Xiuting Yao, Chenxi Yang, Xirui Jia, Zhehao Yu, Conghui Wang, Jingyi Zhao, Yuxi Chen, Bingjie Xie, Hong Zhuang, Congli Sun, Qian Li, Xiaomin Kang, Yu Xiao, Lijie Liu
Mounting evidence suggests that high-fat diet (HFD) consumption increases the risk for depression, but the neurophysiological mechanisms involved remain to be elucidated. Here, we demonstrated that HFD feeding of C57BL/6J mice during the adolescent period (from 4 to 8 weeks of age) resulted in increased depression- and anxiety-like behaviors concurrent with changes in neuronal and myelin structure in the hippocampus. Additionally, we showed that hippocampal microglia in HFD-fed mice assumed a hyperactive state concomitant with increased PSD95-positive and myelin basic protein (MBP)-positive inclusions, implicating microglia in hippocampal structural alterations induced by HFD consumption...
April 9, 2024: Brain, Behavior, and Immunity