Jayati Sarangi, Prasenjit Das, Aijaz Ahmad, Mohamed Sulaiman, Shouriyo Ghosh, Brijnandan Gupta, Rajesh Panwar, Sujoy Pal, Rajni Yadav, Vineet Ahuja, Sudip Sen, Asish D Upadhyay, Nihar R Dash, Atul Sharma, Siddhartha D Gupta
BACKGROUND: Aberrant crypt foci (ACF) are the earliest preneoplastic lesions in human colon, identifiable on chromoendoscopic screening. Our objective was to evaluate the %methylation of APC, CDKN2A, MLH1, RASSF1, MGMT, and WIF1 tumor suppressor genes (TSG) in ACF, corresponding colorectal carcinomas (CRC), and normal colonic mucosal controls. METHODS: In this study, macroscopically normal-appearing mucosal flaps were sampled 5-10 cm away from the tumor mass from 302 fresh colectomy specimens to identify ACF-like lesions...
January 1, 2024: Journal of Cancer Research and Therapeutics