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centenarians,clinical characteristic,

Robert J Pignolo
Exceptional longevity represents an extreme phenotype. Current centenarians are survivors of a cohort who display delayed onset of age-related diseases and/or resistance to otherwise lethal illnesses occurring earlier in life. Characteristics of aging are heterogeneous, even among long-lived individuals. Associations between specific clinical or genetic biomarkers exist, but there is unlikely to be a single biomarker predictive of long life. Careful observations in the oldest old offer some empirical strategies that favor increased health span and life span, with implications for compression of disability, identification and implementation of lifestyle behaviors that promote independence, identification and measurement of more reliable markers associated with longevity, better guidance for appropriate health screenings, and promotion of anticipatory health discussions in the setting of more accurate prognostication...
December 6, 2018: Mayo Clinic Proceedings
Kimberly L Schoonover, Maria I Lapid
OBJECTIVES: Little is known about the hospice experience of centenarians. As the population of centenarians is projected to increase, understanding their unique end-of-life needs will be important to inform delivery of quality end-of-life care. Our objective was to characterize the hospice experience of centenarians. METHODS: A retrospective single-institution cohort study of centenarians enrolled in hospice from January 1, 2015, to December 31, 2017, was conducted to collect demographic and clinical information...
September 19, 2018: Journal of Palliative Care
Jorge A Brenes-Salazar, Jaime de la Fuente, Punnaiah Marella, Hari Chaliki, Christopher Scott, Heidi M Connolly, Roger L Click
Background: Echocardiography has been shown to be a valuable resource in the diagnosis of many cardiac conditions, and can be used in all age groups, from the fetus to the oldest old. In the context of an increasingly aging population, the impact and utility of echocardiography in centenarians is largely unknown. This study is to determine whether echocardiography in centenarians aids in making clinical patient management decisions. Methods: A retrospective review of echocardiograms from 1986 to 2014, at two affiliated tertiary centers, in individuals who were 100 years or older at the time of the examination...
May 2018: Journal of Geriatric Cardiology: JGC
Laura Bonfanti, Silvia Buratti, Luigi Vignali, Giuseppe Lippi, Franco Masini, Michele Bianconcini, Gianfranco Cervellin
A 101 years-old woman was admitted to our Emergency Department (ED) for acute dyspnea which onset nearly two hours before presentation. She had been on hydrochlorothyazyde-amiloride therapy due to mild hypertension. No other relevant features were present in the clinical history. The old lady had never been admitted to the hospital, and she was still living alone. A few days before hospital admission, one of the daughters became ill, so that a caregiver was paid for assisting her 12/24. This new circumstance was reluctantly accepted by the old lady...
January 16, 2018: Acta Bio-medica: Atenei Parmensis
Shannon Freeman, Joshua J Armstrong, Suzanne L Tyas, Eva Neufeld
Centenarians (persons aged 100years and older) are one of the fastest growing cohorts in countries across the world. With the increasing prevalence of centenarians and growing amount of clinical information in large administrative health databases, it is now possible to more fully characterize the health of this unique and heterogeneous population. This study described patterns of health deficits in the centenarian population receiving care from community-based home care services and long-term care facilities (LTCFs) in Ontario, Canada...
December 1, 2017: Experimental Gerontology
Oscar Ribeiro, Natália Duarte, Laetitia Teixeira, Constança Paúl
BACKGROUND: Physical frailty and depression are common comorbid conditions that have important impact on older adults. Few studies however have examined their co-occurrence in centenarians. This paper explores the relationship between the two conditions and the most characteristic depressive symptoms associated with the frailty syndrome. METHODS: Data come from two Portuguese Centenarian Studies. Frailty was measured using Fried's phenotype, which includes at least three clinical signs: exhaustion, weight loss, weakness, slowness, and low physical activity level; the Geriatric Depression Scale was used to assess depression...
January 2018: International Psychogeriatrics
Valdés-Corchado Pedro, Ruiz-Hernández Arturo, Pérez-Moreno Alejandro, Rosas-Carrasco Oscar
BACKGROUND: There is little evidence about the demography and health status of adults aged 100 years and over in Latin America and there are no studies in Mexico. OBJECTIVES: To describe the demographic characteristics and health status of centenarians residing in Mexico City. METHODS: This is a cross-sectional study using a population base of 393 community-dwelling centenarians in Mexico City. A comprehensive geriatric assessment was performed, including demographic information and health status...
2017: BioMed Research International
Tetsuhisa Kitamura, Kosuke Kiyohara, Tasuku Matsuyama, Junichi Izawa, Tomonari Shimamoto, Toshihiro Hatakeyama, Tomoko Fujii, Chika Nishiyama, Taku Iwami
Although the number of centenarians has been rapidly increasing in industrialized countries, no clinical studies evaluated their characteristics and outcomes from out-of-hospital cardiac arrests (OHCAs). This nationwide, population-based, observation of the whole population of Japan enrolled consecutive OHCA centenarians with resuscitation attempts before emergency medical service arrival from 2005 to 2013. The primary outcome measure was 1-month survival from OHCAs. The multivariate logistic regression model was used to assess factors associated with 1-month survival in this population...
March 15, 2016: American Journal of Cardiology
Kathleen O'Connor, David W Coon, Michael Malek-Ahmadi, Brittany N Dugger, Sharon Schofield, Walter Nieri
The purpose of this article is to describe the Longevity Study: Learning From Our Elders, a research program on healthy aging that began in 2007 at the Center for Healthy Aging at Banner Sun Health Research Institute. As of June 2015, 1139 participants (age range of 50-110 years) completed baseline assessments with the majority living in the Sun Cities retirement communities northwest of Phoenix, Arizona but expanding throughout the state. The registry includes over 830 currently active participants with 450 aged 80 years and older, 188 aged 90 and older, and 27 centenarians...
October 2016: Aging Clinical and Experimental Research
Manuel Martínez-Sellés, Albert Massó-van Roessel, Jesús Álvarez-García, Bernardo García de la Villa, Alfonso J Cruz-Jentoft, María Teresa Vidán, Javier López Díaz, Francisco Javier Felix Redondo, Juan Manuel Durán Guerrero, Antoni Bayes-Genis, Antonio Bayes de Luna
BACKGROUND: Data are lacking on the characteristics of atrial activity in centenarians, including interatrial block (IAB). OBJECTIVE: The aim of this study was to describe the prevalence of IAB and auricular arrhythmias in subjects older than 100 years and to elucidate their clinical implications. METHODS: We studied 80 centenarians (mean age 101.4 ± 1.5 years; 21 men) with follow-ups of 6-34 months. Of these 80 centenarians, 71 subjects (88...
March 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Manuel Martínez-Sellés, Bernardo García de la Villa, Alfonso J Cruz-Jentoft, Maria Teresa Vidán, Pedro Gil, Luis Cornide, Miriam Ramos Cortés, José Luis González Guerrero, Sonia María Barros Cerviño, Óscar Díaz Castro, Teresa Pareja, Elisabet Sánchez, Danitza Cimera, Marta Vigara, Javier Balaguer, María Victoria Mogollón Jiménez, Fernando Veiga Fernández, Carlos González Juanatey, Ana Testa Fernández, Jesús Mateos Del Nozal, Sandra Vázquez, Noelia Urueña, Javier López Diaz
BACKGROUND: Data on the cardiac characteristics of centenarians are scarce. Our aim was to describe electrocardiogram (ECG) and echocardiography in a cohort of centenarians and to correlate them with clinical data. METHODS: We used prospective multicenter registry of 118 centenarians (28 men) with a mean age of 101.5±1.7 years. Electrocardiogram was performed in 103 subjects (87.3%) and echocardiography in 100 (84.7%). All subjects underwent a follow-up for at least 6 months...
June 2015: American Heart Journal
Leili Rohani, Adiv A Johnson, Antje Arnold, Alexandra Stolzing
The discovery that somatic cells can be induced into a pluripotent state by the expression of reprogramming factors has enormous potential for therapeutics and human disease modeling. With regard to aging and rejuvenation, the reprogramming process resets an aged, somatic cell to a more youthful state, elongating telomeres, rearranging the mitochondrial network, reducing oxidative stress, restoring pluripotency, and making numerous other alterations. The extent to which induced pluripotent stem cell (iPSC)s mime embryonic stem cells is controversial, however, as iPSCs have been shown to harbor an epigenetic memory characteristic of their tissue of origin which may impact their differentiation potential...
February 2014: Aging Cell
Tom Skyhøj Olsen, Klaus Kaae Andersen
AIM: Reports on centenarians with stroke have thus far been casuistic. We present clinical characteristics and 1-month mortality in 39 centenarians admitted to Danish hospitals with acute stroke within 2000-2010. METHODS: A Danish stroke registry (2000-2010) contains information about 61 935 acute stroke patients among which 39 patients were centenarians. Data included age, sex, civil and housing status, stroke severity (Scandinavian Stroke Scale [SSS], 0 worst to 58 best), computed tomography scan, cardiovascular risk factors and death within 1 month after stroke...
January 2014: Geriatrics & Gerontology International
Leonard W Poon, John L Woodard, L Stephen Miller, Robert Green, Marla Gearing, Adam Davey, Jonathan Arnold, Peter Martin, Ilene C Siegler, Lusine Nahapetyan, Young Sek Kim, William Markesbery
The goals of this article are to (a) establish the concurrent and clinical validity of the Global Deterioration scale in assessing cognitive functions and stages of dementia among centenarians, (b) identify the prevalence of all-cause dementia in representative samples of centenarians, and (c) demonstrate how variations in sample demographic characteristics could significantly affect estimates of dementia prevalence. A quarter of the 244 centenarians in a population-based sample had no objective evidence of memory deficits...
April 2012: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
L D Serova, N D Serova, E V Tereshina, T M Iurina, V N Shabalin
The very old people is a growing population group in Russia and in Moscow in particular that requires more close attention as it demands special medical and social approaches. The investigation was based on data obtained from Moscow district clinics concerning the gender and pathologies structure of people aged 90 yrs and older. In this group women prevailed in total amount and among those older 100 yrs. Striking gender difference was revealed in disturbances of the carbohydrate metabolism. The most frequent pathologies in this population are cardiovascular, nerve and gastrointestine duct systems diseases that have equal prevalence among men and women...
2011: Advances in Gerontology, Uspekhi Gerontologii
D Craig Willcox, Bradley J Willcox, Nien-Chiang Wang, Qimei He, Matthew Rosenbaum, Makoto Suzuki
BACKGROUND: As elite representatives of the rapidly increasing "oldest-old" population, centenarians have become an important model population for understanding human aging. However, as we are beginning to understand more about this important phenotype, another demographic group of even more elite survivors is emerging-so-called "supercentenarians" or those who survive 110-plus years. Little is known about these exceptional survivors. METHODS: We assessed the Okinawa Centenarian Study (OCS) database for all information on supercentenarians...
November 2008: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Suzanne Rogers, Jane Omilian, Jennifer Holcomb, Yunchoon Long
A review of literature indicates that people who experience longevity have certain characteristics and personality traits in common. While family history and health habits play an important role, centenarian research reveals that family support, an optimistic attitude, a sense of purpose, and an ability to manage stress, all can contribute to longevity. Social workers conducted intensive life review interviews with 17 octogenarians receiving dialysis at a clinic in the Detroit suburb Eastpointe, Mich. to learn more about their backgrounds, health habits, and coping styles in order to determine if they shared tendencies found in centenarians, and the implications it had for younger dialysis patients...
August 2008: Nephrology News & Issues
Adnan Sadiq, Muhaddis Choudhury, Kamran Ali, Elsayed Mohamed, Vijay Shetty, Chaim Kabalkin, Alvin Greengart
The centenarian population is increasing, and patients > or =100 years old are encountered more frequently in clinical practice. Cardiovascular disease is the most common cause of death in this subset of patients. We report the echocardiographic characteristics of 63 hospitalized centenarians. Patients ranged in age from 100 to 112 years and were admitted to the hospital for a variety of diagnoses. The mean left ventricular end-diastolic dimension was 3.9 +/- 0.7 cm (2.8 to 5.8), the mean left ventricular end-systolic dimension was 1...
December 15, 2007: American Journal of Cardiology
M Barbieri, A Gambardella, G Paolisso, M Varricchio
Starting from young to very old subjects, aging is associated with a progressive remodeling. Such an age-dependent remodeling process mainly affects anthropometrics, endocrine and thus, also metabolic factors. Interestingly, it occurs in some individuals successfully, while in others unsuccessfully. Centenarians in good health conditions are a very selected group of subjects representing an exceptional condition. Why the centenarians reach the extreme human life span is still unknown. Thus, in this article we will review the best known causes of age-related insulin resistance, outline the main metabolic differences between aged subjects and healthy centenarians, underline the clinical relevance of insulin resistance in the elderly and finally, we will try to propose a unifying hypothesis for explaining the development of insulin resistance with aging...
February 2008: Experimental Gerontology
D Lio, M Malaguarnera, D Maugeri, L Ferlito, E Bennati, L Scola, M Motta, C Caruso
Studies aimed at collecting reference parameters for haematochemical analysis in the elderly are scarce and for the oldest old subjects even more rare. In order to establish the reference values for the most common laboratory text in long living individuals, we measured haematochemical parameters in >100 years old subjects and in aged subjects as control. Six hundred and two centenarians accepted to be enrolled in the study. A case history containing the complete anamnesis, clinical examinations, evaluation of the clinical cognitive and functional tests, was prepared for each centenarian...
February 2008: Experimental Gerontology
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