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submandibular gland

J Zhang, Y Sun, Z Li, H Feng
Adenoid cystic carcinoma (ACC) is rare. One of its characteristics is a high rate of distant metastasis, and the most common site is the lungs, followed by the brain and liver. Bony metastases account for up to 1.96% of cases only, however, and metastasis from the blood to the bones of distal limbs is rare. We report a 62-year-old woman who presented with pain caused by bony metastases as the first symptom eight years after being diagnosed with submandibular ACC. Although such cases are rare, they indicate that when patients who have had cancer visit the hospital with other symptoms, clinicians should make sure to rule out metastasis...
April 8, 2019: British Journal of Oral & Maxillofacial Surgery
Jin-Ye Fu, Chun-Xiao Wu, Shu-Kun Shen, Ying Zheng, Chen-Ping Zhang, Zhi-Yuan Zhang
BACKGROUND: Salivary gland carcinoma ranks the sixth in head and neck cancers while it is relatively rare in its incidence. Epidemiological studies have been based mostly on institutional data, leading to selection bias in incidence evaluation. Most population-based cancer registries have grouped cancers of the minor salivary glands with oral cancer instead of with salivary gland carcinoma as a whole, because of the international disease coding. Thus, the incidence of salivary gland carcinoma has not been well assessed...
April 11, 2019: BMC Cancer
Stephen H Roth, William C Faquin, Cecilia Gimenez, Bhumika Vadalia, Douglas K Frank, Jian Yi Li
Schwannoma-like pleomorphic adenoma is a rare variant of the common benign salivary neoplasm, pleomorphic adenoma. This entity's cytomorphology closely mimics a schwannoma, potentially making a diagnosis of cytologic preparations or of surgical specimens a challenge. To the best of our knowledge, there are only six previous reports of schwannoma-like pleomorphic adenoma with eight total cases in the English language literature prior to the addition of the two cases detailed in this report. Our report includes what we believe to be the first documented case of this entity occurring in the submandibular gland...
April 9, 2019: Head and Neck Pathology
Zhi-Yuan Chen, Yu Zhang, Yan Tu, Wei Zhao, Mei Li
BACKGROUND: Only a few cases of carcinoma ex pleomorphic adenoma arising in the submandibular gland have ever been reported, all with a poor prognosis. The standard treatment for salivary gland carcinoma ex pleomorphic adenoma is surgical resection combined with postoperative radiotherapy, but the necessity of chemotherapy as well as the most appropriate treatment regimen for patients with distant metastasis after radiotherapy remains controversial. CASE SUMMARY: This report presents the case of a 73-year-old woman who suffered submandibular gland carcinoma ex pleomorphic adenoma...
March 26, 2019: World Journal of Clinical Cases
V Manoj, N C Sandeepa, Manickam Selvamani, Marish Panjami
Amelogenesis imperfecta (AI) is a disease primarily affecting amelogenesis, but other various aberrations have been reported in association with this entity. Enamel-renal syndrome (ERS) is a very rare disorder associating AI with nephrocalcinosis. It is known by various synonyms such as AI nephrocalcinosis syndrome, MacGibbon syndrome, Lubinsky syndrome and Lubinsky-MacGibbon syndrome. The purposes of this article are to describe other dental anomalies which are rarely associated with AI making the diagnosis of AI a complex disorder and also to report a rare case of MacGibbon syndrome presented with sialolith of submandibular gland duct which is the first reported case in the literature...
February 2019: Journal of Oral and Maxillofacial Pathology: JOMFP
Yong Tae Hong, Ki Hwan Hong
No abstract text is available yet for this article.
April 9, 2019: Ear, Nose, & Throat Journal
Carlos Saga-Gutierrez, Carlos Miguel Chiesa-Estomba, Ekhiñe Larruscain, José Ángel González-García, Jon Alexander Sistiaga, Xabier Altuna
INTRODUCTION: Sialolithiasis is the most common pathology in the submaxillary gland. The introduction of minimally invasive techniques isolated or associated with sialoendoscopy is replacing glandular resection as a treatment. The conservation of the gland is justified by the recovery of function and a low recurrence rate. The rate of complications is lower in conservative techniques than in submandibular gland resection. PATIENTS AND METHODS: Thirty-three patients with fixed stones in the hilum of the submaxillary gland were treated by transoral sialolitectomy between July 2015 and July 2018, demographic data of the patients such as the number of stones, size, time of hospital stay, complications, pre- and postoperative lingual nerve function, and lithiasis recurrence were collected...
April 8, 2019: Ear, Nose, & Throat Journal
L M Liang, X Z Lin, X J Shao, X D Han, W X Yuan, X L Wang, M Hu
Submandibular gland excision was performed on two patients using trans-oral robotic surgery (TORS). Complications such as the injury of marginal mandibular branch of facial nerve, ranula in the floor of the mouth, and postoperative hemorrhage were not observed. Visible cervical scar can be avoided and esthetic outcome can be expected by using this surgical modality.
April 9, 2019: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
Shalini Bhalla, Naseem Akhtar, Puneet Prakash, Malti Kumari, Madhu Mati Goel
No abstract text is available yet for this article.
March 2019: Indian Journal of Surgical Oncology
Erol Cansiz, Emine Deniz Gozen, Murat Yener
Orocutaneous fistulas in the maxillofacial region may be due to tumor resection, osteoradionecrosis, or trauma, and these defects limit the function of the patients and effect aesthetic and also psychological condition. Articulation and nutrition are also affected by these fistulas. Local flaps can be used for the reconstruction of small- and medium-sized defects with ease. Submandibular gland with its rich blood supply from the facial artery is a practical and useful choice for the reconstruction of mandibular region defects...
2019: Case Reports in Dentistry
Kaname Tachibana, Hirohumi Suzuki, Masako Yamashita, Toshiharu Yamamoto
The distribution and nature of CXCL14-immunoreactive nerve fibers in salivary glands, especially the parotid gland was immunohistochemically investigated. Furthermore, the origin of parotid CXCL14-immunoreactive nerve fibers was determined by retrograde tracing experiments. CXCL14-immunoreactive nerve fibers were localized in the parotid, submandibular, and sublingual glands, particularly in the parotid gland. Double staining using identical sections revealed that a subpopulation of cells neuropeptide Y (NPY)-containing fibers was immunopositive for CXCL14 in the parotid gland...
March 28, 2019: Neuroscience Letters
Nasra N Ayuob, Hanem S Abdel-Tawab, Ahmed A El-Mansy, Soad S Ali
This study assessed the impact of chronic unpredictable mild stress (CUMS) on the structure of mouse salivary glands and the role of musk in alleviating this impact. Forty male albino mice were distributed equally into four groups; control (untreated), CUMS (exposed to CUMS for 4 weeks), CUMS+fluoxetine (FLU) (exposed to CUMS then treated with FLU, CUMS+musk (exposed to CUMS then treated with musk). Behavioral changes and serum corticosterone levels were assessed at the end of the experiment. The submandibular and parotid glands were dissected out and processed for histopathological and immunohistochemical examination using antibodies against alpha smooth muscle actin (ASMA) and brain-derived neurotropic factor (BDNF)...
2019: Journal of Oral Science
Yusuf Dundar, Quinton Mandle, Syed N Raza, Ho-Sheng Lin, John Cramer, Jeffrey M Hotaling
OBJECTIVE: The submandibular gland (SMG) is typically included in level I neck dissection specimens despite limited data demonstrating SMG invasion. The main objective of this article is to determine the rate and pathways of SMG invasion by squamous cell carcinoma of the oral cavity and oropharynx. DATA SOURCES: A systematic review of relevant studies was performed, evaluating articles identified via the PubMed, Cochrane, and Medline databases. REVIEW METHODS: Descriptive features of primary tumors, primary treatment modalities, the rate and pathway of SMG invasion, and survival outcomes, if present, were reported following the PRISMA guidelines...
March 26, 2019: Otolaryngology—Head and Neck Surgery
Baptiste Bertrand, Calum Sinclair Honeyman, Angel Emparanza, Mark McGurk, Issa Elh Ousmane Hamady, Andreas Schmidt, Raphael Sinna, Brigitte Pittet-Cuénod, Narcisse Zwetyenga, Dominique Martin
BACKGROUND: The submental flap is a pedicled island flap with excellent colour match for facial reconstruction. The flap can be raised with muscle, submandibular gland or bone and can be transposed to reach defects up to two thirds of the face. We report the primary author's experience of 25 years using the submental flap from its original description to most recent technical evolutions in both Europe and Africa. METHODS: This is a retrospective study including all patients with facial defects reconstructed using a submental flap between 1991 and 2016...
March 12, 2019: Plastic and Reconstructive Surgery
Aanchal Kakkar, Prerna Guleria, Karan Madan, Rajeev Kumar, Sunil Kumar, Deepali Jain
Mucoepidermoid carcinomas are common malignant salivary gland tumors. Despite recent advances in diagnosis and treatment, there has not been much improvement in outcome of these patients, necessitating identification of novel targeted therapeutic agents. Genomic profiling of mucoepidermoid carcinomas has recently revealed aberrations in BAP1 gene. Therefore, we conducted this study to identify BAP1 loss by immunohistochemistry in these tumors. Mucoepidermoid carcinoma cases were retrieved; hematoxylin-and-eosin stained sections were reviewed...
March 2019: Indian Journal of Otolaryngology and Head and Neck Surgery
Khaled Mosaad Elhusseiny, Fatma Abd-Elshahed Abd-Elhay, Mohamed Gomaa Kamel, Heba Hassan Abd El Hamid Hassan, Heba Hussien Muhammad El Tanany, Truong Hong Hieu, Thuan Minh Tieu, Soon Khai Low, Vincent Hou, Mahmoud Dibas, Nguyen Tien Huy
BACKGROUND: We aimed to investigate the prognostic role of examined (dissected) lymph nodes (ELNs), negative LNs (NLNs), and positive (metastatic) LNs (PLNs) counts and LN ratio (LNR = PLNs/ELNs×100) in patients with major salivary gland cancer (SGC). METHODS: Data were retrieved for major SGC patients diagnosed between 1988 and 2011 from Surveillance, Epidemiology, and End Results program. RESULTS: We have included 5446 patients with major SGC...
March 23, 2019: Head & Neck
Li-Hua Xu, Fei Zhao, Wen-Wen Yang, Chu-Wen Chen, Zhi-Hao Du, Min Fu, Xi-Yuan Ge, Sheng-Lin Li
The incidence of recurrent t(6;9) translocation of the MYB proto‑oncogene to NFIB (the gene that encodes nuclear factor 1 B‑type) in adenoid cystic carcinoma (ACC) tumour tissues is high. However, MYB [the gene that encodes transcriptional activator Myb (MYB)] overexpression is more common, indicating that MYB serves a key role in ACC. The current study aimed to investigate the role of MYB in salivary (S)ACC growth and metastasis. A total of 50 fresh‑frozen SACC tissues and 41 fresh‑frozen normal submandibular gland (SMG) tissues were collected to measure MYB mRNA expression, and to analyse the associations between MYB and epithelial‑mesenchymal transition (EMT) markers...
March 18, 2019: International Journal of Oncology
Tsung-Lin Yang, Hong Li, Floyd Christopher Holsinger, Yoon Woo Koh
BACKGROUND: Cosmetic outcome after submandibular gland (SMG) surgery has greatly improved since the development of robotic surgery through a trans-hairline approach. However, the bulky sizes of robotic arms and the rigid design of camera and instruments in the current multiarm robotic systems increased the surgical difficulty. METHODS: Clinical and preclinical studies demonstrated the surgical configuration and procedures of robotic trans-hairline SMG resection using a flexible, single-port, and multiarm systems...
March 21, 2019: Head & Neck
Susan M Reid, Christine Westbury, David Chong, Bruce R Johnstone, Angela Guzys, Dinah S Reddihough
Sialorrhea is a common problem in children with disability, often negatively affecting socialization, self-esteem, and burden of care. Saliva control surgery is an available option to manage this problem, particularly when other conservative methods have failed. As little is known about the long-term impact of surgery, we followed up 62 patients who had combined bilateral submandibular duct translocation and bilateral sublingual gland excision at our pediatric hospital between 1994 and 2014. Eligible individuals were identified through a search of ICD procedure codes...
March 2, 2019: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
Spencer Dean, Ching-Shuen Wang, Kihoon Nam, Christina L Maruyama, Bryan G Trump, Olga J Baker
OBJECTIVES: SS is characterized by chronic inflammation of the salivary glands leading to loss of secretory function, thereby suggesting specialized pro-resolving mediators targeting inflammation to be a viable option for treating SS. Previous studies demonstrated that aspirin-triggered resolvin D1 (AT-RvD1) prevents chronic inflammation and enhances saliva secretion in a SS-like mouse model when applied before disease onset. However, this therapy cannot be used in SS patients given that diagnosis occurs post-disease onset and no reliable screening methods exist...
March 15, 2019: Rheumatology
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