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Vitamin D supplementation

Zlatan Zvizdic, Emir Haxhija, Adisa Chikha, Emir Milisic, Asmir Jonuzi, Semir Vranic
Objective<br>We present a 17-year-old boy with an incidentally diagnosed left adrenal ganglioneuroma (GN) during the diagnostic work up of alopecia areata (AA). <br> Clinical Presentation and Intervention<br>Laboratory investigations revealed only vitamin D deficiency. Laparoscopic adrenalectomy was performed and GN was confirmed histologically. At follow-up, the vitamin D supplements improved the vitamin D levels followed by the gradual regression of AA. However, AA recurred 18 months later despite the normal serum vitamin D levels and no tumor recurrence...
March 22, 2019: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
Chi Chen, Hualing Zhai, Jing Cheng, Pan Weng, Yi Chen, Qin Li, Chiyu Wang, Fangzhen Xia, Ningjian Wang, Yingli Lu
CONTEXT: Low circulating vitamin D levels have been associated with lower total testosterone. These epidemiological associations, if true, would have public health importance, since vitamin D deficiency is common and correctable. We aimed to test whether genetically lowered vitamin D levels were associated with lower total testosterone (T), using Mendelian randomization (MR) methodology. DESIGN AND SETTING: 4,254 men were enrolled from the SPECT-China study, which was performed in 23 sites in East China during 2014 to 2016...
March 21, 2019: Journal of Clinical Endocrinology and Metabolism
Hesham Abdel-Hady, Sohier Yahia, Ahmed Megahed, Abeer Mosbah, Basma Seif, Eman Nageh, Indrani Bhattacharjee, Hany Aly
OBJECTIVE: To evaluate biochemical and clinical effects of 2 different doses of vitamin D supplementation in preterm infants with late-onset sepsis (LOS). STUDY DESIGN: A double blinded randomized controlled stratified trial included preterm infants with gestational age (GA) ≥28 weeks with LOS. Subjects were randomly assigned to receive 400 or 800 IU/day of vitamin D3. Serum concentrations of 25(OH)D, TNF-α, and IL-6 were measured at enrollment, 7 days after vitamin D supplementation, and at 40 weeks of postmenstrual age (PMA)...
April 2019: Journal of Pediatric Gastroenterology and Nutrition
Clark M Henderson, Susan L Fink, Hanan Bassyouni, Bob Argiropoulos, Lindsay Brown, Thomas J Laha, Konner J Jackson, Raymond Lewkonia, Patrick Ferreira, Andrew N Hoofnagle, Julien L Marcadier
A 58-year-old woman with debilitating ankylosing spondylitis who was born to consanguineous parents was found to have an apparent severe vitamin D deficiency that did not respond to supplementation. Liquid chromatography-tandem mass spectrometry showed the absence of circulating vitamin D-binding protein, and chromosomal microarray confirmed a homozygous deletion of the group-specific component ( GC ) gene that encodes the protein. Congenital absence of vitamin D-binding protein resulted in normocalcemia and a relatively mild disruption of bone metabolism, in this case complicated by severe autoimmune disease...
March 21, 2019: New England Journal of Medicine
Kelly A Reynolds, Margit L W Juhasz, Natasha A Mesinkovska
Atopic dermatitis (AD) is a chronic, inflammatory skin disorder characterized by disruption of epidermal barrier function and aberrant immune response to antigens. Current therapies focus on symptom management by restoring epidermal barrier function with emollients and reducing inflammation. Given the prevalence of "steroid phobia" and reported dissatisfaction with first-line therapies, oral vitamins and supplements have been proposed as promising complementary and alternative therapies. The purpose of this systematic review is to evaluate the evidence for various oral vitamins and supplements for the treatment of AD...
March 20, 2019: International Journal of Dermatology
F Parisi, I di Bartolo, V M Savasi, I Cetin
Pregnancy represents a period of major physiological and metabolic change, aiming to ensure proper fetal growth and development, as well as maternal preservation. This review focuses on maternal nutrition, and particularly on micronutrient deficiencies and supplementation during pregnancy. Nutrient deficiencies and consequences in pregnant women are presented, with an overview of current recommendations for dietary supplementation in pregnancy, even considering the risk of micronutrient overload. Appropriate universal supplementation and prophylaxis/treatment of nutritional needs currently appear to be the most cost-effective goal in low-income countries, thus ensuring adequate intake of key elements including folate, iron, calcium, vitamin D and A...
March 2019: Obstetric Medicine
Juan C Ramirez-Sandoval, Mauricio Arvizu-Hernandez, Cristino Cruz, Barbara Vazquez-Cantu, Luis J Rojas-Concha, Luis Tamez, Fagundo Reynerio, F Enrique Gomez, Ricardo Correa-Rotter
BACKGROUND: Vitamin D deficiency is common in peritoneal dialysis (PD) patients, so its supplementation has been advocated as potentially beneficial. METHODS: Double-blind, placebo-controlled, randomized clinical trial. Subjects on PD treated with high calcium peritoneal dialysate (Ca 3.5 mEq/l) and serum levels of 25-hydroxi vitamin D (25D) < 20 ng/ml were randomized to receive cholecalciferol (4800 IU/daily) or placebo for 16 weeks. The outcome measures were the effects on the osteogenic biomarkers osteoprotegerin (primary endpoint), intact fibroblast growth factor-23 (iFGF23), osteocalcin, osteopontin, iPTH, 1,25-dyhydroxivitamin D (1,25D), and interleukin-6...
March 19, 2019: Journal of Nephrology
Mary Waterhouse, Dallas R English, Bruce K Armstrong, Catherine Baxter, Briony Duarte Romero, Peter R Ebeling, Gunter Hartel, Michael G Kimlin, Donald S A McLeod, Rachel L O'Connell, Jolieke C van der Pols, Alison J Venn, Penelope M Webb, David C Whiteman, Rachel E Neale
Background: Many observational studies have reported an association between vitamin D and non-skeletal health outcomes. The D-Health Trial was launched to determine if supplementing the older population with high monthly doses of Vitamin D can prevent cancer and premature mortality. The intervention is ongoing but here we provide a detailed statistical analysis plan for the primary and secondary outcomes of the D-Health Trial. Methods/design: The D-Health Trial is a double-blind, randomized, placebo-controlled trial...
June 2019: Contemporary Clinical Trials Communications
Canan Gönen Aydın, Yaşar Mahsut Dinçel, Yavuz Arıkan, Süleyman Kasım Taş, Serdar Deniz
Objective: Nowadays, people tend to spend more time in the closed areas and benefit less from sunlight. In this study, we examined the results of vitamin D measurements of athletes from different disciplines in different months and aimed to determine if the synthesis of vitamin D decreases or not according to exercise environment and month. Methods: The study was conducted in participants aged 5-52 years. A total of 555 elite-level sportsmen who were admitted to our Sports Medicine Clinic in the study participated in this study...
2019: SAGE Open Medicine
Susanna Esposito, Alberto Leonardi, Lucia Lanciotti, Marta Cofini, Giulia Muzi, Laura Penta
BACKGROUND: Human growth is a complex mechanism that depends on genetic, environmental, nutritional and hormonal factors. The main hormone involved in growth at each stage of development is growth hormone (GH) and its mediator, insulin-like growth factor 1 (IGF-1). In contrast, vitamin D is involved in the processes of bone growth and mineralization through the regulation of calcium and phosphorus metabolism. Nevertheless, no scientific study has yet elucidated how they interact with one another, especially as a dysfunction in which one influences the other, even if numerous biochemical and clinical studies confirm the presence of a close relationship...
March 18, 2019: Journal of Translational Medicine
Araceli Muñoz-Garach, Beatriz García-Fontana, Manuel Muñoz-Torres
The relationship between vitamin D status, calcium intake and the risk of developing type 2 diabetes (T2D) is a topic of growing interest. One of the most interesting non-skeletal functions of vitamin D is its potential role in glucose homeostasis. This possible association is related to the secretion of insulin by pancreatic beta cells, insulin resistance in different tissues and its influence on systemic inflammation. However, despite multiple observational studies and several meta-analyses that have shown a positive association between circulating 25-hydroxyvitamin D concentrations and the risk of T2D, no randomized clinical trials supplementing with different doses of vitamin D have confirmed this hypothesis definitively...
March 16, 2019: Nutrients
Mahmoud Ali Kaykhaei, Mahdieh Khodadoost, Ali Reza Dashipour, Zahra Haidari, Azra Karimkoshteh, Mahnaz Sandoughi
INTRODUCTION: Vitamin D deficiency is a major health problem which affects about one billion people in the world. Although, vitamin D supplementation is recommended as standard treatment of vitamin D deficiency, there are controversies on dose response relationship. In this regard, the present study aimed to determine the impact of vitamin D3 supplement on raising of serum 25 hydroxyvitamin D[25(OH)D] in healthy subjects with varying degrees of vitamin D deficiency. MATERIALS AND METHODS: In this clinical trial 114 subjects with varying degrees of vitamin D deficiency were entered and divided into three groups: serum levels of 25(OH) D less than 10 ng/ml, 10-20 ng/ml, and 20-30 ng/ml...
March 14, 2019: Endocrine
Amanda R Vest, Michael Chan, Anita Deswal, Michael M Givertz, Carolyn Lekavich, Terry Lennie, Sheldon E Litwin, Lauren Parsly, Jo Ellen Rodgers, Michael W Rich, P Christian Schulze, Aaron Slader, Akshay Desai
Dietary guidance for patients with heart failure (HF) has traditionally focused on sodium and fluid intake restriction, but dietary quality is frequently poor in patients with HF and may contribute to morbidity and mortality. Restrictive dietary counselling can lead to inadequate intake of macronutrients and micronutrients by patients with HF, with the potential for deficiencies of calcium, magnesium, zinc, iron, thiamine, vitamins D, E, K, and folate. Although inadequate intake and low plasma levels of micronutrients have been associated with adverse clinical outcomes, evidence supporting therapeutic repletion is limited...
March 12, 2019: Journal of Cardiac Failure
Monika Berezowska, Shelly Coe, Helen Dawes
OBJECTIVE: to examine the extent of effect vitamin D in Multiple Sclerosis (MS) on pathology and symptoms. METHODS: A literature search was performed in November 2018 (CRD42018103615). Eligibility criteria: randomised control trials in English from 2012 to 2018; a clinical diagnosis of MS; interventions containing vitamin D supplementation (vitamin D3 or calcitriol) in disease activity compared to a control/placebo; improvement in: serum 25(OH)D, relapse rates, disability status by Expanded Disability Status Scale (EDSS) scores, cytokine profile, quality of life, mobility, T2 lesion load and new T2 or T1 Gd enhancing lesions, safety and adverse effects...
March 14, 2019: International Journal of Molecular Sciences
Micaela C Karlsen, Gail Rogers, Akari Miki, Alice H Lichtenstein, Sara C Folta, Christina D Economos, Paul F Jacques, Kara A Livingston, Nicola M McKeown
Public interest in popular diets is increasing, in particular whole-food plant-based (WFPB) and vegan diets. Whether these diets, as theoretically implemented, meet current food-based and nutrient-based recommendations has not been evaluated in detail. Self-identified WFPB and vegan diet followers in the Adhering to Dietary Approaches for Personal Taste (ADAPT) Feasibility Survey reported their most frequently used sources of information on nutrition and cooking. Thirty representative days of meal plans were created for each diet...
March 14, 2019: Nutrients
Paula Guedes Cocate, Gilberto Kac, Berit L Heitmann, Paulo Nadanovsky, Maria Cláudia da Veiga Soares Carvalho, Camila Benaim, Michael Maia Schlüssel, Maria Beatriz Trindade de Castro, Nadya Helena Alves-Santos, Amanda Farnum Baptista, Michael F Holick, Rana R Mokhtar, Alessandra Raymundo Bomfim, Amanda Rodrigues Amorim Adegboye
Background: Periodontitis is a common oral inflammation, which is a risk factor for adverse pregnancy outcomes. Intakes of vitamin D and calcium are inversely associated with occurrence and progression of periodontitis. This study aims to assess the feasibility of a multi-component intervention, including provision of milk powder supplemented with calcium and vitamin D and periodontal therapy (PT), for improving maternal periodontal health and metabolic and inflammatory profiles of low-income Brazilian pregnant women with periodontitis...
2019: Pilot and Feasibility Studies
Minjia Mo, Shijie Wang, Zun Chen, Xiamusiye Muyiduli, Shuojia Wang, Yu Shen, Bule Shao, Minchao Li, Danqing Chen, Zexin Chen, Yunxian Yu
BACKGROUND/OBJECTIVES: Optimal doses of vitamin D (VitD) supplement in different populations are unclear. We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [25(OH)D] concentration, to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different populations. SUBJECTS/METHODS: Literature search was conducted in Embase, etc. Randomized controlled trials about VitD supplemental intakes and their effect on 25(OH)D concentration were enrolled...
March 14, 2019: European Journal of Clinical Nutrition
Sara Karimi, Sanam Tabataba-Vakili, Zahra Yari, Forough Alborzi, Mehdi Hedayati, Nasser Ebrahimi-Daryani, Azita Hekmatdoost
BACKGROUND: The optimum dosage for vitamin D supplementation has not yet been elucidated in patients with Ulcerative colitis (UC). The aim of this study was to investigate the effects of two vitamin D regimens in UC patients with vitamin D deficiency. METHODS: In this double blind randomized clinical trial, 50 patients with mild to moderate UC, who met inclusion criteria, received either 1000 or 2000 IU/day of vitamin D (as low dose or high dose group, respectively) for 12 weeks...
March 11, 2019: Nutrition Journal
Catherine A Chenard, Linda M Rubenstein, Linda G Snetselaar, Terry L Wahls
Multiple sclerosis (MS) is an incurable degenerative disease that attacks the central nervous system. Roy Swank proposed a low saturated fat diet to treat MS around 1950 and showed delayed disease progression in his patients. However, there is insufficient evidence to recommend this diet for MS and default dietary recommendations are the Dietary Guidelines for Americans (DGA). This study assessed the nutritional adequacy of seven-day menus developed by Swank and their compliance with the DGA; menus were modeled for comparison with the DGA Healthy US-Style Eating Pattern (HEP) for males and females 31⁻50 years...
March 13, 2019: Nutrients
Bianca M Arendt, Anastasia Teterina, Paulina Pettinelli, Elena M Comelli, David W L Ma, Scott K Fung, Ian D McGilvray, Sandra E Fischer, Johane P Allard
OBJECTIVE: The aim of this study was to determine whether hepatic gene expression related to hepatocellular carcinoma (HCC) is associated with disease severity and modifiable lifestyle factors in non-alcoholic fatty liver disease (NAFLD). METHODS: In a cross-sectional study, the associations between hepatic gene expression and liver histology, insulin resistance, anthropometrics, diet, and physical activity were assessed in patients with non-alcoholic steatohepatitis (NASH; n = 19) or simple steatosis (SS; n = 20)...
December 13, 2018: Nutrition
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