Mai Owari, Kayo Harada-Shirado, Ryuichi Togawa, Masahiko Fukatsu, Yuki Sato, Koichiro Fukuchi, Mamiko Endo, Hiroshi Takahashi, Satoshi Kimura, Tsukasa Osaki, Masayoshi Souri, Akitada Ichinose, Yoko Shibata, Yuko Hashimoto, Takayuki Ikezoe
Acquired von Willebrand syndrome (aVWS) develops with various underlying diseases. We herein report an individual with aVWS associated with mucosa-associated lymphoid tissue lymphoma in the lungs complicated by hyperviscosity syndrome, Sjögren's syndrome, and hypothyroidism. This patient developed life-threatening hemorrhaging during a lung biopsy despite transfusion of concentrate of plasma-derived VWF/factor VIII. The use of rituximab caused remission of the lymphoma and hyperviscosity syndrome in parallel with the resolution of aVWS...
July 22, 2022: Internal Medicine