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Emily R Finch, Laura J Janke, Colton A Smith, Seth E Karol, Deqing Pei, Cheng Cheng, Sue C Kaste, Hiroto Inaba, Ching-Hon Pui, Joshua Wolf, Mary V Relling
BACKGROUND: Osteonecrosis is a common toxicity associated with glucocorticoid (e.g., dexamethasone and prednisone) treatment of children with acute lymphoblastic leukemia (ALL), but risk factors are incompletely defined. Infections are also a common complication of ALL therapy. Lipopolysaccharide (LPS) is used experimentally to mimic infection-related systemic effects. To our knowledge, the contribution of systemic infections to the risk of glucocorticoid-induced osteonecrosis has not been investigated...
February 13, 2019: Pediatric Blood & Cancer
Joseph L Jilek, Qian-Yu Zhang, Mei-Juan Tu, Pui Yan Ho, Zhijian Duan, Jing-Xin Qiu, Ai-Ming Yu
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related deaths, warranting better therapies. Restoration of tumor-suppressive microRNAs depleted in hepatocellular carcinoma represents a new therapeutic strategy. Herein, we sought to identify a potent microRNA (miRNA) agent that could alleviate HCC tumor burden and improve survival. Among a collection of bioengineered noncoding RNA molecules produced through bacterial fermentation, we identified let-7c agent as the most potent inhibitor of HCC cell viability...
January 24, 2019: Molecular Therapy. Nucleic Acids
Hon-Wai Benjamin Cheng, Pui-Shan Karen Shek, Ching-Wah Man, Oi-Man Chan, Chun-Hung Chan, Kit-Man Lai, Suk-Ching Cheng, Koon-Sim Fung, W K Lui, Carman Lam, Yuen-Kwan Ng, Wan-To Wong, Cherry Wong
BACKGROUND: Noncancer patients with life-limiting diseases often receive more intensive level of care in their final days of life, with more cardiopulmonary resuscitation performed and less do-not-resuscitate (DNR) orders in place. Nevertheless, death is still often a taboo across Chinese culture, and ethnic disparities could negatively affect DNR directives completion rates. OBJECTIVES: We aim to explore whether Chinese noncancer patients are willing to sign their own DNR directives in a palliative specialist clinic, under a multidisciplinary team approach...
February 11, 2019: American Journal of Hospice & Palliative Care
Kit-Lun Yick, Ka-Lai Yeung, Del P Wong, Yee-Nee Lam, Sun-Pui Ng
BACKGROUND: The midsole is an essential assembly of footwear for retaining the shape of the shoe, delivering support to the foot, and serving as a cushioning and stability device for walking. To improve leg muscle balance and muscle co-contraction, we propose a new midsole design for high heels with different hardness levels at the forefoot region. METHODS: Five healthy women participated in the study, with a mean ± SD age of 21.80 ± 4.09 years, and duration of high-heeled shoe wear of 5...
November 2018: Journal of the American Podiatric Medical Association
Masaru Kanekiyo, M Gordon Joyce, Rebecca A Gillespie, John R Gallagher, Sarah F Andrews, Hadi M Yassine, Adam K Wheatley, Brian E Fisher, David R Ambrozak, Adrian Creanga, Kwanyee Leung, Eun Sung Yang, Seyhan Boyoglu-Barnum, Ivelin S Georgiev, Yaroslav Tsybovsky, Madhu S Prabhakaran, Hanne Andersen, Wing-Pui Kong, Ulrich Baxa, Kathryn L Zephir, Julie E Ledgerwood, Richard A Koup, Peter D Kwong, Audray K Harris, Adrian B McDermott, John R Mascola, Barney S Graham
The present vaccine against influenza virus has the inevitable risk of antigenic discordance between the vaccine and the circulating strains, which diminishes vaccine efficacy. This necessitates new approaches that provide broader protection against influenza. Here we designed a vaccine using the hypervariable receptor-binding domain (RBD) of viral hemagglutinin displayed on a nanoparticle (np) able to elicit antibody responses that neutralize H1N1 influenza viruses spanning over 90 years. Co-display of RBDs from multiple strains across time, so that the adjacent RBDs are heterotypic, provides an avidity advantage to cross-reactive B cells...
February 11, 2019: Nature Immunology
Mark A King, Pui W Kong, Maurice R Yeadon
Performance in the flight phase of springboard diving is limited by the amounts of linear and angular momentum generated during the takeoff phase. A planar 8-segment torque-driven simulation model combined with a springboard model was used to investigate optimum takeoff technique for maximising rotation in forward dives from the one metre springboard. Optimisations were run by varying the torque activation parameters to maximise forward rotation potential (angular momentum × flight time) while allowing for movement constraints, anatomical constraints, and execution variability...
January 24, 2019: Journal of Biomechanics
David Kung-Chun Chiu, Misty Shuo Zhang, Aki Pui-Wah Tse, Carmen Chak-Lui Wong
Blood vessels in tumors contain chaotic branching structures and leaky vessel lumens, resulting in uneven supply of oxygen in the tumor microenvironment. High metabolic and proliferation rate of tumor cells further depletes the local oxygen supply. Therefore, hypoxia is a common phenomenon in multiple solid malignancies. Hypoxia-inducible factors (HIFs) regulate the transcription of a spectrum of genes, which are vitally important for tumor cell adaption under hypoxia, and shape the tumor microenvironment to become more favorable for progression...
2019: Methods in Molecular Biology
Janice Siu Chong Wong, W K Chu, Benjamin Fuk Loi Li, Bi Ning Zhang, Chi Pui Pang, Kelvin Kam Lung Chong
Periorbital adipose tissue expansion is a key pathological change in thyroid-associated orbitopathy (TAO). Bone morphogenic protein 4 (BMP4) is instrumental in adipogenesis. We compared site-specific BMP4 expression and its effect on adipogenesis using donor-matched adipose tissue-derived stromal cells (ADSC) from TAO patients. In this study, ADSC were generated from periorbital (eyelid, orbital) and subcutaneous (abdominal) adipose tissue. BMP4 expression was characterized by RT-PCR and immunofluorescent staining and compared among ADSC from the three anatomic depots...
February 2, 2019: Experimental Eye Research
Emma Jun Guo, Jacqueline Pui Wah Chung, Liona Chiu Yee Poon, Tin Chiu Li
In this systematic review, we analysed the reproductive outcomes of hysteroscopic adhesiolysis in women with Asherman syndrome (AS). We searched PubMed, Web of Science and Cochrane Library (from database inception to April 2018) and selected studies that quantitatively described the reproductive outcomes. We assessed study quality and pooled rate data for each outcome. There were 54 studies (4640 women) of varying quality. The pooled rate of pregnancy was 50.7% (95% CI [confidence interval]: 49.1 to 52.3) in 53 studies, early pregnancy loss was 17...
January 3, 2019: Best Practice & Research. Clinical Obstetrics & Gynaecology
Jiaoyang Cai, Jie Yu, Xiaofan Zhu, Shaoyan Hu, Yiping Zhu, Hua Jiang, Chunfu Li, Yongjun Fang, Changda Liang, Xiuli Ju, Xin Tian, Xiaowen Zhai, Jinjin Hao, Qun Hu, Ningling Wang, Hui Jiang, Lirong Sun, Chi Kong Li, Kaili Pan, Minghua Yang, Shuhong Shen, Cheng Cheng, Raul C Ribeiro, Ching-Hon Pui, Jingyan Tang
OBJECTIVES: Before 2003, most children with acute lymphoblastic leukaemia (ALL) abandoned treatment, with only approximately 30% treated in China. With the development of national insurance for underprivileged patients, we assessed the current frequency and causes of treatment abandonment among patients with ALL who were enrolled in the Chinese Children's Cancer Group ALL protocol between 2015 and 2016. METHODS: Demographic, clinical and laboratory data on patients who abandoned treatment, as well as economic and sociocultural data of their families were collected and analysed...
January 31, 2019: Archives of Disease in Childhood
Chak-Yu So, Yat-Yin Lam, Gary Shing-Him Cheung, Kevin Ka-Ho Kam, Anna Kin-Yin Chan, Alex Pui-Wai Lee, Bryan P Yan
Although reported failure rates of the Watchman device are low, the ballshaped device is not suitable for shallow and multilobed left atrial appendages (LAAs). The LAmbre device is available in two configurations - standard (cover 4-6 mm larger in diameter than the umbrella) and special (cover 12- 14 mm larger than the umbrella) - which allows the closure of a wide range of LAA anatomies. This case illustrates that the LAmbre device can be used for complex LAA anatomies that are not suitable for the Watchman device...
February 2019: Journal of Invasive Cardiology
Helen Hoi Lun Tsang, Jason Pui Yin Cheung, Carlos King Ho Wong, Prudence Wing Hang Cheung, Chak Sing Lau, Ho Yin Chung
BACKGROUND: Spondyloarthritis (SpA) has a significant impact on patients' quality of life due to functional impairments. Generic health instruments like the EuroQoL 5-dimension (EQ-5D) is important for the cost-utility analysis of health care interventions and calculation of quality-adjusted life years. However, the applicability of the EQ-5D health measure in Chinese patients with SpA is currently unknown. Hence, the aim of the study is to test the psychometric properties and to validate the use of the EQ-5D health measure for utility analyses in Chinese patients with SpA...
January 30, 2019: Arthritis Research & Therapy
Pierre Cunin, Pui Y Lee, Edy Kim, Angela B Schmider, Nathalie Cloutier, Alexandre Pare, Matthias Gunzer, Roy J Soberman, Steve Lacroix, Eric Boilard, Craig T Lefort, Peter A Nigrovic
Antibody ligation of the murine neutrophil surface protein Ly6G disrupts neutrophil migration in some contexts but not others. We tested whether this variability reflected divergent dependence of neutrophil migration on β2 integrins, adhesion molecules that interact with Ly6G at the neutrophil surface. In integrin-dependent murine arthritis, Ly6G ligation attenuated joint inflammation, even though mice lacking Ly6G altogether developed arthritis normally. By contrast, Ly6G ligation had no impact on integrin-independent neutrophil migration into inflamed lung...
February 12, 2019: Blood Advances
Adeline P N Man, Carmen K M Lam, Benny C P Cheng, Kam-Shing Tang, Pui-Fun Tang
Crew resource management (CRM) was introduced to enhance patient safety and reduce medical errors through multidisciplinary learning experience. This study investigates the impact of locally adopted simulation-based CRM training on participants' perceptions and knowledge. A 32-item web-based questionnaire was administered pre course, 1 month, and 1 year post course to assess changes in perceptions and knowledge. Another 12-item paper-based questionnaire was administered immediately post course to assess reactions...
January 28, 2019: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
Kevin R Krull, Chenghong Li, Nicholas S Phillips, Yin Ting Cheung, Tara M Brinkman, Carmen L Wilson, Gregory T Armstrong, Raja B Khan, Thomas E Merchant, Noah D Sabin, DeoKumar Srivastava, Ching-Hon Pui, Leslie L Robison, Melissa M Hudson, Charles A Sklar, Wassim Chemaitilly
BACKGROUND: The impact of growth hormone deficiency (GHD) on neurocognitive function is poorly understood in survivors of childhood acute lymphoblastic leukemia (ALL). This study examined the contribution of GHD to functional outcomes while adjusting for cranial radiation therapy (CRT). METHODS: Adult survivors of ALL (N = 571; 49% female; mean age, 37.4 years; age range, 19.4-62.2 years) completed neurocognitive tests and self-reported neurocognitive symptoms, emotional distress, and quality of life...
January 28, 2019: Cancer
Xue Deng, Lai-Heung Phoebe Chau, Suk-Yee Chiu, Kwok-Pui Leung, Yong Hu, Wing-Yuk Ip
Axonal degeneration, indicative of surgical decompression, may coexist in carpal tunnel syndrome (CTS) as the disease progresses. However, the current diagnostic and severity gradation system cannot clearly indicate its coexistence, resulting in confusion of appropriate treatment prescription. There are also constraints in conventional methods for differentiation as well. This study aims at introducing an innovative, efficient, and quick screening protocol to differentiate axonal degeneration associated with CTS, using ultrasound and nerve conduction studies (NCS)...
January 11, 2019: Journal of Visualized Experiments: JoVE
Cheryl Sihui Tay, Pui Wah Kong
The study aimed to quantify stroke synchronisation in two-seater crew boat sprint kayaking (K2) using a video-based method, and to assess the intra- and inter-rater reliabilities of this method. Twelve sub-elite sprint kayakers (six males and six females) from a national team were paired into six single-gender K2 crews. The crews were recorded at 120 Hz with a sagittal-view video camera during 200-m time trials. Video analysis identified four meaningful positions of a stroke (catch, immersion, extraction and release)...
December 2018: Journal of Human Kinetics
Bih Yee Chia, Jocelyn Qi-Min Teo, Winnie Lee, Yi Xin Liew, Rachel Pui-Lai Ee, Maciej Piotr Chlebicki, Lynette Lin-Ean Oon, Andrea Lay-Hoon Kwa
BACKGROUND: To minimize Clostridium difficile infections (CDI) incidence which can be life-threatening, Antimicrobial Stewardship Programs (ASP) have often been recommended as a viable solution. Our study aims to evaluate whether ASP interventions have contributed to reducing CDI rates. METHODS: A retrospective review of ASP interventions issued from January 2013 to April 2014 was performed using data from the ASP database of Singapore General Hospital (SGH), a 1600-bed tertiary-care hospital...
January 22, 2019: Journal of Global Antimicrobial Resistance
Zhe Tang, Yi-Ting Fan, Yu Wang, Chun-Na Jin, Ka-Wai Kwok, Alex Pui-Wai Lee
BACKGROUND: Patients with atrial fibrillation (AF) and left atrial (LA) enlargement may develop functional, normal leaflet motion mitral regurgitation (MR) without left ventricular (LV) remodeling. Mitral annular dynamics and LV mechanics are important for preserving normal mitral valve function. The aim of this study was to assess the annular and LV dynamics in patients with AF and functional MR. METHODS: Twenty-one patients with AF with moderate or more MR (AFMR+ group), 46 matched patients with AF with no or mild MR (AFMR- group), and 19 normal patients were retrospectively studied...
January 21, 2019: Journal of the American Society of Echocardiography
G De-Deus, F G Belladonna, A S Zuolo, D M Cavalcante, J C A Carvalhal, M S Carvalho, E M Souza, R T Lopes, E J N L Silva
AIM: To evaluate the performance of XP-endo Finisher R instruments when removing root filling remnants from oval-shaped canals using micro-computed tomographic (micro-CT) imaging as the analytical tool. Passive ultrasonic irrigation (PUI) was used as a reference technique for comparison. METHODOLOGY: Twenty mandibular incisors with oval-shaped canals were matched based on similar anatomic features of the canal (volume, aspect ratio and 3D configuration) after scanning procedures...
January 21, 2019: International Endodontic Journal
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