), peroxynitrite formation, complement factors and proinflammatory mediators, such as cytokines and chemokines, are involved in hepatic diseases...
February 16, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Hamada AbdElgawad, Ahmed M Saleh, Soad Al Jaouni, Samy Selim, Mahmoud O Hassan, Mohammed A M Wadaan, Ahmed M Shuikan, Hussein S Mohamed, Wael N Hozzein
Actinobacteria have received much attention due to their capacity for plant growth promotion, a promising approach in sustainable development of agriculture. Date palm (Phoenix dactylifera L.) is an important crop, particularly in semi-arid regions of the world, due to the high nutritional and health-promoting values of its fruits. The present study was conducted to investigate the utilization of actinobacteria as an approach to support soil fertility and enhance production and functional food value of date palm fruits in a semi-arid environment...
February 11, 2019: Science of the Total Environment
Zhenzhu Sun, Xiaohong Tan, Minglei Xu, Qingying Liu, Huaqun Ye, Cuiyun Zou, Yuanyuan Zhou, Ningning Su, Leling Chen, Anli Wang, Chaoxia Ye
The study investigated the effects of dietary supplementation with dandelion extracts (DE) on growth performance, feed utilization, body composition, serum biochemical, liver histology, immune-related gene expression and CCl4 resistance of hybrid grouper (Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀). A basal diet supplemented with DE at 0% (diet 0%), 0.1% (diet 0.1%), 0.2% (diet 0.2%), 0.4% (diet 0.4%) and 0.8% (diet 0.8%) were fed to hybrid grouper for 8 weeks. The results revealed that dietary DE had not a significant impact on growth performance and feed utilization (P > 0...
February 16, 2019: Fish & Shellfish Immunology
Luana Fernandes, Elsa Ramalhosa, Paula Baptista, José A Pereira, Jorge A Saraiva, Susana I P Casal
Edible flowers consumption and use are an increasing food trend worldwide, although information concerning their nutritional composition and nutraceutical value is still scarce. Thus, the aim of this study was to contribute to the popularization of pansies (Viola × wittrockiana), through the analysis of the nutritional and nutraceutical features of pansies with different colors (white, yellow, and red) and flowering stages. Both flower type and flowering stage influenced the flower composition. When completely open, white and yellow pansies had the highest contents of protein (>2...
February 19, 2019: Journal of Food Science
Li-Chuan Cheng, Chun-Ju Lin, Huei-Ju Liu, Lih-Ann Li
Cigarette sidestream smoke particulate matter (CSSP) is a major source of airborne metals in the indoor environment. However, the health impacts of inhalation of CSSP-bound metals are rarely studied. In this study, we quantify the amount of 37 metals discharged through CSSP from a leading Taiwan brand of cigarette, Long Life. We also estimate cancer and non-cancer risks due to inhalation of these metals and investigate possible modes of toxic action. Long Life CSSP exhibits a distinctive carcinogenic metal profile compared with Western brands...
February 18, 2019: Environmental Science and Pollution Research International
Francesca Colombo, Chiara Di Lorenzo, Luca Regazzoni, Marco Fumagalli, Enrico Sangiovanni, Luís Peres de Sousa, Luigi Bavaresco, Diego Tomasi, Antonella Bosso, Giancarlo Aldini, Patrizia Restani, Mario Dell'Agli
Several studies have shown that fresh grape and its derivatives contain phenolic compounds exhibiting antioxidant and health promoting effects, particularly in relation to the cardiovascular system. In this study, two methods were developed to characterize sixteen varieties of table and wine grapes: (1) a LC-MS method to identify major and minor phenolic compounds; and (2) a HPLC-DAD method to quantify the most representative compounds. Sixty-seven molecules belonging to different classes of phenolic compounds were identified: anthocyanins, flavan-3-ols, flavonols, stilbenes and organic acids...
February 19, 2019: Food & Function
Andrea Rodrigues Vasconcelos, Nilton Barreto Dos Santos, Cristoforo Scavone, Carolina Demarchi Munhoz
Nuclear factor erythroid 2-related factor 2 (Nrf2) regulates the expression of an array of enzymes with important detoxifying and antioxidant functions. Current findings support the role of high levels of oxidative stress in the pathogenesis of neurological disorders. Given the central role played by Nrf2 in counteracting oxidative damage, a number of studies have targeted the modulation of this transcription factor in order to confer neuroprotection. Nrf2 activity is tightly regulated by oxidative stress and energy-based stimuli...
2019: Frontiers in Pharmacology
Naeti Suksomboon, Nalinee Poolsup, Wei Lin
Background: Kiwifruit seems to have beneficial effect on metabolic health because it contains abundant phytochemicals and antioxidants. This study aimed to assess the effect of kiwifruit on metabolic health in participants with cardiovascular risk factors. Methods: Literature was searched from PubMed, CENTRAL, Cumulative Index to Nursing and Allied Health Literature, Web of Science, Scopus, Proquest, Latin American and Carib-bean Health Sciences Literature, International Clinical Trials Registry Platform, Australia New Zealand Clinical Trials Registry, https://clinicaltrials...
2019: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Nho-Eul Song, Chan-Mi Lee, Sang-Ho Baik
Biogenic amines (BAs) are widely present in nearly all fermented foods and beverages, and excess consumption can cause adverse health effects. To prepare BA-free Korean black raspberry wine (BRW), four autochthonous starter yeast strains without hazardous BA synthesis activity were selected and their physiological and biochemical properties were examined. The selected strains were identified as Saccharomyces cerevisiae based on 26S rDNA sequencing and microsatellite analysis. Molecular fingerprinting revealed that isolates were quite different from commercial wine yeast S...
February 15, 2019: Journal of General and Applied Microbiology
Chaoqun Liu, Chunrong Zhong, Renjuan Chen, Xuezhen Zhou, Jiangyue Wu, Juan Han, Xiating Li, Yu Zhang, Qin Gao, Mei Xiao, Xingwen Hu, Guoping Xiong, Weizhen Han, Xuefeng Yang, Liping Hao, Nianhong Yang
BACKGROUND & AIMS: Oxidative stress has been implicated in the pathogenesis of gestational diabetes mellitus (GDM). Vitamin C as natural antioxidant may help to increase the body's antioxidant capacity. The study is aimed to determine whether vitamin C intake during pregnancy is associated with lower risk of GDM. METHODS: Women with singleton pregnancy and without any history of diabetes were drawn from the ongoing Tongji Maternal and Child Health Cohort (TMCHC)...
February 2, 2019: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Yuan Meng, Liang Zhang, Linquan Wang, Chunju Zhou, Yuxian Shangguan, Yang Yang
The enrichment of Cadmium in vegetables is threatening human health. The study aimed to screen Cd low-enriched leafy vegetables and explore whether antioxidative enzymes and heavy metal chelators are synergistic defensive mechanisms. In this paper, the Cd accumulation and translocation of garland chrysanthemum (Chrysanthemum coronarium L.), spinach (Spinacia oleracea L.), and lettuce (Lactuca sativa L.) were examined by soil pot culture and hydroponic experiments. The responses of oxidative stress markers, antioxidative enzymes activity, and thiol pool (cysteine, γ-glutamylcysteine, glutathione, and phytochelatins) content to Cd stress were assayed...
February 14, 2019: Ecotoxicology and Environmental Safety
Ali Khan Shahbaz, Pia Muhammad Adnan Ramzani, Rashid Saeed, Veysel Turan, Muhammad Iqbal, Karolina Lewińska, Farhat Abbas, Muhammad Saqib, Hafiz Muhammad Tauqeer, Mutahar Iqbal, Maryam Fatima, Mahmood-Ur Rahman
Since Ni-rich soils are a threat to the environment, growing edible crops on Ni-rich soils can pose a serious risk to human, animal, plant and ecosystem health and, hence, is considered as a challenging task for the researchers. Contrarily, limiting the bioavailability of Ni in such soils upon the addition of suitable amendments cum foliar spray of proteinogenic amino acids having an objective to alleviate stress to crop plants can considerably reduce the environmental risk. In this pot trail, we substantiate the effects of biochar (BR) and zeolite (ZL) addition in the soil along with proline (PN) spray on the resistance, and stress responses of wheat against Ni as well as on Ni translocation and accumulation in wheat plants grown on a Ni-rich soil contaminated by electroplating effluent...
February 14, 2019: Ecotoxicology and Environmental Safety
Eduarda Escobar, Sabrina Lopes, Cristiano Malavolta, Juliana Bernera Ramalho, Daniele Missio, Hirya Fernandes Pinto, Melina Bucco Soares, Fábio Gallas Leivas, Daniela Dos Santos Brum, Francielli Weber Santos Cibin
The present study assessed the effects of daily supplementation with 33 mg/metabolic weight (MW) of γ-oryzanol on testicular degeneration induced by scrotal insulation in rams. Eight animals were divided into two groups: Control (subjected to scrotal insulation without treatment) and Gamma (subjected to scrotal insulation and γ-oryzanol treatment). The rams were subjected to scrotal insulation by covering the scrotum with a thermal bag for 72 h. Animals in the Gamma group received 33 mg/MW oral γ-oryzanol once-daily, beginning 7 days before insulation and continuing during insulation and for 20 days afterward, for a total treatment period of 30 days...
February 7, 2019: Theriogenology
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