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Corn peptide

Chao Ding, Jack Yang, Cornelis Van't Veer, Tom van der Poll
BACKGROUND: Kinins are short peptides with a wide range of proinflammatory properties that are generated from kininogens in the so-called kallikrein-kinin system. Kinins exert their biological activities through stimulation of two distinct receptor subtypes, the kinin or bradykinin B1 and B2 receptors (B1R, B2R). Acute challenge models have implicated B1R and B2R in the pathogenesis of sepsis. However, their role in the host response during sepsis originating from the lung is not known...
March 12, 2019: Intensive Care Medicine Experimental
Alexander P N A de Porto, Theodora A M Claushuis, Lieve E H van der Donk, Regina de Beer, Onno J de Boer, Sandrine Florquin, Joris J T H Roelofs, Rudi W Hendriks, Tom van der Poll, Cornelis Van't Veer, Alex F de Vos
Platelet Bruton's tyrosine kinase (Btk) is an essential signalling protein for the collagen receptor glycoprotein VI (GPVI) and podoplanin receptor C-type-lectin-like receptor-2, which are platelet receptors implicated in the maintenance of vascular integrity during inflammation. Moreover, platelets, platelet GPVI and Btk are important for host defence during murine bacterial pneumosepsis. The aim of this study was to determine the role of platelet Btk in vascular integrity and host defence during murine pneumosepsis caused by the common human pathogens Streptococcus pneumoniae and Klebsiella pneumoniae ...
March 14, 2019: Thrombosis and Haemostasis
Sofie K D Nielsen, Thomas L Koch, Frank Hauser, Anders Garm, Cornelis J P Grimmelikhuijzen
BACKGROUND: The phyla Cnidaria, Placozoa, Ctenophora, and Porifera emerged before the split of proto- and deuterostome animals, about 600 million years ago. These early metazoans are interesting, because they can give us important information on the evolution of various tissues and organs, such as eyes and the nervous system. Generally, cnidarians have simple nervous systems, which use neuropeptides for their neurotransmission, but some cnidarian medusae belonging to the class Cubozoa (box jellyfishes) have advanced image-forming eyes, probably associated with a complex innervation...
March 6, 2019: BMC Genomics
Jiaxiang Yan, Qiang Shi, Kaihao You, Yanping Li, Qinghua He
Immunoassays play an important role in the monitoring and detection of mycotoxins in food. However, mycotoxin conjugates in the immunoassay system synthesized with toxic mycotoxin as raw material has seriously harmed the environment and human health during and after the performance. In this work, using mycotoxin deoxynivalenol (DON) as a model happen, a selected DON mimotope (phage-displayed peptide) that specifically binds to anti-DON antibody was served as a mimetic competing antigen in electrochemical immunosensor for ultrasensitive and green detection of DON...
January 31, 2019: Journal of Pharmaceutical and Biomedical Analysis
Guoming Li, Wenying Liu, Yuqing Wang, Fuhuai Jia, Yuchen Wang, Yong Ma, Ruizeng Gu, Jun Lu
Corn protein has been identified as an important source of bioactive peptides. Such peptides can be released during hydrolysis induced by proteolytic enzymes or microbial fermentation. Corn peptides have been found to exhibit different functions in vitro and in vivo such as antihypertensive, hepatoprotective, anti-obesity, antimicrobial, antioxidative, mineral-binding and accelerating alcohol metabolism. To date, 22 sequences of bioactive corn peptides have already been identified. There is an increasing commercial interest in the production of corn peptides with the purpose of using them as active ingredients, which may find use in the treatment of liver injury, hypertension, dental carries, oxidative stress, mineral malabsorption and obesity...
2019: Advances in Food and Nutrition Research
Gijs G Zom, Marian M J H P Willems, Selina Khan, Tetje C van der Sluis, Jan Willem Kleinovink, Marcel G M Camps, Gijsbert A van der Marel, Dmitri V Filippov, Cornelis J M Melief, Ferry Ossendorp
BACKGROUND: Ligands for the Toll-like receptor (TLR) family can induce activation of cells of the innate immune system and are widely studied for their potential to enhance adaptive immunity. Conjugation of TLR2-ligand Pam3CSK4 to synthetic long peptides (SLPs) was shown to strongly enhance the induction of antitumor immunity. To further improve cancer vaccination, we have previously shown that the novel TLR2-L Amplivant (AV), a modified Pam3CSK4, potentiates the maturation effects on murine DCs...
December 12, 2018: Journal for Immunotherapy of Cancer
Babs G Sibinga Mulder, Henricus Jm Handgraaf, Danielle J Vugts, Claudia Sewing, Albert D Windhorst, Marieke Stammes, Lioe-Fee de Geus-Oei, Mark W Bordo, J Sven D Mieog, Cornelis Jh van de Velde, John V Frangioni, Alexander L Vahrmeijer
cRGD peptides target integrins associated with angiogenesis (e.g., αv β3 ) and cancer, and have been used as binding ligands for both positron emission tomography (PET) and near-infrared fluorescence (NIRF) optical imaging. This study introduces the hybrid tracer cRGD-ZW800-1-Forte-[89 Zr]Zr-DFO, which is based on a novel zwitterionic fluorophore structure that reduces non-specific background uptake during molecular imaging of tumors. An in vitro binding assay was used to validate tracer performance. 10 nmol ZW800F-cRGD-Zr-DFO was injected in mice (n=7) bearing orthotopic human colorectal tumors (HT29-luc2) for tumor detection with NIRF imaging...
2018: American Journal of Nuclear Medicine and Molecular Imaging
Danjun Guo, Yan Zhang, Juanjuan Zhao, Hui He, Tao Hou
The relationship between hepatoprotective effects of selenium-biofortified corn (Zea mays Linn) peptides (SeCPs) and its antioxidant ability was evaluated and the structure of SeCPs was identified. SeCPs and corn peptides (CPs) both had good antioxidant ability, and the effect of SeCPs was significantly higher than CPs within a certain concentration range (P < 0.05). Additionally, animal experiments indicated that SeCPs (200 mg/kg) had a significantly protective effect against concanavalin A (Con A) induced hepatic lesions, as it significantly declined glutamic-pyruvic transaminase (AST), alanine transaminase (ALT) activities, tumor necrosis factor alpha (TNF-α), interferon (IFN)-γ contents in serum, and malondialdehyde (MDA) contents in liver (P < 0...
January 2019: Journal of Trace Elements in Medicine and Biology
Yuliang Zhang, Yitong Zhang, Maojie Fu, Guohua Yin, Richard T Sayre, Kayla K Pennerman, Fengshan Yang
Glutathione-S-transferases (GST) comprise a multifunctional protein superfamily, which plays important roles as detoxifiers and antioxidants in insects. The GST in Asian corn borer has not been previously characterized. In this study, we cloned, characterized, and expressed the complete GST genes from the midgut of Asian corn borer. Furthermore, we designed htL4440-OfGST vector to exploit this gene for RNA interference (RNAi) strategy to control this pest. A complete GST cDNA sequence in Asian corn borer was obtained by reverse transcription polymerase chain reaction (RT-PCR) and rapid amplification of cDNA ends technology...
September 1, 2018: Journal of Insect Science
A L B Moreira Filho, P R Ferket, R D Malheiros, C J B Oliveira, P C Aristimunha, D E Wilsmann, P E N Givisiez
The effects of in ovo feeding with threonine (Thr) on intestinal morphology, ileal gene expression and performance of broiler chicken between 1 and 21 d of age (d) were assessed. On day 17.5 of incubation, fertile eggs were randomly allotted to 5 treatments of Thr injection in the amniotic fluid (0; 1.75; 3.5; 5.25; 7%, corresponding to 17.5; 35; 52.5 and 70 mg Thr/mL). After hatch, chicks were given a commercial corn-soybean diet up to 21 d. Daily feed intake (FI), body weight (BW), and food conversion ratio (FCR) were measured from 1 to 7, 14, and 21 d of age...
October 15, 2018: Poultry Science
A J Cowieson, M Toghyani, S K Kheravii, S-B Wu, L F Romero, M Choct
A total of 90 male Ross 308 broiler chicks were used in a digestibility and performance bioassay to explore the effect of reduction in dietary protein and digestible amino acids and inclusion of an exogenous mono-component protease on amino acid digestibility, net energy, jejunal gene expression, and bird performance. Four dietary treatments were created by the supplementation, or not, of 2 control diets with a mono-component exogenous protease. The control diets were corn/wheat/soybean meal-based and were formulated to be either nutritionally adequate or reduced in protein and amino acids (around 3%)...
October 5, 2018: Poultry Science
Erminia Massarelli, William William, Faye Johnson, Merrill Kies, Renata Ferrarotto, Ming Guo, Lei Feng, J Jack Lee, Hai Tran, Young Uk Kim, Cara Haymaker, Chantale Bernatchez, Michael Curran, Tomas Zecchini Barrese, Jaime Rodriguez Canales, Ignacio Wistuba, Lerong Li, Jing Wang, Sjoerd H van der Burg, Cornelis J Melief, Bonnie Glisson
Importance: In recurrent human papilloma virus (HPV)-driven cancer, immune checkpoint blockade with anti-programmed cell death 1 (PD-1) antibodies produces tumor regression in only a minority of patients. Therapeutic HPV vaccines have produced strong immune responses to HPV-16, but vaccination alone has been ineffective for invasive cancer. Objective: To determine whether the efficacy of nivolumab, an anti-PD-1 immune checkpoint antibody, is amplified through treatment with ISA 101, a synthetic long-peptide HPV-16 vaccine inducing HPV-specific T cells, in patients with incurable HPV-16-positive cancer...
September 27, 2018: JAMA Oncology
Sylvia Brugman, Wakako Ikeda-Ohtsubo, Saskia Braber, Gert Folkerts, Corné M J Pieterse, Peter A H M Bakker
During recent years the impact of microbial communities on the health of their host (being plants, fish, and terrestrial animals including humans) has received increasing attention. The microbiota provides the host with nutrients, induces host immune development and metabolism, and protects the host against invading pathogens (1-6). Through millions of years of co-evolution bacteria and hosts have developed intimate relationships. Microbial colonization shapes the host immune system that in turn can shape the microbial composition (7-9)...
2018: Frontiers in Nutrition
Eugene Rogozhin, Dmitry Ryazantsev, Alexey Smirnov, Sergey Zavriev
Cereal-derived bioactive peptides with antimicrobial activity have been poorly explored compared to those from dicotyledonous plants. Furthermore, there are a few reports addressing the structural differences between antimicrobial peptides (AMPs) from cultivated and wild cereals, which may shed light on significant varieties in the range and level of their antimicrobial activity. We performed a primary structure analysis of some antimicrobial peptides from wild and cultivated cereals to find out the features that are associated with the much higher antimicrobial resistance characteristic of wild plants...
September 12, 2018: Plants (Basel, Switzerland)
Divyanshu Dubey, Rehana Z Hussain, William A Miller-Little, Amber Salter, Richard Doelger, Olaf Stüve
BACKGROUND: Para-dichlorobenzene (PDCB) is an aromatic hydrocarbon contained in mothballs that is potentially neurotoxic. A potential pathogenic role of PDCB in MS pathogenesis has been suggested. METHODS: To determine the ability of chronic PDCB ingestion to induce CNS autoimmunity in a genetically susceptible mammalian species, naive myelin oligodendrocyte glycoprotein peptide (MOGp )35-55 T cell receptor (TCR) transgenic mice (2D2) on the C57Bl/6 background were orally gavaged once daily with corn oil control, 125 mg/kg PDCB, or 250 mg/kg PDCB for 45 days...
October 15, 2018: Journal of Neuroimmunology
In Jeong Kang, Hyeong Kwon Shim, Jae Hwan Roh, Sunggi Heu, Dong Bum Shin
Northern corn leaf spot and southern corn leaf blight caused by Cochliobolus carbonum (anamorph, Bipolaris zeicola ) and Cochliobolus heterostrophus (anamorph, Bipolaris maydis ), respectively, are common maize diseases in Korea. Accurate detection of plant pathogens is necessary for effective disease management. Based on the polyketide synthase gene (PKS) of Cochliobolus carbonum and the nonribosomal peptide synthetase gene (NRPS) of Cochliobolus heterostrophus , primer pairs were designed for PCR to simultaneously detect the two fungal pathogens and were specific and sensitive enough to be used for duplex PCR analysis...
August 2018: Plant Pathology Journal
Diego Moya, Alfred Ferret, Marta Blanch, Mari Carmen Fuentes, Jose Ignacio Fandiño, Sergio Calsamiglia
Live yeast additives may help optimize ruminal fermentation of high-grain diets, especially when the starch of the ration is highly fermentable. Eight dual flow continuous culture fermenters were used in a 2 × 2 factorial design in two replicated periods of 9 days (six for adaptation and three for sampling) to determine the effect of live yeast and type of cereal on rumen microbial fermentation and nutrient digestibility. Main factors were the addition of live yeast: no yeast (NY) vs. 2 × 107 CFU of yeast/g of diet (LY); and type of cereal in the diet: corn (CO) vs...
August 12, 2018: Journal of Animal Physiology and Animal Nutrition
Bradley R Dotson, Dia Soltan, John Schmidt, Mariam Areskoug, Kenny Rabe, Corné Swart, Susanne Widell, Allan G Rasmusson
BACKGROUND: Trichoderma fungi live in the soil rhizosphere and are beneficial for plant growth and pathogen resistance. Several species and strains are currently used worldwide in co-cultivation with crops as a biocontrol alternative to chemical pesticides even though little is known about the exact mechanisms of the beneficial interaction. We earlier found alamethicin, a peptide antibiotic secreted by Trichoderma, to efficiently permeabilise cultured tobacco cells. However, pre-treatment with Trichoderma cellulase made the cells resistant to subsequent alamethicin, suggesting a potential mechanism for plant tolerance to Trichoderma, needed for mutualistic symbiosis...
August 10, 2018: BMC Plant Biology
Qijun Ruan, Lihua Zeng, Jiaoyan Ren, Xiaoquan Yang
There are two long-standing issues that are holding back the full exploitation of food-based double emulsions: (i) unavailability of large-scale equipment to ensure efficient nondestructive two-step emulsification and (ii) limited food-grade ingredients available to replace polyglycerol polyricinoleate (PGPR) as the primary emulsifier. To overcome these, a facile one-step emulsification strategy was developed to generate a food-grade W/O/W double Pickering emulsion by using corn-peptide-functionalized calcium phosphate (CP-CaP) particles as the emulsifier...
August 15, 2018: Food & Function
Betul Kisioglu, Reyhan Nergiz-Unal
The influence of HFCS (high fructose corn syrup - free fructose) and sucrose (bound fructose) on fetal appetite signals is unknown. This study aimed to determine the effects of HFCS or sucrose on the peptide-mediated appetite regulation in fetal programming of obesity. Sprague Dawley female rats were administered feed and plain water (control) or water containing maltodextrin (vehicle), sucrose, fructose, or HFCS (20%, w/v) for 12 weeks before mating and throughout pregnancy and lactation (ndams = 31; npups = 207)...
July 1, 2018: Nutritional Neuroscience
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