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Antioxidants health

Theerthankar Das, Huai-Jin Choong, Yee Chin Kwang, Hak-Kim Chan, Jim Manos, Philip Chi Lip Kwok, Hien T T Duong
Antibiotic resistance in pathogenic bacteria has emerged as a big challenge to human and animal health and significant economy loss worldwide. Development of novel strategies to tackle antibiotic resistance is of the utmost priority. In this study, we combined glutathione (GSH), a master antioxidant in all mammalian cells, and nitric oxide, a proven biofilm-dispersing agent, to produce GSNO. Resazurin biofilm viability assay, crystal violet biofilm assay, and confocal microscopy techniques showed that GSNO disrupted biofilms of both P...
February 14, 2019: Molecular Pharmaceutics
Ashti Morovati, Bahram Pourghassem Gargari, Parvin Sarbakhsh, Hushyar Azari, Lida Lotfi-Dizaji
Metabolic syndrome (MetS) is a cluster of interconnected serious disorders, which is a major health problem whose prevalence is increasing. Oxidative stress and inflammation contribute to the disease pathogenesis and its complications. The present study aimed to investigate the effect of Cuminum cyminum L. (which has antioxidant and anti-inflammatory properties) essential oil (CuEO) supplementation on inflammatory and antioxidant status in patients with MetS. In this clinical trial, 56 patients with MetS aged 18-60 years received either 75-mg CuEO or placebo soft gel, thrice daily, for 8 weeks...
February 14, 2019: Phytotherapy Research: PTR
Angelico Mendy, Radha Gopal, John F Alcorn, Erick Forno
BACKGROUND AND OBJECTIVE: Chronic lower respiratory diseases (CLRD) increase the risk of type 2 diabetes, which in turn may worsen lung function. Metformin, a common antidiabetic with anti-inflammatory and antioxidant properties, may improve respiratory outcomes. Therefore, we examined the association of metformin use with the risk of mortality from CLRD. METHODS: We analysed data from the National Health and Nutrition Examination Survey during 1988-1994 and 1999-2010 for participants aged 40 years or older who had diabetes and were followed up for mortality through 2011...
February 13, 2019: Respirology: Official Journal of the Asian Pacific Society of Respirology
Mylène Delosière, Agnès Thomas, Claudia Terlouw, Denis Durand
This data article reports the values of indicators of bovine health determined in the plasma of Normand cull-cows at different times of the about 100 days lasting finishing period and at slaughter. The data constitute a large dataset based on the quantification of metabolites and the evaluation of enzymes activities allowing the determination of antioxidant capacity, oxidative stress level, energy and lipid metabolisms, activity of the Hypothalamo-Pituitary-Adrenal axis and the hepatic status in cull-cows.
December 2018: Data in Brief
Deepak M Kasote, Guddadarangavvanahally K Jayaprakasha, Bhimanagouda S Patil
Antioxidant levels are key parameters for studies of food quality, stress responses, and plant health. Herein, we have demonstrated that excised leaf disc has both radical scavenging activity and reducing power, and used this concept to develop 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and potassium permanganate reduction (PPR) leaf disc assays. Reaction time and reagent concentration for these assays were optimized using leaves from spinach, kale, collards, mustard, and watermelon...
February 13, 2019: Scientific Reports
Kamarza Mulia, Farah Fauzia, Elsa Anisa Krisanti
Mangosteen ( Garcinia mangostana L.) is a fruit that is rich in xanthones, utilized as health supplements or additives in food products due to their high antioxidant activities. Choline chloride (ChCl)-based deep eutectic solvents (DESs) with polyalcohols (ethylene glycol, glycerol, propanediols, and butanediols) as hydrogen bonding donors (HBDs) were used to extract the xanthones from the pericarp of mangosteen. DESs with 1,2-propanediol, 1,3-propanediol, and 1,2-butanediol as HBDs (ChCl to HBD mole ratio of 1:3) afforded the highest extraction yields (2...
February 12, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Dong Chang Lee, Hyunsu Choi, Jeong-Min Oh, Do Hee Lee, Sung Won Kim, Soo Whan Kim, Byung Guk Kim, Jin Hee Cho, Joohyung Lee
BACKGROUND: Exposure to urban particulate matter (UPM) has been studied as a cause of various health problems. Although the association between UPM and the respiratory tract has been well studied, further research is required to characterize the effects of UPM on the upper respiratory tract. We investigated the effects of UPM-induced reactive oxygen species (ROS) production on cultured human nasal fibroblasts, as well as the protective effects of α-lipoic acid (ALA) on ROS production and the underlying signaling pathways involved in ROS inhibition...
February 13, 2019: International Forum of Allergy & Rhinology
Michelle E Baker, Kristen N DeCesare, Abby Johnson, Kathleen S Kress, Cynthia L Inman, Edward P Weiss
OBJECTIVE: Healthful dietary patterns have constituents that are known to improve exercise performance, such as antioxidants, nitrates, and alkalizing effects. However, ergogenic effects of such diets have not been evaluated. We hypothesized that a short-term Mediterranean diet results in better exercise performance, as compared to a typical Western diet. METHODS: Eleven recreationally active women (n = 7) and men (n = 4) (body mass index, 24.6 ± 3...
February 13, 2019: Journal of the American College of Nutrition
Chunxiu Lin, Xiaoying Zhang, Jie Xiao, Qiqi Zhong, Yong Kuang, Yong Cao, Yunjiao Chen
The beneficial effects of carnosic acid (CA) on health in terms of antioxidative, anti-inflammatory, antibacterial, anti-cancer and neuroprotective properties have long been recognized. However, the role of CA in aging remains unknown. In the present study, we examined the effects on longevity extension, as well as the mechanism of action, of CA in Caenorhabditis elegans (C. elegans). The results suggest that CA increased the lifespan of C. elegans. Meanwhile, CA was absorbed by the worms and promoted the healthspan of C...
February 13, 2019: Food & Function
Gaia Favero, Francesca Bonomini, Caterina Franco, Rita Rezzani
Fibromyalgia syndrome (FMS) is considered a musculoskeletal disorder associated to other symptoms including chronic pain. Since the hypothesis of FMS etiogenesis is consistent with mitochondrial dysfunction and oxidative stress, we evaluated the pathophysiological correlation among these factors studying some proteins involved in the mitochondrial homeostasis. We focused our attention on the roles of peroxisome proliferator activated receptor gamma coactivator-1alpha (PGC-1α), mitofusin2 (Mfn2), and coenzyme Q10 (CoQ10) in reserpine-induced myalgic (RIM) rats that manifest fibromyalgia-like chronic pain symptoms...
February 11, 2019: International Journal of Molecular Sciences
Zhihang Yuan, Zengenni Liang, Jine Yi, Xiaojun Chen, Rongfang Li, Yong Wu, Jing Wu, Zhiliang Sun
Medicinal herbal plants have been commonly used for intervention in different diseases and improvement of health worldwide. Koumine, an alkaloid monomer found abundantly in Gelsemium plants, can be effectively used as an antioxidant. The purpose of this study was to evaluate the potential protective effect of koumine against hydrogen peroxide (H₂O₂)-induced oxidative stress and apoptosis in porcine intestinal epithelial cell line (IPEC-J2 cells). MTT assays showed that koumine significantly increased cell viability in H₂O₂-mediated IPEC-J2 cells...
February 11, 2019: International Journal of Molecular Sciences
Ali Esmaeili Nadimi, Zahra Ahmadi, Soudeh Khanamani Falahati-Pour, Maryam Mohamadi, Alireza Nazari, Gholamhossein Hassanshahi, Maryam Ekramzadeh
The genus of Pistacia plant systematically fits into the family of Anacardiaceae. Pistachios contain protein, carbohydrate, dietary fibers, fat, folic acid, vitamin K, magnesium and potassium, gama-tocopherols, phytochemicals, and polyphenols. Collectively, these constituents have been shown to possess antioxidant and anti-inflammatory functions to improve overall health when consumed as a healthy diet. We searched the following keywords within the literature databases: pistachio, heart disorders, lipids, weight, antioxidants, and allergy...
February 12, 2019: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
Matheus D Baldissera, Carine F Souza, Sharine N Descovi, Tiago G Petrolli, Aleksandro S da Silva, Bernardo Baldisserotto
Recent evidence has revealed the involvement of oxidative stress and oxidative damage with health impairment and mortality in fish exposed to hypoxia. Thus, natural compounds with antioxidant and free-radical-scavenging properties, such as caffeine, might help to prevent or reduce hepatic damage elicited by hypoxia. Thus, the aim of this study was to evaluate whether dietary supplementation with caffeine could prevent or reduce oxidative damage in the livers of Nile tilapia (Oreochromis niloticus) exposed to hypoxia...
February 12, 2019: Fish Physiology and Biochemistry
K B Fuks, B Woodby, G Valacchi
Tropospheric (ground level) ozone (O3 ) is a secondary pollutant, emerging from other pollutants in the sunshine. Exposure to O3 correlates with higher pulmonary and cardiovascular mortality and affects reproductive health and the central nervous system acutely and chronically. Skin might be a potentially overlooked target organ of ambient O3 . The experimental evidence suggests a positive correlation of O3 exposure with oxidative damage, impaired antioxidant defence and proinflammatory response in the skin...
February 12, 2019: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
Masoomeh Mohammadzadeh, Vahid Ramazani, Mohammad Ali Khalili, Hamed Hamishekar, Laleh Dehghan Marvast, Ali Reza Talebi, Hadi Zare-Zardini, Saeed Ghasemi
The aim of this study was to comprise the effect of catalase on sperm parameters and chromatin in normospermic persons. Semen samples were obtained from fertile men. A certain amount of different concentrations of catalase (0.1, 1, 10, 50, 100, 150 and 200 was added to each vial containing semen. Control group had similar condition to treated groups without treatment. Treatment was done for one hour in incubator and 4 and 24 hr in room temperature. Sperm parameters (motility, viability and morphology) and chromatin were evaluated after incubation...
February 11, 2019: Andrologia
Kouadio Victorien Konan, Tien Canh Le, Mircea Alexandru Mateescu
Malaria is a major public health problem with hundreds of thousands of deaths yearly. Extracts of Peschiera fuchsiaefolia (Pf), an Apocynaceae family plant, are used as malaria treatment by several populations. Artemisinin is another effective largely used antimalarial agent but susceptible to generate resistant forms of Plasmodium. To reduce the risk of new resistant strains' appearance, the WHO recommended artemisinin-based combination therapy (ACT) with another bioactive agent, ensuring a long duration of antiplasmodial activity...
February 11, 2019: AAPS PharmSciTech
Xiaofeng Wang, Myoungjin Son, Chalamaiah Meram, Jianping Wu
Type-2 diabetes (T2D) is one of the major global health challenges and a substantial economic burden. Egg and egg-derived components have been indicated to possess antioxidant, anti-inflammatory, anti-hypertensive, immunomodulatory, and anti-cancer activities. However, the scientific evidence about the benefits of egg on T2D is debatable. The relationship between egg consumption and the risk of T2D from observational epidemiological studies is not consistent. Interventional clinical studies, however, provide promising evidence that egg consumption ameliorates the risk of T2D...
February 8, 2019: Nutrients
María L Del Prado-Audelo, Isaac H Caballero-Florán, Jorge A Meza-Toledo, Néstor Mendoza-Muñoz, Maykel González-Torres, Benjamín Florán, Hernán Cortés, Gerardo Leyva-Gómez
Curcumin is a polyphenol that is obtained from Curcuma longa and used in various areas, such as food and textiles. Curcumin has important anti-inflammatory and antioxidant properties that allow it to be applied as treatment for several emerging pathologies. Remarkably, there are an elevated number of publications deriving from the terms "curcumin" and "curcumin brain diseases", which highlights the increasing impact of this polyphenol and the high number of study groups investigating their therapeutic actions...
February 8, 2019: Biomolecules
João P Trigo, Elisabete M C Alexandre, Jorge A Saraiva, Manuela E Pintado
Fruit and vegetable processing industry is one of the relevant generators of food by-products, which display limited commercial exploitation entailing economic and environmental problems. However, these by-products present a considerable amount of dietary fiber as well as bioactive compounds with important biological activities such as antioxidant and antimicrobial properties. Therefore, the international scientific community has considered the incorporation of their extracts or powders to preserve or fortify food products an area of interest, mainly because nowadays consumers demand the production of safer and health-promoting foods...
February 11, 2019: Critical Reviews in Food Science and Nutrition
Jaime Ballester-Sánchez, Jose Vicente Gil, Claudia Monika Haros, María Teresa Fernández-Espinar
Interest in quinoa as a functional food ingredient is currently emerging. The flours from white, red and black quinoa seeds were analysed in terms of total polyphenol content and antioxidant activity. They were incorporated at 25% on flour basis into the bread dough formula to evaluate their potential to improve the functional properties of wheat breads. The contribution of extractable polyphenols (soluble forms) and the largely unexplored hydrolysable polyphenols (bound forms that can be found in the residues of the former) were taken into account to reflect a realistic health-promoting potential of breads...
February 9, 2019: Plant Foods for Human Nutrition
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