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Osteoarthritis and platelet rich plasma treatment.

Brendan O'Connell, Nicholas Martin Wragg, Samantha Louise Wilson
Osteoarthritis (OA) is a degenerative disease involving joint damage, an inadequate healing response and progressive deterioration of the joint architecture that commonly affects the knee and/or hip joints. It is a major world public health problem and is predicted to increase rapidly with an ageing population and escalating rate of obesity. Autologous blood-derived products possess much promise in the repair and regeneration of tissue and have important roles in inflammation, angiogenesis, cell migration and metabolism in pathological conditions, including OA...
February 13, 2019: Cell and Tissue Research
Volkan Subaşı, Timur Ekiz
This paper presents the cases of 3 females with knee osteoarthritis. All 3 received a single bone marrow aspiration concentrate (BMAC) injection followed one month later by a platelet-rich plasma (PRP) injection. Compared with the baseline values, pain and functionality scores improved in all the patients. The aim of presenting these cases is to highlight that the combined use of intra-articular BMAC and PRP treatments may have positive effects on pain, functional status and quality of life in patients with knee osteoarthritis...
February 2019: Complementary Therapies in Clinical Practice
Janine McKay, Kristian Frantzen, Neeltje Vercruyssen, Kholoud Hafsi, Tyler Opitz, Amelia Davis, William Murrell
The purpose of this manuscript is to provide a current concept review for the rehabilitative management of knee osteoarthritis (KOA) following regenerative medicine intervention. A proposed comprehensive regenerative rehabilitative program has been created, based on a literature review of the current best practices of rehabilitative methods and non-operative management in KOA patients with an emphasis on the goals of regenerative medicine: to optimize self-healing and functional tissue recovery. Regenerative medicine promotes regeneration and joint restoration by using blood-based procedures such as platelet rich plasma, stem cell and cell-based or tissue engineering...
January 2019: Journal of Clinical Orthopaedics and Trauma
Maimuna Marenah, Jinjie Li, Ashok Kumar, William Murrell
The economic and human cost of knee osteoarthritis is forecast to increase. This will impact not only aging individuals, but also the working age members of emerging economies. The current treatment pathways are often costly, time-consuming, and insufficient to manage the degeneration of the knee over the ever-increasing lifespan of patients around the world. In response to the shortcomings of a focus on symptom management, international and high-impact regulators, researchers, clinicians, and most importantly patients, are increasingly interested in the possible management of knee osteoarthritis with novel therapies in the field of regenerative medicine treatments...
January 2019: Journal of Clinical Orthopaedics and Trauma
Diego Delgado, Ane Garate, Hunter Vincent, Ane Miren Bilbao, Rikin Patel, Nicolás Fiz, Steve Sampson, Mikel Sánchez
Knee osteoarthritis (OA) is a degenerative process that slowly destroys the joints producing pain and loss of function, and diminishes the quality of life. Current treatments alleviate this symptomatology but do not stop the disease, being total knee arthroplasty the only definitive solution. Among the emerging treatments, Platelet-Rich Plasma (PRP) has shown promising results in the treatment of OA. However, to improve its effectiveness, it is necessary to approach this pathology targeting the whole joint, not only the cartilage, but including other tissues such as subchondral bone...
January 2019: Journal of Clinical Orthopaedics and Trauma
Mandeep S Dhillon, Sandeep Patel, Tungish Bansal
Platelet rich plasma (PRP) has clearly emerged offering a possible solution that could modify the disease process and offer symptomatic relief in early osteoarthritis of knee. Great efforts are underway to improve PRP products for use in knee osteoarthritis (OA). Upcoming research is focused on the ideal PRP type, dose, frequency of injection and mode of injection. The combination of PRP with biocompatible carriers/scaffolds like gelatin hydrogel and chitosan appear to be promising based on early in vitro and animal studies...
January 2019: Journal of Clinical Orthopaedics and Trauma
Pedro Iván Arias-Vázquez, Carlos Alfonso Tovilla-Zárate, Yazmín Hernández-Díaz, Thelma Beatriz González-Castro, Isela Esther Juárez-Rojop, María Lilia López-Narváez, Deysi Yadira Bermudez-Ocaña, Hugo Adrián Barjau-Madrígal, Gabriela Legorreta-Ramírez
BACKGROUND: Ozone therapy has been widely used to decrease pain related to osteoarthritis, but the effectiveness of this treatment has not been evaluated. OBJECTIVE: To evaluate the effectiveness of ozone therapy in the reduction of pain in patients with knee OA, according to the type of intervention and duration of the effect. TYPE: Meta-analysis LITERATURE SURVEY: We performed an online search using PUBMED, DIALNET, SCIELO, MEDIGRAPHIC and ISCO3 databases. We searched for articles published up to January 2018...
January 28, 2019: PM & R: the Journal of Injury, Function, and Rehabilitation
Ziming Chen, Zhantao Deng, Yuanchen Ma, Junxing Liao, Qingtian Li, Mengyuan Li, Hua Liu, Ganghong Chen, Chaoming Zeng, Qiujian Zheng
Knee osteoarthritis (KOA) is one of the most frequently encountered diseases in the orthopedic department. Existing non-surgical treatments have a limited effect on the repair of cartilage and on bone regeneration. Platelet-rich plasma (PRP) is an autologous bioactive substance that can repair cartilage injury and accelerate bone regeneration effectively. However, reporting of PRP preparation protocols in clinical studies is highly inconsistent, with the majority of studies providing insufficient information to allow the protocol to be reproduced...
January 4, 2019: Journal of Visualized Experiments: JoVE
Francesca Zotti, Massimo Albanese, Luigi Fabrizio Rodella, Pier Francesco Nocini
BACKGROUND: The aims of this narrative review were to examine up-to-date literature in order to evaluate the effectiveness of arthrocentesis or injections with platelet-rich plasma in temporomandibular affections and to compare them to arthrocentesis alone or with hyaluronic acid (HA) or to hyaluronic acid injections. METHODS: The search of international literature was made on the PMC, PubMed and Cochrane databases, including all full-length text of studies on humans focused on osteoarthritis and disc displacements and their treatment with platelet-rich plasma arthrocentesis or injections...
January 11, 2019: International Journal of Molecular Sciences
Ece Uslu Güvendi, Ayhan Aşkin, Güven Güvendi, Hikmet Koçyiğit
Objectives: This study aims to assess whether platelet rich plasma (PRP) is an effective treatment for knee osteoarthritis, and compare its efficiency with corticosteroid treatment in terms of pain control, physical function, and quality of life. Patients and methods: The study included 50 patients (4 males, 46 females; mean age 61.6±6.9 years; range 50 to 75 years) who were diagnosed as grade 3 knee osteoarthritis. Patients were randomized into three groups as corticosteroid group (receiving one corticosteroid injection), single PRP group (receiving one PRP injection), and three PRP group (receiving three PRP injections with one week interval)...
September 2018: Archives of rheumatology
Yong Huang, Xiaolu Liu, Xinliang Xu, Junbin Liu
BACKGROUND: Knee osteoarthritis (KOA) is a degenerative joint disease leading to pain and disability for which no curative treatment exists. Intra-articular (IA) therapies are part of this multimodal approach and are approved by the Food and Drug Administration (FDA) and European Medicines Agency (EMA). Platelet-rich plasma (PRP), hyaluronic acid (HA), and corticosteroids (CS) have been increasingly used in recent years to treat KOA. PURPOSE: To determine whether IA-PRP was superior to IA-HA or IA-CS administration routes in these patients...
January 8, 2019: Der Orthopäde
Ronald E Delanois, Jennifer I Etcheson, Nipun Sodhi, Ralph F Henn, Chukwuweike U Gwam, Nicole E George, Michael A Mont
BACKGROUND: The use of biologic therapies for the management of knee osteoarthritis has increased, despite insufficient evidence of efficacy. Our aim was to complete a systematic review and analysis of reports utilizing the highest level-of-evidence evaluating: (1) platelet-rich plasma injections (PRPs); (2) bone marrow-derived mesenchymal stem cells (BMSCs); (3) adipose-derived mesenchymal stem cells (ADSCs); and (4) amnion-derived mesenchymal stem cells (AMSCs). METHODS: PubMed, Embase, and Cochrane Library databases were queried for studies evaluating PRP injections, BMSCs, ADSCs, and AMSCs in patients with knee osteoarthritis...
December 17, 2018: Journal of Arthroplasty
Jorge Chahla, Brian J Cole
Osteoarthritis (OA) constitutes a significant cause of disability, and it is now recognized as a source of increased mortality. Thus, several therapeutic approaches have been reported in the literature in an attempt to mitigate the symptoms of OA with varying degrees of success. Platelet-rich plasma (PRP) is being increasingly accepted as one of the most efficacious approaches for the symptomatic treatment of mild to moderate OA. Several confounding factors can affect the outcome of PRP such as age, grade of OA, PRP processing technique, and number and timing of these injections...
January 2019: Arthroscopy: the Journal of Arthroscopic & related Surgery
Kuan-Yu Lin, Chia-Chi Yang, Chien-Jen Hsu, Ming-Long Yeh, Jenn-Huei Renn
PURPOSE: To prospectively compare the efficacy of intra-articular injections of platelet-rich plasma (PRP) and hyaluronic acid (HA) with a sham control group (normal saline solution [NS]) for knee osteoarthritis in a randomized, dose-controlled, placebo-controlled, double-blind, triple-parallel clinical trial. METHODS: A total of 87 osteoarthritic knees (53 patients) were randomly assigned to 1 of 3 groups receiving 3 weekly injections of either leukocyte-poor PRP (31 knees), HA (29 knees), or NS (27 knees)...
January 2019: Arthroscopy: the Journal of Arthroscopic & related Surgery
Alfonso Vaquero-Picado, E Carlos Rodríguez-Merchán
From the biomechanical and biological points of view, an arthroscopic meniscal repair (AMR) should always be considered as an option. However, AMR has a higher reoperation rate compared with arthroscopic partial meniscectomy, so it should be carefully indicated.Compared with meniscectomy, AMR outcomes are better and the incidence of osteoarthritis is lower when it is well indicated.Factors influencing healing and satisfactory results must be carefully evaluated before indicating an AMR.Tears in the peripheral third are more likely to heal than those in the inner thirds...
November 2018: EFORT Open Reviews
Alessandro Di Martino, Berardo Di Matteo, Tiziana Papio, Francesco Tentoni, Filippo Selleri, Annarita Cenacchi, Elizaveta Kon, Giuseppe Filardo
BACKGROUND: Platelet-rich plasma (PRP) injections have been proposed as a new conservative option for knee degeneration to provide symptomatic relief and delay surgical intervention. Although the current literature provides some evidence on the benefits of this technique compared with viscosupplementation, no studies have been performed to compare their long-term effects. PURPOSE: To compare the long-term clinical outcomes provided by intra-articular injections of either PRP or hyaluronic acid (HA) to treat knee degenerative disease...
December 13, 2018: American Journal of Sports Medicine
Jose C Alcerro, Carlos J Lavernia
INTRODUCTION: The use of stem cell therapy (SCT) and platelet-rich plasma (PRP) injection for knee osteoarthritis (OA) is extremely controversial and at best experimental stage. These treatments are being offered across the nation for "cash-only payments." Our objectives were to determine (1) what proportion of board-certified orthopedic surgeons in Miami-Dade County offer SCT or PRP and (2) how much do practices charge for these services. METHODS: All board-certified orthopedic surgeons' offices in Miami-Dade County were identified by their American Academy of Orthopaedic Surgeons active membership...
November 28, 2018: Journal of the American Academy of Orthopaedic Surgeons
Ian A Jones, Ryan Togashi, Melissa L Wilson, Nathanael Heckmann, C Thomas Vangsness
Intra-articular drug delivery has a number of advantages over systemic administration; however, for the past 20 years, intra-articular treatment options for the management of knee osteoarthritis (OA) have been limited to analgesics, glucocorticoids, hyaluronic acid (HA) and a small number of unproven alternative therapies. Although HA and glucocorticoids can provide clinically meaningful benefits to an appreciable number of patients, emerging evidence indicates that the apparent effectiveness of these treatments is largely a result of other factors, including the placebo effect...
February 2019: Nature Reviews. Rheumatology
J A Annaniemi, J Pere, S Giordano
BACKGROUND AND AIMS: Intra-articular injections of viscosupplements have been an option in the treatment of knee osteoarthritis. Platelet-rich plasma is an experimental treatment in osteoarthritis. Previous studies have shown that platelet-rich plasma reduces osteoarthritis symptoms in similar proportions as viscosupplements. The aim of this study was to compare platelet-rich plasma versus viscosupplements in terms of symptoms' relief and time to arthroplasty. MATERIAL AND METHODS: A total of 190 patients included in this retrospective study received either intra-articular injections of platelet-rich plasma (94 patients) or hyaluronic acid (86 patients) between January 2014 and October 2017...
November 25, 2018: Scandinavian Journal of Surgery: SJS
Taylor M Southworth, Neal B Naveen, Benedict U Nwachukwu, Brian J Cole, Rachel M Frank
Focal chondral defects of the knee are extremely common and often result in pain, dysfunction, joint deterioration, and, ultimately, the development of osteoarthritis. Due to the limitations of conventional treatments for focal chondral defects of the knee, orthobiologics have recently become an area of interest. Orthobiologics used for cartilage defects include (but are not limited to) bone marrow aspirate concentrate, adipose-derived mesenchymal stem cells, platelet-rich plasma, and micronized allogeneic cartilage...
January 2019: Clinics in Sports Medicine
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