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Angiitis

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https://read.qxmd.com/read/30778690/spontaneous-pulmonary-hematoma-with-diffuse-pulmonary-ossification-requiring-emergency-treatment-a-case-report
#1
Takumi Sonokawa, Takuma Matsui, Kyoshiro Takegahara, Tatsuya Inoue, Takeru Kashiwada, Yasuhiro Terasaki, Jitsuo Usuda
BACKGROUND: Pulmonary hematoma is most often caused by thoracic trauma. However, rare cases of pulmonary hematoma without any obvious cause are sometimes reported, when the condition is referred to as spontaneous or idiopathic pulmonary hematoma. Herein, we report a very rare case-to the best of our knowledge, this is the first case of pulmonary hematoma associated with diffuse pulmonary ossification requiring emergency treatment reported in the English literature. CASE PRESENTATION: Our patient was a 44-year-old man with a history of IgA nephropathy and had no history of trauma or anticoagulant use...
February 18, 2019: Surgical Case Reports
https://read.qxmd.com/read/30716674/atypical-presentation-of-fulminant-primary-central-nervous-system-angiitis
#2
Sean Spence, Denise Ng, Colin Casault
BACKGROUND: Primary Angiitis of the Central Nervous System (PACNS) is a rare cause of CNS vasculitis that should be included as part complete differential diagnosis, especially in cases with suggestive imaging findings and an absence of secondary causes for CNS vasculitis. CASE PRESENTATION: We describe a case of a 47-year-old previously healthy Caucasian male presenting with rapid progression of encephalopathy and fevers. Extensive infectious, autoimmune, and imaging workups were unrevealing...
February 1, 2019: Journal of Neuroimmunology
https://read.qxmd.com/read/30677396/the-formation-and-disordered-degradation-of-neutrophil-extracellular-traps-in-necrotizing-lesions-of-anti-neutrophil-cytoplasmic-antibody-associated-vasculitis
#3
Sakiko Masuda, Mayu Nonokawa, Emika Futamata, Yuka Nishibata, Sari Iwasaki, Takahiro Tsuji, Yutaka Hatanaka, Daigo Nakazawa, Satoshi Tanaka, Utano Tomaru, Tamihiro Kawakami, Tatsuya Atsumi, Akihiro Ishizu
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is characterized by the production of ANCAs and systemic necrotizing vasculitis in small vessels. Disordered regulation of neutrophil extracellular traps (NETs) is critically involved in the pathogenesis of AAV. NETs are web-like DNA decorated with antimicrobial proteins; they are extruded from activated neutrophils. The principal degradation factor of NETs in vivo is DNase I; however, NETs resistant to DNase I can persist in tissues and lead to the production of ANCAs...
January 21, 2019: American Journal of Pathology
https://read.qxmd.com/read/30635475/rcvs-2-score-and-diagnostic-approach-for-reversible-cerebral-vasoconstriction-syndrome
#4
Eva A Rocha, M Akif Topcuoglu, Gisele S Silva, Aneesh B Singhal
OBJECTIVE: To develop a method to distinguish reversible cerebral vasoconstriction syndrome (RCVS) from other large/medium-vessel intracranial arteriopathies. METHODS: We identified consecutive patients from our institutional databases admitted in 2013-2017 with newly diagnosed RCVS (n = 30) or non-RCVS arteriopathy (n = 80). Admission clinical and imaging features were compared. Multivariate logistic regression modeling was used to develop a discriminatory score...
February 12, 2019: Neurology
https://read.qxmd.com/read/30635219/study-on-the-clinical-imaging-and-pathological-characteristics-of-18-cases-with-primary-central-nervous-system-vasculitis
#5
Lin-Jing Wang, De-Zheng Kong, Zhen-Ni Guo, Fu-Liang Zhang, Hong-Wei Zhou, Yi Yang
BACKGROUND: To summarize the characteristics of primary central nervous system vasculitis from clinical, imaging, and pathological aspects by retrospective study. METHODS: From March 2015 to December 2017, the data of the inpatients of primary central nervous system vasculitis in first Hospital of Jilin University were collected, and their clinical manifestation, imaging, and pathological characteristics were analyzed by using a descriptive method. RESULTS: There were 18 patients, 10 males (55...
January 8, 2019: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://read.qxmd.com/read/30528093/recurrent-arterial-ischemic-stroke-with-good-response-to-mycophenolate-mofetil
#6
Benedikte Van Driessche, Patrick Verloo, Nele Herregods, Veerle Mondelaers, Joke Dehoorne, Rudy Van Coster, Helene Verhelst
BACKGROUND: Arterial ischemic stroke is rare in childhood. Often, the diagnosis is made after considerable delay. A thorough workup to pinpoint the underlying etiology is necessary, as a correct diagnosis is the determining factor in treatment decision. In case of primary angiitis of the central nervous system, treatment with corticosteroids and immunosuppressive agents is indicated. CASE STUDY: We described an eleven-year-old boy who presented at the age of six years with left hemiparesis and hemianopia...
November 14, 2018: European Journal of Paediatric Neurology: EJPN
https://read.qxmd.com/read/30504602/a-probable-cerebral-angiitis-after-allogeneic-bone-marrow-transplantation
#7
Hecheng Ren, Lin Ma, Mingsheng Yu, Ming Wei, Long Yin
No abstract text is available yet for this article.
November 2018: Neurology India
https://read.qxmd.com/read/30458827/health-related-quality-of-life-in-children-with-inflammatory-brain-disease
#8
MULTICENTER STUDY
Elina Liu, Marinka Twilt, Pascal N Tyrrell, Anastasia Dropol, Shehla Sheikh, Mark Gorman, Susan Kim, David A Cabral, Rob Forsyth, Heather Van Mater, Suzanne Li, Adam M Huber, Elizabeth Stringer, Eyal Muscal, Dawn Wahezi, Mary Toth, Pavla Dolezalova, Katerina Kobrova, Goran Ristic, Susanne M Benseler
OBJECTIVE: To quantify the impact of inflammatory brain diseases in the pediatric population on health-related quality of life, including the subdomains of physical, emotional, school and social functioning. METHODS: This was a multicenter, observational cohort study of children (< 18 years of age) diagnosed with inflammatory brain disease (IBrainD). Patients were included if they had completed at least one Health Related Quality of Life Questionnaire (HRQoL)...
November 20, 2018: Pediatric Rheumatology Online Journal
https://read.qxmd.com/read/30349711/paraneoplastic-frosted-branch-angiitis-as-first-sign-of-relapsed-hodgkin-lymphoma
#9
Muhamad Alhaj Moustafa, Eric L Crowell, Sherif Elmahdy, Vera Malkovska, Ashvini K Reddy
Frosted branch angiitis (FBA) is a rare form of retinal vasculitis with typical perivascular edema taking the shape of frost on a tree branch. It was reported only twice as the initial presentation of Hodgkin lymphoma (HL). Here, we present the first case of paraneoplastic FBA as the initial sign of HL relapse in an elderly female.
October 2018: Clinical Case Reports
https://read.qxmd.com/read/30273791/clinical-and-imaging-features-distinguishing-susac-syndrome-from-primary-angiitis-of-the-central-nervous-system
#10
M Marrodan, J N Acosta, L Alessandro, V C Fernandez, E Carnero Contentti, N Arakaki, A A Kohler, M P Fiol, S F Ameriso, J Correale
INTRODUCTION: To assess clinical and/or imaging features useful to distinguish between Susac syndrome (SuS) and primary angiitis of central nervous system (PACNS). METHODS: Multicenter retrospective analysis of two cohorts of Argentine patients diagnosed with SuS and PACNS. RESULTS: 13 patients diagnosed with SuS (6 women and 7 men, mean age 35 ± 10 years) and 15 with PACNS (10 women and 5 men, mean age 44 ± 18 years) were analyzed...
September 26, 2018: Journal of the Neurological Sciences
https://read.qxmd.com/read/30254820/intracranial-atherosclerosis-versus-primary-angiitis-of-the-central-nervous-system-a-case-report
#11
Joshua A Ronen, Aileen Nguyen, Jerrica N Mueller, Hyonju Lee
Primary angiitis of the central nervous system (PACNS) is a rare disease with various clinical presentations. It is the preferred name for vasculitis that is confined to the central nervous system (CNS) and is often considered a diagnosis of exclusion in vascular or inflammatory CNS diseases. This case describes a 46-year-old right-handed female with a past medical history of hypertension (HTN), hyperlipidemia (HLD), diabetes mellitus type two (DM2), obesity, and hemorrhagic stroke who was transferred from an outside facility after a one-month hospitalization to be evaluated for CNS vasculitis...
July 23, 2018: Curēus
https://read.qxmd.com/read/30232250/primary-angiitis-of-the-cns-and-reversible-cerebral-vasoconstriction-syndrome-a-comparative-study
#12
Hubert de Boysson, Jean-Jacques Parienti, Jérôme Mawet, Caroline Arquizan, Grégoire Boulouis, Cécilia Burcin, Olivier Naggara, Mathieu Zuber, Emmanuel Touzé, Achille Aouba, Marie-Germaine Bousser, Christian Pagnoux, Anne Ducros
OBJECTIVES: To further improve the distinction between primary angiitis of the CNS (PACNS) and reversible cerebral vasoconstriction syndrome (RCVS). METHODS: We compared 2 large French cohorts of patients with PACNS (n = 110, retrospectively and prospectively enrolled) and RCVS (n = 173, prospectively enrolled). RESULTS: Patients with RCVS were predominantly female ( p < 0.0001), with migraines ( p < 0.0001), and were more often exposed to vasoactive substances ( p < 0...
October 16, 2018: Neurology
https://read.qxmd.com/read/30172703/purified-cd34-cells-versus-peripheral-blood-mononuclear-cells-in-the-treatment-of-angiitis-induced-no-option-critical-limb-ischaemia-12-month-results-of-a-prospective-randomised-single-blinded-non-inferiority-trial
#13
Zhihui Dong, Tianyue Pan, Yuan Fang, Zheng Wei, Shiyang Gu, Gang Fang, Yifan Liu, Yang Luo, Hao Liu, Tiejun Zhang, Meiyu Hu, Daqiao Guo, Xin Xu, Bin Chen, Junhao Jiang, Jue Yang, Zhenyu Shi, Ting Zhu, Yun Shi, Peng Liu, Weiguo Fu
BACKGROUND: Peripheral blood mononuclear cells (PBMNCs) and purified CD34+ cells (PCCs) are increasingly being used at treating no-option critical limb ischaemia (NO-CLI). We aimed to compare the efficacies and uncover the advantages associated with each treatment approach. METHODS: A randomised single-blinded non-inferiority trial (Number: NCT 02089828) was performed. NO-CLI patients were 1:1 randomised to the PBMNCs and PCCs groups, and compared in relation to safety and efficacy outcomes...
September 2018: EBioMedicine
https://read.qxmd.com/read/30109479/clinical-imaging-and-histological-presentations-and-outcomes-of-stroke-related-to-sarcoidosis
#14
Vincent Jachiet, Raphael Lhote, Pierre Rufat, Micheline Pha, Julien Haroche, Sophie Crozier, Corinne Dupel-Potier, Dimitri Psimaras, Zahir Amoura, Fleur Cohen Aubart
OBJECTIVES: Clinical involvement of the nervous system is uncommon during sarcoidosis. Cerebrovascular events are rarely reported during sarcoidosis and may be confused with primary angiitis of the central nervous system. The characteristics and outcomes of cerebrovascular events during sarcoidosis have not been well-evaluated. PATIENTS AND METHODS: We conducted a retrospective case series in our institution with an updated review of the literature from 1962 to 2017 to characterize the clinical presentation, imaging, histology and outcomes of stroke that were thought to be causally related to sarcoidosis...
October 2018: Journal of Neurology
https://read.qxmd.com/read/30079846/primary-angiitis-of-the-central-nervous-system-presenting-with-headache-and-ataxia
#15
Laura Chu, Marsha Eustace, Natalia Pittman
No abstract text is available yet for this article.
August 6, 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://read.qxmd.com/read/30076478/diagnosis-and-treatment-of-primary-central-nervous-system-angiitis
#16
REVIEW
Kaustubh Limaye, Edgar A Samaniego, Harold P Adams
PURPOSE OF REVIEW: Primary central nervous system angiitis (PCNSA) is a rare disease. Varying clinical pictures coupled with lack of sensitive and specific diagnostic tests lead to challenges in management of these patients. This unfortunately may lead to both under- or over-diagnosis and unnecessary treatment. It is important to recognize the different conditions that may mimic the clinical and radiologic presentation. We present a contemporary literature review that should update physicians who encounter this patient population...
August 4, 2018: Current Treatment Options in Neurology
https://read.qxmd.com/read/30042795/amyloid-beta-related-angiitis-with-distinctive-neuro-ophthalmologic-features
#17
Oana M Dumitrascu, Erin M Okazaki, Steven H Cobb, Matthew A Zarka, Stephen A De Souza, Gyanendra Kumar, Cumara B O'Carroll
Amyloid beta-related angiitis (ABRA) is a subtype of cerebral amyloid angiopathy-related inflammation, with distinctive pathology and prognosis compared with cerebral amyloid angiopathy (CAA). On a spectrum of increasing severity, ABRA is considered to be in-between the less aggressive inflammatory-CAA and the more severe primary central nervous system (CNS) angiitis. Whereas retinal pathological changes were described in subjects with primary or secondary CNS angiitis, and non-inflammatory CAA, bilateral posterior pole superficial and peripapillary retinal hemorrhages have not been reported as initial signs in patients with pathology-confirmed ABRA, accompanying neurological spells and characteristic neuroimaging findings...
August 2018: Neuro-ophthalmology
https://read.qxmd.com/read/30034536/primary-angiitis-of-the-central-nervous-system-diagnosis-and-treatment
#18
REVIEW
Carolin Beuker, Antje Schmidt, Daniel Strunk, Peter B Sporns, Heinz Wiendl, Sven G Meuth, Jens Minnerup
Primary angiitis of the central nervous system (PACNS) represents a rare inflammatory disease affecting the brain and spinal cord. Stroke, encephalopathy, headache and seizures are major clinical manifestations. The diagnosis of PACNS is based on the combination of clinical presentation, imaging findings (magnetic resonance imaging and angiography), brain biopsy, and laboratory and cerebral spinal fluid (CSF) values. PACNS can either be confirmed by magnetic resonance angiography (MRA)/conventional angiography or tissue biopsy showing the presence of typical histopathological patterns...
2018: Therapeutic Advances in Neurological Disorders
https://read.qxmd.com/read/29962444/-misleading-cerebral-arterial-wall-gadolinium-enhancement-in-malignant-lymphoma
#19
Hiroyasu Inoue, Keita Sakurai, Yuuya Kanou, Kentaro Yamada, Hiroyuki Yuasa
A previously healthy, 77-year-old woman presented with gradual cognitive decline and acute gait imbalance. On admission, despite no obvious paralysis, she tilted to the right. Her Mini-Mental State Examination score was slightly low (23/30). Gadolinium-enhanced, high-resolution T1 -weighted MRI showed abnormal arterial wall enhancement at the bilateral middle cerebral and right internal carotid arteries. The combination of arterial and parenchymal enhancement limited to the central nervous system (CNS), normal laboratory data including soluble interleukin-2 receptor, and random skin and bone-marrow biopsies was suggested of primary angiitis of the CNS (PACNS)...
July 27, 2018: Rinshō Shinkeigaku, Clinical Neurology
https://read.qxmd.com/read/29957380/immune-cell-profiling-in-the-cerebrospinal-fluid-of-patients-with-primary-angiitis-of-the-central-nervous-system-reflects-the-heterogeneity-of-the-disease
#20
Daniel Strunk, Andreas Schulte-Mecklenbeck, Kristin S Golombeck, Gerd Meyer Zu Hörste, Nico Melzer, Carolin Beuker, Antje Schmidt, Heinz Wiendl, Sven G Meuth, Catharina C Gross, Jens Minnerup
Primary angiitis of the central nervous system (PACNS) is a rare and heterogeneous inflammatory disease of the CNS vasculature with poorly understood pathophysiology. Comprehensive immune-cell phenotyping revealed increased frequencies of leukocytes in the cerebrospinal fluid (CSF) of PACNS patients compared to patients with multiple sclerosis, ischemic stroke, and somatoform disorders (n = 18 per group). Changes in the intrathecal immune-cell profile were heterogeneous in PACNS. While proportions of T-cell subsets remained unaltered, some PACNS patients showed a shift toward NK- or B cells...
August 15, 2018: Journal of Neuroimmunology
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