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Diabetes AND Ulcers

Pei-Yueng Lee, Pui-Wah Kong, Yong-Hao Pua
BACKGROUND: Previous reliability studies on peak plantar pressure measurements in patients with previous diabetic foot ulceration (DFU) did not stratify their analyses according to whether the foot had a previous ulcer. RESEARCH QUESTION: Does test-retest reliability of peak foot pressure measurements from the various foot regions differ between the ulcerated and non-ulcerated feet? METHODS: Data from 23 participants with peripheral neuropathy and healed plantar DFU were analysed in this test-retest reliability comparison study...
February 4, 2019: Gait & Posture
Abinaya Manivannan, Jin-Hee Kim, Do-Sun Kim, Eun-Su Lee, Hye-Eun Lee
Raphanus sativus (Radish) belongs to the Brassicaceae family and is a widely consumed root vegetable all around the world. The nutritional and medicinal values of radishes have been proven by several researches. Extracts prepared from the aerial and underground parts of radishes have been used in the treatment of stomach disorders, urinary infections, hepatic inflammation, cardiac disorders and ulcers in folk medicine since the ancient times. The pharmaceutical potential of radishes is attributed to the presence of its beneficial secondary metabolites, such as glucosinolates, polyphenols and isothiocyanates...
February 14, 2019: Nutrients
Jesús Martín-Vaquero, Ascensión Hernández Encinas, Araceli Queiruga-Dios, Juan José Bullón, Alfonso Martínez-Nova, Jose Torreblanca González, Cristina Bullón-Carbajo
One of the diseases that could affect diabetic patients is the diabetic foot problem. Unnoticed minor injuries and subsequent infection can lead to ischemic ulceration, and may end in a foot amputation. Preliminary studies have shown that there is a positive relationship between increased skin temperature and the pre⁻ulceration phase. Hence, we have carried out a review on wearables, medical devices, and sensors used specifically for collecting vital data. In particular, we are interested in the measure of the foot⁻temperature...
February 14, 2019: Sensors
José Luis Lázaro-Martínez, Yolanda García-Álvarez, Francisco Javier Álvaro-Afonso, Esther García-Morales, I Sanz-Corbalán, Raúl Juan Molines-Barroso
OBJECTIVE: To describe the outcomes of a new product based on negatively charged polystyrene microspheres (NCM) technology, in non-responding diabetic foot ulcers (DFU). METHODS: A clinical case series of patients with a hard-to-heal DFU treated with NCM were recruited between March and June 2017 in a specialised diabetic foot unit. DFUs were treated daily with NCM over four weeks, although the health professional could decide to continue NCM treatment in some patients...
February 2, 2019: Journal of Wound Care
Safak Ozer Balin, Ayse Sagmak Tartar, Kader Uğur, Faruk Kilinç, Selda Telo, Ali Bal, Mehmet Balin, Ayhan Akbulut
This study was undertaken to evaluate the diagnostic and prognostic values of pentraxin-3 (PTX-3) in patients with infected diabetic foot ulcers (IDFU) as well as to assess the association between PTX-3 levels and IDFU severity. This study included 60 IDFU patients (Group 1), 45 diabetic patients without DFU (Group 2), and 45 healthy controls. Patients with IDFU were divided into mild, moderate, and severe subgroups based on classification of clinical severity. Patients who underwent amputation were also documented...
February 15, 2019: International Wound Journal
Musarrat Riaz, Zahid Miyan, Nazish Waris, Syed I H Zaidi, Bilal Tahir, Asher Fawwad, Abdul Basit
To compare the outcomes of diabetic foot ulcers (DFU) in terms of healing and lower extremity amputation (LEA) rate before and after training of multidisciplinary foot care team (MDFCT). Subjects were categorised into two groups; Group-A cases seen between 1997 and 2006 (before upgrading of training and services of MDFCT) and Group-B cases seen between 2007 and 2016 (after upgrading of training and services of MDFCT). Baseline demographic characteristics, biochemical results, and outcomes of DFU in terms of healing or amputation were analysed by using statistical package social science (SPSS) version 20...
February 15, 2019: International Wound Journal
Michael L Anthony, Kimberly S Cravey, Said A Atway
Only a small percentage of the general diabetic population develops Charcot neuroarthropathy. Charcot arthropathy greatly increases the risk of foot complications. At our academic institution, there appeared to be an increased incidence of Charcot arthropathy in transplant patients. We hypothesized that Charcot neuroarthropathy incidence is higher in the diabetic patients who had received kidney or kidney-pancreas transplants. The charts of 1000 patients were reviewed from January 2000 to January 2011. Four hundred and eighty-seven patients were included in the study...
February 11, 2019: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
Larissa Lucena Périco, Vinícius Peixoto Rodrigues, Rie Ohara, Vânia Vasti Alfieri Nunes, Lúcia Regina Machado da Rocha, Wagner Vilegas, Catarina Dos Santos, Clélia Akiko Hiruma-Lima
ETHNOPHARMACOLOGICAL RELEVANCE: Eugenia punicifolia (Kunth) DC. (Myrtaceae), an Amazonian medicinal plant known as "pedra-ume-caá," is popularly used as a natural remedy for inflammation, wounds, infections, diabetes, fever, and flu. Its anti-inflammatory, antinociceptive, and gastroprotective effects have already been characterized. We evaluated the gastric healing effect of the hydroalcoholic extract of the leaves of E. punicifolia (HEEP) in male and female Wistar rats against nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol...
February 11, 2019: Journal of Ethnopharmacology
Anıl Murat Öztürk, Meltem Taşbakan, Dilek Yeşim Metin, Can Yener, Serhat Uysal, Ilgın Yıldırım Şımşır, İlgen Ertam, Hüsnü Pullukçu, Bilgin Arda, Şevki Çetinkalp
Background/aim: Clinicians often neglect fungal infections and do not routinely investigate deep tissue from the wound for fungal culture and sensitivity due to insufficient information in the literature. In this study, we aimed to evaluate fungal etiology of invasive fungal diabetic foot which is rarely reported in the literature. Materials and methods: The patients who were unresponsive to antibiotic therapy and those with positive fungal in bone or deep tissue culture were enrolled in the study...
February 11, 2019: Turkish Journal of Medical Sciences
Francisco Javier Álvaro-Afonso, José Luis Lázaro-Martínez, Nikolaos Papanas
Diabetic foot ulcers (DFUs) have a complex pathophysiology and require an expert multidisciplinary treatment. There are several, both systemic and local, risk factors for DFUs. A recent meta-analysis of 18 studies has now provided robust evidence on the detrimental effect of smoking on healing of DFUs. Indeed, healing rates were consistently lower among smokers than among nonsmokers. Based on this new evidence, it is reasonable to consider the utility of smoking cessation programs. Incorporation of the latter into the holistic therapeutic strategy for DFUs may be anticipated to improve healing rates, but this remains to be shown...
December 2018: International Journal of Lower Extremity Wounds
Carl J Barrick, Omobola Onikoyi, Nektarios I Lountzis, Tanya Ermolovich, Stephen M Purcell
Necrobiosis lipoidica (NL) is a granulomatous inflammatory skin disease strongly associated with diabetes mellitus (DM). Red-brown papules expanding into plaques with erythematous indurated borders on the lower extremities are characteristic of NL. Diagnosis is made clinically; however, biopsy of lesions confirms the diagnosis. Untreated NL may ulcerate and lead to further complications, but progression to superimposed pyoderma vegetans (PV) is not a known occurrence.
January 2019: Cutis; Cutaneous Medicine for the Practitioner
Kimie Takehara, Makoto Oe, Yumiko Ohashi, Yuichiro Tsunemi, Takashi Kadowaki, Hiromi Sanada
PURPOSE: The primary aim of this study was to compare patient reported versus clinician-observed nonulcerative foot conditions in patients attending a diabetic foot clinic and deemed at risk for diabetic foot ulcers. DESIGN: Retrospective review of medical records. SUBJECTS AND SETTING: The medical records of 126 patients with diabetes mellitus and deemed at risk for developing diabetic foot ulcers were reviewed. All patients received care from a diabetic foot outpatient clinic in a university-based hospital in Tokyo, Japan, between November 2008 and October 2009...
February 8, 2019: Journal of Wound, Ostomy, and Continence Nursing
James E McKinley, Allen Perkins
Peripheral neuropathies (PNs) are a group of conditions caused by damage to the peripheral nervous system. PN is a condition commonly seen in the family medicine setting and can lead to reduced quality of life due to pain, ulceration, and falls. More than 100 etiologies of PN have been identified; the most common are metabolic, drug-related, and systemic etiologies. Common treatable etiologies include diabetes and other medical conditions. Screening is recommended only for patients with suspected diabetic PN...
February 2019: FP Essentials
Nguyen Van Quan, Tran Dang Xuan, Hoang-Dung Tran, Nguyen Thi Dieu Thuy, Le Thu Trang, Can Thu Huong, Yusuf Andriana, Phung Thi Tuyen
The fruits of Canarium tramdenum are commonly used as foods and cooking ingredients in Vietnam, Laos, and the southeast region of China, whilst the leaves are traditionally used for treating diarrhea and rheumatism. This study was conducted to investigate the potential use of this plant bark as antioxidants, and α-amylase and α-glucosidase inhibitors. Five different extracts of C. tramdenum bark (TDB) consisting of the extract (TDBS) and factional extracts hexane (TDBH), ethyl acetate (TDBE), butanol (TDBB), and water (TDBW) were evaluated...
February 9, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Andrew J Hale, Emily Vicks, Mary T LaSalvia, John M Giurini, Adolf W Karchmer
Diabetic foot infections are a common cause of morbidity and mortality in the United States, and successful treatment often requires an aggressive and prolonged approach. Recent work has elucidated the importance of appropriate therapy for a given severity of diabetic foot infection, and highlighted the ongoing risk such patients have for subsequent invasive life-threatening infection should diabetic foot ulcers fail to heal. The authors describe the case of a man with diabetes who had prolonged, delayed healing of a diabetic foot ulcer...
November 2018: Journal of the American Podiatric Medical Association
Francisco Javier Álvaro-Afonso, Jose Luis Lázaro-Martínez, Yolanda García-Álvarez, Nikolaos Papanas
No abstract text is available yet for this article.
December 2018: Annals of Translational Medicine
Yolanda García-Álvarez, José Luis Lázaro-Martínez, Raúl Juan Molines-Barroso
No abstract text is available yet for this article.
December 2018: Annals of Translational Medicine
Linda Wennberg, Sarah Widgren, Rimma Axelsson, Kurt Gerok-Andersson, Börje Åkerlund
AIM: To investigate at a national level the multidisciplinary team (MDT) care of patients with diabetes mellitus and foot complications. METHODS: A questionnaire was sent to all 75 Swedish hospitals with emergency departments, which were grouped according to size. RESULTS: The response rate was 92 %, 58/69 of the hospitals have a foot team. Most teams have access to an internal medicine specialist/diabetologist, podiatrist and orthotist. Fewer teams reported access to an orthopaedic surgeon and infectious diseases specialist and only half to a vascular surgeon...
February 7, 2019: Diabetes Research and Clinical Practice
Irene Sanz-Corbalán, José Luis Lázaro-Martínez, Yolanda García-Álvarez, Esther García-Morales, Francisco Álvaro-Afonso, Raúl Molines-Barroso
The aim of this study is to evaluate the prevalence of digital deformities in patients with diabetes mellitus according to the McGlamry classification and relate the types of digital deformities with the history of digital ulcer. A cross-sectional study was performed in the diabetic foot unit between September 2016 and September 2017. All consecutive patients were classified by digital deformities according to the McGlamry classification (flexor stabilization, flexor substitution, and extensor substitution) using slow-motion videos...
February 6, 2019: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
R F M van Doremalen, J J van Netten, J G van Baal, M M R Vollenbroek-Hutten, F van der Heijden
AIMS: Infrared thermal imaging (IR) is not yet routinely implemented for early detection of diabetic foot ulcers (DFU), despite proven clinical effectiveness. Low-cost, smartphone-based IR-cameras are now available and may lower the threshold for implementation, but the quality of these cameras is unknown. We aim to validate a smartphone-based IR-camera against a high-end IR-camera for diabetic foot assessment. METHODS: We acquired plantar IR images of feet of 32 participants with a current or recently healed DFU with the smartphone-based FLIR-One and the high-end FLIR-SC305...
February 6, 2019: Diabetes Research and Clinical Practice
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