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https://read.qxmd.com/read/30776080/t-vec-in-advanced-melanoma-complete-response-in-a-heart-and-kidney-transplant-patient-a-case-report
#1
J Ressler, R Silmbrod, A Stepan, F Tuchmann, A Cicha, K Uyanik-Ünal, C Hoeller
Talimogene laherparepvec (T-VEC) is a intralesional oncolytic virotherapy, licensed in the European Union (EU) for locoregional advanced melanoma of American Joint Committee on Cancer (AJCC) stages IIIB, IIIC and IVM1a. Organ transplant recipients (OTRs) are so far excluded from all clinical trials dealing with immunotherapies due to the risk of transplant rejection. A 58-year-old caucasian male with a history of a heart and kidney transplantation in 2014 was diagnosed with melanoma (Breslow thickness of 1...
February 18, 2019: British Journal of Dermatology
https://read.qxmd.com/read/30766811/unusual-sites-of-metastatic-and-benign-i-131-uptake-in-patients-with-differentiated-thyroid-carcinoma
#2
Shanmuga S Palaniswamy, Padma Subramanyam
Introduction: Differentiated thyroid carcinoma (DTC) is the most common pathological type of thyroid carcinoma, which includes papillary and follicular subtypes. DTC is usually indolent, characterized by good prognosis, and long-term survival. Total thyroidectomy is the mainstay of treatment in DTC which is followed by diagnostic whole body 131I (WBI) scan. Like other primary malignancies of the head and neck, DTC follows a consistent pattern of spread in the cervical LNs. The central compartment, level VI and VII, is the first sentinel node followed by spread to the lateral compartments levels II-V, followed by the contralateral side...
November 2018: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/30746956/metastatic-tumors-in-the-pancreas-the-role-of-endoscopic-ultrasound-guided-fine-needle-aspiration
#3
Maite Betés, Santiago González Vázquez, Alejandro Bojórquez, María Dolores Lozano, José Ignacio Echeveste, Laura García Albarrán, Miguel Muñoz Navas, Jose Carlos Súbtil
BACKGROUND AND OBJECTIVES: there are few published data on the use of EUS guided fine-needle aspiration in secondary pancreatic lesions. We describe the largest series published so far in a European country. PATIENTS AND METHODS: a retrospective review of the cases identified in our institution from 2004 to 2016 has been recorded. The clinical data are described, comparing the latency period from the primary tumor diagnosis to the detection of the pancreatic metastasis and the survival of patients according to the cytological diagnosis...
February 11, 2019: Revista Española de Enfermedades Digestivas
https://read.qxmd.com/read/30742390/-left-sided-renal-cell-cacrinoma-with-vena-cava-inferior-thrombus-totally-laparoscopic-removal
#4
D V Perlin, A A Vorobiev, V P Zippunnikov, I N Dymkov
A surgical treatment of patients with tumor thrombus in the inferior vena cava (IVC) of levels II-III, originating from the left renal vein involves performing thrombectomy, radical nephrectomy and lymph nodes dissection. In most cases it requires major open surgery which leads to complications in 38% of patients and perioperative mortality of 4-10%. In recent years, the laparoscopic radical nephrectomy with thrombectomy have been gradually introduced. However, there are anecdotal reports about performing of such interventions in case of left-sided renal tumor with thrombus in the IVC...
December 2018: Urologii︠a︡
https://read.qxmd.com/read/30741758/anaplastic-lymphoma-kinase-alk-positive-tumors-clinical-radiographic-and-molecular-profiles-and-uncommon-sites-of-metastases-in-patients-with-lung-adenocarcinoma
#5
Rohan Gupta, Idoroenyi Amanam, Syed Rahmanuddin, Isa Mambetsariev, Yingyu Wang, Charity Huang, Karen Reckamp, Lalit Vora, Ravi Salgia
INTRODUCTION: Anaplastic lymphoma kinase (ALK) gene rearrangements are observed in about 4% to 8% non-small cell lung cancer (NSCLC). ALK+ tumors have been associated with increased pleural and pericardial disease. Our primary objective was to determine the uncommon sites of metastasis of ALK+ NSCLC. Secondary objectives included study of coexisting mutations and factors impacting survival of ALK+ NSCLC. METHODS: All patients with metastatic ALK+ NSCLC at the City of Hope Cancer Center in Duarte, California from 2010 to 2017 were selected for retrospective chart review...
February 5, 2019: American Journal of Clinical Oncology
https://read.qxmd.com/read/30738795/radiological-response-heterogeneity-is-of-prognostic-significance-in-metastatic-renal-cell-carcinoma-treated-with-vascular-endothelial-growth-factor-targeted-therapy
#6
Peter E Hall, Scott T C Shepherd, Janet Brown, James Larkin, Robert Jones, Christy Ralph, Robert Hawkins, Simon Chowdhury, Ekaterini Boleti, Amit Bahl, Kate Fife, Andrew Webb, Simon J Crabb, Thomas Geldart, Robert Hill, Joanna Dunlop, Duncan McLaren, Charlotte Ackerman, Akhila Wimalasingham, Luis Beltran, Paul Nathan, Thomas Powles
BACKGROUND: Response evaluation criteria in solid tumours (RECIST) is widely used to assess tumour response but is limited by not considering disease site or radiological heterogeneity (RH). OBJECTIVE: To determine whether RH or disease site has prognostic significance in patients with metastatic clear-cell renal cell carcinoma (ccRCC). DESIGN, SETTING, AND PARTICIPANTS: A retrospective analysis was conducted of a second-line phase II study in patients with metastatic ccRCC (NCT00942877), evaluating 138 patients with 458 baseline lesions...
February 6, 2019: European Urology Focus
https://read.qxmd.com/read/30701116/atypical-metastasis-to-the-head-and-neck-region-an-analysis-of-11-patients
#7
Bayram Şahin, Can Doruk, Mehmet Çelik, Erkan Öztürk, Selçuk Güneş, Ökkeş Erkan Kıyak
Objective: We present 11 patients with distant metastases to the head and neck from an infraclavicularly located primary tumor and discuss the management strategies including the clinical presentation, treatment modalities, and prognosis. Methods: The retrospective data of the pathology reports and operation notes of 1239 patients who had undergone any kind of oncological surgical intervention between 2005 and 2017 were analyzed. All of the 11 patients included in the study were evaluated in our department's tumor board, and all patients with an operable lesion had undergone surgery...
December 2018: Turkish Archives of Otorhinolaryngology
https://read.qxmd.com/read/30691666/differentiating-intrapulmonary-metastases-from-different-primary-tumors-via-quantitative-dual-energy-ct-based-iodine-concentration-and-conventional-ct-attenuation
#8
Dominik Deniffel, Andreas Sauter, Julia Dangelmaier, Alexander Fingerle, Ernst J Rummeny, Daniela Pfeiffer
INTRODUCTION: To investigate the utility of quantitative dual-energy spectral CT derived iodine concentration (IC), in comparison with conventional CT attenuation, for the differentiation of pulmonary metastases from different primary malignancies. MATERIALS AND METHODS: CT scans were performed on a dual-layer spectral CT. We retrospectively evaluated pulmonary metastases of 130 patients (77 men and 53 women, mean age 63, range 22-87) with primary bone (OS) (osteosarcoma; n = 6), breast (invasive-ductal adenocarcinoma; n = 17), colorectal (CRC) (adenocarcinoma; n = 27), head and neck (HNC) (squamous cell carcinoma; n = 17), kidney (RCC) (clear-cell renal cell carcinoma; n = 10), lung (adenocarcinoma; n = 12), pancreato-biliary (PBC) (adenocarcinoma; n = 18), prostate (adenocarcinoma; n = 5), soft tissue (undifferentiated pleomorphic sarcoma; n = 6), skin (malignant melanoma; n = 6), and urinary tract (transitional-cell carcinoma; n = 6) malignancies...
February 2019: European Journal of Radiology
https://read.qxmd.com/read/30685878/surgical-treatment-of-liver-metastases-from-kidney-cancer-a-systematic-review
#9
REVIEW
Enrico Pinotti, Mauro Montuori, Alessandro Giani, Fabio Uggeri, Mattia Garancini, Luca Gianotti, Fabrizio Romano
BACKGROUND: Liver metastases are present in 20.3% of metastatic kidney cancers. The aim of this literature review was to assess the efficacy of surgical treatment for hepatic metastasis from kidney cancer. METHODS: An extended web search of the literature was independently performed in March 2018 by two authors according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. RESULTS: Through electronic searches, we identified 935 potentially relevant citations...
January 26, 2019: ANZ Journal of Surgery
https://read.qxmd.com/read/30683032/-a-case-of-endometrium-adenocarcinoma-with-multiple-cavitary-pulmonary-metastasis
#10
Görkem Vayısoğlu Şahin, Gülistan Karadeniz, Gülru Polat, Fatma Demirci Üçsular, Zekiye Aydoğdu, Enver Yalnız
Pulmonary metastases are usually seen as parenchymal nodules, lymphatic-interstitial spread and pleural effusion, however cavitary and cystic metastatic lesions are rare. While breast cancer, gastrointestinal tumors, kidney tumors, malignant melanoma, sarcomas, lymphoma and leukemia mostly metastasize to the lung, endometrial adenocarcinoma rarely metastasizes. A 73-year-old woman with multiple cystic-cavitary lung lesions was referred to our clinic because of chronic cough. She had endometrial adenocarcinoma metastasis to the lung...
December 2018: Tüberküloz Ve Toraks
https://read.qxmd.com/read/30666287/the-need-for-bone-biopsies-in-the-diagnosis-of-new-bone-lesions-in-patients-with-a-known-primary-malignancy-a-comparative-review-of-117-biopsy-cases
#11
Liang Zhang, Yichao Wang, Yutong Gu, Yingyong Hou, Zixian Chen
Objective: This study used a clinical dataset to investigate the proportion of the newly found bone lesions in malignant patients diagnosed by biopsy as being benign, malignant but unrelated to the primary malignancy, or bone metastases of the primary malignancy. The clinical factors that might affect the correlation between bone lesions and the primary malignancy were also analyzed. It is expected to obtain some information contributing to the clinical decision-making regarding the need for biopsy of these lesions from the research results...
February 2019: Journal of Bone Oncology
https://read.qxmd.com/read/30643781/subungual-metastasis-of-an-adenocarcinoma-of-the-prostate-in-a-finger
#12
Ramón García-Galaviz, Judith Domínguez-Cherit, Claudia Caro-Sánchez, Elizabeth Salazar-Rojas
Cutaneous metastasis is a rare event occurring most frequently in patients previously diagnosed with cancer. However, subungual metastases are even less frequent. The most common neoplasms associated with the latter are lung, kidney, and breast neoplasms. Lung cancer is the main cause of subungual metastases in the fingers, and genitourinary tract tumors are the main cause of subungual metastases in the toes. This is the first case report of an adenocarcinoma of the prostate with subungual metastasis.
November 2018: Skin Appendage Disorders
https://read.qxmd.com/read/30643112/pressurized-intraperitoneal-aerosol-chemotherapy-pipac-for-peritoneal-metastases-in-solid-organ-graft-recipients-first-experience
#13
Philipp Horvath, Can Yurttas, Florian Struller, Hans Bösmüller, Ulrich M Lauer, Silvio Nadalin, Alfred Königsrainer, Marc André Reymond
BACKGROUND Therapy of peritoneal metastases (PM) in solid organ transplant recipients is challenging. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) might constitute a new therapeutic opportunity for these patients. MATERIAL AND METHODS This was a single-center, retrospective analysis of prospective registry data (NCT03210298) in a tertiary care center between 1.7.2016 and 31.12.2017. Intraperitoneal administration of oxaliplatin 92 mg/m² body surface or a combination of cisplatin 7.5 mg/m² and doxorubicin 1...
January 15, 2019: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://read.qxmd.com/read/30627905/soluble-ligand-of-the-immune-checkpoint-receptor-spd-l1-in-blood-serum-of-patients-with-renal-cell-carcinoma
#14
N E Kushlinskii, E S Gershtein, A A Morozov, I O Goryacheva, M L Filipenko, A A Alferov, S D Bezhanova, V V Bazaev, I A Kazantseva
The content of the soluble ligand of the immune checkpoint receptor (sPD-L1) was determined in the blood serum of 106 patients with renal cell carcinoma and 11 patients with benign kidney tumors by direct ELISA (Human sPD-L1 Platinum ELISA; Affimetrix, eBioscience). The control group included 19 healthy men and 18 women. Serum level of sPD-L1 significantly surpassed the control values in both patients with primary renal cancer (p<0.0001) and in patients examined during disease progression (p<0.05). In patients with benign kidney tumors, the level of this marker was significantly higher than in the control (p<0...
January 9, 2019: Bulletin of Experimental Biology and Medicine
https://read.qxmd.com/read/30622170/measurement-and-quantitative-characterization-of-whole-body-pharmacokinetics-of-exogenously-administered-t-cells-in-mice
#15
Antari Khot, Matsueda Satoko, Veena A Thomas, Richard C Koya, Dhaval K Shah
Here we have investigated whole-body pharmacokinetics (PK) of exogenously administered T cells in a mouse model of melanoma, and have development of a physiologically based pharmacokinetic (PBPK) model to quantitatively characterize the data. T cells were isolated from the spleen of tumor-bearing mice, activated, and labeled with Cr-51 to facilitate the quantification. Labeled T cells were injected in the tumor-bearing mice and PK was measured in 19 different tissues. It was found that T cells disappear from the blood rapidly after administration, and accumulate in the tissues to various extent...
January 8, 2019: Journal of Pharmacology and Experimental Therapeutics
https://read.qxmd.com/read/30577391/role-of-stereotactic-body-radiation-therapy-for-the-management-of-oligometastatic-renal-cell-carcinoma
#16
Ciro Franzese, Davide Franceschini, Lucia Di Brina, Giuseppe Roberto DʼAgostino, Pierina Navarria, Tiziana Comito, Pietro Mancosu, Stefano Tomatis, Marta Scorsetti
PURPOSE: Kidney cancer has been increasing 1.7% annually. Renal cell carcinoma is the most common kidney cancer and it can metastasize. Our aim was to analyze patients treated with stereotactic body radiation therapy of renal cell carcinoma metastases. MATERIALS AND METHODS: A total of 58 patients (73 lesions) were treated from 2004 to 2016. Patients were candidates for analysis if a maximum of 3 metastases were diagnosed and the primary tumor was resected. Toxicity was classified according to Common Terminology Criteria for Adverse Events version 3...
January 2019: Journal of Urology
https://read.qxmd.com/read/30549183/initial-evaluation-of-pet-ct-with-18-f-fsu-880-targeting-prostate-specific-membrane-antigen-in-prostate-cancer-patients
#17
Tsuneo Saga, Yuji Nakamoto, Takayoshi Ishimori, Takahiro Inoue, Yoichi Shimizu, Hiroyuki Kimura, Shusuke Akamatsu, Takayuki Goto, Hiroyuki Watanabe, Kosuke Kitaguchi, Masao Watanabe, Masahiro Ono, Hideo Saji, Osamu Ogawa, Kaori Togashi
This first-in-man study was carried out to evaluate the safety, whole-body distribution, dose estimation, and lesion accumulation of 18 F-FSU-880, a newly developed probe targeting prostate-specific membrane antigen. Six prostate cancer patients with known metastatic lesions underwent serial whole-body PET/computed tomography (CT) with 18 F-FSU-880. Blood and urine were analyzed before and after PET/CT. Accumulation of 18 F-FSU-880 in organs and metastatic lesions in serial PET images were evaluated by measuring the standardized uptake values...
December 13, 2018: Cancer Science
https://read.qxmd.com/read/30541323/tumor-to-tumor-metastasis-a-unique-case-of-clear-cell-renal-cell-carcinoma-harboring-metastasis-of-adenocarcinoma-of-unknown-origin
#18
Bartoš Vladimír
BACKGROUND: The tumor-to-tumor metastasis is exclusively rare finding, in which one malignant neoplasia metastasizes to another tumor of different origin. CASE: The author describes an 68-year-old woman, who was found to have a solitary tumor in the right kidney, as well as multiple tumor nodules in the liver. She underwent a radical nephrectomy. A histology of lesion in the kidney revealed a conventional clear cell renal cell carcinoma (RCC) harboring multiple metastatic foci of another adenocarcinoma...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://read.qxmd.com/read/30538068/improved-survival-outcomes-for-kidney-cancer-patients-with-brain-metastases
#19
I Alex Bowman, Alisha Bent, Tri Le, Alana Christie, Zabi Wardak, Yull Arriaga, Kevin Courtney, Hans Hammers, Samuel Barnett, Bruce Mickey, Toral Patel, Tony Whitworth, Strahinja Stojadinovic, Raquibul Hannan, Lucien Nedzi, Robert Timmerman, James Brugarolas
BACKGROUND: Brain metastases (BM) occur frequently in patients with metastatic kidney cancer and are a significant source of morbidity and mortality. Although historically associated with a poor prognosis, survival outcomes for patients in the modern era are incompletely characterized. In particular, outcomes after adjusting for systemic therapy administration and International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) risk factors are not well-known. PATIENTS AND METHODS: A retrospective database of patients with metastatic renal cell carcinoma (RCC) treated at University of Texas Southwestern Medical Center between 2006 and 2015 was created...
December 5, 2018: Clinical Genitourinary Cancer
https://read.qxmd.com/read/30534449/nephrectomy-for-metastatic-kidney-tumor-in-patients-with-differentiated-thyroid-cancer-a-report-of-two-cases
#20
Haruhiko Yamazaki, Takeshi Kishida, Go Noguchi, Hiroyuki Iwasaki, Nobuyasu Suganuma, Katsuhiko Masudo, Hirotaka Nakayama, Toshinari Yamashita, Takashi Yamanaka, Yuko Sugawara, Yuka Matsubara, Kaori Kohagura, Yasushi Rino, Munetaka Masuda
The occurrence of renal tumors originating from thyroid cancer is extremely rare with a few effective treatments for renal metastases. Here, we report the cases of two patients with differentiated thyroid cancer who underwent nephrectomy for a metastatic kidney tumor. Case 1 was a 74-year-old man who was diagnosed with right kidney tumor 10 years after initial surgery for papillary thyroid cancer (PTC). Right nephrectomy was performed, and the pathology was metastatic PTC. Case 2 was a 68-year-old woman who was diagnosed with left kidney tumor 24 years after surgery for follicular thyroid carcinoma (FTC)...
2018: Case Reports in Endocrinology
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