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NIR Fluorescence

Xuan Zhang, Li Zhang, Wei-Wei Ma, Yong Zhou, Zhen-Ni Lu, Suying Xu
A benzothiazole-based near-infrared (NIR) ratiometric fluorescent probe ( HBT-Cys ) was developed for discriminating cysteine (Cys) from homocysteine (Hcy) and glutathione (GSH). The probe was designed by masking phenol group in the conjugated benzothiazole derivative with methacrylate group that could be selectively removed by Cys, and therefore an intramolecular charge transfer (ICT) fluorescence was switched on in the NIR region. In the absence of Cys, the probe exhibited a strong blue fluorescence emission at 431 nm, whereas a NIR fluorescence emission at 710 nm was significantly enhanced accompanied by a decrease of emission at 431 nm in the presence of Cys, allowing a ratiometric fluorescence detection of Cys...
2019: Frontiers in Chemistry
Jiacheng Lin, Xiaodong Zeng, Yuling Xiao, Lin Tang, Jinxia Nong, Yufang Liu, Hui Zhou, Bingbing Ding, Fuchun Xu, Hanxing Tong, Zixin Deng, Xuechuan Hong
Near-infrared II fluorescence imaging holds great promise for in vivo imaging and imaging-guided surgery with deep penetration and high spatiotemporal resolution. However, most NIR-II aromatic luminophores suffer from the notorious aggregation-caused quenching (ACQ) effect in the aqueous solution, which largely hinders their biomedical application in vivo . In this study, the first NIR-II organic aggregation-induced emission (AIE) fluorophore ( HLZ-BTED ), encapsulated as nanoparticles ( HLZ-BTED dots) for in vivo biomedical imaging, was designed and synthesized...
January 28, 2019: Chemical Science
Xiong-Jie Zhao, Yu-Ting Li, Yu-Ren Jiang, Bing-Qing Yang, Ce Liu, Zhi-Hong Liu
Hydrogen sulfide (H2 S) has been considered to be involved in cytoprotective processes and redox signaling. It is very meaningful to track and analyze it in mitochondria. Herein, we report a novel "turn-on" mitochondria-targeting near-infrared fluorescent probe (Mito-NIR-SH) for detection of H2 S in living cells, which was designed and synthesized by introducing 2,4-dinitrophenyl as fluorescence quenching group and H2 S response moiety into Changsha near-infrared fluorophore (CS-OH). The structure of the fluorophore and the probe were characterized by 1 H NMR, 13 C NMR and mass spectrometry...
May 15, 2019: Talanta
Bruno F O Nascimento, Nelson A M Pereira, Artur J M Valente, Teresa M V D Pinho E Melo, Marta Pineiro
Porphyrins are known therapeutic agents for photodynamic therapy of cancer and also imaging agents for NIR fluorescence imaging, MRI, or PET. A combination of interesting features makes tetrapyrrolic macrocycles suitable for use as theranostic agents whose full potential can be achieved using nanocarriers. This review provides an overview on nanotheranostic agents based on polymeric micelles and porphyrins developed so far.
February 15, 2019: Pharmaceutics
M Bedyńska, G Szewczyk, T Klepacka, K Sachadel, T Maciejewski, D Szukiewicz, A Fijałkowska
PURPOSE: To establish the surgical, demographic and histopathological factors associated with inaccurate sentinel lymph nodes (SLNs) identification using indocyanine green (ICG) and near-infrared (NIR) fluorescence imaging in uterine and cervical neoplasms during both open and laparoscopic surgery. METHODS: We reviewed patients with atypical endometrial hyperplasia (AEH), clinical stage I and II cervical cancer or uterine malignancies who underwent primary surgery with SLN mapping between September 2015 and January 2018...
February 14, 2019: Archives of Gynecology and Obstetrics
Hudifah Rabie, Yixiao Zhang, Nicholas Pasquale, Maureen J Lagos, Philip E Batson, Ki-Bum Lee
Nondestructive neurotransmitter detection and real-time monitoring of stem cell differentiation are both of great significance in the field of neurodegenerative disease and regenerative medicine. Although luminescent biosensing nanoprobes have been developed to address this need, they have intrinsic limitations such as autofluorescence, scattering, and phototoxicity. Upconversion nanoparticles (UCNPs) have gained increasing attention for various biomedical applications due to their high photostability, low auto-fluorescent background, and deep tissue penetration; however, UCNPs also suffer from low emission intensities due to undesirable energy migration pathways...
February 13, 2019: Advanced Materials
David Buhrke, Neslihan N Tavraz, Daria M Shcherbakova, Luisa Sauthof, Marcus Moldenhauer, Francisco Vélazquez Escobar, Vladislav V Verkhusha, Peter Hildebrandt, Thomas Friedrich
Phytochromes are red/far-red light sensing photoreceptors employing linear tetrapyrroles as chromophores, which are covalently bound to a cysteine (Cys) residue in the chromophore-binding domain (CBD, composed of a PAS and a GAF domain). Recently, near-infrared (NIR) fluorescent proteins (FPs) engineered from bacterial phytochromes binding biliverdin IXα (BV), such as the iRFP series, have become invaluable probes for multicolor fluorescence microscopy and in vivo imaging. However, all current NIR FPs suffer from relatively low brightness...
February 12, 2019: Scientific Reports
Xinqi Zhou, Yuan Fang, Lauren Lesiak, Cliff Stains
Chemotherapeutic agents generally suffer from off-target cytotoxicity in noncancerous cell types, leading to undesired side effects. As a result, significant effort has been put into identifying compounds that are selective for cancerous versus noncancerous cell types. Our lab has recently developed a series of near-infrared (NIR) fluorophores containing a phosphinate functionality at the bridging position of the xanthene scaffold, termed Nebraska Red (NR) fluorophores. Herein, we report the selective cytotoxicity of one NR derivative, NR744, against HeLa (cervical cancer) cells versus NIH-3T3 (noncancerous fibroblast) cells...
February 12, 2019: Chembiochem: a European Journal of Chemical Biology
Shashank Shankar Chetty, Selvarasu Praneetha, Kavitha Govarthanan, Rama Shanker Verma, Arumugam Vadivel Murugan
Acute liver injury is a critical syndrome ascribed to prevalent death of hepatocyte and imperatively requires a liver transplantation. Such methodology is certainly hampered due to deficit of healthy donors. In this regard, stem cells-based regenerative therapies are attractive in repairing injured tissues and organs for medical applications. However, it is crucial to understand the migration, engraftment and regeneration capabilities of transplanted stem cells in the living animal models. For the first time, we demonstrate rapid labeling of umbilical cord-derived mesenchymal stem cells (MSCs) with near-infrared (NIR) fluorescent CuInS2-ZnS nanocrystals (CIZS-NCs) to develop an innovative nano-bioconjugates (MSCs-CIZS-NBCs) that exhibit 98% labeling efficiency...
February 11, 2019: ACS Applied Materials & Interfaces
M Carmen Ortega-Liebana, M Mar Encabo-Berzosa, Alvaro Casanova, M Desiree Pereboom, Octavio Alda, Jose Luis Hueso, Jesus Santamaria
This work describes the synthesis of nitrogen-doped carbon nanodots (CNDs) synthesized from ethylene diamine tetra acetic acid (EDTA) as a precursor and their application as luminescent agents with a dual-mode theranostic role as near-infrared (NIR) triggered imaging and photodynamic therapy agents. Interestingly, these fluorescent CNDs are more rapidly and selectively internalized in tumor cells and exhibit no cytotoxicity until remotely activated with a NIR illumination source. These CNDs are excellent candidates for photo-theranostic purposes, i...
February 11, 2019: Chemistry: a European Journal
G Kate Park, Jeong Heon Lee, Andrew Levitz, Georges El Fakhri, Nathaniel S Hwang, Maged Henary, Hak Soo Choi
Longitudinal tracking of living cells is crucial to understanding the mechanism of action and toxicity of cell-based therapeutics. To quantify the presence of administered cells in the host tissue without sacrifice of animals, labeling of the target cells with a nontoxic and stable contrast agent is a prerequisite. However, such long-term live cell tracking is currently limited by the lack of fluorophores with steady optical and physicochemical properties in the near-infrared (NIR) window. Herein, for the first time, the design of fixable cell-tracking NIR fluorophores (CTNFs) with high optical properties, excellent cell permeation and retention, and high stability against chemical treatments is reported...
February 10, 2019: Advanced Materials
Xianfeng Lin, Xiuhong Lu, Junliang Zhou, Hang Ren, Xiaochun Dong, Weili Zhao, Zhongjian Chen
Novel cyanine-based fluorescent probes for the detection of H2 S were developed. The probes developed are stable under physiological conditions. The water soluble fluorescent probe 2 displayed ultrafast and specific response to H2 S displaying NIR fluorescence of 115-fold turn-on with the detection limit of 11 nM without assistance of organic solvent or surfactant. Cell imaging experiments indicated that probe 2 was cell-permeable and was able to detect H2 S sensitively in lysosomes. Moreover, our probe was able to detect H2 S intrinsically produced H2 S through enzymatic/non-enzymatic biosynthetic pathway from Cys/GSH...
January 30, 2019: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Aimee DiMarco, Ravi Chotalia, Ruth Bloxham, Charlotte McIntyre, Neil Tolley, F Fausto Palazzo
BACKGROUND: The inability to identify the pathological gland at surgery results in failure to cure hyperparathyroidism in 2-5%. The poorly understood characteristic of parathyroid tissue to manifest autofluorescence (AF) under near-infrared (NIR) light has been promoted as an intraoperative adjunct in parathyroid surgery. This study sought to explore potential clinical correlates for AF and assess the clinical utility of AF in parathyroid surgery. METHODS: Consecutive patients undergoing parathyroid surgery for primary and renal disease were included...
February 8, 2019: World Journal of Surgery
Pranav Mandovra, Vishaka Kalikar, Roy V Patankar
BACKGROUND: Intraoperative ureteral injury is rare, but a grave complication during laparoscopic surgery. Several methods for intraoperative localization of ureters are described with their own pitfalls. Intraoperative localization using near-infrared (NIR) fluorescence with indocyanine green (ICG) is an easier and assured method during laparoscopic pelvic surgeries. METHOD: From September 2017 to December 2017, patients undergoing laparoscopic pelvic surgeries were administered cystoscopic-guided intraureteral ICG immediately preoperatively with tip of a 6-Fr ureteral catheter...
February 8, 2019: Surgical Innovation
Simona la Gatta, Francesco Milano, Gianluca M Farinola, Angela Agostiano, Mariangela Di Donato, Andrea Lapini, Paolo Foggi, Massimo Trotta, Roberta Ragni
The photosynthetic Reaction Center (RC) from the purple bacterium Rhodobacter sphaeroides has unique photoconversion capabilities, that can be exploited in assembly biohybrid devices for applications in solar energy conversion. Extending the absorption cross section of isolated RC through covalent functionalization with ad-hoc synthesized artificial antennas is a successful strategy to outperform the efficiency of the pristine photoenzyme under visible light excitation. Here we report a new heptamethine cyanine antenna that, upon covalent binding to RC, forms a biohybrid (hCyN7-RC) which, under white light excitation, has doubled photoconversion efficiency versus the bare photoenzyme...
February 2, 2019: Biochimica et biophysica acta. Bioenergetics
Yan Gao, Fei Wang, Weicheng Huang, Chunyu Yang, Wei Guo, Chuanqi Song, Qun Zhang, Bin Yang, Yanling Xu, Chongshen Guo
Precise oncotherapy requires effective cancer treatments that are guided by clinical imaging techniques. One of the most representative cases is multi-imaging-guided phototherapy. This study presents a novel multifunctional theranostic agent of SnxWO3 tungsten bronze, which is an excellent light absorber in the near infrared (NIR) range. Theoretical calculations based on density functional theory confirm that the insertion of donor Sn atoms into orthorhombic WO3 gives rise to the broadband visible-NIR absorption...
February 5, 2019: Nanoscale
Lei G Wang, Ian Munhenzva, Martha Sibrian-Vázquez, Jorge O Escobedo, Catherine H Kitts, Frank R Fronczek, Robert M Strongin
Fluorescent small molecules enable researchers and clinicians to visualize biological events in living cells, tissues, and organs in real time. Herein, the focus is on the structure and properties of the relatively rare benzo[a]xanthenes that exhibit enhanced steric and electronic interactions due to their annulated structures. Three types of fluorophores were synthesized: (i) pH and solvent dependent seminaphtho-rhodafluors, (ii) pH and solvent independent seminaphthorhodafluors, and (iii) pH-independent but solvent sensitive seminaphthorho-damines...
February 5, 2019: Journal of Organic Chemistry
Jyoti Roy, Miranda Kaake, Philip S Low
Overexpression of Luteinizing Hormone Releasing Hormone Receptor (LHRH-R) in various cancers and restricted expression of the receptor in healthy cells qualifies it as a valuable cancer biomarker. Previously, LHRH-R targeted peptides have been utilized to deliver attached payloads to LHRH-R expressing cancers. We report here for the first time the utilization of a small molecule non-peptidic ligand (BOEPL) of LHRH-R to deliver attached payloads to LHRH-R positive tumors. For this purpose, we linked the BOEPL ligand to a near infrared dye via various linkers...
January 4, 2019: Oncotarget
Jianhua Zou, Peng Wang, Ya Wang, Gongyuan Liu, Yewei Zhang, Qi Zhang, Jinjun Shao, Weili Si, Wei Huang, Xiaochen Dong
Improving the deep-tissue phototherapy (PDT) efficiency in the near-infrared (NIR) region has become one of the major challenges in clinics for cancer treatment. Developing intelligent photosensitizers (PSs) responding to tumor-specific signals sensitively to minimize side effects is another major challenge for tumor phototherapy. Herein, three phenyl-based boron dipyrromethene (BODIPY) compounds with different numbers of diethylaminophenyl groups introduced onto the BODIPY core have been designed and synthesized by the Knoevenagel condensation reaction...
January 7, 2019: Chemical Science
Wei-Kai Tsai, Chun-I Wang, Chia-Hsien Liao, Chun-Nien Yao, Tsai-Jhen Kuo, Ming-Ho Liu, Chao-Ping Hsu, Shu-Yi Lin, Chang-Yi Wu, Joseph R Pyle, Jixin Chen, Yang-Hsiang Chan
Semiconducting polymer dots (Pdots) have recently emerged as a new type of ultrabright fluorescent probe that has been proved to be very useful for biomedical imaging. However, Pdots often suffer from serious fluorescence aggregation-caused quenching (ACQ) especially for near-infrared (NIR) fluorescent Pdots. This article compared two strategies to overcome the ACQ effect in near-infrared emissive Pdot systems: aggregation-induced emission (AIE) and anti-aggregation-caused quenching (anti-ACQ). The results show that the anti-ACQ platform outperforms the AIE system...
January 7, 2019: Chemical Science
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